Clinical trials, biomarkers, microbiome, genetics, AI, basic science, and emerging IBD research.
Page 29 of 65 · 3110 articles
Accurate recognition and standardized reporting of IBD-associated dysplasia help guide surveillance and surgical decisions because some dysplastic variants are flat, endoscopically invisible, and linked to advanced or...
Treatment resistance is a major hurdle in IBD care; this review maps how microbiota, immune imbalance, and epigenetics may work together to cause drug-resistant disease and suggests potential precision strategies that...
IBD patients sometimes have low iron or zinc and may try supplements. This trial tested whether two phytase-containing dietary supplements are acceptable and whether they change iron and zinc absorption in adults with...
A new oral drug, LMT503, is entering first-in-human testing for people with Crohn's disease and ulcerative colitis. Early-phase trials establish safety and how the body handles a drug—important first steps before any...
This narrative review surveys novel biomarkers and therapeutic strategies for adult IBD, topics that could affect diagnosis, monitoring, and future treatment options for people with Crohn's disease or ulcerative colitis.
Microbiome-based treatments target inflammation and microbial balance — central issues in IBD — and could offer new therapeutic options. This review collates clinical and mechanistic evidence but warns that results are...
JAK inhibitors are used to treat IBD and act broadly on immune signalling; understanding their cell-specific effects may explain who benefits, who doesn’t, and why adverse effects occur. This is directly relevant to...
Mental health symptoms are common in people with IBD and may be influenced by both psychological and biological factors. A virtual, group psychotherapy program tailored to IBD could increase access to treatment and help...
Sleep timing and morning light are modifiable, nonpharmacologic factors that could influence IBD quality of life and symptoms. If effective, a simple at-home light therapy could be an accessible adjunct to usual care.
This registry entry describes a completed Phase 2 study of a new IV drug (tulisokibart) for moderate–severe ulcerative colitis, including safety endpoints and a companion diagnostic — information patients may want when...
This trial tests a novel cell-derived extracellular vesicle therapy (DB-3Q) for people with Crohn’s disease who have not responded to standard advanced therapies. It may offer a different biologic approach if proven safe...
This observational study aims to link nutritional status and the dietary inflammatory potential to IBD activity and to test whether simple blood-derived inflammatory indices can serve as noninvasive markers of disease...
This study looks at how immunomodulators are actually used with biologic drugs in real-world practice when a national reimbursement policy forces biologic interruptions.
If you or someone you care for is not responding to anti‑TNF drugs for ulcerative colitis, this review explains biological reasons why that may happen and points toward research directions that could lead to better tests...
Researchers are investigating circRNAs as potential biomarkers and therapeutic targets in IBD because they may help explain disease mechanisms and lead to better diagnostics or treatments in the future.
Depressive symptoms during remission were associated with worse long-term physical, mental, and disease-specific quality of life, so attending to mental health can matter for overall wellbeing in IBD.
The study outlines a strategy to target corticosteroids to inflamed intestinal tissue by exploiting PLA2 overexpression, which could reduce systemic steroid side effects if the approach translates to biological models...
The review presents an emerging nanotechnology (TCM-derived carbon-dot nanozymes) that could offer new multitarget anti-inflammatory and antioxidant approaches for IBD, addressing limitations of current therapies and...
Researchers identified potential anti‑inflammatory mechanisms in a multi‑component herbal formula relevant to IBD pathways (NF‑κB, IL‑17) and showed in vitro reduction of pro‑inflammatory cytokines, which could guide...
Patient-derived intestinal organoids offer a human-relevant platform that could improve understanding of pediatric IBD biology and help predict individual treatment responses — potentially reducing trial-and-error...
Anaemia is a common and impactful complication in children diagnosed with IBD; knowing how often it occurs, which subtypes are most frequent, and its link with disease activity can guide monitoring and management...
This review directly compares surgery-first versus biologic-first strategies for localized ileocaecal Crohn's disease and suggests early resection can lower later treatment needs and leave some patients off medication,...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Pharmacological...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Sensors and Actuators...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Phytomedicine.
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Fitoterapia.
This mouse study suggests that acute colitis can alter liver immune responses—reducing CD8 T cells and shifting macrophages toward an anti-inflammatory M2 state—which may affect autoimmune cholangitis. That connection...
People with ulcerative colitis may be interested because the study identifies a botanical extract (Cortex Phellodendri alkaloids) that reduced disease in a mouse model and restored intestinal barrier markers, suggesting...
People with UC may care because the study identifies a compound and a signaling pathway that lowered inflammation and tissue injury in a commonly used mouse model of colitis, suggesting potential future therapeutic...
This review highlights probiotic and synbiotic approaches centered on L. plantarum that aim to rebalance gut microbiota and support the intestinal barrier—areas of direct interest to people with IBD seeking adjunctive,...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from International...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from International...
This study points to a plant-derived compound (Astragalus polysaccharides) that reduced colitis severity in a rat model by interfering with HMGB1/TLR4-driven neutrophil extracellular trap formation—pathways implicated in...
Spiritual and existential concerns can affect coping and quality of life for people with IBD, but these needs are rarely assessed systematically. Validated, culturally adapted questionnaires could help clinicians and...
Digital health tools could offer more continuous monitoring and self-management support for people with IBD, potentially helping detect flares earlier and improve quality of life. This review collects existing evidence...
The study maps cell-level programs in ileum and colon that associate with failure to respond to biologic therapies, suggesting specific cellular markers and niches that could help explain treatment resistance and guide...
The study identifies distinct fecal bile acid signatures in CRC versus UC that might help develop noninvasive tests to distinguish malignancy from chronic inflammatory disease of the colon.
The study suggests a common environmental pollutant could worsen intestinal inflammation in experimental colitis and identifies molecular pathways that might mediate that effect, which could be relevant to understanding...
Based on the title and source metadata, this appears to be a clinical trial phase 2 related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Microbiome, and Research and clinical trials. The original article is from Human Vaccines &...
The study provides a more rigorous, leakage-free machine-learning analysis of a major IBD microbiome cohort and proposes reproducible microbial and metabolic pathway candidates that could eventually help IBD diagnosis or...
The findings suggest blood DNA methylation changes may mark UC long before symptoms start; that could eventually enable earlier risk identification or research into preventing progression to symptomatic disease.
People with IBD who don’t respond well to ustekinumab may need alternative options. This study will track how patients fare after switching to guselkumab in routine clinical care and report rates of deep remission at one...
The study explores breath VOCs as a possible noninvasive biomarker for IBD activity, which could offer easier, more acceptable monitoring than colonoscopy or stool tests.
AIFOR-CD aims to validate an AI-derived digital pathology score that could objectively measure intestinal fibrosis from routine ileal biopsies.
Identifying common multimorbidity patterns and using machine learning to predict premature mortality could help health systems and clinicians prioritize integrated care for people with IBD, potentially improving outcomes...
