Article Archive

Page 17 of 100 · 4759 patient-friendly summaries

Post-Operative Ketorolac in Children After Crohn's Ileocecectomy.
Pediatric surgery international

Post-Operative Ketorolac in Children After Crohn's Ileocecectomy.

Postoperative pain control choices after ileocecectomy could affect Crohn's flare risk and opioid exposure. A pediatric center-level analysis found no association between ketorolac and flares and suggested reduced opioid...

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Curcumin in inflammatory bowel disease: highlighting gut microbiota-metabolite-host interactions.
Food & function

Curcumin in inflammatory bowel disease: highlighting gut microbiota-metabolite-host interactions.

Curcumin is a common dietary compound that reaches the colon and may interact with gut bacteria and host immune and barrier pathways implicated in IBD. Understanding these interactions could inform dietary approaches or...

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Enterotype-based stratification identifies clinically distinct microbial subtypes in inflammatory bowel disease.
Inflammatory bowel diseases

Enterotype-based stratification identifies clinically distinct microbial subtypes in inflammatory bowel disease.

Microbiome patterns in this study were linked to inflammation (fecal calprotectin) and higher chance of needing treatment escalation. If validated, enterotype stratification could help predict disease course or tailor...

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Intraoperative endoscopic stricturotomy combined with strictureplasty for multiple small bowel strictures in Crohn’s disease: a pilot case series
Surgical Endoscopy

Intraoperative endoscopic stricturotomy combined with strictureplasty for multiple small bowel strictures in Crohn’s disease: a pilot case series

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Strictureplasty. The original article is from Surgical Endoscopy.

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Comparative Effectiveness of Vedolizumab and Ustekinumab in Biologic-Experienced Ulcerative Colitis: A Real-World Multicenter Study from the Güntürk Group
Turkish Journal of Gastroenterology

Comparative Effectiveness of Vedolizumab and Ustekinumab in Biologic-Experienced Ulcerative Colitis: A Real-World Multicenter Study from the Güntürk Group

Patients and clinicians choosing a next biologic after prior biologic failure may find evidence here that effectiveness is broadly similar between vedolizumab and ustekinumab overall, with potential differences depending...

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Targeting the Microbiota–Metabolism–Immunity Axis: Active Components of Traditional Chinese Medicine in Colitis-Associated Colorectal Cancer
International Journal of Molecular Sciences

Targeting the Microbiota–Metabolism–Immunity Axis: Active Components of Traditional Chinese Medicine in Colitis-Associated Colorectal Cancer

The review links TCM-derived compounds to mechanisms (microbiota, metabolites, immunity) that are implicated in progression from chronic colitis to colorectal cancer, which is an important long-term risk for people with...

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Biopsy-Based Molecular Signatures Predicting Therapeutic Response in Ulcerative Colitis
International Journal of Molecular Sciences

Biopsy-Based Molecular Signatures Predicting Therapeutic Response in Ulcerative Colitis

If validated, mucosal biomarkers like SPARC and SPP1 might help predict who will not respond to infliximab, potentially guiding treatment choices and avoiding ineffective therapy for some people with UC.

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Unlocking the therapeutic potential of traditional Chinese medicine in Crohn’s disease: from multi-target mechanisms to clinical promise
Frontiers in Immunology

Unlocking the therapeutic potential of traditional Chinese medicine in Crohn’s disease: from multi-target mechanisms to clinical promise

People with Crohn’s disease may see emerging interest in traditional Chinese medicine as a multi-target approach that could complement standard treatments and affect immune pathways, the gut barrier, and the microbiome.

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An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan
ClinicalTrials.gov

An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan

People with ulcerative colitis and their clinicians may find real-world safety and disease-activity data helpful when deciding about upadacitinib (Rinvoq) treatment. Observational registries can reveal how a drug...

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A Retrospective Study to Evaluate Treat-to-Target and Disease Modification in Adult Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting
ClinicalTrials.gov

A Retrospective Study to Evaluate Treat-to-Target and Disease Modification in Adult Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting

The study describes real-world use of a treat-to-target approach in adults with Crohn's disease and ulcerative colitis, which may influence how clinicians monitor disease and adjust therapy in routine care.

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ACEBROPHYLLINE REPROGRAMS INFLAMMATORY AND REDOX SIGNALLING IN EXPERIMENTAL ULCERATIVE COLITIS: A DOSE-DEPENDENT STUDY.
Georgian medical news

ACEBROPHYLLINE REPROGRAMS INFLAMMATORY AND REDOX SIGNALLING IN EXPERIMENTAL ULCERATIVE COLITIS: A DOSE-DEPENDENT STUDY.

Preclinical research suggests acebrophylline might reduce inflammation and oxidative stress in an experimental mouse model of ulcerative colitis, which could be an early step toward new treatments that target multiple...

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Impact of Vedolizumab on Bowel Urgency in Ulcerative Colitis: Post Hoc Analysis of the GEMINI 1, VISIBLE 1, and VARSITY Trials.
Gastro hep advances

Impact of Vedolizumab on Bowel Urgency in Ulcerative Colitis: Post Hoc Analysis of the GEMINI 1, VISIBLE 1, and VARSITY Trials.

Bowel urgency is a common, distressing symptom in ulcerative colitis that matters for quality of life. This analysis indicates vedolizumab may reduce urgency and that early improvement is linked to better clinical and...

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Ameliorative Effects of the White Jade Snail Secretion on DSS-Induced Ulcerative Colitis in Mice
Current Issues in Molecular Biology

Ameliorative Effects of the White Jade Snail Secretion on DSS-Induced Ulcerative Colitis in Mice

Preclinical work identifies a natural-product mixture that reduced inflammation, improved gut barrier markers, and changed the microbiome in a mouse model of ulcerative colitis. This could be an early step toward new...

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GART expression is associated with a proliferative and purine-metabolic ISC-like epithelial state in ulcerative colitis
Frontiers in Immunology

GART expression is associated with a proliferative and purine-metabolic ISC-like epithelial state in ulcerative colitis

The study identifies a molecular epithelial program (GART-associated) linked to proliferation and purine metabolism in ulcerative colitis, which could inform future mechanistic research and biomarker development relevant...

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Integrated genetic and functional analyses reveal the pathogenic effects of a novel STXBP3 variant in very-early-onset inflammatory bowel disease with immunodeficiency
Frontiers in Immunology

Integrated genetic and functional analyses reveal the pathogenic effects of a novel STXBP3 variant in very-early-onset inflammatory bowel disease with immunodeficiency

The study identifies and functionally validates a new STXBP3 variant that likely causes VEOIBD with immunodeficiency, which can help explain disease in affected infants and inform genetic counseling and further research.

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Forsythiae Fructus polysaccharides mitigate DSS colitis by modulating gut microbiota-derived palmitic acid and PI3K/AKT pathway.
International journal of biological macromolecules

Forsythiae Fructus polysaccharides mitigate DSS colitis by modulating gut microbiota-derived palmitic acid and PI3K/AKT pathway.

The study suggests a new microbiota–metabolite–immune pathway (palmitic acid → PI3K/AKT → NETs) that may drive colitis and that Forsythia polysaccharides can modify, which could point to future microbiota-targeted...

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Colon-targeted delivery of α-terpineol via ZIF-8 alleviates ulcerative colitis by anti-inflammatory and gut microbiota-metabolism modulation.
International journal of pharmaceutics

Colon-targeted delivery of α-terpineol via ZIF-8 alleviates ulcerative colitis by anti-inflammatory and gut microbiota-metabolism modulation.

The paper describes a novel colon-targeted delivery system that improved local drug retention, reduced dosing frequency, and changed microbiota and metabolic markers in a mouse model of UC — developments that could...

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Gut microbiome enterotypes associate with distinct metabolomic landscapes and clinical outcomes in inflammatory bowel disease: a multi‑omics dissection
Gut Pathogens

Gut microbiome enterotypes associate with distinct metabolomic landscapes and clinical outcomes in inflammatory bowel disease: a multi‑omics dissection

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Microbiome, and Research and clinical trials. The original article is from Gut Pathogens.

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TNF-α and IL-1β Antibodies Alongside Exogenous IL-10 Treatment Ameliorates DSS-Induced Colitis by Modulating the Apoptosis-Autophagy Pathways in Splenic Macrophages
Journal of Clinical Immunology & Microbiology

TNF-α and IL-1β Antibodies Alongside Exogenous IL-10 Treatment Ameliorates DSS-Induced Colitis by Modulating the Apoptosis-Autophagy Pathways in Splenic Macrophages

The study tests combined neutralization of two pro-inflammatory cytokines plus IL‑10 in a mouse colitis model and reports reduced inflammation and restored macrophage cellular pathways, which may inform future IBD...

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America's alarming bowel disease epidemic: Experts reveal the lifestyle habits driving Crohn's surge... the surprising colon cancer paradox... and simple tweaks to reduce your risk
dailymail.com

America's alarming bowel disease epidemic: Experts reveal the lifestyle habits driving Crohn's surge... the surprising colon cancer paradox... and simple tweaks to reduce your risk

Crohn's is becoming more common among younger Americans and long-term uncontrolled inflammation raises colorectal cancer risk. Understanding possible lifestyle and medical factors can help patients and clinicians focus...

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Hesperetin mitigates IBD-associated bone loss via Akkermansia muciniphila enrichment and IDA-driven gut-bone axis crosstalk.
Journal of orthopaedic translation

Hesperetin mitigates IBD-associated bone loss via Akkermansia muciniphila enrichment and IDA-driven gut-bone axis crosstalk.

People with IBD are at increased risk of bone loss; this study points to a microbiome-related pathway (A. muciniphila and an IDA metabolite) that might protect bone in an experimental colitis model, which could...

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Natural Polymer-Based Hydrogels for Localized Therapy in Inflammatory Bowel Disease: From Smart Materials to Clinical Translation.
Journal of inflammation research

Natural Polymer-Based Hydrogels for Localized Therapy in Inflammatory Bowel Disease: From Smart Materials to Clinical Translation.

Localized hydrogel drug delivery aims to concentrate therapy at inflamed gut sites while reducing systemic side effects — a potentially useful approach for people with IBD who have inadequate response or intolerable...

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Oral delivery of recombinant Lactococcus lactis expressing an IL-23 inhibitor as a potential therapeutic strategy for experimental colitis
Drug Delivery

Oral delivery of recombinant Lactococcus lactis expressing an IL-23 inhibitor as a potential therapeutic strategy for experimental colitis

The study explores a novel, non-invasive way to deliver an IL-23–blocking protein to the gut using engineered Lactococcus lactis, which could eventually offer an alternative to systemic biologics for controlling...

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Inflammatory comorbidity and quality-of-life burden in psoriasis with multiple biologic failure: a retrospective cohort study
Springer Science and Business Media LLC

Inflammatory comorbidity and quality-of-life burden in psoriasis with multiple biologic failure: a retrospective cohort study

Patients with multiple biologic failures appear more likely to have inflammatory comorbidities (including IBD) and to experience worse dermatology-related quality of life despite similar early skin improvement. That...

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An Oral Nanozyme Microsupplement Converts Pathological ROS Into a Colon‐Adhesive Shield for Long‐Term Neutrophil‐Directed Remission of Ulcerative Colitis
Advanced Materials

An Oral Nanozyme Microsupplement Converts Pathological ROS Into a Colon‐Adhesive Shield for Long‐Term Neutrophil‐Directed Remission of Ulcerative Colitis

The study describes a new nanozyme-based oral formulation that reduced NET formation and improved mucosal healing in a mouse model of ulcerative colitis, suggesting a novel preclinical approach to long‑term...

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The Gut–Liver Immune Axis in Celiac Disease, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Outcomes of a Rare but Significant Triad
Springer Science and Business Media LLC

The Gut–Liver Immune Axis in Celiac Disease, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Outcomes of a Rare but Significant Triad

PSC co-occurring with celiac disease appears more common than expected and is associated with a high rate of liver complications (including cirrhosis) and frequent coexisting IBD—information that may affect monitoring...

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Recent advances in antioxidant nanozymes for the treatment of inflammatory bowel disease.
Nanomedicine : nanotechnology, biology, and medicine

Recent advances in antioxidant nanozymes for the treatment of inflammatory bowel disease.

Nanozyme-based therapeutics are an emerging experimental strategy that aim to reduce oxidative stress and modulate immune responses in the inflamed gut — mechanisms directly relevant to IBD pathophysiology.

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Recent developments in the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases.
Expert review of gastroenterology & hepatology

Recent developments in the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases.

Oxidative stress may be a key driver of inflammation in IBD and could point to new biomarkers or adjunctive treatments (dietary changes, antioxidant strategies, or targeted pathways like Nrf2 and ferroptosis) that...

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Lactococcus lactis Oral delivery of recombinantexpressing an IL-23 inhibitor as a potential therapeutic strategy for experimental colitis.
Drug delivery

Lactococcus lactis Oral delivery of recombinantexpressing an IL-23 inhibitor as a potential therapeutic strategy for experimental colitis.

This study explores a novel, non-invasive way to block IL-23 — an important inflammatory driver in IBD — by orally delivering small IL-23 inhibitors using engineered Lactococcus lactis in mouse colitis models.

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