Evidence types
Clinical study articles covering observational research, trial reports, and human data relevant to Crohn's disease and IBD.
Page 6 of 21 · 1007 articles
Based on the title and source metadata, this appears to be a clinical study related to Ustekinumab, IL-12/23 inhibitor, and Medications. The original article is from idp.nature.com.
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from International Journal...
Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and CRP. The original article is from Journal of medical biochemistry.
This study directly compares two rescue medications used when intravenous steroids fail in acute severe ulcerative colitis, reporting similar short-term remission and safety but a slower early response with tacrolimus —...
Orofacial granulomatosis often co-occurs with Crohn's disease and appears linked to a distinct Crohn's phenotype and treatment needs. The findings suggest that advanced therapies can be effective for OFG-associated CD...
Distinguishing Crohn’s disease from intestinal tuberculosis is a frequent problem in TB-endemic areas; a validated mobile ML tool could help clinicians make more accurate, faster diagnostic decisions and avoid...
Microbial amino-acid metabolites may be active players in IBD biology and could become useful biomarkers or therapeutic targets. Understanding these metabolites helps explain links between the microbiome, immune...
A blood biomarker that flags higher risk for complicated Crohn's could help identify people who may need closer monitoring or earlier treatment escalation before clear symptoms or endoscopic inflammation appear.
Biologics can be critical for treating moderate-to-severe IBD, but cost and treatment failure limit access and long‑term use in this Indian cohort. Understanding uptake and reasons for stopping helps target interventions...
Patient engagement in treatment decisions can affect satisfaction, adherence, and care planning. This study identifies practical factors (treatment options, trusted providers, community support) associated with higher...
People diagnosed as IBDU want to know whether their disease course, treatment needs, and chance of later being reclassified differ from typical UC or Crohn's disease.
A formulation that increases oral absorption of quercetin and reduces inflammation in animal models could point toward new flavonoid-based therapies for ulcerative colitis, but findings are preclinical.
Findings describe how often and when dysplasia recurs after ESD for UC-associated neoplasia, information that can affect decisions about endoscopic treatment versus colectomy and surveillance planning.
The study compares ustekinumab effectiveness between biologic‑naïve and biologic‑experienced Crohn’s patients and links clinical response to better quality of life and reduced anxiety — information relevant when...
Predicting which children with Crohn disease will need surgery — and roughly when — could help families and clinicians plan treatments, monitoring, and discussions about elective bowel resection earlier in the disease...
A non-invasive MRI method that correlates with histology and endoscopic scores could reduce the need for frequent colonoscopy for assessing IBD activity and help monitor treatment response, especially when endoscopy is...
Crohn’s disease prevalence and new diagnoses are rising rapidly in Korea, especially among people in their 20s and 30s; that affects demand for diagnosis, long-term care, and affordable treatment.
The study suggests a mechanism (reduced intestinal oxalate transport) that could make common “healthy” plant foods aggravate intestinal inflammation in some people with Crohn’s or ulcerative colitis, which could affect...
This work looks for molecular signals that might help explain how long-term ulcerative colitis can be connected to higher colorectal cancer risk. Identifying shared genes and spatial patterns could eventually guide...
Researchers planned to study whether patterns in the gut microbiome correlate with clinical diagnoses (including Crohn’s and UC), which could inform future biomarker work. The study is suspended, so no results are...
Patients and clinicians using ustekinumab may be able to use an early (around 3 months) drug concentration to help predict short-term remission, while routine repeated monitoring later on may be less informative for...
A plant-derived polysaccharide improved inflammation, gut barrier markers, and metabolic measures in a mouse model of diabetes-linked ulcerative colitis — findings that could point to new research directions for...
Patient-informed refinements to ePRO design and study operations could reduce burden and missing data in high-frequency daily symptom reporting, which matters for study quality and for patients asked to report symptoms...
Perceived stress affects quality of life and may influence symptom burden, disease management, and mental health in people with IBD. Updated PSQ benchmarks from a contemporary cohort help researchers and clinicians...
The study suggests that asymptomatic C. difficile colonization may not predict return of IBD activity in patients who are in remission, which could influence how clinicians interpret positive C. difficile tests in people...
Antibiotics can cause microbiome injury that increases risk of C. difficile and may worsen long-term health issues; identifying ways to protect the gut microbiome during antibiotic use could be especially relevant for...
The project investigates how TNFR1 and TNFR2 differently control epithelial repair in the colon—mechanisms that may explain why many patients on anti‑TNF biologics do not achieve lasting mucosal healing and could point...
The project targets a molecular regulator of tuft cells, which help control mucosal immune responses and have been linked to chronic gut inflammation such as ulcerative colitis. Discovering how OCA-T2 shapes tuft cell...
The study identifies epithelial IFN‑I signaling as a driver of barrier failure in anti‑TNF refractory Crohn’s disease and suggests that blocking IFN‑I could be a rescue strategy for patients who do not respond to...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Crohn's & colitis 360.
Mucosal colonisation by adherent‑invasive E. coli has been implicated in Crohn’s disease for some patients; this study suggests FMT can change the mucosal microbiome and clear AIEC in a small pilot cohort, which could be...
This large national-registry study identifies clinical features linked with needing optimization of biologic or small-molecule therapies in CD and UC. That helps show which patient groups more often require...
Findings about increased LRRK2 in colonic tissue may point to shared immune or genetic mechanisms between Crohn’s disease and neurological disorders, which could be relevant for future research and biomarker development.
The review suggests LJF contains compounds that may reduce intestinal inflammation, support gut barrier health, and influence microbiota—areas directly relevant to ulcerative colitis and colorectal cancer risk. However,...
Histology and endoscopy are both used to assess UC activity; knowing which histologic score is reliable and practical helps clinicians and pathologists standardize monitoring and may streamline reporting in routine care.
A noninvasive, explainable model that combines CT enterography radiomics with CRP could make it easier to monitor mucosal healing in small‑bowel Crohn’s disease without repeated invasive enteroscopy, especially after...
Shifting care toward disease modification could reduce long-term bowel damage and disability for people with Crohn's disease by prioritizing earlier, more effective treatment and exploring prevention strategies.
The study suggests ED presentation symptoms predict admission differently in UC versus CD, which could affect triage and short-term risk assessment for IBD patients. Knowing which symptoms are stronger predictors by...
Early effective treatment may change long-term outcomes in Crohn's disease. Understanding the timing of a potential "window of opportunity" could affect decisions about when to start or escalate therapy.
A blood biomarker that helps predict primary non-response to anti‑TNF drugs could spare some patients ineffective therapy, reduce delays to alternative treatments, and inform shared decision‑making before starting...
S1PR1 drugs (S1P modulators) are an important drug class for IBD; a selective S1PR1 agonist with less S1PR3 activity could mean fewer heart-related side effects. This preclinical work highlights a possible new candidate...
The report identifies rare, East-Asian–enriched genetic variants that appear to affect age at IBD diagnosis and disease progression, which could help explain clinical differences in Korean patients and guide future...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from The Korean journal of internal medicine.
Setons are often used to control sepsis in complex anal fistula, but this study suggests outcomes are worse when Crohn's disease is present, meaning clinicians may view long-term setons as temporary measures in CD rather...
The findings give clinicians and patients data on how often biologic therapy leads to endoscopic remission in biologic‑naïve patients with isolated small‑bowel Crohn's disease, and they suggest similar effectiveness...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Tests and monitoring. The original article is from Frontiers in immunology.
If you're living with Crohn's disease, earlier and better diagnosis (for example, more cross-sectional imaging) may partly explain falling surgery rates over time. This study suggests system-level diagnostic improvements...
Automated analysis of full-length endoscopy videos could standardise assessment of UC activity, identify spatial patterns of inflammation, and better estimate histological healing—information that may influence treatment...
