Crohn's disease

Oral and upper-GI involvement in Crohn's can be missed and may change how disease is diagnosed and managed. A focused review helps clinicians and researchers spot gaps in diagnostics and treatment research.

Patients with IBD often have joint and skin comorbidities that drive symptoms and treatment choices.

A potential link between ultra-processed food intake and Crohn’s relapse could influence dietary conversations for people in remission, but the current evidence is weak and not definitive.

Many patients and clinicians seek safer, non-immunosuppressive options for Crohn’s disease. This randomized trial found LDN did not induce endoscopic or clinical remission, though it may reduce fatigue—information that...

Genetic evidence for causal links between other diseases (for example asthma or multiple sclerosis) and IBD can help researchers prioritize biological pathways and potential therapeutic targets, and may explain why some...

Based on the title and source metadata, this appears to be a patient education related to Crohn's disease, Inflammatory bowel disease, and Community and awareness. The original article is from fox2detroit.com.

Local foundation stories can point people with Crohn’s or colitis toward community support, volunteering opportunities, and local resources. They may help viewers find ways to get involved or access services nearby.

Based on the title and source metadata, this appears to be a patient story related to Crohn's disease and Community and awareness. The original article is from msn.com.

Because PG is linked to IBD and can be triggered by surgery, a perioperative immunosuppressive approach reported here may be relevant to patients with IBD who have had prior PG or are planning reconstructive surgery.

Fibrosis and stricture formation are important complications in Crohn’s disease; a biopsy-based, quantitative way to measure collagen architecture could help research into fibrotic disease mechanisms and eventually...

The study suggests that a simple, multidomain functional measure (intrinsic capacity) is linked to later IBD risk and that combining it with genetic risk may better identify people at higher risk—especially for Crohn’s...

For people with multi-refractory Crohn’s disease or ulcerative colitis, adding a JAK inhibitor to an existing biologic (advanced combination therapy) may convert partial responses into deeper remission in selected cases,...

Patients who lose response to standard upadacitinib dosing may have a practical option—dose re‑escalation—that could improve symptoms and reduce steroid needs according to a small retrospective cohort summarized here.

Cure8 found this source from onlinelibrary.wiley.com, but the page could not be read reliably yet. It is tagged for Crohn's disease, Inflammatory bowel disease, and Diet and lifestyle. Open the original article for the...

Psoriasis and Crohn’s disease share immune pathways that affect treatment choices. Some biologics work across both conditions while others (notably IL-17 inhibitors) may be inappropriate for patients with active IBD.

This atlas maps when and where regenerative gene programs turn on in the intestine and highlights molecular features (like interferon responses and hypertranscription) that overlap with human Crohn’s disease, so it could...

Diet is a modifiable factor that could influence IBD risk through effects on the gut microbiome and immune pathways.

The study shows malnutrition is common in Crohn’s disease and much more likely during active inflammation, highlighting the need for routine nutritional screening and more than one type of assessment.

This registry study shows many people with IBD in Kazakhstan had clinically active disease at enrollment and identifies factors linked with active UC and CD. It highlights potential gaps in disease control and...

Persistent fatigue is a common disabling symptom in IBD even during remission; a structured adapted physical activity program could offer a non-drug way to improve daily functioning if the trial shows benefit.

People with stricturing Crohn’s disease currently lack effective medical treatments to prevent or reverse intestinal fibrosis; this trial explores a probiotic approach (and trehalose) aimed at stimulating autophagy, a...

Drug developers use mass-balance (ADME) studies to learn how a new drug is absorbed and cleared, which helps guide dosing, safety testing, and further trials.

A parasitic infection (Ascaris) can closely imitate Crohn’s disease or microscopic colitis and lead to harmful misdiagnosis and unnecessary immunosuppression. Patients in or from helminth-endemic areas with new IBD-like...

Both EEN and the Crohn’s disease exclusion diet are used to induce remission in children with Crohn’s disease. Evidence that they perform similarly through 52 weeks may help families and clinicians choose the approach...

This study builds a large, public single-cell map of the gut in Crohn’s disease that identifies cell types and gene programs linked to inflammation. That can help researchers find new drug targets and explain why some...

Based on the title and source metadata, this appears to be a case report related to Crohn's disease and Procedures and surgery. The original article is from Gastrointestinal endoscopy.

This real-world multicenter study provides short-term effectiveness and safety data for upadacitinib in a difficult-to-treat Crohn’s population in China, which may inform treatment decisions and risk discussions.

These methods could help researchers and clinicians better identify which treatments are likely to work for which patients by combining trials and EHR data, accounting for multiple outcomes and missing data — relevant to...

If you have Crohn’s disease, upper GI biopsies showing focally enhanced gastritis or focally active inflammation could support a diagnosis of upper GI involvement and are associated with other histologic findings like...

If confirmed, molecular or microbial markers found at surgery could help identify Crohn’s patients at higher risk of postoperative endoscopic recurrence and inform closer monitoring or preventative strategies after...

Food choices can affect Crohn’s symptoms, flares, and nutritional health. A short self-assessment can help you decide whether to change your diet or seek professional nutrition support.

The findings suggest that early biologic and immunomodulator treatment may reduce the need for first surgery in Crohn's disease, which is directly relevant to treatment planning and expectations for people with IBD.

Switching biologics is a frequent and consequential decision in children with IBD; using TDM and a mechanism‑based approach can help choose whether to optimize, switch within class, or change drug class.

Local university rankings matter because they spotlight research and faculty whose work can influence future treatments for autoimmune diseases like Crohn’s disease.

Malnutrition was common and much more frequent during active Crohn’s disease in this South Asian cohort, which matters because poor nutritional status affects treatment tolerance, recovery, and quality of life.

Community support can make a big practical and emotional difference for people with IBD who face major surgery and medical bills. Human stories also help raise awareness about the everyday impact of Crohn’s disease on...

Dating and relationships raise specific emotional and practical questions for people with Crohn’s (disclosure, symptom management, medication side effects). This article offers real-world tips to help people navigate...

Based on the title and source metadata, this appears to be a patient education related to Crohn's disease, Inflammatory bowel disease, and Mental health and quality of life. The original article is from msn.com.

Mental health conditions (depression, anxiety, ADHD) appear to increase before and after IBD diagnosis, suggesting psychological care may be needed earlier in the diagnostic pathway and long term.

The study highlights a bacterial gene that helps adherent-invasive E. coli (AIEC) colonize the gut — a mechanism that has been linked to Crohn's disease. Understanding how AIEC colonizes could guide future research into...

The findings show earlier and more frequent use of imaging, endoscopic assessment, anti-TNF therapy, and seton placement for active perianal fistulizing Crohn’s disease over recent years — practices that may affect...

A blood test (serum REG3α) may help identify people at higher risk of developing complicated Crohn's disease years before diagnosis and predict progression in established disease, which could inform monitoring or early...

Physical activity may be a modifiable factor that could improve fitness, inflammation, symptoms like fatigue, and quality of life in children with IBD. This trial will provide objective, randomized data relevant to...

Awareness events connect people with Crohn’s and ulcerative colitis to local resources, support networks, and advocacy efforts. They can raise visibility and reduce isolation for people living with IBD.

Based on the title and source metadata, this appears to be a patient education related to Crohn's disease, Inflammatory bowel disease, and Tests and monitoring. The original article is from msn.com.

AIEC bacteria have been linked to Crohn’s disease; this study identifies a bacterial gene (rfaG) that helps AIEC express adhesins and colonize the gut in experimental models, which could point to future research paths...

PSC — a serious bile-duct disease linked to IBD — was found on MRCP in about 1 in 10 people at IBD diagnosis, often without abnormal liver blood tests. Early radiological detection could affect monitoring and specialist...

Researchers used machine learning and molecular docking plus small animal tests to link a common plasticizer (DEP) with molecular changes seen in pediatric Crohn’s disease. This could point to environmental exposures...