Genetics and genomics

This project tests whether common nanoplastics that people ingest could damage the gut barrier, alter gut microbes’ estrogen metabolism, and injure enteric nerves — processes that might increase risk or severity of IBD.

Researchers aim to build and study tiny gut phages (Microviridae) that are largely known only from DNA sequences. Learning how these phages shape microbial communities could help explain virome-linked changes seen in...

Genetic evidence for causal links between other diseases (for example asthma or multiple sclerosis) and IBD can help researchers prioritize biological pathways and potential therapeutic targets, and may explain why some...

This atlas maps when and where regenerative gene programs turn on in the intestine and highlights molecular features (like interferon responses and hypertranscription) that overlap with human Crohn’s disease, so it could...

This study builds a large, public single-cell map of the gut in Crohn’s disease that identifies cell types and gene programs linked to inflammation. That can help researchers find new drug targets and explain why some...

The work highlights macrophage metabolic programs and specific genes that may help classify UC molecular subtypes and suggest candidate biomarkers or therapeutic targets related to macrophage-driven inflammation.

If AJs and E-cadherin signaling influence intestinal inflammation, that could change how researchers think about IBD causes and point to new molecular targets for study.

The study suggests that genetic and single-cell signatures of cellular senescence may affect IBD susceptibility, pointing to possible new biomarkers or pathways relevant to disease risk and future therapies.

The work searches for shared blood-based gene signatures and biomarkers across HLA-B27–linked diseases (including Crohn’s disease and ulcerative colitis), which could point to common mechanisms or cross-disease...

Understanding PTMs may help researchers identify new biomarkers or therapeutic targets for ulcerative colitis, which could eventually lead to better treatments or tests. For people with UC, this explains part of why...

Researchers working on IBD molecular mechanisms or biomarker discovery may find this AI-driven approach useful because it can detect temporal gene-expression patterns and suggest pathways linked to treatment response...

The paper proposes ISG20 as a shared molecular link between RA and IBD, which could help explain why the two diseases co-occur and point to a candidate biomarker for identifying patients at risk of both conditions.

This work suggests that non-immune stromal cells can hold an epigenetic ‘memory’ that keeps intestinal tissue in a disease-promoting state, which may help explain relapse or incomplete responses to immune-focused...

Cure8 found this source from The Journal of investigative dermatology, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease, Genetics and genomics, and Research and clinical trials....

The project aims to enable simultaneous RNA-level profiling of microbes and host cells from human biopsies, which could reveal early microbial and host gene-expression patterns linked to subclinical Crohn’s disease and...

Blood biomarkers that predict vedolizumab response could help patients and clinicians choose the most effective therapy sooner and avoid ineffective treatments. The study suggests LRG and MCP‑1 may differentiate...

People with UC face higher cardiovascular risk; this study links a specific ITGA4 genetic variant (rs1143674 CC) with subclinical atherosclerosis in UC patients over 40, which could help identify higher-risk individuals...

People with IBD may care because this study connects a genetic risk region to a molecular mechanism that restrains inflammation in T cells, offering a potential new biological clue about disease causes and future...

If validated, blood-based AI predictors of organ-specific aging might help flag organs aging faster in people with Crohn’s disease or other conditions, potentially enabling earlier monitoring or research into causes....

This project aims to improve prediction of autoimmune disease onset and immunotherapy-related autoimmunity by combining genetics and plasma proteins.

This study links genetic risk variants to how intestinal epithelial cells respond and regenerate, which is directly relevant to IBD where barrier function and inflammation matter.

This work points to new genes and immune-cell mechanisms that could help explain unexplained genetic risk for Crohn’s disease and suggests that genes known for other diseases might play unanticipated roles in gut...

The study proposes two transcriptomic markers (LIMK1, PKM) that may help characterize an IBD-associated, mitochondria–ER membrane–related transcriptional state and could guide future biomarker or mechanistic research.

Identifies gene and microbiome patterns linked to progression from inflammation to irreversible bowel fibrosis in Crohn’s disease, which could eventually help predict who is at higher risk and inform prevention...

IBD patients face higher risk of osteoporosis; identifying shared, apoptosis-related genes may help explain why and point to future biomarkers or therapeutic targets. The study links specific genes (WNT1, S100A8) to both...

Fibrosis (irreversible bowel scarring) is a major cause of surgery in Crohn’s disease. This study points to molecular and microbiome patterns that may help predict or distinguish fibrosis from active inflammation, which...

Fibrosis (irreversible bowel scarring) is a major cause of surgery in Crohn’s disease. Identifying molecular and microbial markers tied to fibrosis could eventually help predict who’s at higher risk and guide earlier,...

Identifies candidate gene signatures tied to MAM-related transcriptional states in IBD that could become biomarkers or guide mechanistic research into immune–metabolic pathways relevant to disease.

The study links shared gene-expression patterns between IBD and ankylosing spondylitis and highlights STAT3 as a potential shared biomarker or therapeutic target, which could be relevant for understanding overlapping...

The study identifies shared genetic signals and cell types (especially T cells) between ulcerative colitis and psoriasis, which could help explain their clinical co-occurrence and suggest pathways for future research or...

This study links blood gene signatures shared between Parkinson’s disease and intestinal inflammation to astrocyte-associated molecular changes in the brain, identifying HSP90AA1 as a candidate stress-responsive hub.

This study maps how Crohn’s-associated genetic variants may act at a distance in specific immune cells (ILC3), revealing new candidate genes and mechanisms — including an unexpected role for CLN3 — that could point to...

This project seeks to clarify how gut microbes and diet drive CD4+ T cell responses—mechanisms that are central to intestinal tolerance and to diseases like IBD. A better map of TCR–antigen pairs and how tolerance breaks...

First‑degree relatives of people with IBD may worry about their own risk and consider diet as a way to reduce that risk. The study suggests how beliefs about genetics and diet influence whether relatives make preventive...

Many people with Crohn’s disease have ongoing inflammation despite stable medication. If dietary personalization can reduce inflammation, it could offer a nonpharmacologic add-on to help bridge gaps without immediate...

Researchers and clinicians looking for blood- or tissue-based molecular tests for IBD may find these integrated transcriptomic analyses useful because they identify candidate diagnostic biomarkers and highlight shared...

If you are Ashkenazi Jewish or care for someone who is, research shows higher group-level risk for Crohn’s disease, ulcerative colitis and lactose intolerance—so awareness and early evaluation for gut symptoms may be...

This study expands knowledge of UC genetics in an understudied Indian population and points to genes and pathways that could help explain disease mechanisms different from those identified in Western cohorts. That could...

The work narrows down which genes are likely influenced by Crohn’s disease–associated regulatory DNA in a specific gut immune cell type, helping researchers prioritize targets and understand disease mechanisms.

Finding shared genes (CLDN8, ABCA12) suggests common inflammatory mechanisms between ulcerative colitis and psoriasis, which could inform future biomarkers or therapies relevant to patients with either or both...

The study links patient-specific non-coding genetic variation to epithelial regulatory networks and to differences in disease severity and response in a large UC trial, suggesting genetics could help explain why some...

Epigenetic control of intestinal epithelial cells can shape gut microbes and influence colitis severity; understanding SETD2’s role could point to new mechanistic targets for IBD research and microbiome-directed...

Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Genetics and genomics. The original article is from msn.com.

The work helps bridge genetic association signals and the specific immune cells in the intestine where they may act, offering new candidate genes and a method that can probe rare cell types important to IBD biology.

ILC3s live in the intestine and help regulate barrier function and inflammation, so mapping how genetic variants affect gene regulation in these rare cells helps connect inherited risk signals to plausible biology for...

Mapping 3D genome contacts in rare gut immune cells connects Crohn’s disease genetic risk variants to specific genes and pathways, which can clarify disease mechanisms and guide future drug-target research. The study...

ILC3s are rare but important for gut immunity; linking Crohn’s disease genetic risk to the genes they regulate helps move from statistical association toward biological mechanisms that could explain disease pathways.

This study helps move beyond assigning GWAS risk variants to the nearest gene by mapping 3D promoter contacts in gut-enriched ILC3s, so it uncovers new candidate genes and pathways that could explain Crohn’s and other...