Condition

Inflammatory bowel disease

Broader IBD news covering Crohn's disease, ulcerative colitis, research, treatments, monitoring, and patient care.

Page 22 of 88 · 4183 articles

Evaluation of Blood and Stool Biomarkers Across Three Fecal Calprotectin Platforms and Combination Testing for Predicting Endoscopic and Histologic Outcomes in Inflammatory Bowel Disease
Europe PMC

Evaluation of Blood and Stool Biomarkers Across Three Fecal Calprotectin Platforms and Combination Testing for Predicting Endoscopic and Histologic Outcomes in Inflammatory Bowel Disease

Noninvasive fecal biomarkers are widely used to track IBD activity. Knowing whether different FC assays give comparable results and whether combining tests adds value affects how patients and clinicians interpret...

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Alterations of Serotonin System-Related Biomarkers and Their Association with Disease Activity in Patients with Ulcerative Colitis: A Systematic Review and Meta-analysis
INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

Alterations of Serotonin System-Related Biomarkers and Their Association with Disease Activity in Patients with Ulcerative Colitis: A Systematic Review and Meta-analysis

Cure8 could only read part of this source from INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, so this card uses cautious topic tags instead of a full summary. It is tagged...

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Ulcerative colitis, but not Crohn’s disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification
Frontiers in Immunology

Ulcerative colitis, but not Crohn’s disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification

The study suggests ulcerative colitis shows greater mucosal immune variability across sex, age and severity than Crohn’s disease, which could affect how patients are grouped for research or future personalized...

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Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation.
International immunopharmacology

Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation.

This identifies a metabolism-related epithelial gene (PCK1) linked to inflammation in UC and suggests acetyl‑L‑carnitine can partially reverse those changes in cell and mouse models—information that could guide future...

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Bowel Urgency Is More Strongly Associated with Biochemical, Endoscopic, and Histological Disease Activity than Other Clinical Symptoms in Ulcerative Colitis.
Internal medicine (Tokyo, Japan)

Bowel Urgency Is More Strongly Associated with Biochemical, Endoscopic, and Histological Disease Activity than Other Clinical Symptoms in Ulcerative Colitis.

If you have UC, bowel urgency may indicate active inflammation more reliably than some other symptoms. Recognizing urgency could help prompt timely objective testing and treatment decisions.

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Comparative serious infection and sepsis risks with advanced therapies in IMIDs: a Bayesian network meta-analysis.
The Journal of infection

Comparative serious infection and sepsis risks with advanced therapies in IMIDs: a Bayesian network meta-analysis.

This pooled analysis compares serious-infection and sepsis risks across advanced therapies used in immune-mediated inflammatory diseases, including IBD. It suggests JAK inhibitors are linked to higher serious-infection...

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Guselkumab Versus Risankizumab for Ulcerative Colitis: Real-World Comparison of Post-Induction Outcomes.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Guselkumab Versus Risankizumab for Ulcerative Colitis: Real-World Comparison of Post-Induction Outcomes.

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Guselkumab. The original article is from Clinical gastroenterology and hepatology...

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Multicentre, prospective, observational study on the effectiveness and safety of upadacitinib for active perianal fistulising Crohn's disease in patients with prior anti-tumour necrosis factor failure: a study protocol.
BMJ open

Multicentre, prospective, observational study on the effectiveness and safety of upadacitinib for active perianal fistulising Crohn's disease in patients with prior anti-tumour necrosis factor failure: a study protocol.

Perianal fistulising Crohn's disease is hard to treat and often fails anti-TNF drugs. This study will provide real-world data on whether upadacitinib can be effective and safe for patients with refractory perianal...

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Comparative effectiveness of infliximab vs vedolizumab as first-line biologic therapy in moderate-to-severe ulcerative colitis: A prospective, multicenter, real-world study
Inflammatory Bowel Diseases

Comparative effectiveness of infliximab vs vedolizumab as first-line biologic therapy in moderate-to-severe ulcerative colitis: A prospective, multicenter, real-world study

This study compares two commonly used biologics as first-line therapy for moderate-to-severe ulcerative colitis and reports better short- and long-term effectiveness for vedolizumab with similar safety. The results could...

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Single-cell profiling reveals stromal niche and α5β1 regulation of neutrophil phenotypes in ulcerative colitis
bioRxiv

Single-cell profiling reveals stromal niche and α5β1 regulation of neutrophil phenotypes in ulcerative colitis

The study suggests stromal fibroblasts can drive pro-inflammatory neutrophil programs in ulcerative colitis and that targeting fibroblast-associated pathways may reduce neutrophil-driven inflammation—information that...

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Preexisting depression and early outcomes in inflammatory bowel disease: a propensity score-matched cohort study.
Proceedings (Baylor University. Medical Center)

Preexisting depression and early outcomes in inflammatory bowel disease: a propensity score-matched cohort study.

Depression before an IBD diagnosis was linked to more early treatment escalation and acute-care use after diagnosis. Recognizing preexisting depression could help clinicians identify patients who may benefit from closer...

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Marine-Derived Polysaccharides Against Ulcerative Colitis: Sources, Structures, and Multi-Target Mechanisms
Marine Drugs

Marine-Derived Polysaccharides Against Ulcerative Colitis: Sources, Structures, and Multi-Target Mechanisms

The review highlights marine polysaccharides as multi-target agents that could modulate inflammation, the microbiome, and the gut barrier—processes central to ulcerative colitis—and points to possible roles as functional...

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Anti-Inflammatory Protein Hydrolysate Screened from Crayfish Shells Attenuates Colitis by Oxidative Stress Suppression, Inflammation Reduction and Barrier Reconstruction
Foods

Anti-Inflammatory Protein Hydrolysate Screened from Crayfish Shells Attenuates Colitis by Oxidative Stress Suppression, Inflammation Reduction and Barrier Reconstruction

The study identifies a food-industry by-product (crayfish shells) as a source of peptides that reduced inflammation and improved barrier and antioxidant markers in cell and mouse colitis models—research that could inform...

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Integrative Multi-Omics and Machine Learning Reveal Senescent Fibroblast-Associated ADAMTS2 as a Critical Indicator of Intestinal Inflammation in IBD.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Integrative Multi-Omics and Machine Learning Reveal Senescent Fibroblast-Associated ADAMTS2 as a Critical Indicator of Intestinal Inflammation in IBD.

Identifies a fibroblast senescence signature and highlights ADAMTS2 as a candidate biomarker linked to inflammation and fibrosis in IBD, which could guide future diagnostic or therapeutic research relevant to Crohn’s...

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Intracorporeal Versus Extracorporeal Anastomosis in Minimally Invasive Ileocecectomy or Ileocolic Resection for Crohn's Disease: A Systematic Review and Meta-Analysis.
Journal of laparoendoscopic & advanced surgical techniques. Part A

Intracorporeal Versus Extracorporeal Anastomosis in Minimally Invasive Ileocecectomy or Ileocolic Resection for Crohn's Disease: A Systematic Review and Meta-Analysis.

This systematic review focuses on two ways surgeons reconnect the bowel after minimally invasive right-sided surgery for Crohn’s disease. It found fewer overall postoperative complications with intracorporeal anastomosis...

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The role of blood lymphocyte levels in evaluating endoscopic remission of inflammatory bowel disease
European journal of medical research

The role of blood lymphocyte levels in evaluating endoscopic remission of inflammatory bowel disease

A simple blood lymphocyte percentage could be a convenient, non-invasive marker to help distinguish endoscopic remission from active disease in both Crohn’s and ulcerative colitis; chemokines CXCL10 and CCL25 may also...

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Distribution of CARD15/NOD2 Variants in Crohn’s Disease, Ulcerative Colitis, and Healthy Controls in a Djiboutian Population
Gastrointestinal Disorders

Distribution of CARD15/NOD2 Variants in Crohn’s Disease, Ulcerative Colitis, and Healthy Controls in a Djiboutian Population

The report explores NOD2/CARD15 variants in a Djiboutian IBD cohort and suggests higher variant frequencies in Crohn’s disease, which could point to population-specific genetic susceptibility. It also raises khat use as...

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Tumor necrosis factor-like cytokine 1 A antagonists for inflammatory bowel disease: A systematic review and meta-analysis
Indian Journal of Gastroenterology

Tumor necrosis factor-like cytokine 1 A antagonists for inflammatory bowel disease: A systematic review and meta-analysis

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease and Research and clinical trials. The original article is from Indian Journal of...

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Interaction between intestinal microbiota, inflammatory cytokines, and the expression of miR-330-3p and miR-515-5p in patients with ulcerative colitis.
Journal of medical biochemistry

Interaction between intestinal microbiota, inflammatory cytokines, and the expression of miR-330-3p and miR-515-5p in patients with ulcerative colitis.

The paper links specific gut bacteria, inflammatory cytokines, and two microRNAs with UC activity, which could point toward new diagnostic biomarkers or targets for research into disease mechanisms.

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Metabolic regulation of gut barrier integrity in IBD: protein, lipid, and carbohydrate pathways.
Frontiers in nutrition

Metabolic regulation of gut barrier integrity in IBD: protein, lipid, and carbohydrate pathways.

Dietary macronutrients affect microbiota, barrier integrity, and mucosal immunity in ways that could alter IBD activity. Understanding these pathways could inform more targeted dietary strategies beyond generic...

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Extracellular vesicle-based therapies in IBD: immunomodulation, regeneration, and translation.
Frontiers in immunology

Extracellular vesicle-based therapies in IBD: immunomodulation, regeneration, and translation.

Extracellular vesicle (EV) therapies are being explored as new ways to modulate immune responses and promote mucosal repair in IBD, which could eventually expand treatment options beyond current biologics and small...

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Insight into Ulcerative Colitis and Associated Diarrhea: Exploring the Interplay of Cellular and Molecular Axis with Advancement in Treatments.
Recent advances in inflammation & allergy drug discovery

Insight into Ulcerative Colitis and Associated Diarrhea: Exploring the Interplay of Cellular and Molecular Axis with Advancement in Treatments.

Persistent diarrhea is a common, quality-of-life–limiting problem in ulcerative colitis; this review synthesizes how epithelial transport, barrier damage, immune signaling, mitochondria, and microbiota interact and...

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Multimodal Imaging-Based Anatomical Characterization of DSS-Induced Experimental Ulcerative Colitis in Rat Model.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

Multimodal Imaging-Based Anatomical Characterization of DSS-Induced Experimental Ulcerative Colitis in Rat Model.

Non-invasive imaging biomarkers that track intestinal inflammation and structure could speed preclinical testing of IBD therapies and guide translational imaging research relevant to clinical monitoring of ulcerative...

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Janus Kinase Inhibitors for Acute Severe Ulcerative Colitis: Comparing Upadacitinib to Tofacitinib and Rescue to Sequential Salvage therapy.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Janus Kinase Inhibitors for Acute Severe Ulcerative Colitis: Comparing Upadacitinib to Tofacitinib and Rescue to Sequential Salvage therapy.

This study compares two JAK inhibitors (upadacitinib and tofacitinib) used as rescue therapy for acute severe ulcerative colitis and reports lower 1‑year colectomy rates with upadacitinib. That could influence choices...

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Rising burden of inflammatory Bowel disease in Northeastern Italy: a population-based analysis of prevalence and incidence trends from 2012 to 2024.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Rising burden of inflammatory Bowel disease in Northeastern Italy: a population-based analysis of prevalence and incidence trends from 2012 to 2024.

The study documents substantial increases in Crohn’s disease and ulcerative colitis prevalence and changing incidence patterns in Northeastern Italy from 2012–2024, which may affect healthcare demand and resource...

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Revisiting the role of lymphatics in Crohn’s disease
Inflammatory Bowel Diseases

Revisiting the role of lymphatics in Crohn’s disease

If lymphatic dysfunction helps cause or sustain Crohn’s inflammation, it could explain some classic disease features (patchy, transmural inflammation and mesenteric changes) and point to new treatment approaches aimed at...

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Anti-TNF-refractory inflammatory bowel disease associated with a novel XIAP frameshift variant successfully treated with ustekinumab.
Clinical journal of gastroenterology

Anti-TNF-refractory inflammatory bowel disease associated with a novel XIAP frameshift variant successfully treated with ustekinumab.

Identifying a genetic cause (XIAP frameshift variant) helped explain why anti‑TNF drugs failed and why blocking IL‑12/23 with ustekinumab led to improvement; that connection could influence treatment choices for similar...

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Multicenter Validation of a ResNet50-Based Deep Convolutional Network for Endoscopic Grading of Ulcerative Colitis Severity
Springer Science and Business Media LLC

Multicenter Validation of a ResNet50-Based Deep Convolutional Network for Endoscopic Grading of Ulcerative Colitis Severity

Automated, validated grading of UC on colonoscopy images could reduce variability between endoscopists and help standardize severity assessment that influences treatment planning.

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