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Ulcerative colitis

Ulcerative colitis news across medications, symptoms, monitoring, procedures, research, access, and daily life.

Page 10 of 40 · 1915 articles

Inflammatory Bowel Disease: From Multifactorial and Metabolic Pathogenesis to Systemic Disease and Precision Medicine
Metabolites

Inflammatory Bowel Disease: From Multifactorial and Metabolic Pathogenesis to Systemic Disease and Precision Medicine

This review reframes IBD as a systemic disease influenced by gut microbes, metabolism, and immune interactions — which matters because it points toward better ways to stratify patients, monitor disease, and personalize...

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Spray drying-assisted development of hydroxypropyl methylcellulose acetate succinate microparticles for andrographolide delivery: an in-vivo study in experimental ulcerative colitis
Drug Delivery and Translational Research

Spray drying-assisted development of hydroxypropyl methylcellulose acetate succinate microparticles for andrographolide delivery: an in-vivo study in experimental ulcerative colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Drug Delivery and...

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Supplementation of Bacillus cereus Enhances Anti-Colitis Effects of Triple Probiotics in Mice: Correlative Evidence for a Gut Microbiota–Spermidine-Related Axis in Quadruple-Probiotic Protection
Nutrients

Supplementation of Bacillus cereus Enhances Anti-Colitis Effects of Triple Probiotics in Mice: Correlative Evidence for a Gut Microbiota–Spermidine-Related Axis in Quadruple-Probiotic Protection

This study suggests a specific four-strain probiotic cocktail may better protect against experimental colitis than the three-strain mix, potentially via microbiota-driven increases in spermidine — a microbial metabolite...

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Proanthocyanidins in immune-mediated inflammatory diseases: molecular mechanisms and therapeutic potential
Frontiers in Pharmacology

Proanthocyanidins in immune-mediated inflammatory diseases: molecular mechanisms and therapeutic potential

People with IBD may be interested because the review highlights a class of dietary polyphenols that could influence inflammation and immune pathways involved in Crohn’s disease and ulcerative colitis. It summarizes...

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KARAP Exacerbates Intestinal Inflammation Through Promoting Kyn-AhR-dependent Neutrophil Activation in Ulcerative Colitis.
Cellular and molecular gastroenterology and hepatology

KARAP Exacerbates Intestinal Inflammation Through Promoting Kyn-AhR-dependent Neutrophil Activation in Ulcerative Colitis.

The paper identifies a neutrophil-related immune pathway (KARAP → IDO1–kynurenine → AhR → IL-22) that contributes to mucosal inflammation in ulcerative colitis, suggesting a potential new target for research and drug...

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Terminalia arjuna Biological Activities, Medicinal Uses, and Nutritional Effects of(Roxb. ex DC.) Wight & Arn.: Phytochemical Insights and Therapeutic Benefits in Ulcerative Colitis Management-A Detailed Review.
Food science & nutrition

Terminalia arjuna Biological Activities, Medicinal Uses, and Nutritional Effects of(Roxb. ex DC.) Wight & Arn.: Phytochemical Insights and Therapeutic Benefits in Ulcerative Colitis Management-A Detailed Review.

People with ulcerative colitis may be interested in plant-based therapies that could reduce gut inflammation or support mucosal health. This review compiles preclinical evidence suggesting Terminalia arjuna has...

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UBE2L6 drives ulcerative colitis progression by promoting BIRC2 degradation and activating non-canonical NF-κB signalling
Inflammation Research

UBE2L6 drives ulcerative colitis progression by promoting BIRC2 degradation and activating non-canonical NF-κB signalling

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Inflammation Research.

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Successful combination therapy with ustekinumab and intensive granulocyte and monocyte adsorptive apheresis in highly refractory pediatric ulcerative colitis: pathophysiological rationale and clinical outcome
Immunological Medicine

Successful combination therapy with ustekinumab and intensive granulocyte and monocyte adsorptive apheresis in highly refractory pediatric ulcerative colitis: pathophysiological rationale and clinical outcome

Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis, Inflammatory bowel disease, and Ustekinumab. The original article is from Immunological Medicine.

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Ferulic acid – A promising candidate molecule for the treatment of colitis
European Journal of Microbiology and Immunology

Ferulic acid – A promising candidate molecule for the treatment of colitis

This review highlights a plant-derived compound, ferulic acid, that showed anti-colitis effects in experimental studies, suggesting a potential new adjunctive therapy pathway worth watching for future clinical research.

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Impact of Smoking on the Effectiveness of Advanced Therapies in Inflammatory Bowel Disease: Active Smoking Is Associated with Reduced Effectiveness of Anti-TNF Treatment
Medicina

Impact of Smoking on the Effectiveness of Advanced Therapies in Inflammatory Bowel Disease: Active Smoking Is Associated with Reduced Effectiveness of Anti-TNF Treatment

The study suggests active smoking reduces the effectiveness of anti-TNF biologics in people with IBD, which could affect treatment response and the need to switch or escalate therapies. This supports including smoking...

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Machine learning meets network toxicology: identifying LOXL2 as a key player in ulcerative colitis
Toxicological Research

Machine learning meets network toxicology: identifying LOXL2 as a key player in ulcerative colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and AI and data science. The original article is from Toxicological Research.

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Patterns and factors associated with dose escalation during maintenance treatment for inflammatory bowel disease: a population-based cohort study.
Sage open chronic disease

Patterns and factors associated with dose escalation during maintenance treatment for inflammatory bowel disease: a population-based cohort study.

Dose increases are common during IBD maintenance and vary a lot by drug and patient profile. Knowing which treatments and patient factors are linked to escalation can help patients and clinicians plan monitoring and...

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Patient-reported first-use usability of the noncommercial MyTARGET mobile application among adults with inflammatory bowel disease: a cross-sectional survey.
Frontiers in digital health

Patient-reported first-use usability of the noncommercial MyTARGET mobile application among adults with inflammatory bowel disease: a cross-sectional survey.

High first-use usability suggests MyTARGET could be acceptable to many adults with IBD and that targeted refinements (error handling, demonstrating time savings) might improve uptake and recommendation.

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Evaluation of Blood and Stool Biomarkers Across Three Fecal Calprotectin Platforms and Combination Testing for Predicting Endoscopic and Histologic Outcomes in Inflammatory Bowel Disease
Europe PMC

Evaluation of Blood and Stool Biomarkers Across Three Fecal Calprotectin Platforms and Combination Testing for Predicting Endoscopic and Histologic Outcomes in Inflammatory Bowel Disease

Noninvasive fecal biomarkers are widely used to track IBD activity. Knowing whether different FC assays give comparable results and whether combining tests adds value affects how patients and clinicians interpret...

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Alterations of Serotonin System-Related Biomarkers and Their Association with Disease Activity in Patients with Ulcerative Colitis: A Systematic Review and Meta-analysis
INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

Alterations of Serotonin System-Related Biomarkers and Their Association with Disease Activity in Patients with Ulcerative Colitis: A Systematic Review and Meta-analysis

Cure8 could only read part of this source from INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, so this card uses cautious topic tags instead of a full summary. It is tagged...

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Ulcerative colitis, but not Crohn’s disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification
Frontiers in Immunology

Ulcerative colitis, but not Crohn’s disease, displays demographically and clinically driven mucosal immune heterogeneity: implications for patient stratification

The study suggests ulcerative colitis shows greater mucosal immune variability across sex, age and severity than Crohn’s disease, which could affect how patients are grouped for research or future personalized...

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Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation.
International immunopharmacology

Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation.

This identifies a metabolism-related epithelial gene (PCK1) linked to inflammation in UC and suggests acetyl‑L‑carnitine can partially reverse those changes in cell and mouse models—information that could guide future...

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Bowel Urgency Is More Strongly Associated with Biochemical, Endoscopic, and Histological Disease Activity than Other Clinical Symptoms in Ulcerative Colitis.
Internal medicine (Tokyo, Japan)

Bowel Urgency Is More Strongly Associated with Biochemical, Endoscopic, and Histological Disease Activity than Other Clinical Symptoms in Ulcerative Colitis.

If you have UC, bowel urgency may indicate active inflammation more reliably than some other symptoms. Recognizing urgency could help prompt timely objective testing and treatment decisions.

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Guselkumab Versus Risankizumab for Ulcerative Colitis: Real-World Comparison of Post-Induction Outcomes.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Guselkumab Versus Risankizumab for Ulcerative Colitis: Real-World Comparison of Post-Induction Outcomes.

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Guselkumab. The original article is from Clinical gastroenterology and hepatology...

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Comparative effectiveness of infliximab vs vedolizumab as first-line biologic therapy in moderate-to-severe ulcerative colitis: A prospective, multicenter, real-world study
Inflammatory Bowel Diseases

Comparative effectiveness of infliximab vs vedolizumab as first-line biologic therapy in moderate-to-severe ulcerative colitis: A prospective, multicenter, real-world study

This study compares two commonly used biologics as first-line therapy for moderate-to-severe ulcerative colitis and reports better short- and long-term effectiveness for vedolizumab with similar safety. The results could...

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Single-cell profiling reveals stromal niche and α5β1 regulation of neutrophil phenotypes in ulcerative colitis
bioRxiv

Single-cell profiling reveals stromal niche and α5β1 regulation of neutrophil phenotypes in ulcerative colitis

The study suggests stromal fibroblasts can drive pro-inflammatory neutrophil programs in ulcerative colitis and that targeting fibroblast-associated pathways may reduce neutrophil-driven inflammation—information that...

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Preexisting depression and early outcomes in inflammatory bowel disease: a propensity score-matched cohort study.
Proceedings (Baylor University. Medical Center)

Preexisting depression and early outcomes in inflammatory bowel disease: a propensity score-matched cohort study.

Depression before an IBD diagnosis was linked to more early treatment escalation and acute-care use after diagnosis. Recognizing preexisting depression could help clinicians identify patients who may benefit from closer...

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Marine-Derived Polysaccharides Against Ulcerative Colitis: Sources, Structures, and Multi-Target Mechanisms
Marine Drugs

Marine-Derived Polysaccharides Against Ulcerative Colitis: Sources, Structures, and Multi-Target Mechanisms

The review highlights marine polysaccharides as multi-target agents that could modulate inflammation, the microbiome, and the gut barrier—processes central to ulcerative colitis—and points to possible roles as functional...

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A causal machine learning framework for treatment personalization in clinical trials: application to ulcerative colitis
BMC Medical Research Methodology

A causal machine learning framework for treatment personalization in clinical trials: application to ulcerative colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, AI and data science, and Research and clinical trials. The original article is from BMC Medical Research...

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Study to Assess Treatment Patterns and Outcomes With Upadacitinib in Adult Participants With Inflammatory Bowel Disease in Belgium
ClinicalTrials.gov

Study to Assess Treatment Patterns and Outcomes With Upadacitinib in Adult Participants With Inflammatory Bowel Disease in Belgium

Real-world registry data on upadacitinib can help patients and clinicians understand how the drug performs outside clinical trials, including patterns of use, effectiveness, and safety over time.

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The role of blood lymphocyte levels in evaluating endoscopic remission of inflammatory bowel disease
European journal of medical research

The role of blood lymphocyte levels in evaluating endoscopic remission of inflammatory bowel disease

A simple blood lymphocyte percentage could be a convenient, non-invasive marker to help distinguish endoscopic remission from active disease in both Crohn’s and ulcerative colitis; chemokines CXCL10 and CCL25 may also...

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Distribution of CARD15/NOD2 Variants in Crohn’s Disease, Ulcerative Colitis, and Healthy Controls in a Djiboutian Population
Gastrointestinal Disorders

Distribution of CARD15/NOD2 Variants in Crohn’s Disease, Ulcerative Colitis, and Healthy Controls in a Djiboutian Population

The report explores NOD2/CARD15 variants in a Djiboutian IBD cohort and suggests higher variant frequencies in Crohn’s disease, which could point to population-specific genetic susceptibility. It also raises khat use as...

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Interaction between intestinal microbiota, inflammatory cytokines, and the expression of miR-330-3p and miR-515-5p in patients with ulcerative colitis.
Journal of medical biochemistry

Interaction between intestinal microbiota, inflammatory cytokines, and the expression of miR-330-3p and miR-515-5p in patients with ulcerative colitis.

The paper links specific gut bacteria, inflammatory cytokines, and two microRNAs with UC activity, which could point toward new diagnostic biomarkers or targets for research into disease mechanisms.

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Extracellular vesicle-based therapies in IBD: immunomodulation, regeneration, and translation.
Frontiers in immunology

Extracellular vesicle-based therapies in IBD: immunomodulation, regeneration, and translation.

Extracellular vesicle (EV) therapies are being explored as new ways to modulate immune responses and promote mucosal repair in IBD, which could eventually expand treatment options beyond current biologics and small...

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Insight into Ulcerative Colitis and Associated Diarrhea: Exploring the Interplay of Cellular and Molecular Axis with Advancement in Treatments.
Recent advances in inflammation & allergy drug discovery

Insight into Ulcerative Colitis and Associated Diarrhea: Exploring the Interplay of Cellular and Molecular Axis with Advancement in Treatments.

Persistent diarrhea is a common, quality-of-life–limiting problem in ulcerative colitis; this review synthesizes how epithelial transport, barrier damage, immune signaling, mitochondria, and microbiota interact and...

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Multimodal Imaging-Based Anatomical Characterization of DSS-Induced Experimental Ulcerative Colitis in Rat Model.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

Multimodal Imaging-Based Anatomical Characterization of DSS-Induced Experimental Ulcerative Colitis in Rat Model.

Non-invasive imaging biomarkers that track intestinal inflammation and structure could speed preclinical testing of IBD therapies and guide translational imaging research relevant to clinical monitoring of ulcerative...

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