Clinical trials, biomarkers, microbiome, genetics, AI, basic science, and emerging IBD research.
Page 14 of 65 · 3081 articles
A single‑patient report suggests guselkumab (IL‑23 inhibitor) may control both refractory pyoderma gangrenosum and coexisting Crohn disease when several prior treatments failed.
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Journal of Drug Delivery Science and...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Chemical Engineering...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Colloids and Surfaces...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis and Research and clinical trials. The original article is from Biochemical and Biophysical Research Communications.
A multimodal, simpler activity score could improve practical disease monitoring when full ileocolonoscopy isn’t possible and help standardize treat-to-target practice across centers.
The study identifies an A. muciniphila strain (WW001) that strengthened barrier function and reduced inflammation in lab and mouse models of colitis, pointing to a possible microbiome-based probiotic strategy for IBD...
FMT is an active area of research that could affect future IBD treatments; patients with IBD commonly experience obesity and complex care decisions. Updates on FDA-approved FMT products and ongoing Crohn’s studies may...
The review and original research highlighted here focus on AI-driven multi-omics and single-cell approaches that aim to improve biomarker discovery, diagnosis, and personalized treatment strategies relevant to Crohn’s...
Routinely collected healthcare data can reveal how Crohn’s disease is managed and experienced in everyday practice, helping fill gaps left by clinical trials. A broader, data-driven measure of disease burden could better...
Interstitial lung disease (ILD) is an underrecognized extraintestinal complication in IBD that in this study was relatively common (12%) and associated with a substantially increased risk of death.
A validated prediction score that reliably rules out clinically significant CT findings could reduce unnecessary CT imaging, radiation exposure, and costs for people with Crohn's disease experiencing acute symptoms.
Circulating glycoprotein signals may help explain how systemic inflammation in IBD interacts with metabolic liver disease (MASLD). If validated, they could improve risk stratification for liver complications beyond...
Organoid models aim to reproduce human intestinal biology more closely than traditional cell lines or animal models, which could improve understanding of IBD mechanisms and help develop or personalize therapies.
This press release signals a step toward a new local, regenerative approach for treating complex perianal fistulas—a difficult Crohn’s complication with limited options. If clinical trials proceed, the therapy could add...
The study shows functional differences in how Crohn’s versus healthy fecal microbiota ferment substrates, with CD cultures making less beneficial butyrate and more ethanol/amino acids. That could inform future...
The study links macrophage CD38-driven NAD depletion to intestinal inflammation and shows that restoring NAD or blocking CD38 reduced disease in experimental colitis—suggesting a new metabolic target for IBD therapies.
This trial tests a non‑invasive capsule that samples the small intestine directly to search for microbial or metabolite signatures linked to symptoms and disease. If successful, it could help researchers identify...
Understanding why some IBD ulcers fail to heal could help researchers develop better treatments or biomarkers to predict healing, which matters because mucosal healing reduces hospitalizations, surgeries, and cancer...
Timing of mesalamine might change how much drug reaches the colon, gut inflammation markers, and the microbiome — which could affect symptom control or monitoring for people with UC. This trial tests that idea in people...
A microbiome-targeted, food-grade supplement could offer a non-immunosuppressive option for people with mild-to-moderate ulcerative colitis who remain inflamed or want to delay immunosuppressive/biologic therapy. The...
This registry will gather real-world safety and effectiveness data on infliximab in Chinese children with moderate-to-severe Crohn's disease, which can help clinicians and families understand how the drug performs...
The study identifies CDK9 inhibition as a way to reduce IL‑6/STAT3 signaling and protect the colonic epithelial barrier in preclinical models, suggesting a potential new therapeutic approach for ulcerative colitis...
IBD and obstructive sleep apnea may influence each other through shared biological processes (barrier dysfunction, dysbiosis, immune activation, intermittent hypoxia), so understanding this could affect screening and...
Viruses in the gut (including bacteriophages) could influence inflammation and the intestinal barrier in IBD, so understanding the virome may point to new research directions or therapies.
The work suggests specific host genes and cell types that might mediate links between gut microbes and IBD, which could direct future laboratory research into mechanisms and potential biomarkers.
Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Radiation...
Shorter hospital stay after colorectal surgery can reduce disruption, infection risk, and costs. This review suggests ERAS pathways can shorten length of stay for people with IBD without increasing short-term...
This case series points to risankizumab as a potential option for children with IBD who have failed multiple biologics, and it reports use of noninvasive monitoring like intestinal ultrasound.
The article reports a new oral nanozyme that combines imaging and ROS-scavenging therapy aimed at IBD lesions—an early-stage approach that could one day enable targeted, noninvasive treatment and lesion tracking.
Children with Crohn's and their clinicians often need noninvasive, accessible ways to monitor small-bowel disease. If validated elsewhere, IUS with the reported BWT thresholds could reduce reliance on MRE, which is...
The study reports that Chlorella-derived polysaccharide AHP reduced inflammation, supported barrier repair, and changed gut microbiota in cell and mouse colitis models—suggesting a potential new bioactive candidate for...
The study links macrophage-driven CD38 activity to NAD+ depletion in colitis and shows that restoring NAD+ or blocking CD38 improved disease in experimental models — suggesting a new biological pathway that could lead to...
Cure8 could only read part of this source from Cirugía y Cirujanos (English Edition), so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and...
If validated, AI-enhanced vascular assessment during endoscopy could give clearer, more reproducible information about mucosal and histologic healing — which matters for monitoring disease activity and guiding treatment...
This large real-world study found upadacitinib was associated with lower risk of treatment failure and more corticosteroid-free stability compared with several other advanced therapies for ulcerative colitis —...
The paper links MKL1 to intestinal epithelial repair and shows it is elevated in IBD tissues, suggesting MKL1 helps restore the gut lining after injury — a key process in IBD recovery.
The study suggests a bacterial lysate and L-arginine can restore intestinal barrier function in cell and mouse models — a process that could be relevant to IBD because barrier dysfunction contributes to disease activity.
The report highlights a serious drug-related complication (pancytopenia/myelosuppression and hair loss) in a patient treated with azathioprine plus sulfasalazine for ulcerative colitis, suggesting clinicians and patients...
Hospitalized patients with acute severe ulcerative colitis often need rescue therapy to avoid colectomy.
Non-specialist physicians often manage IBD where specialists are scarce. If reliable, AI tools could improve non-specialists' clinical reasoning and decision-making for IBD care.
New computational tools that tie gene-expression to metabolic flux could help researchers identify metabolic pathways or biomarkers linked to ulcerative colitis, which might eventually inform research on disease...
Nanoencapsulated flavonoids are proposed as a way to improve delivery of biologically active dietary compounds to the inflamed gut in IBD; a rational design framework could accelerate translation from bench research to...
The paper identifies subtype-specific changes in enteric glial cells and mast cell activity in microscopic colitis and shows some treatment-associated reductions after budesonide; that helps explain disease biology and...
The study suggests that serum zinc by itself may not be a reliable indicator of endoscopic inflammation in UC; nutritional status and inflammation (for example albumin and CRP) can confound zinc levels.
Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from idp.nature.com.
The trial suggests starting infliximab early can delay the need for further biologic escalation in children with moderate-to-severe Crohn’s disease, and that stopping anti‑TNF after induction often leads to relapse.
If creeping fat and mesenteric inflammation matter in your Crohn’s disease, this study suggests a new mechanism linking adipocyte autophagy to proinflammatory lipid mediators (oxylipins) and local immune activation —...
