Crohn's disease

IL-22 links microbial metabolites to epithelial repair and inflammation; clarifying these pathways could inform future therapies or dietary/microbiome approaches to promote mucosal healing without worsening inflammation.

The paper presents a validated lab method to detect and quantify enantiomeric impurities in upadacitinib, which supports drug quality and safety for patients treated with JAK‑1 inhibitors for IBD and other conditions.

Patients with hidradenitis suppurativa have higher baseline IBD risk, and IL-17 inhibitors are effective HS treatments. People with Crohn’s disease or ulcerative colitis (or those at risk) may worry whether these drugs...

People with IBD who need shoulder replacement may face higher short-term risks after surgery, including infections, pneumonia, sepsis, emergency visits, and a greater chance of needing revision operations. Knowing this...

Patients who present with new radiologic terminal ileitis sometimes develop Crohn’s disease. Identifying simple blood and imaging markers that predict who is at higher risk could help prioritize follow-up or specialist...

Patients cared for in accredited IBD units reported better experience and higher satisfaction in this study, which suggests that accreditation may improve patient-centred aspects of care even if self-reported disease...

A validated Spanish IBD-Disk gives Spanish-speaking patients and clinicians a brief, validated tool to measure disability and global health in IBD, supporting consistent monitoring and research across Spanish-speaking...

Patients with moderate-to-severe Crohn's disease who do not respond to anti-TNF drugs have limited options. This study suggests combining ustekinumab with upadacitinib may improve endoscopic healing versus either drug...

If a panenteric capsule can replace colonoscopy plus small-bowel imaging for initial diagnosis, it could offer a less invasive, single-test pathway for many people suspected of having Crohn's disease. That may reduce the...

This trial describes a large Phase 3 extension study collecting long-term safety and tolerability data for tulisokibart (MK-7240), an investigational TL1A-targeting antibody for Crohn’s disease and ulcerative colitis....

Psychological distress is common in IBD and often goes unaddressed; a peer-led virtual program could expand access to emotional support and inform larger trials if found feasible and acceptable.

This registry could collect real-world outcome data about hyperbaric oxygen therapy for many conditions that sometimes overlap with IBD care (Crohn’s disease, ulcerative colitis, pouchitis, rectovaginal fistula).

Fistulas between the intestine and bladder are a serious, though uncommon, complication of long‑standing Crohn’s disease and often require surgery. Robotic, minimally invasive approaches may allow complex resections and...

Malnutrition is common and can worsen outcomes in IBD; this case shows use of combined enteral and parenteral nutritional support for severe malnutrition in newly diagnosed Crohn’s disease, including perioperative...

Differences in urbanisation and socioeconomic development may help explain rising IBD rates in newly industrialised regions and point to where earlier diagnosis and healthcare planning might be needed. The association...

The findings highlight that older adults are less likely to be prescribed advanced IBD therapies, which could reflect prescribing patterns, comorbidities, insurance factors, or access issues relevant to treatment...

Identifies a molecule (CCL3) linked to more severe inflammation in IBD tissues, which could help researchers develop new biomarkers or treatments targeting immune-cell recruitment and polarization.

The study suggests higher dietary antioxidant intake (measured by CDAI) may be linked to lower Crohn's disease risk and that inflammation biomarkers could partly explain the association—information potentially relevant...

Depression is common in Crohn’s disease and appears linked to immune and microbial signals from the gut. Understanding gut–brain mechanisms could improve how mood symptoms are detected and treated in people with IBD.

AMPs are central to gut immune balance and are being explored as new therapies for IBD and related gut diseases. For people with Crohn’s or IBD, understanding AMPs helps explain research directions aimed at restoring...

SRCEUS may offer higher-resolution, noninvasive assessment of intestinal microvascular changes that correspond to Crohn disease activity, which could improve monitoring and reduce reliance on invasive tests.

Based on the title and source metadata, this appears to be an opinion or commentary related to Crohn's disease, Inflammatory bowel disease, and Tests and monitoring. The original article is from Radiology.

Cure8 found this source from auntminnie.com, but the page could not be read reliably yet. It is tagged for Crohn's disease, Inflammatory bowel disease, and Tests and monitoring. Open the original article for the full...

Cure8 could only read part of this source from tradingview.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Inflammatory bowel disease, and Research and clinical...

Clinical trials test new treatments that could become options for people with moderate to severe Crohn’s disease. This sponsor-supported notice also highlights the need for broader representation in research, which...

Based on the title and source metadata, this appears to be a case report related to Crohn's disease, Inflammatory bowel disease, and Procedures and surgery. The original article is from Baylor University Medical Center...

Stress and psychological distress are common in people with IBD and may influence symptoms and inflammation. This trial tests whether an 8‑week MBSR program can improve psychological wellbeing and whether those benefits...

This trial tests standardized encapsulated fecal microbiota products as a microbiome-directed therapy for active Crohn’s disease, focusing on whether donor microbes engraft in the ileum and colon and whether that relates...

Malnutrition and growth failure at diagnosis are common in children with IBD—especially Crohn’s—and can indicate higher inflammatory burden. Monitoring and addressing nutrition and growth is important because most...

This review highlights shared biomarkers and mechanisms between early Crohn's disease and post-operative recurrence, which could improve prediction and lead to preventive strategies for recurrence after surgery.

The study suggests a hidden, early molecular defect that leaves intestinal cells primed to die even during clinical remission, which could help explain why flares recur. Measuring these molecular signals might eventually...

Nurse-led, protocolized care can make delivery of complex biologic and small-molecule IBD treatments safer and more consistent.

Cure8 found this source from youtube.com, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease, Crohn's disease, and Community and awareness. Open the original article for the full...

People with IBD often worry whether their disease affects fertility or embryo health. This study directly looks at embryo chromosomal normality during IVF and found similar euploidy rates in patients with and without...

Cure8 found this source from Ophthalmology, but the page could not be read reliably yet. It is tagged for Crohn's disease, Inflammatory bowel disease, and Complications. Open the original article for the full details.

The work links climate and sociodemographic context to IBD burden in tropical regions, which can influence diagnostic recognition, resource needs, and research priorities for communities where IBD is rising.

This study links genetic variation in fatty-acid–desaturase genes with membrane PUFA profiles and inflammatory markers in Crohn’s disease. If replicated, erythrocyte desaturase indices could become integrative biomarkers...

A controlled trial found low-dose naltrexone did not induce endoscopic or clinical remission in Crohn's disease, but it showed a possible benefit for reducing fatigue. Patients seeking symptom relief without...

The study targets REV-ERBα, a regulator of TH17 cells that contribute to Crohn’s disease and ulcerative colitis, so its findings could identify new molecular pathways to target for IBD therapies.

Researchers aim to build and study tiny gut phages (Microviridae) that are largely known only from DNA sequences. Learning how these phages shape microbial communities could help explain virome-linked changes seen in...

This project aims to map microbe-specific T cells in Crohn's disease using single-cell RNA and TCR sequencing. Findings could reveal antigen-specific mechanisms driving IBD and help lay groundwork for targeted...

The project targets patients with refractory IBD who lack effective options; a new allogeneic stromal cell therapy could expand treatment choices for people who fail multiple drugs. The work focuses on immune pathways...

This project could introduce a novel, microbiome-targeted oral therapy for Crohn’s disease if the Phase II trial confirms safety and clinical benefit; that matters because many patients need new options when current...

Knowing biomarkers that predict who will respond to IL23 p19 inhibitors could help people with IBD avoid trial-and-error therapy choices. Understanding whether increasing risankizumab dosing after loss of response...

This project aims to understand how gut-adapted eosinophils support immune homeostasis or drive pathology in conditions that include IBD and eosinophilic GI disorders, with the goal of enabling more precise...

Pregnant people with IBD or other autoimmune diseases often face tough choices about continuing biologics or JAK inhibitors. CARE-HP aims to produce broader, disease-specific evidence to help patients and clinicians...

This project aims to develop a new anti-inflammatory therapy targeting TREM-1 on macrophages, a pathway implicated in IBD. If successful, the approach could offer an alternative for patients who do not respond to current...

A quantitative, biopsy-based measure of collagen architecture could help study intestinal fibrosis, which underlies stricture formation in Crohn’s disease. Feasibility data support further validation work that may lead...