New leadership hires and a planned Phase 2 program mean prifemilast — an oral PDE4B-selective investigational drug — is moving toward larger IBD studies. People with IBD who want more oral treatment options or who follow...

High out-of-pocket costs and insurance practices can force people with Crohn’s and other chronic autoimmune diseases to delay or stop biologic therapy, which has direct consequences for disease control and quality of...

A vedolizumab biosimilar could increase access to an important biologic treatment for people with moderate‑to‑severe UC and Crohn’s disease by offering a potentially lower‑cost alternative. Regulatory review by the FDA...

Cure8 found this source from grandviewresearch.com, but the page could not be read reliably yet. It is tagged for Fistula and Procedures and surgery. Open the original article for the full details.

A commonly used probiotic, E.

This review suggests SSRIs and SNRIs may influence both brain and gut pathways relevant to symptom burden in IBD and DGBI — potentially improving mood, pain, motility, and aspects of inflammation. That could matter for...

The study identifies Gardenia-derived pectic polysaccharides that reduced inflammation and restored colon health in a mouse colitis model, suggesting a possible microbiome-mediated protective effect relevant to IBD...

The study explores a multi-herb formula that the authors report reduces inflammation and alters gut microbiota in a mouse model of ulcerative colitis, suggesting possible biological mechanisms worth further study.

The study identifies macrophage-derived microvesicles as modulators of intestinal barrier function and ER stress in ulcerative colitis models, suggesting a new mechanism that could be relevant to mucosal healing...

If confirmed, an endocytoscopic appearance that corresponds to a specific miRNA and chemokine pattern could help clinicians assess mucosal inflammation during colonoscopy and prioritize biopsies or treatment decisions...

A Phase 3 study is testing whether oral tofacitinib can induce and maintain remission in children with moderate-to-severe ulcerative colitis — a key step before pediatric regulatory approvals and wider clinical use.

This registered Phase 2/3 program is evaluating guselkumab (an IL‑23 inhibitor) for moderate–severe Crohn's disease and could expand treatment options if trials show benefit and safety. The studies include clinical and...

This study could validate a noninvasive stool-test strategy (FIT + fecal calprotectin) to triage which long-standing UC patients need colonoscopy, potentially improving surveillance efficiency and adherence.

People with IBD may have a higher-than-expected rate of biopsy-confirmed celiac disease in this Northern Indian cohort, and standard anti-tTG blood tests can be falsely positive in IBD. Confirmatory duodenal biopsy is...

This study suggests plant-derived exosome-like nanoparticles from a traditional herbal decoction may reduce inflammation, oxidative stress, and alter gut microbiota in a mouse model of colitis — an early preclinical step...

AI could help standardize endoscopic and histologic scoring in IBD, speed capsule endoscopy interpretation, and improve lesion detection — changes that might affect monitoring and diagnosis workflows for people with...

This study suggests erythritol — a common non-nutritive sweetener — may worsen experimental colitis and depression-like behavior in mice via microbiome and metabolic changes, raising questions about how ultra-processed...

Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis, Inflammatory bowel disease, and Complications. The original article is from Cureus.

People with IBD may face higher-than-expected rates of hypertensive disorders in pregnancy; identifying predictors could help target monitoring and preventive strategies. The study suggests prior HDP and gestational...

Cure8 found this source from Alimentary pharmacology & therapeutics, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and CRP. Open the original article for...

Cure8 could only read part of this source from bignewsnetwork.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Access, cost, and policy.

This study suggests that in IBD (and other diseases) the gut microbiome may lose long-associated symbionts and shift toward larger-genome, metabolically flexible microbes—an evolutionary perspective that could help...

This study evaluates a less invasive endoscopic option (needle-knife stricturotomy) for Crohn’s-related anorectal strictures and reports real-world outcomes and factors linked to recurrence — information that can inform...

Mesalamine can rarely cause myocarditis, creating a challenge for ongoing UC treatment. This report shows upadacitinib was used successfully as an alternative when biologics were considered higher cardiac risk and...

This study provides region-specific pediatric IBD data from the Philippines, highlighting prevalence of very-early-onset disease, perianal involvement in Crohn's, and factors (diagnostic delay, wasting, pancolitis)...

The report suggests Kono‑S is safe and feasible with shorter hospital stays and fewer ileostomies in this early-adoption cohort, which could matter to patients and surgeons planning ileocecal resection.

This study provides real-world data on how well ustekinumab is kept on treatment and its safety in an Arab IBD population—information that can help patients and clinicians understand longer-term use outside clinical...

Patients with Crohn's reported more relapses and are more likely to see diet as a relapse trigger; nutritional therapy (including elemental diets) is used more often in Crohn's than UC in this Japanese sample. This...

Identifies genetic and immune-pathway differences that may explain why Behçet's disease shows more intestinal involvement in some populations—insight that could inform research into IBD-like gut inflammation and future...

Faster remission can reduce symptoms, school disruption, and steroid exposure for children with IBD. If earlier infliximab level checks reliably speed remission, clinicians could adjust dosing sooner to improve outcomes.

Some rare appendiceal cancers can present like treatment-resistant Crohn’s disease. Considering malignancy is important when ileocecal strictures persist despite dilation and biopsies are negative.

The PD‑1/PD‑L1 pathway helps suppress harmful inflammation in IBD but can later allow colorectal tumors to avoid immune attack; understanding this balance matters for patients concerned about long‑term cancer risk and...

This meta-analysis pools randomized trial data and finds that FMT increased both clinical and endoscopic remission in ulcerative colitis versus placebo, which could matter to patients and clinicians exploring...

Environmental exposures from agricultural chemicals may affect the gut microbiome and intestinal inflammation, which could be one factor influencing IBD risk or flares. Understanding these links could point to preventive...

The article connects everyday activities like gardening and spending time in nature to microbial exposure that some researchers link to lower rates of autoimmune and inflammatory conditions, including Crohn’s disease and...

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Materials Today Bio.

S1P receptor modulators are an emerging oral class of advanced therapy for moderate-to-severe ulcerative colitis; a systematic review that pools multiple RCTs helps clarify how effective and safe the class appears to be...

The criteria were tested specifically in patients with psoriasis, uveitis, or IBD presenting with chronic back pain—groups at higher risk of axSpA—so results inform how well the new criteria perform in these real‑world...

Vitamin D may support intestinal barrier integrity and immune regulation—pathways central to mucosal healing and disease control in IBD. Understanding the evidence helps patients and clinicians consider vitamin D as a...

Researchers aim to create computational tools to identify cell–cell signaling that controls the mix of epithelial cell types in mucosal tissues. For IBD, such tools could help reveal signals that change intestinal...

Researchers are studying necroptosis — a form of inflammatory cell death — because it appears to contribute to inflammatory bowel disease and other inflammatory conditions. Understanding the molecular steps could point...

Researchers are developing a novel drug-discovery approach to degrade GATA3, a protein that drives Th2 inflammation in ulcerative colitis. New therapies that more directly target immune drivers could eventually help...

Frequent, accurate assessment of bowel inflammation and fibrosis is critical for Crohn's disease care. Ultrasound is safe, accessible, and could provide a low-cost biomarker to monitor disease activity, fibrosis, and...

People with IBD and other IMIDs sometimes receive overlapping biologic or targeted therapies during treatment changes or combination regimens.

People with PsD or IBD — or both — may develop the other condition years later, and the order of diagnoses appears linked to timing of the second disease and to differences in mortality for some groups. That could affect...

Injection site pain and local reactions can affect comfort and willingness to continue injectable biologic therapy.

People with both IBD and another immune-mediated disease (psoriatic disease) had more hospital admissions and higher inpatient costs over ten years in this population.

SpA is a frequent but underrecognized extraintestinal manifestation in people with IBD; validated screening tools can help identify patients who need rheumatology evaluation. Earlier detection may address joint symptoms...