Article Archive

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Terminalia arjuna Biological Activities, Medicinal Uses, and Nutritional Effects of(Roxb. ex DC.) Wight & Arn.: Phytochemical Insights and Therapeutic Benefits in Ulcerative Colitis Management-A Detailed Review.
Food science & nutrition

Terminalia arjuna Biological Activities, Medicinal Uses, and Nutritional Effects of(Roxb. ex DC.) Wight & Arn.: Phytochemical Insights and Therapeutic Benefits in Ulcerative Colitis Management-A Detailed Review.

People with ulcerative colitis may be interested in plant-based therapies that could reduce gut inflammation or support mucosal health. This review compiles preclinical evidence suggesting Terminalia arjuna has...

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UBE2L6 drives ulcerative colitis progression by promoting BIRC2 degradation and activating non-canonical NF-κB signalling
Inflammation Research

UBE2L6 drives ulcerative colitis progression by promoting BIRC2 degradation and activating non-canonical NF-κB signalling

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Inflammation Research.

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Successful combination therapy with ustekinumab and intensive granulocyte and monocyte adsorptive apheresis in highly refractory pediatric ulcerative colitis: pathophysiological rationale and clinical outcome
Immunological Medicine

Successful combination therapy with ustekinumab and intensive granulocyte and monocyte adsorptive apheresis in highly refractory pediatric ulcerative colitis: pathophysiological rationale and clinical outcome

Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis, Inflammatory bowel disease, and Ustekinumab. The original article is from Immunological Medicine.

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Ferulic acid – A promising candidate molecule for the treatment of colitis
European Journal of Microbiology and Immunology

Ferulic acid – A promising candidate molecule for the treatment of colitis

This review highlights a plant-derived compound, ferulic acid, that showed anti-colitis effects in experimental studies, suggesting a potential new adjunctive therapy pathway worth watching for future clinical research.

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Pathogen‐Specific Bloodstream Infections Associated With Tumour Necrosis Factor‐α Inhibitors, Vedolizumab and Ustekinumab in Inflammatory Bowel Disease: A Danish Nationwide Case‐Control Study 2010–2024
Alimentary Pharmacology & Therapeutics

Pathogen‐Specific Bloodstream Infections Associated With Tumour Necrosis Factor‐α Inhibitors, Vedolizumab and Ustekinumab in Inflammatory Bowel Disease: A Danish Nationwide Case‐Control Study 2010–2024

This study compares bloodstream infection risk across commonly used biologics for IBD, which could affect decisions about choosing or monitoring biologic therapy. It also highlights that steroid co-use may increase...

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Maternal–Fetal Exposome and Early-Life Microbiota–Pattern Recognition Receptors Signaling in Inflammatory Bowel Disease Susceptibility: A Mechanistic Review
International Journal of Molecular Sciences

Maternal–Fetal Exposome and Early-Life Microbiota–Pattern Recognition Receptors Signaling in Inflammatory Bowel Disease Susceptibility: A Mechanistic Review

If true, prenatal and early-life exposures could influence long-term IBD risk by shaping immune development and the gut microbiome, which may help explain why some people develop IBD and others don’t.

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Trendy, but Are They Safe? Current Popular Diets and Their Use in Inflammatory Bowel Diseases: Narrative Review
Nutrients

Trendy, but Are They Safe? Current Popular Diets and Their Use in Inflammatory Bowel Diseases: Narrative Review

Diet is a modifiable factor many people with IBD try to use to manage symptoms and disease; this review summarizes what is and isn’t supported by current evidence for popular diets and structured nutritional therapies.

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Impact of Smoking on the Effectiveness of Advanced Therapies in Inflammatory Bowel Disease: Active Smoking Is Associated with Reduced Effectiveness of Anti-TNF Treatment
Medicina

Impact of Smoking on the Effectiveness of Advanced Therapies in Inflammatory Bowel Disease: Active Smoking Is Associated with Reduced Effectiveness of Anti-TNF Treatment

The study suggests active smoking reduces the effectiveness of anti-TNF biologics in people with IBD, which could affect treatment response and the need to switch or escalate therapies. This supports including smoking...

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Machine learning meets network toxicology: identifying LOXL2 as a key player in ulcerative colitis
Toxicological Research

Machine learning meets network toxicology: identifying LOXL2 as a key player in ulcerative colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and AI and data science. The original article is from Toxicological Research.

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Targeted oral peptide therapy for inflammatory bowel disease: focus on the IL-23 receptor antagonist icotrokinra.
Expert opinion on emerging drugs

Targeted oral peptide therapy for inflammatory bowel disease: focus on the IL-23 receptor antagonist icotrokinra.

Based on the title and source metadata, this appears to be an opinion or commentary related to Inflammatory bowel disease and Research and clinical trials. The original article is from Expert opinion on emerging drugs.

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Patterns and factors associated with dose escalation during maintenance treatment for inflammatory bowel disease: a population-based cohort study.
Sage open chronic disease

Patterns and factors associated with dose escalation during maintenance treatment for inflammatory bowel disease: a population-based cohort study.

Dose increases are common during IBD maintenance and vary a lot by drug and patient profile. Knowing which treatments and patient factors are linked to escalation can help patients and clinicians plan monitoring and...

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Patient-reported first-use usability of the noncommercial MyTARGET mobile application among adults with inflammatory bowel disease: a cross-sectional survey.
Frontiers in digital health

Patient-reported first-use usability of the noncommercial MyTARGET mobile application among adults with inflammatory bowel disease: a cross-sectional survey.

High first-use usability suggests MyTARGET could be acceptable to many adults with IBD and that targeted refinements (error handling, demonstrating time savings) might improve uptake and recommendation.

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Creeping Fat in Crohn's Disease: Association or Prognostic Factor?
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Creeping Fat in Crohn's Disease: Association or Prognostic Factor?

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from The Turkish journal of...

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A Reproducible Bibliometric Analysis of Perianal Fistula in Crohn's Disease Research (1992-2025): Retrieval Sensitivity and Knowledge Structure.
Journal of visualized experiments : JoVE

A Reproducible Bibliometric Analysis of Perianal Fistula in Crohn's Disease Research (1992-2025): Retrieval Sensitivity and Knowledge Structure.

A bibliometric map of perianal fistula research helps patients and clinicians see how much work exists, which centers and authors lead the field, and which topics cluster together—useful when looking for expertise or...

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Evaluation of Blood and Stool Biomarkers Across Three Fecal Calprotectin Platforms and Combination Testing for Predicting Endoscopic and Histologic Outcomes in Inflammatory Bowel Disease
Europe PMC

Evaluation of Blood and Stool Biomarkers Across Three Fecal Calprotectin Platforms and Combination Testing for Predicting Endoscopic and Histologic Outcomes in Inflammatory Bowel Disease

Noninvasive fecal biomarkers are widely used to track IBD activity. Knowing whether different FC assays give comparable results and whether combining tests adds value affects how patients and clinicians interpret...

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Alterations of Serotonin System-Related Biomarkers and Their Association with Disease Activity in Patients with Ulcerative Colitis: A Systematic Review and Meta-analysis
INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

Alterations of Serotonin System-Related Biomarkers and Their Association with Disease Activity in Patients with Ulcerative Colitis: A Systematic Review and Meta-analysis

Cure8 could only read part of this source from INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, so this card uses cautious topic tags instead of a full summary. It is tagged...

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Ulcerative colitis, but not Crohn’s disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification
Frontiers in Immunology

Ulcerative colitis, but not Crohn’s disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification

The study suggests ulcerative colitis shows greater mucosal immune variability across sex, age and severity than Crohn’s disease, which could affect how patients are grouped for research or future personalized...

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Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation.
International immunopharmacology

Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation.

This identifies a metabolism-related epithelial gene (PCK1) linked to inflammation in UC and suggests acetyl‑L‑carnitine can partially reverse those changes in cell and mouse models—information that could guide future...

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Bowel Urgency Is More Strongly Associated with Biochemical, Endoscopic, and Histological Disease Activity than Other Clinical Symptoms in Ulcerative Colitis.
Internal medicine (Tokyo, Japan)

Bowel Urgency Is More Strongly Associated with Biochemical, Endoscopic, and Histological Disease Activity than Other Clinical Symptoms in Ulcerative Colitis.

If you have UC, bowel urgency may indicate active inflammation more reliably than some other symptoms. Recognizing urgency could help prompt timely objective testing and treatment decisions.

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Comparative serious infection and sepsis risks with advanced therapies in IMIDs: a Bayesian network meta-analysis.
The Journal of infection

Comparative serious infection and sepsis risks with advanced therapies in IMIDs: a Bayesian network meta-analysis.

This pooled analysis compares serious-infection and sepsis risks across advanced therapies used in immune-mediated inflammatory diseases, including IBD. It suggests JAK inhibitors are linked to higher serious-infection...

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Guselkumab Versus Risankizumab for Ulcerative Colitis: Real-World Comparison of Post-Induction Outcomes.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Guselkumab Versus Risankizumab for Ulcerative Colitis: Real-World Comparison of Post-Induction Outcomes.

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Guselkumab. The original article is from Clinical gastroenterology and hepatology...

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Multicentre, prospective, observational study on the effectiveness and safety of upadacitinib for active perianal fistulising Crohn's disease in patients with prior anti-tumour necrosis factor failure: a study protocol.
BMJ open

Multicentre, prospective, observational study on the effectiveness and safety of upadacitinib for active perianal fistulising Crohn's disease in patients with prior anti-tumour necrosis factor failure: a study protocol.

Perianal fistulising Crohn's disease is hard to treat and often fails anti-TNF drugs. This study will provide real-world data on whether upadacitinib can be effective and safe for patients with refractory perianal...

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Comparative effectiveness of infliximab vs vedolizumab as first-line biologic therapy in moderate-to-severe ulcerative colitis: A prospective, multicenter, real-world study
Inflammatory Bowel Diseases

Comparative effectiveness of infliximab vs vedolizumab as first-line biologic therapy in moderate-to-severe ulcerative colitis: A prospective, multicenter, real-world study

This study compares two commonly used biologics as first-line therapy for moderate-to-severe ulcerative colitis and reports better short- and long-term effectiveness for vedolizumab with similar safety. The results could...

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