Article Archive

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Fraxin alleviates intestinal epithelial cell necrosis in ulcerative colitis by inhibiting the P2Y₁₄R/cAMP/PKA/CREB signaling pathway.
International immunopharmacology

Fraxin alleviates intestinal epithelial cell necrosis in ulcerative colitis by inhibiting the P2Y₁₄R/cAMP/PKA/CREB signaling pathway.

Preclinical evidence that a natural compound (Fraxin) can reduce epithelial necrosis and inflammation in UC models points to a potential new target (P2Y14R/cAMP/PKA/CREB) for future drug research and possibly novel...

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Fecal Microbiota Transfer for Recurrent Clostridioides difficile Infection: A Retrospective Single-Center Analysis.
Zeitschrift fur Gastroenterologie

Fecal Microbiota Transfer for Recurrent Clostridioides difficile Infection: A Retrospective Single-Center Analysis.

FMT is shown here to be an effective option for treating recurrent C. difficile infection, including for patients who also have IBD — a group often vulnerable to recurrent infections and complications.

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Separating Prognostic Association from Treatment-Effect Modification of a Baseline Mucosal Inflammatory-Response Score in Ulcerative Colitis Biologic Trials.
Clinics and research in hepatology and gastroenterology

Separating Prognostic Association from Treatment-Effect Modification of a Baseline Mucosal Inflammatory-Response Score in Ulcerative Colitis Biologic Trials.

Researchers and clinicians want biomarkers that predict outcome or tailor treatment. This study suggests a mucosal gene-expression score is prognostic and declines in responders, but it does not yet show the score...

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Technical Considerations for Magnetic Resonance Imaging of the Bowel.
Magnetic resonance imaging clinics of North America

Technical Considerations for Magnetic Resonance Imaging of the Bowel.

MRE is a key, non-radiating test for Crohn’s disease that can show active inflammation and complications that endoscopy may miss, so updates on technique matter for diagnosis and monitoring. Better imaging technique can...

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Fatigue across physical and mental health conditions: results from a multicenter study at the German Center for Mental Health.
Journal of psychosomatic research

Fatigue across physical and mental health conditions: results from a multicenter study at the German Center for Mental Health.

The study directly compares fatigue levels across several chronic conditions using the same validated tools, offering context for how fatigue in IBD compares to other illnesses. That context can help patients and...

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Defining and measuring disease burden in Crohn's disease: a systematic literature review.
Scandinavian journal of gastroenterology

Defining and measuring disease burden in Crohn's disease: a systematic literature review.

Patients and clinicians use the term "disease burden" to describe more than inflammation alone; it affects symptoms, daily function, mental health, and healthcare use. A clearer, integrated way to measure burden could...

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Antibody-mediated immune responses and inflammatory bowel disease: insights from genetic correlation and Mendelian randomization
Archives of medical science : AMS

Antibody-mediated immune responses and inflammatory bowel disease: insights from genetic correlation and Mendelian randomization

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Archives of medical science : AMS.

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Multimodal biomarkers and prediction models for stricturing and penetrating progression in Crohn's disease
Frontiers in medicine

Multimodal biomarkers and prediction models for stricturing and penetrating progression in Crohn's disease

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Crohn's disease, Inflammatory bowel disease, and Biomarkers. The original article is from Frontiers in medicine.

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Fresh ginseng-derived vesicle-like nanoparticles protect against intestinal barrier injury in inflammatory bowel disease via the miR-29a-5p/TLR4 axis
Frontiers in immunology

Fresh ginseng-derived vesicle-like nanoparticles protect against intestinal barrier injury in inflammatory bowel disease via the miR-29a-5p/TLR4 axis

Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease and Research and clinical trials. The original article is from Frontiers in immunology.

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Loss of Acid Ceramidase in Myeloid Cells Protects From Chronic Colitis in IL10 ‐Deficient Mice
The FASEB Journal

Loss of Acid Ceramidase in Myeloid Cells Protects From Chronic Colitis in IL10 ‐Deficient Mice

The study identifies acid ceramidase in myeloid cells as a regulator of sphingolipid metabolites and immune cell recruitment in a mouse model of chronic colitis, pointing to a possible new therapeutic target for IBD.

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A narrative review of sex-related differences in inflammatory bowel disease-associated cardiovascular and thrombotic risk: epidemiology, mechanisms, and prevention strategies
Translational gastroenterology and hepatology

A narrative review of sex-related differences in inflammatory bowel disease-associated cardiovascular and thrombotic risk: epidemiology, mechanisms, and prevention strategies

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease and Complications. The original article is from Translational gastroenterology and...

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PREDICT-UC, infliximab pharmacokinetics, and the pursuit of personalised rescue therapy in acute severe ulcerative colitis
Translational gastroenterology and hepatology

PREDICT-UC, infliximab pharmacokinetics, and the pursuit of personalised rescue therapy in acute severe ulcerative colitis

For people hospitalized with acute severe UC, the findings suggest that measuring early infliximab pharmacokinetics could help personalize rescue therapy and potentially reduce colectomy risk by identifying who may need...

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The appendix and ulcerative colitis: from an unsolved connection to a therapeutic strategy
Translational gastroenterology and hepatology

The appendix and ulcerative colitis: from an unsolved connection to a therapeutic strategy

Based on the title and source metadata, this appears to be an opinion or commentary related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Translational...

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Gut Microbiota-Driven Neuroimmune Crosstalk in Ulcerative Colitis: From Mechanisms to Therapeutic Implications
Biomedicines

Gut Microbiota-Driven Neuroimmune Crosstalk in Ulcerative Colitis: From Mechanisms to Therapeutic Implications

Understanding microbiota–neuroimmune interactions could explain why symptoms like urgency and pain persist in some people with UC and may point to new treatment strategies that go beyond conventional anti-inflammatory...

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Digital cognitive behavioural self-management programme for fatigue, pain, urgency and incontinence in inflammatory bowel disease
Translational gastroenterology and hepatology

Digital cognitive behavioural self-management programme for fatigue, pain, urgency and incontinence in inflammatory bowel disease

Based on the title and source metadata, this appears to be an opinion or commentary related to Inflammatory bowel disease, Fatigue, and Pain. The original article is from Translational gastroenterology and hepatology.

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Reconsidering therapeutic strategies after biologic failure in ulcerative colitis: appendectomy versus Janus kinase inhibition
Translational gastroenterology and hepatology

Reconsidering therapeutic strategies after biologic failure in ulcerative colitis: appendectomy versus Janus kinase inhibition

Based on the title and source metadata, this appears to be an opinion or commentary related to Ulcerative colitis, Inflammatory bowel disease, and Tests and monitoring. The original article is from Translational...

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Ulcerative colitis, but not Crohn's disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification.
Frontiers in immunology

Ulcerative colitis, but not Crohn's disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification.

The findings suggest that tissue-based immune profiling may better identify biologically distinct subgroups in ulcerative colitis than blood tests, which could affect research on personalized treatment or trial...

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Short telomeres, but not accelerated epigenetic or proteomic age, increase fibrotic lung disease risk: Mendelian randomisation with pleiotropy dissection and independent replication
Europe PMC

Short telomeres, but not accelerated epigenetic or proteomic age, increase fibrotic lung disease risk: Mendelian randomisation with pleiotropy dissection and independent replication

If replicated and confirmed, the genetic evidence that shorter telomeres increase risk of fibrotic lung disease (IPF) helps clarify that telomere length itself — not just telomerase-pathway genes — may be relevant to...

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Macleaya cordata Extract Ameliorates DSS-Induced Ulcerative Colitis via Inhibiting M1 Macrophages and Reshaping Gut Microbiota
Antioxidants

Macleaya cordata Extract Ameliorates DSS-Induced Ulcerative Colitis via Inhibiting M1 Macrophages and Reshaping Gut Microbiota

This study suggests a plant extract (Macleaya cordata) and its component sanguinarine reduced inflammation and improved colitis signs in mice by changing gut bacteria and macrophage activation — mechanisms relevant to...

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Postmarketing reporting patterns of Candida-related events associated with bimekizumab and selective IL-17A inhibitors in psoriasis: a FAERS and JADER pharmacovigilance study.
Frontiers in pharmacology

Postmarketing reporting patterns of Candida-related events associated with bimekizumab and selective IL-17A inhibitors in psoriasis: a FAERS and JADER pharmacovigilance study.

Patients with psoriasis (and clinicians treating them) using IL‑17 pathway inhibitors may want to know whether certain fungal infections are being reported more often for newer agents; the paper highlights more frequent...

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Purinergic signaling in the gut neuro-glial-immune axis: mechanisms of homeostasis, inflammation, and gastrointestinal dysfunction.
Frontiers in gastroenterology (Lausanne, Switzerland)

Purinergic signaling in the gut neuro-glial-immune axis: mechanisms of homeostasis, inflammation, and gastrointestinal dysfunction.

Purinergic signaling connects nerves, immune cells, epithelium, and microbiota in the gut — pathways that can influence inflammation, motility, and pain relevant to IBD. Understanding these mechanisms could point to new...

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Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

A Phase 3 study is testing whether upadacitinib is safe and effective for children with moderate-to-severe Crohn's disease who have not responded to or cannot take other therapies. Positive results could expand treatment...

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Dexpanthenol attenuates anxiety-like behaviors and inflammatory factors in a rat model of acetic acid-induced colitis
BMC Pharmacology and Toxicology

Dexpanthenol attenuates anxiety-like behaviors and inflammatory factors in a rat model of acetic acid-induced colitis

The study links an experimental treatment (dexpanthenol) to reduced inflammatory cytokines and improved anxiety-like behaviors in a rat colitis model, which is relevant to research on inflammation-driven gut–brain...

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Diagnostic Value of Gastrointestinal Ultrasound (GIUS), Including Doppler and Contrast-Enhanced Ultrasound (CEUS), in the Assessment of Inflammatory Bowel Disease Activity: A Scoping Review
Journal of Clinical Medicine

Diagnostic Value of Gastrointestinal Ultrasound (GIUS), Including Doppler and Contrast-Enhanced Ultrasound (CEUS), in the Assessment of Inflammatory Bowel Disease Activity: A Scoping Review

Noninvasive GI ultrasound (including Doppler/CEUS) could reduce the need for frequent endoscopies for monitoring IBD activity and, when combined with biomarkers, may improve accuracy of disease assessment. However,...

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Changes in Serum MMP-9 and TIMP-1 Concentrations in Children with Inflammatory Bowel Disease over a Six-Month Observation Period
International Journal of Molecular Sciences

Changes in Serum MMP-9 and TIMP-1 Concentrations in Children with Inflammatory Bowel Disease over a Six-Month Observation Period

If reliable, blood biomarkers that track IBD activity could help noninvasively follow children with Crohn’s disease or ulcerative colitis. This study suggests MMP-9 and TIMP-1 change with disease course but did not show...

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Longitudinal Metaproteomic and Lysine Crotonylation Remodeling Defines Clinical Response to Fecal Microbiota Transplantation in Ulcerative Colitis
openRxiv

Longitudinal Metaproteomic and Lysine Crotonylation Remodeling Defines Clinical Response to Fecal Microbiota Transplantation in Ulcerative Colitis

The work suggests new molecular readouts (fecal metaproteomics and lysine crotonylation) that could help explain why some people with ulcerative colitis respond to FMT while others do not, potentially guiding future...

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Leucine-rich alpha-2 glycoprotein reflects transmural inflammation assessed by through-the-scope endoscopic ultrasonography: A prospective study in small-bowel Crohn’s disease
World Journal of Gastroenterology

Leucine-rich alpha-2 glycoprotein reflects transmural inflammation assessed by through-the-scope endoscopic ultrasonography: A prospective study in small-bowel Crohn’s disease

A blood biomarker that reflects transmural inflammation could help monitor small-bowel Crohn’s disease noninvasively and might predict risk of rehospitalization.

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This is a Single-center, Prospective, Single-arm Clinical Study Designed to Evaluate the Efficacy and Safety of Oral Aeromonas sp. MTB Phage Therapy for Pouchitis in Patients With Ulcerative Colitis (UC).
ClinicalTrials.gov

This is a Single-center, Prospective, Single-arm Clinical Study Designed to Evaluate the Efficacy and Safety of Oral Aeromonas sp. MTB Phage Therapy for Pouchitis in Patients With Ulcerative Colitis (UC).

This early-phase trial explores a novel, targeted bacteriophage treatment for pouchitis linked to an Aeromonas-associated pathogen (MTB). For people with pouchitis after IPAA, a safe, effective phage therapy could...

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