Condition

Crohn's disease

Crohn's disease news across medications, symptoms, tests, procedures, complications, research, access, and daily life.

Page 4 of 53 · 2513 articles

Technical Considerations for Magnetic Resonance Imaging of the Bowel.
Magnetic resonance imaging clinics of North America

Technical Considerations for Magnetic Resonance Imaging of the Bowel.

MRE is a key, non-radiating test for Crohn’s disease that can show active inflammation and complications that endoscopy may miss, so updates on technique matter for diagnosis and monitoring. Better imaging technique can...

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Defining and measuring disease burden in Crohn's disease: a systematic literature review.
Scandinavian journal of gastroenterology

Defining and measuring disease burden in Crohn's disease: a systematic literature review.

Patients and clinicians use the term "disease burden" to describe more than inflammation alone; it affects symptoms, daily function, mental health, and healthcare use. A clearer, integrated way to measure burden could...

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Multimodal biomarkers and prediction models for stricturing and penetrating progression in Crohn's disease
Frontiers in medicine

Multimodal biomarkers and prediction models for stricturing and penetrating progression in Crohn's disease

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Crohn's disease, Inflammatory bowel disease, and Biomarkers. The original article is from Frontiers in medicine.

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Ulcerative colitis, but not Crohn's disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification.
Frontiers in immunology

Ulcerative colitis, but not Crohn's disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification.

The findings suggest that tissue-based immune profiling may better identify biologically distinct subgroups in ulcerative colitis than blood tests, which could affect research on personalized treatment or trial...

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Short telomeres, but not accelerated epigenetic or proteomic age, increase fibrotic lung disease risk: Mendelian randomisation with pleiotropy dissection and independent replication
Europe PMC

Short telomeres, but not accelerated epigenetic or proteomic age, increase fibrotic lung disease risk: Mendelian randomisation with pleiotropy dissection and independent replication

If replicated and confirmed, the genetic evidence that shorter telomeres increase risk of fibrotic lung disease (IPF) helps clarify that telomere length itself — not just telomerase-pathway genes — may be relevant to...

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Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

A Phase 3 study is testing whether upadacitinib is safe and effective for children with moderate-to-severe Crohn's disease who have not responded to or cannot take other therapies. Positive results could expand treatment...

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Changes in Serum MMP-9 and TIMP-1 Concentrations in Children with Inflammatory Bowel Disease over a Six-Month Observation Period
International Journal of Molecular Sciences

Changes in Serum MMP-9 and TIMP-1 Concentrations in Children with Inflammatory Bowel Disease over a Six-Month Observation Period

If reliable, blood biomarkers that track IBD activity could help noninvasively follow children with Crohn’s disease or ulcerative colitis. This study suggests MMP-9 and TIMP-1 change with disease course but did not show...

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Leucine-rich alpha-2 glycoprotein reflects transmural inflammation assessed by through-the-scope endoscopic ultrasonography: A prospective study in small-bowel Crohn’s disease
World Journal of Gastroenterology

Leucine-rich alpha-2 glycoprotein reflects transmural inflammation assessed by through-the-scope endoscopic ultrasonography: A prospective study in small-bowel Crohn’s disease

A blood biomarker that reflects transmural inflammation could help monitor small-bowel Crohn’s disease noninvasively and might predict risk of rehospitalization.

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Multimodal prediction of infliximab initiation within 6 months after initiation of conventional therapy in pediatric Crohn's disease: A multicenter algorithm development and validation study.
Journal of pediatric gastroenterology and nutrition

Multimodal prediction of infliximab initiation within 6 months after initiation of conventional therapy in pediatric Crohn's disease: A multicenter algorithm development and validation study.

Predicting early need for infliximab could help identify children with Crohn’s disease who may benefit from earlier biologic therapy instead of prolonged conventional treatment. A reliable prediction tool may shorten...

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IL-11 in fibrostenotic Crohn’s disease: historical agonism, the selective-inhibition hypothesis, and evidence thresholds for translation
Frontiers in Pharmacology

IL-11 in fibrostenotic Crohn’s disease: historical agonism, the selective-inhibition hypothesis, and evidence thresholds for translation

IL-11 is implicated in fibrostenotic Crohn’s disease; determining whether it is a reversible therapeutic target could lead to treatments that prevent or reverse strictures rather than only managing inflammation or...

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TRANSPLANTE DE MICROBIOTA NO TRATAMENTO DA DOENÇA DE CROHN
Anais do XI Congresso Médico Universitário da USCS (XI COMUSCS)

TRANSPLANTE DE MICROBIOTA NO TRATAMENTO DA DOENÇA DE CROHN

Based on the title and source metadata, this appears to be a conference abstract related to Crohn's disease, Inflammatory bowel disease, and Microbiome. The original article is from Anais do XI Congresso Médico...

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Real-world clinical outcomes, prognostic factors, and safety profile of upadacitinib in patients with inflammatory bowel disease
World Journal of Gastrointestinal Endoscopy

Real-world clinical outcomes, prognostic factors, and safety profile of upadacitinib in patients with inflammatory bowel disease

Real-world data on upadacitinib help patients and clinicians understand how the drug performs outside clinical trials, including how long patients stay on treatment, remission rates, and common side effects.

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New composite outcomes data show patients treated with Lilly's Omvoh (mirikizumab-mrkz) achieved comprehensive corticosteroid-free disease control in ulcerative colitis and ...
prnewswire.com

New composite outcomes data show patients treated with Lilly's Omvoh (mirikizumab-mrkz) achieved comprehensive corticosteroid-free disease control in ulcerative colitis and ...

These results suggest mirikizumab can achieve multiple treatment goals at once — symptoms, objective inflammation measures, and steroid-free status — outcomes that matter to people with IBD because they reflect both...

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A review on MMP-2 modulating agents from natural and synthetic sources and their role in inflammatory bowel disease.
Inflammopharmacology

A review on MMP-2 modulating agents from natural and synthetic sources and their role in inflammatory bowel disease.

MMP-2 regulates tissue remodeling and inflammation in IBD; targeting it might help prevent barrier damage, chronic inflammation, or fibrosis but requires selective approaches to avoid harming normal repair processes.

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Comment on "predictors of time to surgical recurrence after ileal or ileocolonic resection in Crohn's disease: role of integrin αvβ6 and development of a predictive nomogram".
Updates in surgery

Comment on "predictors of time to surgical recurrence after ileal or ileocolonic resection in Crohn's disease: role of integrin αvβ6 and development of a predictive nomogram".

Based on the title and source metadata, this appears to be a case report related to Crohn's disease and Research and clinical trials. The original article is from Updates in surgery.

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Analysis of the Intestinal Microbiota in Crohn’s Disease and Therapeutic Potential of Thymus Essential Oils
Bacteria

Analysis of the Intestinal Microbiota in Crohn’s Disease and Therapeutic Potential of Thymus Essential Oils

Findings highlight cultivable gut microbiota differences in Crohn’s disease versus controls and present preliminary in vitro antimicrobial activity of two thyme essential oils—topics that may interest patients following...

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Microbiota-Associated Metabolites as Biomarkers and Therapeutic Opportunities in Inflammatory Bowel Disease
Nutrients

Microbiota-Associated Metabolites as Biomarkers and Therapeutic Opportunities in Inflammatory Bowel Disease

Microbiota-derived metabolites are linked to inflammation and gut barrier function, so they could become biomarkers or therapeutic targets for Crohn’s disease and ulcerative colitis. Patients may see future tests or...

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GM-CSF modulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohns disease
bioRxiv

GM-CSF modulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohns disease

Findings suggest GM-CSF signaling may help limit epithelial injury and shape immune cell states in Crohn’s disease, which could be relevant to understanding inflammation and future therapies targeting innate immunity or...

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Serum proteins predict incident inflammatory bowel disease 14 years before diagnosis: a machine-learning and Cox modelling in the UK Biobank

Protein biomarkers that predict IBD years before diagnosis could enable earlier detection, inform risk-stratified monitoring, and reveal early disease pathways that might be targeted to prevent or delay onset.

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Severe malnutrition and persistent myopenia despite weight recovery in newly diagnosed stricturing Crohn's disease: A case report.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

Severe malnutrition and persistent myopenia despite weight recovery in newly diagnosed stricturing Crohn's disease: A case report.

Muscle loss (myopenia) can persist in Crohn's disease even after weight recovery and clinical remission, which may affect long-term outcomes. Identifying persistent muscle depletion with body composition measures could...

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