Clinical trials, biomarkers, microbiome, genetics, AI, basic science, and emerging IBD research.
Page 28 of 65 · 3110 articles
Finding reliable blood biomarkers for ulcerative colitis activity could make monitoring disease flares easier and less dependent on invasive tests. NGAL and S100A12 rising with active disease suggests they might help...
Researchers identified licochalcone B as a compound that reduced inflammation and repaired gut barrier in a mouse colitis model by affecting PI3K/AKT signaling and purine metabolism. For people following IBD research,...
Sarcopenia (loss of muscle mass/strength) was common among hospitalized adults with active UC and linked to inflammation, changes in blood metabolites (bile acids, acylcarnitines), and shifts in the gut microbiome.
The work highlights macrophage metabolic programs and specific genes that may help classify UC molecular subtypes and suggest candidate biomarkers or therapeutic targets related to macrophage-driven inflammation.
The work links a PD risk gene (LRRK2 G2019S) to increased intestinal NET formation and enteric α-synuclein in mouse colitis, suggesting a neutrophil-mediated inflammatory route by which gut inflammation and microbiota...
AIEC bacteria have been linked to Crohn’s disease; this study identifies a bacterial gene (rfaG) that helps AIEC express adhesins and colonize the gut in experimental models, which could point to future research paths...
If AJs and E-cadherin signaling influence intestinal inflammation, that could change how researchers think about IBD causes and point to new molecular targets for study.
The study links a common environmental chemical (BPA) to worse epithelial injury and inflammation in colitis models, highlighting a potential environmental contributor to IBD-relevant epithelial dysfunction and...
PSC — a serious bile-duct disease linked to IBD — was found on MRCP in about 1 in 10 people at IBD diagnosis, often without abnormal liver blood tests. Early radiological detection could affect monitoring and specialist...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from fingerlakes1.com.
The study suggests that anti‑TNF treatment in IBD is associated with weaker and less cross‑reactive antibody and memory B‑cell responses after COVID‑19 booster vaccination, which may reduce durability of protection and...
Researchers used machine learning and molecular docking plus small animal tests to link a common plasticizer (DEP) with molecular changes seen in pediatric Crohn’s disease. This could point to environmental exposures...
Cure8 found this source from onlinelibrary.wiley.com, but the page could not be read reliably yet. It is tagged for Research and clinical trials. Open the original article for the full details.
Vitamin D deficiency is common in people with IBD and this study suggests correcting deficiency may help rebalance immune cells and the microbiome—potentially supporting inflammation control alongside standard...
People with COPD can have coexisting type‑2 inflammatory conditions, and those conditions become more common with higher blood eosinophil counts. Knowing this may influence clinicians’ attention to extra‑pulmonary T2...
Protease and serpin activity affect the gut barrier, immunity, and microbial ecology—processes central to IBD. Integrating these pathways could help identify biomarkers or targets that explain why IBD varies between...
Preclinical results suggest a fermented yak milk–derived probiotic strain may protect against colitis in mice by improving barrier function, lowering inflammatory cytokines, and changing the gut microbiome—mechanisms...
People with Crohn’s who have had ileal or ileocolic surgery often worry about needing another operation; this study seeks clinical and biomarker predictors to estimate that risk. Understanding predictors could help...
Patients and clinicians often seek adjunctive options to improve symptoms, quality of life, or reduce treatment burden. This trial tests whether Bacillus spore probiotics added to standard care can provide measurable...
Mapping microbes and metabolites directly from different gut regions could reveal location-specific changes linked to IBD activity and help researchers develop better biomarkers or targeted treatments.
Faster, reliable reading of capsule endoscopy videos could shorten diagnostic delays and make small-bowel evaluation easier for people with suspected Crohn’s disease. If AI preserves accuracy while reducing review time,...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and AI and data science. The original article is from International journal of surgery...
If you or your clinician are using upadacitinib for Crohn’s, intestinal ultrasound early in treatment may help predict who will not respond and who is more likely to relapse on maintenance dosing, potentially guiding...
If confirmed, a simple calprotectin test on fistula scrapings could help predict which Crohn’s patients are likely to heal after primary surgical fistula closure and which may need additional therapies, potentially...
Microbial tryptophan metabolites may help restore the intestinal barrier via AhR signaling, a process that could reduce inflammation and symptom-driving permeability in IBD. Understanding this pathway could point to...
Clear, reproducible ultrasound definitions for transmural healing and response could help clinicians track deeper intestinal healing beyond mucosal assessment and allow trials to use consistent imaging endpoints.
Identifies mast-cell–derived IL-13 as a likely contributor to intestinal fibrosis in Crohn disease, a complication not reliably prevented by current anti-inflammatory treatments. The finding points to a specific immune...
The study suggests that air pollutant NO2 may promote a perforin-producing CD8+ T cell response linked to colonic inflammation in UC and highlights CDC25B as a potential mechanistic link—information that could guide...
The study suggests that in some people with IBD who have Candida overgrowth, systemic antifungal therapy (fluconazole) can change gut microbes and metabolites in ways linked to better disease activity over 8 weeks. That...
The review highlights metabolic pathways (mTOR–glycolysis) that drive inflammation and barrier dysfunction in ulcerative colitis, which could point to new kinds of targeted therapies beyond current immunosuppressive...
This study maps cell types in newly diagnosed pediatric Crohn's and links diagnostic cell patterns to disease severity and anti‑TNF treatment response. That could help predict which children are likely to benefit from...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Drug...
Cure8 found this source from The lancet. Gastroenterology & hepatology, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Research and clinical trials. Open the original article...
This study explores genetic risk variants (NOD2/CARD15) and local environmental factors (khat use) among young adults with IBD in Djibouti — information that may help explain regional differences in Crohn’s disease and...
Researchers are exploring ways to repair the intestinal barrier to reduce both gut inflammation and related liver problems; this study shows one nanoparticle approach that worked in mice.
The study expands the map of gut archaea and identifies archaeal species associated with IBD/UC, suggesting new microbial biomarkers and potential microbe–microbe interactions that might influence inflammation.
Market and late-stage trial updates can indicate which new therapies may become available and influence treatment options, access, and research priorities for Crohn's disease over the coming years.
If you have IBD, emerging forms of regulated cell death may help explain ongoing intestinal inflammation and could become targets for future tests or treatments. This review highlights multiple RCD pathways linked to...
People with UC have lower baseline gut microbial diversity and slower recovery after PEG bowel preparation; improving recovery of beneficial microbes could matter for symptom stability and gut health. This study suggests...
Altered tryptophan metabolism and AhR signaling were linked to fecal-water-induced DNA damage in IBD samples, suggesting a possible pathway connecting inflammation and epithelial genotoxic stress — a mechanism relevant...
A cellular atlas that links diagnostic biopsy cell states to treatment outcomes could help predict which children are likely to have severe or anti‑TNF‑resistant Crohn's disease, informing future research on personalized...
This study maps cell-level signatures in newly diagnosed pediatric Crohn’s and links them to later severity and responses to anti-TNF treatment, which could help predict which children will respond to biologic therapy...
This matters because many patients and clinics face procurement-driven switches from reference biologics to biosimilars; early evidence here suggests short-term outcomes and treatment persistence are similar after...
The FDA approval expands an approved biologic option (ustekinumab/Stelara) to children aged two and older with moderately to severely active ulcerative colitis, giving families and clinicians another treatment choice. It...
The study suggests a steroid‑sparing combination (low‑dose atorvastatin plus reduced prednisolone) may produce stronger anti‑inflammatory and antioxidant effects than either drug alone in an animal model of ulcerative...
This preclinical study suggests that a specific gut microbe (Bacteroides acidifaciens) and the bile acid UDCA can reduce inflammation in a mouse colitis model by improving barrier function and dampening NLRP3-driven...
People with chronic colitis/IBD have higher rates of cardiovascular disease. This mouse study identifies a gut microbiota → immune cell → cardiac pathway (TLR4–GBP1) that might explain that link and point to future...
Identifying baseline cellular states that predict disease course or response to anti‑TNF could help researchers develop predictive biomarkers and new therapeutic strategies for pediatric Crohn’s disease.
