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Research and clinical trials

Clinical trials, biomarkers, microbiome, genetics, AI, basic science, and emerging IBD research.

Page 7 of 34 · 1606 articles

Beyond Clinical Toxicity: Repositioning the Truelove and Witts Criteria in the Treat-to-Target Era of Acute Severe Ulcerative Colitis
Gastroenterology Insights

Beyond Clinical Toxicity: Repositioning the Truelove and Witts Criteria in the Treat-to-Target Era of Acute Severe Ulcerative Colitis

The T&W criteria are still used to define severe UC on admission, but relying on them alone may delay recognition of steroid non‑response and escalation decisions. Integrating biomarkers, endoscopy, and imaging can help...

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Inflammatory and Immune Cytoprofiles of Active Ulcerative Colitis from Crohn’s Disease—Insights from Multivariable Modeling
International Journal of Molecular Sciences

Inflammatory and Immune Cytoprofiles of Active Ulcerative Colitis from Crohn’s Disease—Insights from Multivariable Modeling

Distinct circulating immune signatures could help differentiate active UC from CD and suggest disease-specific pathways that might guide future biomarkers or therapies.

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Circulating microRNAs as biomarkers of disease activity and treatment response in Crohn’s disease patients receiving infliximab or vedolizumab: a longitudinal cohort study
Frontiers in Medicine

Circulating microRNAs as biomarkers of disease activity and treatment response in Crohn’s disease patients receiving infliximab or vedolizumab: a longitudinal cohort study

If validated, blood microRNAs could become noninvasive biomarkers to help track inflammation and predict biochemical response to infliximab or vedolizumab in Crohn’s disease, complementing CRP and fecal calprotectin.

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The trajectory of inflammatory bowel disease in east and southeast Asia: transitioning from acceleration in incidence to compounding prevalence.
The lancet. Gastroenterology & hepatology

The trajectory of inflammatory bowel disease in east and southeast Asia: transitioning from acceleration in incidence to compounding prevalence.

Rising incidence in east and southeast Asia means more people will live with IBD over coming decades, which affects healthcare planning, access to specialists, and resource needs. Understanding regional trajectories can...

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Periodontal ligament stem cells ameliorate experimental colitis by restoring macrophage mitochondrial homeostasis associated with PINK1/Parkin-related mitochondrial quality control.
Biochimica et biophysica acta. Molecular basis of disease

Periodontal ligament stem cells ameliorate experimental colitis by restoring macrophage mitochondrial homeostasis associated with PINK1/Parkin-related mitochondrial quality control.

This preclinical study links periodontal ligament stem cells to reduced colitis severity in mice by restoring macrophage mitochondrial function and activating PINK1/Parkin-associated mitophagy, suggesting a possible new...

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Profiling Systemic IgG-Targeted Gut Microbiota Reveals Disease Activity–Associated Bacterial Signatures in Ulcerative Colitis
MDPI AG

Profiling Systemic IgG-Targeted Gut Microbiota Reveals Disease Activity–Associated Bacterial Signatures in Ulcerative Colitis

This study suggests that specific gut bacteria targeted by systemic IgG are associated with UC activity and inflammation, which could eventually help identify microbial signals linked to flares or systemic inflammation.

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Apoptosis-related genes bridge inflammatory bowel disease and osteoporosis: A bioinformatic analysis.
PloS one

Apoptosis-related genes bridge inflammatory bowel disease and osteoporosis: A bioinformatic analysis.

IBD patients face higher risk of osteoporosis; identifying shared, apoptosis-related genes may help explain why and point to future biomarkers or therapeutic targets. The study links specific genes (WNT1, S100A8) to both...

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Epigenetic modulation of stromal cell states underpins pathological tissue niches in Crohn's disease
nature.com

Epigenetic modulation of stromal cell states underpins pathological tissue niches in Crohn's disease

The paper maps distinct stromal cell states tied to inflamed versus fibrotic tissue niches in Crohn’s disease and shows that these states have different chromatin configurations and drug-modifiable properties — pointing...

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LIMK1 PKM andas Integratively Identified Transcriptomic Signatures in Inflammatory Bowel Disease.
Omics : a journal of integrative biology

LIMK1 PKM andas Integratively Identified Transcriptomic Signatures in Inflammatory Bowel Disease.

Identifies candidate gene signatures tied to MAM-related transcriptional states in IBD that could become biomarkers or guide mechanistic research into immune–metabolic pathways relevant to disease.

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Azoreductase-Responsive NIR Fluorescent Self-Assembled Probe for Hypoxia Imaging of Tumors, Hindlimb Ischemia, and Ulcerative Colitis
Analytical Chemistry

Azoreductase-Responsive NIR Fluorescent Self-Assembled Probe for Hypoxia Imaging of Tumors, Hindlimb Ischemia, and Ulcerative Colitis

The probe targets azoreductase-driven hypoxia, a mechanism linked to ulcerative colitis and other hypoxia-associated diseases; a reliable real-time imaging method could help research and eventually guide treatments.

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A dysregulated stromal remodelling programme characterises prior anti-TNF failure in ulcerative colitis
openRxiv

A dysregulated stromal remodelling programme characterises prior anti-TNF failure in ulcerative colitis

The study suggests a specific stromal and MAPK/EGFR signalling programme linked to prior anti‑TNF failure in ulcerative colitis, which could help explain why some patients are less responsive to later therapies and point...

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Role of Sodium Phenylbutyrate and Suramin in the Prevention of Ulcerative Colitis Induced by Dextran Sulfate Sodium
Experimed

Role of Sodium Phenylbutyrate and Suramin in the Prevention of Ulcerative Colitis Induced by Dextran Sulfate Sodium

Preclinical data suggest sodium phenylbutyrate and suramin may reduce inflammation and oxidative stress in a mouse model of ulcerative colitis, pointing to possible therapeutic mechanisms worth further study.

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Metabolic glycoengineered exosomes enable in situ PD-L1-Fc assembly for targeted immunotherapy in ulcerative colitis
Journal of Nanobiotechnology

Metabolic glycoengineered exosomes enable in situ PD-L1-Fc assembly for targeted immunotherapy in ulcerative colitis

This study presents a targeted immunotherapy approach designed to concentrate an immune‑modulating protein (PD‑L1‑Fc) in the inflamed colon, which could in future reduce systemic side effects of biologic immunomodulators...

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A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease
ClinicalTrials.gov

A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease

Patients and clinicians are interested in whether combining two targeted biologic therapies can induce stronger endoscopic healing for people with difficult-to-treat Crohn's disease, and whether benefit can be maintained...

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Functional Outcomes in Ulcerative Colitis Patients With Ileal Pouch Anal Anastomosis Treated With High Intensity Focused Electromagnetic Stimulation
ClinicalTrials.gov

Functional Outcomes in Ulcerative Colitis Patients With Ileal Pouch Anal Anastomosis Treated With High Intensity Focused Electromagnetic Stimulation

People with an ileal pouch after UC/IBDU often struggle with fecal incontinence and reduced quality of life. This trial is testing a noninvasive device (Emsella chair) aimed at improving incontinence and patient-reported...

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A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
ClinicalTrials.gov

A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis

A new pediatric Phase 3 trial of filgotinib could broaden approved treatment choices for children and teens with moderate-to-severe ulcerative colitis, especially for those who have not responded to or cannot tolerate...

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Intestinal Ultrasound for the Evaluation of Pouchitis and Other Outcomes After Ileal Pouch-Anal Anastomosis
ClinicalTrials.gov

Intestinal Ultrasound for the Evaluation of Pouchitis and Other Outcomes After Ileal Pouch-Anal Anastomosis

Pouchitis is a common complication after IPAA and noninvasive tools to detect inflammation could make monitoring easier and less burdensome than repeated pouchoscopy. This trial tested whether intestinal ultrasound can...

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Prevalence of Depressive Disorders in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis of Studies With Diagnoses Verified Using Structured Interviews
JCC Plus

Prevalence of Depressive Disorders in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis of Studies With Diagnoses Verified Using Structured Interviews

Depressive disorders—diagnosed using structured clinical interviews—appear to be relatively common in people with IBD, which has implications for screening and referral to mental health care within IBD clinics.

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Impact of Prior Biologic Mechanism of Action on Anti-TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study.
Alimentary pharmacology & therapeutics

Impact of Prior Biologic Mechanism of Action on Anti-TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study.

The study addresses a practical question for people with IBD: whether sequencing anti-TNF therapy after a biologic from a different class affects how well the anti-TNF works. Shorter durability — especially in ulcerative...

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Integrated Transcriptomic and Machine-Learning Analyses Identify Shared Na+ Overload-Related Gene Signatures in Inflammatory Bowel Disease and Ankylosing Spondylitis
Genes

Integrated Transcriptomic and Machine-Learning Analyses Identify Shared Na+ Overload-Related Gene Signatures in Inflammatory Bowel Disease and Ankylosing Spondylitis

The study links shared gene-expression patterns between IBD and ankylosing spondylitis and highlights STAT3 as a potential shared biomarker or therapeutic target, which could be relevant for understanding overlapping...

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Author Correction: Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease
Nature Biotechnology

Author Correction: Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease

This correction updates duplicated data points and clarifies methods in a preclinical synthetic-biology study about engineered materials that secrete therapeutic proteins for IBD, which affects interpretation and...

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TRDMT1-dependent m5C modification of TLR4 mediates the protective effects of Shaoyao decoction in TNBS-induced Crohn's disease
International Immunopharmacology

TRDMT1-dependent m5C modification of TLR4 mediates the protective effects of Shaoyao decoction in TNBS-induced Crohn's disease

Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from International...

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Orally administrable photo-crosslinked coumaroyl-modified gelatin-CNC nanofibers for ulcerative colitis environment-triggered release of 5-aminosalicylic acid
Journal of Nanobiotechnology

Orally administrable photo-crosslinked coumaroyl-modified gelatin-CNC nanofibers for ulcerative colitis environment-triggered release of 5-aminosalicylic acid

Targeted release of mesalamine to the colon could increase local drug levels and reduce upper-GI exposure and systemic side effects. New delivery platforms may improve effectiveness for ulcerative colitis without...

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Lactobacillus plantarum Attenuates Intestinal Inflammation and Prolongs Remission in Experimental Models of Crohn’s Disease
Probiotics and Antimicrobial Proteins

Lactobacillus plantarum Attenuates Intestinal Inflammation and Prolongs Remission in Experimental Models of Crohn’s Disease

The study suggests a probiotic strain (Lactobacillus plantarum) reduced inflammation and prolonged remission in multiple mouse models of Crohn’s-like disease, indicating microbiome-based approaches might be promising to...

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Integrated multi-omics analysis reveals common genetic architecture between ulcerative colitis and psoriasis.
Human immunology

Integrated multi-omics analysis reveals common genetic architecture between ulcerative colitis and psoriasis.

The study identifies shared genetic signals and cell types (especially T cells) between ulcerative colitis and psoriasis, which could help explain their clinical co-occurrence and suggest pathways for future research or...

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Guchang capsule alleviates inflammatory bowel disease by downregulating lncRNA THRIL and inhibiting the p38 MAPK/NF-κB signaling pathway.
Molecular immunology

Guchang capsule alleviates inflammatory bowel disease by downregulating lncRNA THRIL and inhibiting the p38 MAPK/NF-κB signaling pathway.

The study identifies a possible molecular mechanism (THRIL downregulation and inhibition of p38 MAPK/NF-κB) by which a traditional Chinese medicine preparation reduced inflammation in mouse and cell models of colitis,...

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Surfactant-tailored alginate/pectin hydrogel beads delivering polydeoxyribonucleotide for inflammatory symptom alleviation and gut microbiota regulation.
International journal of biological macromolecules

Surfactant-tailored alginate/pectin hydrogel beads delivering polydeoxyribonucleotide for inflammatory symptom alleviation and gut microbiota regulation.

New targeted-delivery research could lead to treatments that reduce gut inflammation while also shifting the microbiome — both relevant to IBD management. However, this report is preclinical and does not mean the therapy...

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Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.
Gut

Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.

Finding neutralising anti-IL-10 antibodies in a subset of children with IBD may help explain why some patients have more severe, treatment‑resistant disease and points to a potential biomarker for risk stratification.

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Cross-Disease Microbiome Signatures Associated with Autoimmune Disorders: A Comparative Meta-Analysis of Public Sequencing Datasets
Europe PMC

Cross-Disease Microbiome Signatures Associated with Autoimmune Disorders: A Comparative Meta-Analysis of Public Sequencing Datasets

Shared gut microbiome shifts across autoimmune diseases could suggest common microbial factors relevant to immune regulation and might eventually inform diagnostics or therapies relevant to people with IBD.

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GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohns disease
bioRxiv

GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohns disease

The study highlights GM‑CSF as a spatial regulator of myeloid–lymphoid interactions in ulcerated ileal tissue, which may help researchers and clinicians understand mechanisms that drive inflammation and epithelial injury...

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Knowledge Mapping of Clinical Evidence and Mechanistic Research on Tongxie Yaofang for Ulcerative Colitis: A Bibliometric Analysis
Journal of Visualized Experiments

Knowledge Mapping of Clinical Evidence and Mechanistic Research on Tongxie Yaofang for Ulcerative Colitis: A Bibliometric Analysis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis and Research and clinical trials. The original article is from Journal of Visualized Experiments.

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