Article Archive

Page 23 of 100 · 4765 patient-friendly summaries

Identification of Transcriptional Hippo Response Signature Connecting Inflammatory Bowel Disease and Colorectal Cancer Progression
medRxiv

Identification of Transcriptional Hippo Response Signature Connecting Inflammatory Bowel Disease and Colorectal Cancer Progression

This study maps a shared transcriptional programme linking inflamed IBD tissue to colorectal cancer pathways, highlighting potential biomarker and prevention targets relevant to the inflammation-to-cancer transition.

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Fecal calprotectin changes after polyethylene glycol bowel preparation in patients with ulcerative colitis in remission
Inflammatory Bowel Diseases

Fecal calprotectin changes after polyethylene glycol bowel preparation in patients with ulcerative colitis in remission

Fecal calprotectin is commonly used to monitor IBD activity. If bowel prep raises calprotectin modestly, that could affect how post-procedure results are interpreted and avoid unnecessary treatment changes.

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Navigating microbial balance: Insights and interventions for optimal health amid antibiotic treatment in inflammatory bowel disease
Heliyon

Navigating microbial balance: Insights and interventions for optimal health amid antibiotic treatment in inflammatory bowel disease

Antibiotics can substantially change gut microbes; for people with IBD those changes may affect inflammation and gut barrier function. The review summarizes microbiome-targeted strategies that patients and clinicians may...

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Improving Endoscopic Scoring Accuracy in Pediatric Inflammatory Bowel Disease: Impact of a Focused Training Intervention
Endoscopy International Open

Improving Endoscopic Scoring Accuracy in Pediatric Inflammatory Bowel Disease: Impact of a Focused Training Intervention

Consistent, accurate endoscopic scoring matters for treatment decisions and trial outcomes in pediatric IBD. If focused training meaningfully improves scoring—especially for SES‑CD—it could reduce variability in clinical...

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Genetically predicted circulating polyunsaturated fatty acids and Crohn's disease susceptibility: A two-sample mendelian randomization study.
Medicine

Genetically predicted circulating polyunsaturated fatty acids and Crohn's disease susceptibility: A two-sample mendelian randomization study.

If confirmed, genetic evidence that higher omega-3 levels or a lower omega-6/omega-3 ratio relate to lower Crohn’s disease risk could point to biological pathways worth studying and might guide research into prevention...

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Bidirectional causal associations between Sjögren syndrome and gastrointestinal disorders: A two-sample Mendelian randomization study.
Medicine

Bidirectional causal associations between Sjögren syndrome and gastrointestinal disorders: A two-sample Mendelian randomization study.

People with Sjögren syndrome or clinicians caring for them may be interested because genetic data suggest Sjögren syndrome could modestly raise gastric ulcer risk and — unexpectedly — associate with lower IBS risk, while...

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Dietary choline prevents colitis-driven carcinogenesis via SLC5A7-dependent Notch1 degradation and goblet cell reprogramming.
Mucosal immunology

Dietary choline prevents colitis-driven carcinogenesis via SLC5A7-dependent Notch1 degradation and goblet cell reprogramming.

IBD patients have higher risk of colitis-associated colorectal cancer; this study suggests dietary choline might protect the intestinal barrier and reduce inflammation-driven tumor risk via a nutrient–transporter–Notch1...

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Managing IBS-Like Symptoms in Quiescent Inflammatory Bowel Disease: A Meta-Analysis of Randomized Trials.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Managing IBS-Like Symptoms in Quiescent Inflammatory Bowel Disease: A Meta-Analysis of Randomized Trials.

People with IBD in remission commonly continue to have IBS-like symptoms; this review summarizes randomized trial evidence for symptom-directed treatments and finds no definitive best option.

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Stabilizing Macrophage Immune States through Fusion-Enabled Nanoparticle-Based Intracellular Drug Depots for Durable Ulcerative Colitis Therapy
ACS Nano

Stabilizing Macrophage Immune States through Fusion-Enabled Nanoparticle-Based Intracellular Drug Depots for Durable Ulcerative Colitis Therapy

Researchers are exploring ways to durably modulate macrophages in ulcerative colitis because persistent pro-inflammatory macrophages sustain tissue inflammation and impair healing.

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Biologics, small molecules, and extraintestinal malignancies in inflammatory bowel disease: practical questions and evidence-based answers.
Inflammatory bowel diseases

Biologics, small molecules, and extraintestinal malignancies in inflammatory bowel disease: practical questions and evidence-based answers.

People with IBD often need long-term advanced therapies. Cancer risk concerns commonly influence treatment choices—this review compiles current evidence to help patients and clinicians weigh risks when starting or...

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GPR97 is a novel diagnostic biomarker and immunomodulatory target in ulcerative colitis: evidence from integrated bioinformatics and experimental validation
Springer Science and Business Media LLC

GPR97 is a novel diagnostic biomarker and immunomodulatory target in ulcerative colitis: evidence from integrated bioinformatics and experimental validation

Finding reliable diagnostic biomarkers could help detect UC earlier and clarify immune mechanisms that drive disease; GPR97 is proposed here as such a marker and a possible immunomodulatory target, which may interest...

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A full-thickness spatial transcriptomics atlas of medically refractory ulcerative colitis identifies niche signatures associated with biologic non-response
Frontiers in Immunology

A full-thickness spatial transcriptomics atlas of medically refractory ulcerative colitis identifies niche signatures associated with biologic non-response

Spatial mapping of immune niches in refractory UC identified tissue signatures (neutrophil-rich ulcer-bed niches and TLS/plasma-cell programmes) that were associated with failure to respond to biologic drugs across adult...

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Inflammatory Bowel Disease: From Multifactorial and Metabolic Pathogenesis to Systemic Disease and Precision Medicine
Metabolites

Inflammatory Bowel Disease: From Multifactorial and Metabolic Pathogenesis to Systemic Disease and Precision Medicine

This review reframes IBD as a systemic disease influenced by gut microbes, metabolism, and immune interactions — which matters because it points toward better ways to stratify patients, monitor disease, and personalize...

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Spray drying-assisted development of hydroxypropyl methylcellulose acetate succinate microparticles for andrographolide delivery: an in-vivo study in experimental ulcerative colitis
Drug Delivery and Translational Research

Spray drying-assisted development of hydroxypropyl methylcellulose acetate succinate microparticles for andrographolide delivery: an in-vivo study in experimental ulcerative colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Drug Delivery and...

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
ClinicalTrials.gov

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

This trial tests several targeted therapies (including risankizumab) alone and in combination for adults with moderate to severe Crohn's disease, aiming to measure endoscopic remission and safety. Positive findings could...

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Supplementation of Bacillus cereus Enhances Anti-Colitis Effects of Triple Probiotics in Mice: Correlative Evidence for a Gut Microbiota–Spermidine-Related Axis in Quadruple-Probiotic Protection
Nutrients

Supplementation of Bacillus cereus Enhances Anti-Colitis Effects of Triple Probiotics in Mice: Correlative Evidence for a Gut Microbiota–Spermidine-Related Axis in Quadruple-Probiotic Protection

This study suggests a specific four-strain probiotic cocktail may better protect against experimental colitis than the three-strain mix, potentially via microbiota-driven increases in spermidine — a microbial metabolite...

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The Diagnostic Value of Dual-energy CT Multi-parameters in Differentiating Colorectal Cancer from Inflammatory Thickening of the Colorectal Wall.
Current medical imaging

The Diagnostic Value of Dual-energy CT Multi-parameters in Differentiating Colorectal Cancer from Inflammatory Thickening of the Colorectal Wall.

Distinguishing colorectal cancer from IBD-related inflammatory thickening can be challenging but crucial for treatment decisions. If validated, DECT parameters could offer a noninvasive tool to improve diagnostic...

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Proanthocyanidins in immune-mediated inflammatory diseases: molecular mechanisms and therapeutic potential
Frontiers in Pharmacology

Proanthocyanidins in immune-mediated inflammatory diseases: molecular mechanisms and therapeutic potential

People with IBD may be interested because the review highlights a class of dietary polyphenols that could influence inflammation and immune pathways involved in Crohn’s disease and ulcerative colitis. It summarizes...

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Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn’s disease
Nature Genetics

Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn’s disease

Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Nature Genetics.

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Cardiovascular outcomes associated With GLP-1 and dual GLP-1/GIP receptor agonists in patients with type 2 diabetes and inflammatory bowel disease: A retrospective real-world cohort study.
PloS one

Cardiovascular outcomes associated With GLP-1 and dual GLP-1/GIP receptor agonists in patients with type 2 diabetes and inflammatory bowel disease: A retrospective real-world cohort study.

People who have both IBD and type 2 diabetes are at increased cardiovascular risk; this study suggests GLP-1–based therapies may be associated with lower rates of several heart and thrombotic events in that group.

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KARAP Exacerbates Intestinal Inflammation Through Promoting Kyn-AhR-dependent Neutrophil Activation in Ulcerative Colitis.
Cellular and molecular gastroenterology and hepatology

KARAP Exacerbates Intestinal Inflammation Through Promoting Kyn-AhR-dependent Neutrophil Activation in Ulcerative Colitis.

The paper identifies a neutrophil-related immune pathway (KARAP → IDO1–kynurenine → AhR → IL-22) that contributes to mucosal inflammation in ulcerative colitis, suggesting a potential new target for research and drug...

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