Article Archive

Page 8 of 56 · 2666 patient-friendly summaries

Sustained drug-free remission of refractory ulcerative colitis following rituximab therapy for Epstein-Barr virus-positive mucocutaneous ulcer.
Gastroenterology report

Sustained drug-free remission of refractory ulcerative colitis following rituximab therapy for Epstein-Barr virus-positive mucocutaneous ulcer.

Cure8 found this source from Gastroenterology report, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Procedures and surgery. Open the original article...

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Vitamin D and Intestinal Diseases: Impact on Intestinal Immunity and Gut Barrier Function
Diseases

Vitamin D and Intestinal Diseases: Impact on Intestinal Immunity and Gut Barrier Function

Vitamin D appears linked to immune regulation, gut barrier health, and the microbiome—processes relevant to IBD and other intestinal disorders. Understanding this could affect how clinicians monitor and study vitamin D...

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Persistent elevation of serum LBP, IL-23 and IL-6 in infliximab-maintained Crohn's disease: a case–control study from Iraq with the serum LBP/albumin ratio as a novel composite biomarker
Journal of Genetic Engineering and Biotechnology

Persistent elevation of serum LBP, IL-23 and IL-6 in infliximab-maintained Crohn's disease: a case–control study from Iraq with the serum LBP/albumin ratio as a novel composite biomarker

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Infliximab. The original article is from Journal of Genetic Engineering and...

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Living well with Crohn’s & Colitis fatigue, pain and urgency/faecal incontinence: the IBD-BOOST research programme including an RCT
Europe PMC

Living well with Crohn’s & Colitis fatigue, pain and urgency/faecal incontinence: the IBD-BOOST research programme including an RCT

Many people with IBD experience persistent fatigue, pain and faecal incontinence even when inflammation is controlled; this programme tested a supported online self-management approach to help those symptoms and assessed...

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VOICE-Early Response to Vedolizumab and IL-23 Antagonists in Participants With Crohn's Disease: A Prospective Observational Study
ClinicalTrials.gov

VOICE-Early Response to Vedolizumab and IL-23 Antagonists in Participants With Crohn's Disease: A Prospective Observational Study

Patients and clinicians often want to know how quickly symptoms improve after starting a biologic. This study is designed to compare early patient‑reported symptom changes after starting vedolizumab versus IL‑23...

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Study to Assess Change in Disease Activity of Risankizumab Treatment in Japanese Participants With Moderate to Severe Ulcerative Colitis
ClinicalTrials.gov

Study to Assess Change in Disease Activity of Risankizumab Treatment in Japanese Participants With Moderate to Severe Ulcerative Colitis

This registry will track how people with moderate to severe ulcerative colitis do on risankizumab in routine Japanese clinical practice, which may provide information about real-world remission rates and longer-term...

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Integrated Multi-Omics Analysis of Antarctica Krill Oil in Alleviating DSS-Induced Colitis and Modulating Gut Microbiota in Mice
Marine Drugs

Integrated Multi-Omics Analysis of Antarctica Krill Oil in Alleviating DSS-Induced Colitis and Modulating Gut Microbiota in Mice

This animal study suggests Antarctic krill oil may reduce inflammation and weight loss in a mouse model of ulcerative colitis and works alongside changes in gut microbiota and metabolites—findings that could inform...

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Ecological assembly of mucosal and fecal microbiomes in ulcerative colitis across genes, functions, and species
Frontiers in Microbiology

Ecological assembly of mucosal and fecal microbiomes in ulcerative colitis across genes, functions, and species

This paper offers a multi-layered ecological perspective on UC-associated microbiome changes that could help researchers identify which microbial functions or taxa are driven more by random processes versus selection in...

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Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries.
Paediatric drugs

Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries.

Children with IBD often wait years for medicines to be approved after adult approvals; this review shows many ongoing paediatric trials for biologics and small molecules that could improve treatment options.

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Lactobacillus brevis Desulfovibrio ZFM820 modulates intestinal ecological sulfur homeostasis to alleviate-driven colitis.
Food & function

Lactobacillus brevis Desulfovibrio ZFM820 modulates intestinal ecological sulfur homeostasis to alleviate-driven colitis.

The study suggests a new microbiome-based strategy that targets toxic hydrogen sulfide production and boosts host detoxification — a mechanism potentially relevant to some forms of IBD driven by sulfur-metabolizing...

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Dietary oxalate and intestinal inflammation: Evidence from experimental colitis and inflammatory bowel disease patient cohorts.
Cellular and molecular gastroenterology and hepatology

Dietary oxalate and intestinal inflammation: Evidence from experimental colitis and inflammatory bowel disease patient cohorts.

If dietary oxalate influences gut inflammation, it could be a modifiable dietary factor for some people with IBD and might help explain variability in symptoms. The study points to transporters as potential markers of...

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Letter to the Editor: Microbial metabolites and immune regulation in inflammatory bowel disease and metabolic dysfunction-associated steatotic liver disease
World Journal of Gastroenterology

Letter to the Editor: Microbial metabolites and immune regulation in inflammatory bowel disease and metabolic dysfunction-associated steatotic liver disease

Researchers and clinicians studying IBD, and patients interested in how gut microbes and immune signaling might connect bowel inflammation with fatty liver disease, will find the discussion relevant to future precision...

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Acceptability and Feasibility of Mindfulness-Based Cognitive Therapy in Adults with Inflammatory Bowel Disease: A Mixed-Methods Study
Mindfulness

Acceptability and Feasibility of Mindfulness-Based Cognitive Therapy in Adults with Inflammatory Bowel Disease: A Mixed-Methods Study

IBD patients often face high psychological burden; knowing whether MBCT is acceptable and feasible helps patients and clinicians weigh it as a support option. Practical barriers (time, fatigue, disease activity) and...

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Development of Hydrophobic Tag Based HDAC6 Degrader for Ulcerative Colitis Treatment.
Journal of medicinal chemistry

Development of Hydrophobic Tag Based HDAC6 Degrader for Ulcerative Colitis Treatment.

The study introduces a novel preclinical therapeutic approach that selectively degrades HDAC6 and reduced inflammation in a mouse model of colitis, suggesting a potential new drug-discovery avenue relevant to ulcerative...

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VIGIL: Vision-Language Guided Multiple Instance Learning Framework for Ulcerative Colitis Histological Healing Prediction.
IEEE transactions on bio-medical engineering

VIGIL: Vision-Language Guided Multiple Instance Learning Framework for Ulcerative Colitis Histological Healing Prediction.

The study presents an AI method that combines endoscopic images and diagnostic text to predict histological healing in ulcerative colitis, which could help non-invasive assessment and reduce annotation effort in...

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Extracellular Vesicles Derived from Elaeocarpus braceanus Alleviate DSS-Induced Ulcerative Colitis in Mice Through Multiple Pathways.
Nanomaterials (Basel, Switzerland)

Extracellular Vesicles Derived from Elaeocarpus braceanus Alleviate DSS-Induced Ulcerative Colitis in Mice Through Multiple Pathways.

The study suggests a novel plant-derived nanoparticle approach reduced inflammation and repaired barrier function in a mouse model of colitis and changed the gut microbiome — a potential early-stage route for new IBD...

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An Open-Label, Comparative, Parallel Clinical Trial of the Safety, Pharmacokinetics and Immunogenicity of the Ustekinumab Biosimilar GNR-068 and the Originally Developed Ustekinumab as a Reference Drug After a Single Subcutaneous Administration in Healthy Male Volunteers
Antibodies

An Open-Label, Comparative, Parallel Clinical Trial of the Safety, Pharmacokinetics and Immunogenicity of the Ustekinumab Biosimilar GNR-068 and the Originally Developed Ustekinumab as a Reference Drug After a Single Subcutaneous Administration in Healthy Male Volunteers

Ustekinumab treats Crohn’s disease and ulcerative colitis; a biosimilar that shows similar pharmacokinetics and safety could expand treatment options and affect availability and cost.

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Evolving role of intestinal ultrasound in the evaluation of Crohn's disease: A clinical- radiological perspective
European Journal of Radiology Open

Evolving role of intestinal ultrasound in the evaluation of Crohn's disease: A clinical- radiological perspective

Intestinal ultrasound is increasingly used to evaluate Crohn’s disease because it’s noninvasive, repeatable, and can detect activity and some complications—potentially reducing reliance on more invasive tests. Wider...

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Molecular regulatory mechanism of TRPV4-mediated calcium-dependent 5-HT secretion from enterochromaffin cells and its involvement in ulcerative colitis
PLOS One

Molecular regulatory mechanism of TRPV4-mediated calcium-dependent 5-HT secretion from enterochromaffin cells and its involvement in ulcerative colitis

The study links a cellular signaling pathway that increases serotonin release from gut enterochromaffin cells to inflammation in a mouse model of ulcerative colitis. If confirmed, blocking TRPV4 could become a research...

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Stigma management, social support, and quality of life among adults with Crohnʼs disease and ulcerative colitis in Saudi Arabia: A cross-sectional study
Saudi Journal of Gastroenterology

Stigma management, social support, and quality of life among adults with Crohnʼs disease and ulcerative colitis in Saudi Arabia: A cross-sectional study

Stigma and social support appear to meaningfully relate to quality of life for adults with IBD in Saudi Arabia. Understanding which coping strategies and support sources help could inform patient education and support...

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Treatment persistence after switching between anti-tumor necrosis factor agents and tofacitinib in ulcerative colitis: A nationwide claims-based cohort study in South Korea.
Therapeutic advances in gastroenterology

Treatment persistence after switching between anti-tumor necrosis factor agents and tofacitinib in ulcerative colitis: A nationwide claims-based cohort study in South Korea.

Patients and clinicians considering sequencing of advanced UC therapies may care because this study reports differences in how long patients stayed on second-line treatment depending on the order of anti-TNF agents and...

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Identification of TIMP1 as a Key Regulator of Ferroptosis in Ulcerative Colitis Through Bioinformatics and Functional Experiments.
Gastroenterology research and practice

Identification of TIMP1 as a Key Regulator of Ferroptosis in Ulcerative Colitis Through Bioinformatics and Functional Experiments.

The study suggests TIMP1 may help drive ferroptosis, inflammation, and epithelial barrier dysfunction in ulcerative colitis; targeting TIMP1 could eventually inform new therapies or biomarkers if confirmed in further...

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Receptor interacting protein kinase 1 as a potential therapeutic target in inflammatory bowel disease: biological rationale and emerging clinical evidence.
Expert opinion on investigational drugs

Receptor interacting protein kinase 1 as a potential therapeutic target in inflammatory bowel disease: biological rationale and emerging clinical evidence.

This review highlights a potential new class of IBD drugs (RIPK1 inhibitors) that target inflammatory and cell-death pathways implicated in epithelial injury. For people with IBD, it signals an area of active research...

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Mistakes in the management of irritable bowel syndrome-diarrhoeal subtype and mimics: a narrative review.
Current medical research and opinion

Mistakes in the management of irritable bowel syndrome-diarrhoeal subtype and mimics: a narrative review.

People labelled with IBS-D may actually have treatable organic conditions that require different tests and treatments; avoiding diagnostic mistakes can speed appropriate care and reduce unnecessary symptom-focused...

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