Clinical trials, biomarkers, microbiome, genetics, AI, basic science, and emerging IBD research.
Page 21 of 65 · 3102 articles
MRE is a key radiation-free imaging tool for children with Crohn’s disease; this review summarizes its clinical utility and how it fits with other pediatric-focused diagnostic approaches in Japan.
Genetic evidence that PBC may causally influence risk of IBD (and UC specifically) could help explain observed co-occurrence of these autoimmune diseases and point researchers toward shared pathways worth studying.
A new small molecule that blocks the NLRP3 inflammasome via ProRS could point to future drug strategies for ulcerative colitis — a pathway involved in intestinal inflammation that matters to people with IBD. This is...
The paper connects a host microRNA (miR-29a) to gut microbiota bile-acid metabolism and an anti-inflammatory bile acid (LCA). If similar mechanisms apply in people, it could point to new biological targets or biomarkers...
The study introduces a colon-targeted EGCG delivery system that reduced inflammation and improved microbial and metabolic markers in a mouse model of UC, suggesting a potential new therapeutic approach worth further...
Candidalysin is a toxin from Candida albicans that can damage epithelial barriers and trigger inflammation. If candidalysin contributes to intestinal inflammation or barrier dysfunction, it could help explain fungal...
The study connects a genetic regulator (PACSIN2) and Rac1 signaling to cellular responses to mercaptopurine, a drug used in IBD, offering a possible explanation for why some patients experience thiopurine-related gut...
Phages shape the gut microbial community and may behave differently in inflamed guts. Understanding phage evolution in IBD could eventually inform microbiome-targeted therapies or explain disease-associated microbial...
TGF-β1 is a central regulator implicated in inflammation control, development of fibrosis, and possible cancer progression in Crohn’s disease; advances in this area could inform future treatments or biomarker...
Cure8 could only read part of this source from tradingview.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Crohn's disease, and Inflammatory bowel disease.
An orally dosed, gut-targeted PDE4 prodrug entering Phase 2 could offer a new locally acting anti-inflammatory option for people with UC or Crohn’s, potentially with fewer systemic side effects than older PDE4 drugs.
The paper suggests that reduced folate transport can raise markers of inflammation-associated colon tumor initiation in mice, which is relevant because people with IBD are at higher risk for folate deficiency and colon...
Cure8 could only read part of this source from tradingview.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Inflammatory bowel disease and Research and clinical trials.
Treating fibrotic strictures would address an unmet need in Crohn’s disease — current approved drugs target inflammation, not established fibrosis. Positive Phase 2a signals could eventually lead to a new pharmacologic...
Based on the title and source metadata, this appears to be an opinion or commentary related to Inflammatory bowel disease and Research and clinical trials. The original article is from Current opinion in pharmacology.
Baseline MRE features may help predict which Crohn's strictures will not improve with advanced medical therapy, informing monitoring and surgical planning. Better stratification could guide decisions about earlier...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Frontiers in...
Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease and Research and clinical trials. The original article is from Frontiers in immunology.
This study suggests a commonly eaten medicinal fruit extract has stable polyphenols through digestion and reduced inflammation in a zebrafish colitis model, which may be relevant to research into dietary approaches for...
Sustained fibroblast-to-myofibroblast transition (FMT) is linked to intestinal fibrosis and tumor-related stromal changes that can worsen outcomes in IBD. Understanding the cellular crosstalk that drives FMT could point...
Researchers link a bacterial metabolic pathway (pdu/pduB) in AIEC to intestinal inflammation and show that host vitamin B12 availability can reduce bacterial invasion and colitis in mice—suggesting a modifiable host...
Patients and clinicians often need real-world data on how methotrexate is actually used in IBD outside trials—this study shows it’s commonly paired with biologics, usually given subcutaneously, and has a median use of...
Cure8 could only read part of this source from tradingview.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Inflammatory bowel disease and Research and clinical trials.
Cure8 could only read part of this source from tradingview.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Crohn's disease, and Research and clinical trials.
Biopsy-based keratin patterns might help distinguish IBD, microscopic colitis, and IBS—conditions that can look similar clinically—so this could improve diagnostic accuracy if validated.
PG is a serious skin complication that can occur with UC. This report suggests guselkumab—an IL‑23 blocker used in IBD and dermatology—helped resolve PG in one patient without loss of UC remission, which could be...
People with UC often use probiotics or microbiome-directed therapies alongside prescription drugs. Understanding probiotic–drug interactions could explain why individuals respond differently to IBD treatments and may...
If AIEC contribute to Crohn’s disease in some people, this study suggests bacterial metabolism linked to vitamin B12 can change how invasive and inflammatory those bacteria are. That points to the possibility of...
This trial tests a novel, tissue-derived cell therapy applied directly to intestinal ulcers — an approach that could lead to new local healing treatments for people with Crohn’s disease if proven safe and effective.
A new Phase 2 trial is testing afimkibart (RO7790121) for moderate-to-severe Crohn's disease; people with Crohn's disease who have failed prior treatments may be especially interested in emerging therapies.
Enteral nutrition (Modulen IBD) is being evaluated as a non-drug induction and maintenance strategy in children with Crohn’s disease; patients and caregivers may be interested because EEN can affect remission, nutrition,...
This study links an epigenetic mechanism in macrophages (H2A.Z deposition) to microbial metabolites (butyrate) and to genetic variants associated with IBD, which may help explain persistent inflammation and variable...
Chronic antibiotic-refractory pouchitis is a common, impactful complication after ileal pouch-anal anastomosis that can worsen quality of life and increase the risk of pouch failure. Patients and clinicians need clearer...
Many people with UC try dietary supplements; this randomized trial tested grape seed extract and found a measurable reduction in an inflammation blood marker (hs‑CRP) but no clear improvement in most other measured...
This preclinical study connects an herbal medicine to changes in gut microbiota, inflammation, and intestinal barrier function in a mouse model of ulcerative colitis — findings that could inform future research on new...
People with ulcerative colitis may be interested because the study explores a plant extract that reduced inflammation markers in a common animal model of colitis, suggesting a possible new avenue for drug discovery or...
A decreasing need for IBD-related surgery after pediatric diagnosis could mean fewer major operations and related recovery for children and young adults. It may reflect the growing use of advanced medical therapies in...
A common heart drug, verapamil, reduced disease signs in a mouse model of colitis and altered inflammation and the gut microbiota — suggesting a possible avenue for future IBD research. These are preclinical results, so...
Noninvasive fecal calprotectin levels tracked with endoscopic disease activity in children with colonic Crohn's disease, suggesting FC could help reduce repeat endoscopies and better monitor treatment response.
The study maps layer-specific gene programs in fibrostenotic Crohn's disease and pinpoints the submucosa as a hotspot for fibromuscular remodeling that underlies strictures and bowel obstruction risk.
This study identifies reproducible molecular patterns in UC tissue that could help researchers target non-immune pathways (metabolic/mitochondrial) in addition to inflammation, and it highlights that apparently...
The review connects Western diet-driven metabolic shifts in the gut, immune cells, and microbiota to ulcerative colitis mechanisms and highlights metabolism-targeting therapies as a potential future avenue for treatment.
Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease and Research and clinical trials. The original article is from Tobacco induced diseases.
Researchers are studying how proteins from both the host and microbes in the gut relate to Crohn’s disease features. Findings could point to new noninvasive biomarkers or therapeutic strategies to correct dysbiosis,...
This trial represents an early-stage clinical test of a new investigational drug (ATTO-1091) for people with ulcerative colitis; Phase 1 studies establish initial safety and how the drug behaves in the body, which are...
The study aims to map the specific peptide targets of T cells driving organ inflammation in autoimmune diseases, which could guide development of antigen-specific, tolerogenic treatments relevant to Crohn's disease and...
This trial tests whether adding nitazoxanide—an antiparasitic with reported antimicrobial and anti-inflammatory effects—can improve symptoms in people with mild-to-moderate ulcerative colitis. If effective, it could...
Transmural healing may better reflect the full depth of inflammation in Crohn’s disease than mucosal healing alone and is associated with improved long-term outcomes in many studies. If validated and adopted, TH could...
