Clinical trials, biomarkers, microbiome, genetics, AI, basic science, and emerging IBD research.
Page 11 of 65 · 3080 articles
People with ulcerative colitis face long-term health risks beyond the gut. This study suggests that getting a colectomy early after diagnosis might be linked to lower long-term risk of cardiovascular disease and type 2...
This study links a neutrophil protein (ANXA3) to both ulcerative colitis and ischaemic stroke and suggests a compound (ginsenoside Rb1) can bind ANXA3 and reduce neutrophil hyperactivation in lab tests — a potential...
The work highlights molecular differences between PSC-UC and typical UC that could help explain higher colorectal cancer risk in PSC-UC and suggests candidate miRNA biomarkers (eg, miR-155) for further study.
Engineered extracellular vesicles are an emerging, targeted therapy approach that could someday improve immune control, mucosal healing, and drug delivery in IBD and reduce colitis-associated cancer risk. The review...
Relatives of people with IBD are at higher risk; this study aims to identify early markers or behaviors that predict who develops IBD so prevention or earlier diagnosis might become possible.
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Canadian Association of...
Based on the title and source metadata, this appears to be an observational study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Canadian Association...
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Crohn's disease, Inflammatory bowel disease, and Microbiome. The original article is from Immunity, inflammation...
The paper suggests that changes in how microbes interact (community plasticity and network structure) may underlie microbiome differences seen in ulcerative colitis and could point toward ecology-informed biomarkers or...
Researchers are exploring ways to deliver steroids like budesonide more precisely to the intestine while avoiding stomach leakage and sudden drug release. If translated to humans, such a formulation could improve local...
This study identifies a new molecular pathway (JAK2–STAT4–AK4–mtDNA) linked to inflammatory macrophage activity in experimental colitis and presents a plant-derived alkaloid mixture (TAMR) that modulates that pathway....
The paper suggests a molecular link (RHBDF2–ADAM17–TNFα) between ulcerative colitis and blood–brain barrier disruption, which could explain some neurological comorbidities of UC and identify targets for future therapies.
This review summarises the rapidly changing drug landscape for Crohn’s disease and ulcerative colitis, including newly approved biologics and small molecules and several emerging therapies that may affect future...
Oral delivery of protective proteins or biologic therapies could make future IBD treatments easier to take and better at reaching the gut lining.
Researchers are exploring ways to deliver steroids to the inflamed gut while lowering systemic side effects; a nanoparticle carrier that protects the epithelium and concentrates drug in the colon could, if translated,...
The study suggests a noninvasive spleen-targeted ultrasound approach can reduce gut and brain inflammation and improve behavior in a mouse colitis model, mediated by vagal signaling—pointing to a possible new avenue for...
Transmural healing on CT enterography was associated with fewer hospitalizations over long follow-up, which could matter for long-term disease management and monitoring strategies in Crohn’s disease.
Accurate, radiation-free imaging at the point of care can speed diagnosis and management of strictures, abscesses, and fistulas in Crohn’s disease. Improved ultrasound techniques may help determine who needs surgery or...
Perianal fistulas are common and burdensome in Crohn’s disease; this large multicenter Korean study quantifies high rates of complex fistulas, frequent recurrence, and suggests biologic therapy is associated with fewer...
Cure8 could only read part of this source from Intestinal Research, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Crohn's disease, and Inflammatory bowel disease.
A reliable endoscopic method that matches histology could reduce the need for biopsies and speed decisions about remission and treatment in UC. Patients and clinicians interested in noninvasive, real‑time inflammation...
Some people with ulcerative colitis continue to have IBS-like symptoms (bloating, irregular bowel movements, cramping) even when inflammation is minimal.
The study links T cell metabolism and epigenetics to inflammation in IBD, highlighting GSK3β as a possible drug target. That could guide future therapies aimed at dampening pathogenic T cells in Crohn’s disease.
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Genome Medicine.
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease, Crohn's disease, and Biosimilars. The original article is from Arquivos de...
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of inflammation...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from The American journal of gastroenterology.
Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease and Research and clinical trials. The original article is from Research in pharmaceutical sciences.
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Microbiome, and Research and clinical trials. The original article is from Nature Reviews...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Nano Today.
A pediatric trial of budesonide rectal foam could provide evidence about a locally acting steroid option for children with distal ulcerative colitis. Trial results may affect treatment choices for pediatric distal...
The molecular interaction between acetylation and ubiquitination on NLRP3 and GSDMD could help explain mechanisms of inflammatory cell death relevant to UC and point to new biomarker or therapeutic targets, but direct...
Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of Translational Medicine.
Berries are a familiar, dietary source of anti-inflammatory bioactive compounds that might help reduce intestinal inflammation and improve biomarkers relevant to IBD. Patients often seek safe, complementary strategies...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Microbiome, and Diet and lifestyle. The original article is from Probiotics and Antimicrobial Proteins.
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from International Journal of Drug Delivery...
For people with Crohn’s disease, this study suggests that biologic drugs reduce inflammation in both proximal and distal small bowel to a similar degree, as measured by capsule endoscopy.
Curcumin is a common dietary compound that reaches the colon and may interact with gut bacteria and host immune and barrier pathways implicated in IBD. Understanding these interactions could inform dietary approaches or...
Microbiome patterns in this study were linked to inflammation (fecal calprotectin) and higher chance of needing treatment escalation. If validated, enterotype stratification could help predict disease course or tailor...
For people with UC who do not respond to tacrolimus, adding infliximab may induce remission and reduce the short-term need for colectomy. The findings point to a potential rescue strategy and an option to transition to...
This project explores whether common environmental chemicals (PFAS) might change biological processes years before IBD appears, which could help explain some cases of Crohn’s disease and ulcerative colitis and point...
Patients and clinicians choosing a next biologic after prior biologic failure may find evidence here that effectiveness is broadly similar between vedolizumab and ustekinumab overall, with potential differences depending...
The review links TCM-derived compounds to mechanisms (microbiota, metabolites, immunity) that are implicated in progression from chronic colitis to colorectal cancer, which is an important long-term risk for people with...
If validated, mucosal biomarkers like SPARC and SPP1 might help predict who will not respond to infliximab, potentially guiding treatment choices and avoiding ineffective therapy for some people with UC.
People with Crohn’s disease may see emerging interest in traditional Chinese medicine as a multi-target approach that could complement standard treatments and affect immune pathways, the gut barrier, and the microbiome.
Vitamin D deficiency is common in people with IBD and can affect bone health and possibly immune function.
People with ulcerative colitis and their clinicians may find real-world safety and disease-activity data helpful when deciding about upadacitinib (Rinvoq) treatment. Observational registries can reveal how a drug...
The study describes real-world use of a treat-to-target approach in adults with Crohn's disease and ulcerative colitis, which may influence how clinicians monitor disease and adjust therapy in routine care.
