Clinical trials, biomarkers, microbiome, genetics, AI, basic science, and emerging IBD research.
Page 20 of 65 · 3102 articles
Early effective treatment may change long-term outcomes in Crohn's disease. Understanding the timing of a potential "window of opportunity" could affect decisions about when to start or escalate therapy.
The paper links ileitis and changes in enterohepatic bile-acid composition to altered Th17 immune activity, suggesting bile-acid balance could influence inflammation in Crohn’s disease and might be a target for future...
The study links IRF5 to worse intestinal inflammation in UC and shows that reducing IRF5 activity lessens disease in a mouse model, suggesting IRF5 could be a future therapeutic target or biomarker.
The study presents a cell-free EV therapy that reduced inflammation in an experimental colitis model by reprogramming dendritic cells, which could inform future IBD treatments. It highlights a specific immunoregulatory...
The study presents a new inflammation-responsive oral delivery system designed to concentrate antioxidant and anti-inflammatory activity in the colon, which could—if translated safely to humans—offer a way to treat...
Patients and clinicians using vedolizumab may be interested because the review links higher trough concentrations to better remission outcomes—most convincingly for endoscopic remission in UC—and provides descriptive...
This method could let researchers study human intestinal tissue and its immune environment directly, potentially improving understanding of IBD mechanisms and how individual patients’ tissues respond to therapies.
The exposome perspective emphasizes that many non-genetic, potentially modifiable environmental factors likely influence IBD risk. Understanding these factors could help guide prevention research and public-health...
A blood biomarker that helps predict primary non-response to anti‑TNF drugs could spare some patients ineffective therapy, reduce delays to alternative treatments, and inform shared decision‑making before starting...
The study suggests some autoimmune diseases common in IBD patients—ulcerative colitis and primary sclerosing cholangitis—may be genetically linked to higher pancreatitis risk. That could help researchers understand...
This preclinical study links NOX1/4 and NLRP3 pathways to ferroptosis and iron metabolism in a mouse colitis model, highlighting potential mechanistic targets that could inform future precision therapies for ulcerative...
The study links high levels of the bile acid DCA to microbiome and metabolite changes that correlate with intestinal inflammation in mice, suggesting a possible pathway connecting high‑fat diets to colitis risk.
The review suggests that specific Klebsiella pneumoniae strains could connect chronic IBD inflammation with rectal cancer risk, pointing to possible biomarker or prevention targets that may be relevant for people with...
PSC commonly co-occurs with IBD in children; understanding clinical phenotypes and reliable monitoring tools helps families and clinicians track disease and plan follow-up.
S1PR1 drugs (S1P modulators) are an important drug class for IBD; a selective S1PR1 agonist with less S1PR3 activity could mean fewer heart-related side effects. This preclinical work highlights a possible new candidate...
The review describes a novel preclinical approach—catalytic nanozymes—that aims to reduce oxidative stress and re-balance immune responses in ulcerative colitis, which could eventually lead to new treatments for patients...
Single-cell and spatial multi-omics help explain why many patients do not respond to current biologics and JAK inhibitors and point toward molecular and cellular biomarkers that could one day guide more precise treatment...
The report identifies rare, East-Asian–enriched genetic variants that appear to affect age at IBD diagnosis and disease progression, which could help explain clinical differences in Korean patients and guide future...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from The Korean journal of internal medicine.
Setons are often used to control sepsis in complex anal fistula, but this study suggests outcomes are worse when Crohn's disease is present, meaning clinicians may view long-term setons as temporary measures in CD rather...
A new fluorescent probe designed from bile acids may help image inflammation and has shown anti-inflammatory/antioxidant activity in cell studies relevant to ulcerative colitis, which could inform future diagnostic or...
The findings give clinicians and patients data on how often biologic therapy leads to endoscopic remission in biologic‑naïve patients with isolated small‑bowel Crohn's disease, and they suggest similar effectiveness...
Spatially resolved profiling could identify the specific cell neighborhoods and signaling circuits that drive disease in a person’s gut tissue, which may help predict who will respond to particular biologics or small...
Noninvasive detection of intestinal fibrosis activity could help identify patients at risk of progressive scarring and surgery, and enable development or targeting of anti-fibrotic treatments for Crohn's disease.
Older adults with IBD face tradeoffs between effectiveness and safety of advanced therapies; this study aims to identify immune‑aging and frailty markers that might predict who is more likely to benefit without serious...
This trial tests whether starting with one biologic or targeted therapy versus another (and the sequence of switches) affects remission, safety, and quality of life for people with moderate-to-severe ulcerative colitis —...
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Ulcerative colitis, Colorectal cancer, and Diet and lifestyle. The original article is from Food science &...
Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Advances and Applications...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Tests and monitoring. The original article is from Frontiers in immunology.
If you're living with Crohn's disease, earlier and better diagnosis (for example, more cross-sectional imaging) may partly explain falling surgery rates over time. This study suggests system-level diagnostic improvements...
Based on the title and source metadata, this appears to be an opinion or commentary related to Inflammatory bowel disease and Research and clinical trials. The original article is from Alimentary pharmacology &...
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease and Mental health and quality of life. The original article is from Cureus.
Automated analysis of full-length endoscopy videos could standardise assessment of UC activity, identify spatial patterns of inflammation, and better estimate histological healing—information that may influence treatment...
The analysis compares rescue drugs used when severe ulcerative colitis doesn't respond to IV steroids — a high-stakes situation where avoiding colectomy matters.
Postoperative endoscopic recurrence is common after ileocolonic resection for Crohn’s disease; this study suggests biologic drugs started after surgery are linked to lower recurrence rates. Knowing which biologics...
Financial barriers are common among US adults with IBD and are linked to delayed care and skipping medications — problems that can worsen disease control and quality of life.
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Materials Today Bio.
The findings identify a natural microbial metabolite (urolithin A) that appears to strengthen the intestinal barrier and aid tissue repair via a specific receptor and inflammasome pathway, suggesting new, more targeted...
The article highlights a natural gut-microbe product (urolithin A) that may help repair the intestinal lining by activating a protective molecular pathway.
A blood biomarker that tracks both symptoms and endoscopic inflammation could help with noninvasive monitoring of ulcerative colitis activity and reduce reliance on invasive procedures if validated.
Researchers are testing whether blocking three inflammation pathways at once can reduce tissue inflammation more than single drugs. If ex vivo results show stronger effects, it could guide development of multi-target...
Patients with ulcerative colitis and their clinicians may be interested because the study tests whether adding pentoxifylline to standard mesalamine improves disease activity measured by the Mayo Score over 6 months.
Head-to-head comparisons between biologics are uncommon but useful for patients and clinicians deciding between agents. This study specifically compares ustekinumab and infliximab for remission, safety, and quality of...
Postoperative recurrence is common after intestinal resection for Crohn's disease, but clinicians currently lack reliable molecular biomarkers or validated models to predict who will relapse.
Long-term safety information matters for people with ulcerative colitis considering or already taking filgotinib, because LTE studies track adverse events and lab changes over years. Findings from such a study can...
The study identifies a macrophage-driven mechanism (IL-1β–linked ferroptosis-like lipid peroxidation) that may contribute to epithelial injury in Crohn’s disease, suggesting new biological targets that could eventually...
If UPFs increase Crohn's risk by lowering DHA, that points to a measurable metabolic pathway linking diet and disease. Understanding this could inform dietary prevention strategies or targeted nutrition research for...
Improved detection of divergent RNA viruses in gut metatranscriptomes could help researchers better characterize the viral component of the microbiome in IBD and explore possible viral contributions to disease biology or...
