Condition

Inflammatory bowel disease

Broader IBD news covering Crohn's disease, ulcerative colitis, research, treatments, monitoring, and patient care.

Page 21 of 88 · 4183 articles

GPR97 is a novel diagnostic biomarker and immunomodulatory target in ulcerative colitis: evidence from integrated bioinformatics and experimental validation
Springer Science and Business Media LLC

GPR97 is a novel diagnostic biomarker and immunomodulatory target in ulcerative colitis: evidence from integrated bioinformatics and experimental validation

Finding reliable diagnostic biomarkers could help detect UC earlier and clarify immune mechanisms that drive disease; GPR97 is proposed here as such a marker and a possible immunomodulatory target, which may interest...

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A full-thickness spatial transcriptomics atlas of medically refractory ulcerative colitis identifies niche signatures associated with biologic non-response
Frontiers in Immunology

A full-thickness spatial transcriptomics atlas of medically refractory ulcerative colitis identifies niche signatures associated with biologic non-response

Spatial mapping of immune niches in refractory UC identified tissue signatures (neutrophil-rich ulcer-bed niches and TLS/plasma-cell programmes) that were associated with failure to respond to biologic drugs across adult...

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Inflammatory Bowel Disease: From Multifactorial and Metabolic Pathogenesis to Systemic Disease and Precision Medicine
Metabolites

Inflammatory Bowel Disease: From Multifactorial and Metabolic Pathogenesis to Systemic Disease and Precision Medicine

This review reframes IBD as a systemic disease influenced by gut microbes, metabolism, and immune interactions — which matters because it points toward better ways to stratify patients, monitor disease, and personalize...

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Spray drying-assisted development of hydroxypropyl methylcellulose acetate succinate microparticles for andrographolide delivery: an in-vivo study in experimental ulcerative colitis
Drug Delivery and Translational Research

Spray drying-assisted development of hydroxypropyl methylcellulose acetate succinate microparticles for andrographolide delivery: an in-vivo study in experimental ulcerative colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Drug Delivery and...

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
ClinicalTrials.gov

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

This trial tests several targeted therapies (including risankizumab) alone and in combination for adults with moderate to severe Crohn's disease, aiming to measure endoscopic remission and safety. Positive findings could...

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Supplementation of Bacillus cereus Enhances Anti-Colitis Effects of Triple Probiotics in Mice: Correlative Evidence for a Gut Microbiota–Spermidine-Related Axis in Quadruple-Probiotic Protection
Nutrients

Supplementation of Bacillus cereus Enhances Anti-Colitis Effects of Triple Probiotics in Mice: Correlative Evidence for a Gut Microbiota–Spermidine-Related Axis in Quadruple-Probiotic Protection

This study suggests a specific four-strain probiotic cocktail may better protect against experimental colitis than the three-strain mix, potentially via microbiota-driven increases in spermidine — a microbial metabolite...

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The Diagnostic Value of Dual-energy CT Multi-parameters in Differentiating Colorectal Cancer from Inflammatory Thickening of the Colorectal Wall.
Current medical imaging

The Diagnostic Value of Dual-energy CT Multi-parameters in Differentiating Colorectal Cancer from Inflammatory Thickening of the Colorectal Wall.

Distinguishing colorectal cancer from IBD-related inflammatory thickening can be challenging but crucial for treatment decisions. If validated, DECT parameters could offer a noninvasive tool to improve diagnostic...

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Proanthocyanidins in immune-mediated inflammatory diseases: molecular mechanisms and therapeutic potential
Frontiers in Pharmacology

Proanthocyanidins in immune-mediated inflammatory diseases: molecular mechanisms and therapeutic potential

People with IBD may be interested because the review highlights a class of dietary polyphenols that could influence inflammation and immune pathways involved in Crohn’s disease and ulcerative colitis. It summarizes...

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Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn’s disease
Nature Genetics

Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn’s disease

Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Nature Genetics.

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Cardiovascular outcomes associated With GLP-1 and dual GLP-1/GIP receptor agonists in patients with type 2 diabetes and inflammatory bowel disease: A retrospective real-world cohort study.
PloS one

Cardiovascular outcomes associated With GLP-1 and dual GLP-1/GIP receptor agonists in patients with type 2 diabetes and inflammatory bowel disease: A retrospective real-world cohort study.

People who have both IBD and type 2 diabetes are at increased cardiovascular risk; this study suggests GLP-1–based therapies may be associated with lower rates of several heart and thrombotic events in that group.

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KARAP Exacerbates Intestinal Inflammation Through Promoting Kyn-AhR-dependent Neutrophil Activation in Ulcerative Colitis.
Cellular and molecular gastroenterology and hepatology

KARAP Exacerbates Intestinal Inflammation Through Promoting Kyn-AhR-dependent Neutrophil Activation in Ulcerative Colitis.

The paper identifies a neutrophil-related immune pathway (KARAP → IDO1–kynurenine → AhR → IL-22) that contributes to mucosal inflammation in ulcerative colitis, suggesting a potential new target for research and drug...

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UBE2L6 drives ulcerative colitis progression by promoting BIRC2 degradation and activating non-canonical NF-κB signalling
Inflammation Research

UBE2L6 drives ulcerative colitis progression by promoting BIRC2 degradation and activating non-canonical NF-κB signalling

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Inflammation Research.

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Successful combination therapy with ustekinumab and intensive granulocyte and monocyte adsorptive apheresis in highly refractory pediatric ulcerative colitis: pathophysiological rationale and clinical outcome
Immunological Medicine

Successful combination therapy with ustekinumab and intensive granulocyte and monocyte adsorptive apheresis in highly refractory pediatric ulcerative colitis: pathophysiological rationale and clinical outcome

Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis, Inflammatory bowel disease, and Ustekinumab. The original article is from Immunological Medicine.

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Ferulic acid – A promising candidate molecule for the treatment of colitis
European Journal of Microbiology and Immunology

Ferulic acid – A promising candidate molecule for the treatment of colitis

This review highlights a plant-derived compound, ferulic acid, that showed anti-colitis effects in experimental studies, suggesting a potential new adjunctive therapy pathway worth watching for future clinical research.

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Pathogen‐Specific Bloodstream Infections Associated With Tumour Necrosis Factor‐α Inhibitors, Vedolizumab and Ustekinumab in Inflammatory Bowel Disease: A Danish Nationwide Case‐Control Study 2010–2024
Alimentary Pharmacology & Therapeutics

Pathogen‐Specific Bloodstream Infections Associated With Tumour Necrosis Factor‐α Inhibitors, Vedolizumab and Ustekinumab in Inflammatory Bowel Disease: A Danish Nationwide Case‐Control Study 2010–2024

This study compares bloodstream infection risk across commonly used biologics for IBD, which could affect decisions about choosing or monitoring biologic therapy. It also highlights that steroid co-use may increase...

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Maternal–Fetal Exposome and Early-Life Microbiota–Pattern Recognition Receptors Signaling in Inflammatory Bowel Disease Susceptibility: A Mechanistic Review
International Journal of Molecular Sciences

Maternal–Fetal Exposome and Early-Life Microbiota–Pattern Recognition Receptors Signaling in Inflammatory Bowel Disease Susceptibility: A Mechanistic Review

If true, prenatal and early-life exposures could influence long-term IBD risk by shaping immune development and the gut microbiome, which may help explain why some people develop IBD and others don’t.

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Trendy, but Are They Safe? Current Popular Diets and Their Use in Inflammatory Bowel Diseases: Narrative Review
Nutrients

Trendy, but Are They Safe? Current Popular Diets and Their Use in Inflammatory Bowel Diseases: Narrative Review

Diet is a modifiable factor many people with IBD try to use to manage symptoms and disease; this review summarizes what is and isn’t supported by current evidence for popular diets and structured nutritional therapies.

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Impact of Smoking on the Effectiveness of Advanced Therapies in Inflammatory Bowel Disease: Active Smoking Is Associated with Reduced Effectiveness of Anti-TNF Treatment
Medicina

Impact of Smoking on the Effectiveness of Advanced Therapies in Inflammatory Bowel Disease: Active Smoking Is Associated with Reduced Effectiveness of Anti-TNF Treatment

The study suggests active smoking reduces the effectiveness of anti-TNF biologics in people with IBD, which could affect treatment response and the need to switch or escalate therapies. This supports including smoking...

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Machine learning meets network toxicology: identifying LOXL2 as a key player in ulcerative colitis
Toxicological Research

Machine learning meets network toxicology: identifying LOXL2 as a key player in ulcerative colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and AI and data science. The original article is from Toxicological Research.

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Targeted oral peptide therapy for inflammatory bowel disease: focus on the IL-23 receptor antagonist icotrokinra.
Expert opinion on emerging drugs

Targeted oral peptide therapy for inflammatory bowel disease: focus on the IL-23 receptor antagonist icotrokinra.

Based on the title and source metadata, this appears to be an opinion or commentary related to Inflammatory bowel disease and Research and clinical trials. The original article is from Expert opinion on emerging drugs.

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Patterns and factors associated with dose escalation during maintenance treatment for inflammatory bowel disease: a population-based cohort study.
Sage open chronic disease

Patterns and factors associated with dose escalation during maintenance treatment for inflammatory bowel disease: a population-based cohort study.

Dose increases are common during IBD maintenance and vary a lot by drug and patient profile. Knowing which treatments and patient factors are linked to escalation can help patients and clinicians plan monitoring and...

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Patient-reported first-use usability of the noncommercial MyTARGET mobile application among adults with inflammatory bowel disease: a cross-sectional survey.
Frontiers in digital health

Patient-reported first-use usability of the noncommercial MyTARGET mobile application among adults with inflammatory bowel disease: a cross-sectional survey.

High first-use usability suggests MyTARGET could be acceptable to many adults with IBD and that targeted refinements (error handling, demonstrating time savings) might improve uptake and recommendation.

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Creeping Fat in Crohn's Disease: Association or Prognostic Factor?
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Creeping Fat in Crohn's Disease: Association or Prognostic Factor?

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from The Turkish journal of...

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