Clinical trials, biomarkers, microbiome, genetics, AI, basic science, and emerging IBD research.
Page 7 of 33 · 1564 articles
Fibrosis (irreversible bowel scarring) is a major cause of surgery in Crohn’s disease. Identifying molecular and microbial markers tied to fibrosis could eventually help predict who’s at higher risk and guide earlier,...
The paper maps distinct stromal cell states tied to inflamed versus fibrotic tissue niches in Crohn’s disease and shows that these states have different chromatin configurations and drug-modifiable properties — pointing...
The work points to measurable molecular and microbial patterns that may help distinguish treatable inflammation from progressive fibrosis and suggests AI could aid in building predictive tools from limited samples —...
Identifies candidate gene signatures tied to MAM-related transcriptional states in IBD that could become biomarkers or guide mechanistic research into immune–metabolic pathways relevant to disease.
The probe targets azoreductase-driven hypoxia, a mechanism linked to ulcerative colitis and other hypoxia-associated diseases; a reliable real-time imaging method could help research and eventually guide treatments.
The study suggests a specific stromal and MAPK/EGFR signalling programme linked to prior anti‑TNF failure in ulcerative colitis, which could help explain why some patients are less responsive to later therapies and point...
Preclinical data suggest sodium phenylbutyrate and suramin may reduce inflammation and oxidative stress in a mouse model of ulcerative colitis, pointing to possible therapeutic mechanisms worth further study.
This study presents a targeted immunotherapy approach designed to concentrate an immune‑modulating protein (PD‑L1‑Fc) in the inflamed colon, which could in future reduce systemic side effects of biologic immunomodulators...
Patients and clinicians are interested in whether combining two targeted biologic therapies can induce stronger endoscopic healing for people with difficult-to-treat Crohn's disease, and whether benefit can be maintained...
People with an ileal pouch after UC/IBDU often struggle with fecal incontinence and reduced quality of life. This trial is testing a noninvasive device (Emsella chair) aimed at improving incontinence and patient-reported...
A new Phase 2 trial is testing SL-325 given IV for moderate-to-severe Crohn's disease with endoscopic response as the primary outcome. The study targets people who have not responded to or cannot tolerate several...
The study tests whether combining a standardized coping-skills program with biologic therapy improves emotional well-being and clinical/endoscopic outcomes in people with early Crohn's disease—addressing common...
A new pediatric Phase 3 trial of filgotinib could broaden approved treatment choices for children and teens with moderate-to-severe ulcerative colitis, especially for those who have not responded to or cannot tolerate...
A new oral investigational drug (HRS-7085) is entering early human testing for moderate-to-severe ulcerative colitis. People with UC who have not benefited from approved therapies may be interested in trial options and...
Pouchitis is a common complication after IPAA and noninvasive tools to detect inflammation could make monitoring easier and less burdensome than repeated pouchoscopy. This trial tested whether intestinal ultrasound can...
A large clinical registry can help researchers learn more about IBD patterns, potential causes, and who might be eligible for future clinical trials. For patients, joining may help advance research and make it easier to...
Researchers are testing whether short-term dual therapy with vedolizumab plus tofacitinib can induce remission in people with moderate–severe UC who have failed prior TNF blockers. If effective and safe, this approach...
AI tools could make objective disease assessment faster and more consistent, help detect inflammation beyond what symptoms suggest, and ultimately support more personalized treatment choices for people with Crohn’s...
Depressive disorders—diagnosed using structured clinical interviews—appear to be relatively common in people with IBD, which has implications for screening and referral to mental health care within IBD clinics.
The study addresses a practical question for people with IBD: whether sequencing anti-TNF therapy after a biologic from a different class affects how well the anti-TNF works. Shorter durability — especially in ulcerative...
The study links shared gene-expression patterns between IBD and ankylosing spondylitis and highlights STAT3 as a potential shared biomarker or therapeutic target, which could be relevant for understanding overlapping...
Patients with IBD commonly change or restrict their diets and often want reliable guidance. This study tested automated personalized feedback plus an online nutrition portal and found improved food-related quality of...
This correction updates duplicated data points and clarifies methods in a preclinical synthetic-biology study about engineered materials that secrete therapeutic proteins for IBD, which affects interpretation and...
Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from International...
The paper describes a preclinical demonstration that a plant-derived compound reduced inflammation and changed gut microbiota and metabolite profiles in a mouse colitis model, suggesting a possible route for future...
Targeted release of mesalamine to the colon could increase local drug levels and reduce upper-GI exposure and systemic side effects. New delivery platforms may improve effectiveness for ulcerative colitis without...
The study suggests a probiotic strain (Lactobacillus plantarum) reduced inflammation and prolonged remission in multiple mouse models of Crohn’s-like disease, indicating microbiome-based approaches might be promising to...
The study identifies shared genetic signals and cell types (especially T cells) between ulcerative colitis and psoriasis, which could help explain their clinical co-occurrence and suggest pathways for future research or...
The study identifies a possible molecular mechanism (THRIL downregulation and inhibition of p38 MAPK/NF-κB) by which a traditional Chinese medicine preparation reduced inflammation in mouse and cell models of colitis,...
Bile acids shaped by gut microbes can influence inflammation and metabolism, so understanding these pathways could lead to new biomarkers or treatments relevant to people with IBD.
New targeted-delivery research could lead to treatments that reduce gut inflammation while also shifting the microbiome — both relevant to IBD management. However, this report is preclinical and does not mean the therapy...
Finding neutralising anti-IL-10 antibodies in a subset of children with IBD may help explain why some patients have more severe, treatment‑resistant disease and points to a potential biomarker for risk stratification.
Shared gut microbiome shifts across autoimmune diseases could suggest common microbial factors relevant to immune regulation and might eventually inform diagnostics or therapies relevant to people with IBD.
The study suggests anti-TNF failure in Crohn's may be driven by pre-existing cytokine interaction networks and loss of regulatory feedback, which could help explain why some patients don't respond to TNF-blocking...
The study highlights GM‑CSF as a spatial regulator of myeloid–lymphoid interactions in ulcerated ileal tissue, which may help researchers and clinicians understand mechanisms that drive inflammation and epithelial injury...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis and Research and clinical trials. The original article is from Journal of Visualized Experiments.
Cure8 indexed source-provided abstract text from National Center for Health Statistics (U.S.), but this record did not meet the threshold for a full Cure8 brief. It is tagged for Inflammatory bowel disease and Research...
Shattuck Labs plans to advance a DR3-targeting bispecific antibody (SL-325) into a Phase 2b trial for Crohn's disease, which is relevant to people watching new investigational biologics for IBD. The report is a...
AI could help make IBD assessments (endoscopy, histology, imaging, biomarkers) more objective and faster, which may improve monitoring, treatment selection, and early detection of complications for people with Crohn’s...
Shows that in Crohn’s disease, inflammatory changes in circulating monocytes appear before they enter the gut, which could help explain persistent intestinal macrophage dysfunction and may guide future biomarker or...
If PALI-2108 proves safe and effective in Phase 2 trials, it could add a new oral treatment option for people with ulcerative colitis and Crohn’s disease. Early Phase 1 signals and a funded Phase 2 program mean the...
Growth and new approvals for Skyrizi and Rinvoq may increase treatment options and influence which drugs gastroenterologists prescribe for Crohn’s disease and ulcerative colitis. Changes in approvals, dosing options, and...
Based on the title and source metadata, this appears to be a clinical trial phase 2 related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from t.co.
Researchers used genetics plus single-cell sequencing and ELISA to prioritize plasma protein ratios that may causally relate to ulcerative colitis. If validated in larger studies, such biomarkers could help with...
If you have IBD, the mouth and gums may be part of shared inflammatory pathways with your gut. Periodontitis is associated with higher odds of having IBD in cross-sectional studies and has a modest link to later...
Identifies factors that may raise the chance of developing pouchitis after IPAA — useful for patients considering or recovering from proctocolectomy and for clinicians planning perioperative care or monitoring.
People with IBD and other immune-mediated inflammatory diseases may be at risk for lasting symptoms after COVID-19, and those symptoms were associated with worse quality of life in this study. Awareness can help...
Hospitalized patients with acute severe ulcerative colitis face high short-term risk of colectomy and need effective rescue strategies; this trial tests a personalized, adaptive approach to inpatient medical therapy and...
