Article Archive

Page 18 of 56 · 2666 patient-friendly summaries

To Clarify the Independent Role of Digital Learning and Nurse Support in the Self-Management of Inflammatory Bowel Disease
Digestive Diseases and Sciences

To Clarify the Independent Role of Digital Learning and Nurse Support in the Self-Management of Inflammatory Bowel Disease

Self-management support—whether through digital learning tools or nurse-delivered programs—can affect daily life for people with IBD. Understanding which element drives benefit could shape future care options and how...

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Mechanism and Active ingredients of Gancao Qinlian Granules in ameliorating ulcerative colitis:integrated in vivo, in vitro, network pharmacology and untargeted metabolomics investigation.
Journal of ethnopharmacology

Mechanism and Active ingredients of Gancao Qinlian Granules in ameliorating ulcerative colitis:integrated in vivo, in vitro, network pharmacology and untargeted metabolomics investigation.

The paper presents integrated preclinical evidence that a multi-herb formula (GQG) can reduce inflammation and alter gut microbiota and metabolites in a mouse model of ulcerative colitis, highlighting possible mechanisms...

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Efficacy and safety of ulcerative colitis therapies do not differ by age: A post hoc analysis of randomized controlled trials
PubMed Central

Efficacy and safety of ulcerative colitis therapies do not differ by age: A post hoc analysis of randomized controlled trials

Cure8 could only read part of this source from PubMed Central, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Research and clinical...

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Long-term outcomes of laser therapy for perianal fistulising Crohn’s disease: a single-center retrospective cohort study
Developments and Experiments in Health and Medicine

Long-term outcomes of laser therapy for perianal fistulising Crohn’s disease: a single-center retrospective cohort study

Perianal fistulas in Crohn’s disease are hard to treat and preserving continence is important. Long-term data suggesting laser ablation can achieve sustained healing in some patients are relevant for treatment decisions.

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Shifts in Mucosa‐Associated Microbiota Reflect Inflammation Gradient in Postoperative Crohn's Disease
JCC Plus

Shifts in Mucosa‐Associated Microbiota Reflect Inflammation Gradient in Postoperative Crohn's Disease

Microbial changes after ileocecal resection appear linked to the degree of postoperative inflammation; understanding these changes could help predict or prevent Crohn’s recurrence after surgery.

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Therapeutic Potential of Bioactive Natural Product in Crohn’s Disease: Focus on Redox Homeostasis and Inflammatory Signalling
Natural Products Analysis

Therapeutic Potential of Bioactive Natural Product in Crohn’s Disease: Focus on Redox Homeostasis and Inflammatory Signalling

People with Crohn’s may be interested because the review discusses novel natural compounds that target oxidative stress and inflammation — pathways involved in disease activity — and highlights formulation challenges...

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Proximally dominant inflammation at colonoscopy predicts pan-colonic histological remission following oral vancomycin therapy in pediatric ulcerative colitis
Digestive and Liver Disease

Proximally dominant inflammation at colonoscopy predicts pan-colonic histological remission following oral vancomycin therapy in pediatric ulcerative colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Colonoscopy. The original article is from Digestive and Liver Disease.

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Prospective real-world experience with risankizumab in difficult-to-treat Crohn’s disease: results from the Dutch Initiative on Crohn and Colitis Registry
PubMed Central

Prospective real-world experience with risankizumab in difficult-to-treat Crohn’s disease: results from the Dutch Initiative on Crohn and Colitis Registry

The study provides real-world effectiveness and safety data for risankizumab in a largely difficult-to-treat Crohn's population, showing about half achieved corticosteroid-free clinical remission at 24 weeks —...

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Inflammatory bowel disease and risk of perineal injury in primiparous vaginal births: a retrospective cohort study
PubMed Central

Inflammatory bowel disease and risk of perineal injury in primiparous vaginal births: a retrospective cohort study

This helps people with IBD and their care teams make delivery plans: if perianal disease is not active, having IBD alone was not linked to higher perineal injury risk in first-time vaginal births in this study.

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Modified Crohn's Disease Exclusion Diet and exclusive enteral nutrition (EEN) resolve oral dysbiosis in pediatric Crohn's disease: a prospective cohort study
PubMed Central

Modified Crohn's Disease Exclusion Diet and exclusive enteral nutrition (EEN) resolve oral dysbiosis in pediatric Crohn's disease: a prospective cohort study

The oral microbiome in children with Crohn's disease appears to reflect disease severity and changes with treatment, suggesting a potential noninvasive biomarker for monitoring response to nutritional therapies like CDED...

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Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.
Materials today. Bio

Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.

IBD and other lower-GI disorders may benefit from oral hydrogel platforms that improve local drug delivery while deliberately engaging the gut microbiota. Understanding this research direction helps patients and...

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Synergistic effects of partial enteral nutrition combined with Ustekinumab in induction and maintenance therapy for Crohn's disease: Real-world experience from a multicentre cohort.
Clinical nutrition (Edinburgh, Scotland)

Synergistic effects of partial enteral nutrition combined with Ustekinumab in induction and maintenance therapy for Crohn's disease: Real-world experience from a multicentre cohort.

Adding partial enteral nutrition to ustekinumab was associated with better clinical, endoscopic, radiologic, and nutritional outcomes at 52 weeks in this multicentre real-world cohort of Crohn’s disease patients. This...

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pH-responsive microgels containing multifunctional ginsenoside Rh2-based liposomes remodel intestinal environment to enhance celastrol therapy for ulcerative colitis.
Materials today. Bio

pH-responsive microgels containing multifunctional ginsenoside Rh2-based liposomes remodel intestinal environment to enhance celastrol therapy for ulcerative colitis.

The study describes a colon-targeted delivery system that enhanced local anti-inflammatory, barrier-repair, and microbiota-restoring effects of celastrol in a mouse UC model. If translatable, this approach could lead to...

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Discovery of self-assembled nanoparticles from Rubia cordifolia L. before and after carbonization and mechanistic study on their targeted therapy for ulcerative colitis
Phytomedicine

Discovery of self-assembled nanoparticles from Rubia cordifolia L. before and after carbonization and mechanistic study on their targeted therapy for ulcerative colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Phytomedicine.

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Thymoquinone–chromium–psyllium nanocomposite mitigates ulcerative colitis in association with miR-200a/NRF2 enhancement and JAK/STAT modulation
Journal of Drug Delivery Science and Technology

Thymoquinone–chromium–psyllium nanocomposite mitigates ulcerative colitis in association with miR-200a/NRF2 enhancement and JAK/STAT modulation

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Drug...

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Effects of Spirulina phycocyanin on Caco-2 cell injury and ulcerative colitis in mice
International Journal of Biological Macromolecules

Effects of Spirulina phycocyanin on Caco-2 cell injury and ulcerative colitis in mice

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from International Journal...

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Curcumin-loaded tetrahedral framework nucleic acids reshape intestinal homeostasis in ulcerative colitis by coordinating barrier repair, microbiota reconstruction, and immune modulation
Materials Today Bio

Curcumin-loaded tetrahedral framework nucleic acids reshape intestinal homeostasis in ulcerative colitis by coordinating barrier repair, microbiota reconstruction, and immune modulation

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Materials Today Bio.

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A systematic review and meta-analysis of acupuncture for intestinal protection and underlying mechanisms in animal models of ulcerative colitis.
Medicine

A systematic review and meta-analysis of acupuncture for intestinal protection and underlying mechanisms in animal models of ulcerative colitis.

People with IBD may see growing interest in nonpharmacologic approaches like acupuncture; this review summarizes preclinical evidence suggesting acupuncture can reduce inflammation and support intestinal barrier proteins...

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Association between inflammatory bowel disease and ankylosing spondylitis: Mendelian randomization of a different database and meta-analysis.
Medicine

Association between inflammatory bowel disease and ankylosing spondylitis: Mendelian randomization of a different database and meta-analysis.

This study suggests that genetic risk for Crohn disease and ulcerative colitis may causally increase the risk of developing ankylosing spondylitis, an inflammatory joint condition that commonly co-occurs with IBD.

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The causal association between inflammatory bowel disease and pancreatitis: A 2-sample Mendelian randomization study.
Medicine

The causal association between inflammatory bowel disease and pancreatitis: A 2-sample Mendelian randomization study.

If true, a causal link between IBD and pancreatitis could help explain why people with Crohn’s disease or ulcerative colitis sometimes develop acute or chronic pancreatitis and could guide research into shared biological...

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Real-world data on clinical response to inflammatory bowel disease biological treatments in patients with concurrent primary sclerosing cholangitis: a case-control study.
Gastroenterology report

Real-world data on clinical response to inflammatory bowel disease biological treatments in patients with concurrent primary sclerosing cholangitis: a case-control study.

This study suggests that people with PSC-IBD may respond differently to some biologic treatments: infliximab and vedolizumab had similar early effectiveness versus IBD alone, but ustekinumab showed a lower early response...

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Clinical Characteristics of Patients Presenting with Moderate-to-Severe Atopic Dermatitis and Concomitant Inflammatory Bowel Diseases: a Multicenter Retrospective Study
Dermatology Practical & Conceptual

Clinical Characteristics of Patients Presenting with Moderate-to-Severe Atopic Dermatitis and Concomitant Inflammatory Bowel Diseases: a Multicenter Retrospective Study

This study suggests adults with moderate-to-severe atopic dermatitis may have a higher-than-expected prevalence of IBD compared with general population estimates, and AD often precedes IBD—so dermatologists and patients...

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Monitoring morning heart rate variability in an elite female long jumper with ulcerative colitis during the build-up to the 2020 Tokyo Olympics: A 58-week case study
International Journal of Sports Science & Coaching

Monitoring morning heart rate variability in an elite female long jumper with ulcerative colitis during the build-up to the 2020 Tokyo Olympics: A 58-week case study

People with IBD and their clinicians are often looking for objective ways to monitor disease-related changes. This study suggests morning HRV may add useful, noninvasive information about condition and readiness in an...

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Metabolite 4-hydroxybenzoic acid, modulated by cigarette smoke exposure, functions as a protective factor in dextran sodium sulfate-induced colitis
Journal of Gastroenterology

Metabolite 4-hydroxybenzoic acid, modulated by cigarette smoke exposure, functions as a protective factor in dextran sodium sulfate-induced colitis

This preclinical study suggests cigarette smoke alters gut microbes and metabolites in ways that can either protect or worsen colitis depending on the model; it identifies 4-HBA as a metabolite that reduced inflammation...

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Infliximab originator and biosimilars have similar efficacy in children with inflammatory bowel disease.
Journal of pediatric gastroenterology and nutrition

Infliximab originator and biosimilars have similar efficacy in children with inflammatory bowel disease.

This large pediatric registry study suggests children starting infliximab biosimilars have similar 12‑month clinical outcomes and treatment durability as those starting the originator drug — reassuring for patients and...

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End User Needs and Perspectives for a Digital Opioid Safety Tool in Adolescents and Young Adults With Inflammatory Bowel Disease: A Qualitative Human-Centered Design Study.
JMIR formative research

End User Needs and Perspectives for a Digital Opioid Safety Tool in Adolescents and Young Adults With Inflammatory Bowel Disease: A Qualitative Human-Centered Design Study.

Adolescents and young adults with IBD commonly face pain and may receive opioids; a digital tool designed with patient and clinician input could help reduce opioid-related risks and improve coordination of pain care.

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Polygenic Risk Scores Show Distinct Genetic Architectures of IBD-Associated Comorbidities.
Digestive diseases and sciences

Polygenic Risk Scores Show Distinct Genetic Architectures of IBD-Associated Comorbidities.

Shows which IBD comorbidities may be driven in part by shared inherited genetic risk and which likely reflect non-genetic factors, information that could shape future risk stratification and screening approaches for...

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Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease.

This study links bile-acid signaling through FXR in dendritic cells to regulation of Tph cells, a T-cell subset found in IBD. Understanding these immune pathways could point to new biological mechanisms relevant to...

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Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives.
Annals of medicine

Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives.

Granulomas on biopsy can indicate infection, IBD (including Crohn’s), sarcoidosis, or malignancy; knowing the likely causes and gaps in diagnostic testing helps guide follow-up. The diagnosis mix differed by organ and...

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Deep Learning‐Based Automated Bowel Wall Thickness Measurement in Intestinal Ultrasound for Inflammatory Bowel Disease
JCC Plus

Deep Learning‐Based Automated Bowel Wall Thickness Measurement in Intestinal Ultrasound for Inflammatory Bowel Disease

Automating bowel wall thickness measurement could make intestinal ultrasound more consistent and reliable for monitoring inflammation in IBD, which matters to patients and clinicians tracking disease activity.

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Frailty Rather Than Age Increases the Risk of Infections in Patients With Inflammatory Bowel Disease Treated With Biologics: An Observational Retrospective Cohort Study
JCC Plus

Frailty Rather Than Age Increases the Risk of Infections in Patients With Inflammatory Bowel Disease Treated With Biologics: An Observational Retrospective Cohort Study

Patients with IBD who are frail appear to have a substantially higher risk of infections while on biologic therapies compared with fit patients. Recognizing frailty before and during treatment could improve risk...

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