Clinical study

Postoperative endoscopic recurrence is common after ileocolonic resection for Crohn’s disease; this study suggests biologic drugs started after surgery are linked to lower recurrence rates. Knowing which biologics...

Financial barriers are common among US adults with IBD and are linked to delayed care and skipping medications — problems that can worsen disease control and quality of life.

A blood biomarker that tracks both symptoms and endoscopic inflammation could help with noninvasive monitoring of ulcerative colitis activity and reduce reliance on invasive procedures if validated.

If UPFs increase Crohn's risk by lowering DHA, that points to a measurable metabolic pathway linking diet and disease. Understanding this could inform dietary prevention strategies or targeted nutrition research for...

MRE is a key radiation-free imaging tool for children with Crohn’s disease; this review summarizes its clinical utility and how it fits with other pediatric-focused diagnostic approaches in Japan.

Genetic evidence that PBC may causally influence risk of IBD (and UC specifically) could help explain observed co-occurrence of these autoimmune diseases and point researchers toward shared pathways worth studying.

TGF-β1 is a central regulator implicated in inflammation control, development of fibrosis, and possible cancer progression in Crohn’s disease; advances in this area could inform future treatments or biomarker...

Baseline MRE features may help predict which Crohn's strictures will not improve with advanced medical therapy, informing monitoring and surgical planning. Better stratification could guide decisions about earlier...

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Frontiers in...

This study suggests a commonly eaten medicinal fruit extract has stable polyphenols through digestion and reduced inflammation in a zebrafish colitis model, which may be relevant to research into dietary approaches for...

Sustained fibroblast-to-myofibroblast transition (FMT) is linked to intestinal fibrosis and tumor-related stromal changes that can worsen outcomes in IBD. Understanding the cellular crosstalk that drives FMT could point...

Biopsy-based keratin patterns might help distinguish IBD, microscopic colitis, and IBS—conditions that can look similar clinically—so this could improve diagnostic accuracy if validated.

Chronic antibiotic-refractory pouchitis is a common, impactful complication after ileal pouch-anal anastomosis that can worsen quality of life and increase the risk of pouch failure. Patients and clinicians need clearer...

Many people with UC try dietary supplements; this randomized trial tested grape seed extract and found a measurable reduction in an inflammation blood marker (hs‑CRP) but no clear improvement in most other measured...

A decreasing need for IBD-related surgery after pediatric diagnosis could mean fewer major operations and related recovery for children and young adults. It may reflect the growing use of advanced medical therapies in...

Noninvasive fecal calprotectin levels tracked with endoscopic disease activity in children with colonic Crohn's disease, suggesting FC could help reduce repeat endoscopies and better monitor treatment response.

This study identifies reproducible molecular patterns in UC tissue that could help researchers target non-immune pathways (metabolic/mitochondrial) in addition to inflammation, and it highlights that apparently...

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease and Research and clinical trials. The original article is from Tobacco induced diseases.

If confirmed, distinct circulating T- and B-cell patterns could help researchers and clinicians better understand immune differences in patients who have both ankylosing spondylitis and Crohn's disease, and could point...

If confirmed, a pathology marker visible on routine biopsy (EGC patterns by SOX10 IHC) could help predict which children with ulcerative colitis are more likely to have improved mucosal inflammation over the first year,...

A model that predicts one-year risks for surgery and complications by Montreal phenotype could help identify patients at higher short-term risk and guide research into targeted monitoring or interventions.

The paper suggests that the same herbal formula can produce different absorbed components and target interactions depending on oral versus colonic delivery, which could influence therapeutic effects in ulcerative colitis...

A simple blood-derived neutrophil activation marker (Neut-RI) correlated with clinical disease activity in ulcerative colitis and outperformed fecal calprotectin and CRP in this study, suggesting a potential low-cost,...

Fungi in the gut appear to influence immune pathways implicated in IBD and other autoimmune diseases, suggesting new therapeutic targets and microbiome-based interventions that could affect disease activity.

Short periods of extreme heat may modestly increase the chance of hospitalization for IBD and Crohn’s disease. Patients and clinicians should be aware that temperature extremes could be a trigger for worsening disease...

Researchers found a candidate shared microbial signal across colorectal cancer, Crohn’s disease, and liver cirrhosis that points to redox-related microbial functions; this could guide future biomarker or experimental...

If validated, impaired oxalate handling could help explain why some people with IBD react differently to the same plant-rich diet and point to new dietary or microbiome-based interventions to reduce gut inflammation.

The study tests a molecular technique (ATR-FTIR) with machine learning on biopsy tissue to find signals linked to future dysplasia/CRC risk in IBD — a potential complement to colonoscopic surveillance if validated.

Shows molecular correlates (reduced IL‑17 signaling and IL‑1β) linked with mucosal healing after exclusive enteral nutrition in children with Crohn's disease, which may help researchers develop biomarkers or understand...

Pathology reports often list microscopic findings that reflect disease activity. Knowing which histologic features are frequently seen in relapsing ulcerative colitis helps patients and clinicians interpret biopsy...

PUC often behaves differently and more aggressively than adult-onset UC; understanding pediatric‑specific causes and treatments could lead to better, more effective therapies for children.

Accurate methods and dataset labels matter for researchers reproducing transcriptomic analyses and for clinicians interpreting translational implications. The corrigendum clarifies which datasets and experimental models...

This project investigates how estrogen receptor signaling in intestinal epithelial cells drives sex-specific responses to injury and inflammation that may influence ulcerative colitis risk and progression.

Patients and clinicians struggle to predict relapse in ulcerative colitis because current endoscopic, histologic, and noninvasive biomarkers are imperfect. A tissue-based imaging and spatial-omics approach could identify...

The study links a common dietary compound (oxalate) to worsened intestinal inflammation in IBD and identifies reduced gut oxalate-transport gene activity and microbiome differences as possible mechanisms—findings that...

If true, using infliximab drug-level modeling plus routine blood tests could help predict who has mucosal healing without immediate endoscopy, potentially reducing invasive procedures and improving monitoring for people...

The study shows that fecal (luminal) and mucosal microbiome and metabolite profiles capture different aspects of pediatric IBD—activity versus phenotype—so combined sampling may give a fuller picture for research and...

A blood biomarker that reliably indicates mucosal healing could reduce reliance on colonoscopy, help monitor disease activity more frequently, and better guide treatment decisions in UC.

The work identifies factors that predict loss of response to infliximab and suggests maintenance drug levels are the strongest predictor, which could influence monitoring strategies for people with Crohn's disease on...

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Digestive and liver...

Serum LRG1 is a candidate blood biomarker for mucosal inflammation in UC, but anti-TNF drugs may suppress its levels and cause false-negative results. This affects noninvasive monitoring and decisions based on LRG1...

The mucus layer and goblet cells are central to colonic barrier function; understanding goblet cell diversity and plasticity could point to new ways to restore the mucus barrier in UC and improve disease control.

Surgeons and other clinicians managing IBD patients need to understand current biologic and immunomodulator options, their risks, and implications for surgical timing and perioperative care.

The study suggests a common plant compound (oxalate) may build up in the intestines of people with IBD because transporter proteins are reduced, potentially worsening inflammation. If confirmed, this could influence...

Imaging found increased visceral fat in children with Crohn's despite normal BMI, which could reveal inflammation-related risk not apparent from weight alone. Visceral adiposity was linked to markers of inflammation and...

Patients with ulcerative colitis may develop advanced neoplasia after seemingly complete endoscopic removal of dysplasia. Detecting genomic alterations in adjacent, histologically normal margins could identify...

Monogenic causes (especially IL-10RA mutations) are common in infant-onset IBD and are linked to more severe disease and higher mortality; early genetic testing and consideration of HSCT may change prognosis.

A non-invasive test (intestinal ultrasound) that predicts whether patients stay on biologic therapy could reduce the need for frequent endoscopy and help guide monitoring decisions.