Condition
Broader IBD news covering Crohn's disease, ulcerative colitis, research, treatments, monitoring, and patient care.
Page 12 of 48 · 2295 articles
Patients with Crohn's who develop intra-abdominal abscesses often face decisions about antibiotics, drainage, or surgery. Predictors like abscess size and imaging appearance may help estimate the chance of needing...
The study points to a new inflammation mechanism (VDAC1 → mtDNA → cGAS–STING) that may drive ulcerative colitis and identifies a natural compound, SEI, that blocks it in lab and mouse models; this could guide future drug...
The review links specific therapies and surgical options to outcomes that matter to people with IBD — mucosal healing, lower hospitalizations, and reduced need for surgery — and highlights that combining medical and...
People with an ileal pouch (J‑pouch) may experience pouch inflammation (pouchitis). This report suggests starting GLP‑1 receptor agonists might be followed by pouchitis in some cases, which could affect medication...
The paper identifies a new mechanism (VDAC1-driven mtDNA release activating cGAS–STING) that may drive inflammation in ulcerative colitis and a candidate compound (senkyunolide I) that blocks this pathway in preclinical...
The paper describes a new immunometabolic mechanism that strengthened intestinal barrier function and reduced colitis in mice, suggesting a potential pathway to develop therapies that boost ILC3-driven IL-22 production...
People with IBD and other IMIDs often need ongoing medication during pregnancy.
Sarcopenia or low muscle mass may be linked with worse endoscopic healing and reduced durability of biologic therapy in IBD, particularly Crohn's disease, which could matter for prognosis and treatment planning if...
The study investigates how specific gut bacterial strains can change colitis severity in experimental models — important because microbes are a focus of IBD research and potential therapies.
People with UC in remission who still have gut–brain interaction symptoms often look for safe ways to improve symptoms or gut microbiota balance.
Mirikizumab is being tested specifically in children with moderate-to-severe Crohn’s disease; successful results could expand treatment options for pediatric IBD. The study measures both symptom-based and endoscopic...
This trial is testing whether continued mirikizumab treatment helps children and teens with ulcerative colitis or Crohn’s disease achieve and maintain remission over the long term. Results could expand pediatric...
Real-world PSP registries can show how long people stay on vedolizumab and how it’s used alongside or compared with other advanced therapies like tofacitinib. That information can help patients and clinicians understand...
People with IBD who have no or few symptoms but still have moderate–severe inflammation on endoscopy face uncertainty about whether to switch therapies to aim for endoscopic remission.
Dietary strategies like the Mediterranean diet and time-restricted feeding could be low-risk ways to influence gut microbiota, short-chain fatty acids, and inflammation in people with ulcerative colitis; this trial will...
The study suggests a Moringa-derived polysaccharide may reduce inflammation in a mouse model of ulcerative colitis by altering gut microbiota, metabolites, and inflammatory/antioxidant signaling — a potential preclinical...
This review links lactic acid bacteria ecology in engineered communities to potential applications in gut health and IBD research, which could guide future microbiome-based interventions.
An extra mRNA COVID-19 vaccine dose produced only modest increases in antibody and T‑cell responses in immunosuppressed children (including those with IBD), so vaccine protection may still be lower than in healthy...
The study suggests blood metabolite patterns differ by biologic therapy and identifies candidate biomarkers that might help develop less-invasive monitoring tools for inflammation and treatment effects in Crohn’s...
Cure8 could only read part of this source from South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, so this card uses cautious topic tags instead of a full summary. It is tagged for Inflammatory...
Preneoplastic (adenomatous and serrated) polyps can be precursors to colorectal cancer, so knowing how common they are and what raises risk may affect surveillance planning for people with ulcerative colitis.
Respiratory viral infections can be more serious in immunosuppressed patients. This study suggests systemic steroids (prednisolone) — but not biologics or immunomodulators in this dataset — were linked to higher...
If you had biologic treatment before bowel surgery, this study suggests restarting the same class of biologic after ileocolonic resection may prevent postoperative recurrence as well as switching to a new class — and may...
Researchers and clinicians are increasingly studying combinations of IBD drugs because single‑drug remission rates have plateaued; dual therapy may improve outcomes for patients who have failed prior treatments.
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...
If you have PSC-IBD or care for someone who does, this study suggests the gut microbiota and its ability to make secondary bile acids may help drive inflammation and colorectal dysplasia risk.
Researchers are exploring natural compounds that may modulate gut microbes, barrier function, and immune signaling relevant to ulcerative colitis.
Intestinal fibrosis causes strictures and surgery in many people with Crohn's disease; new RNA-based antifibrotic strategies delivered by nanocarriers could offer non-surgical treatment options in the future if they can...
For people with ulcerative colitis who have already tried and failed one or more advanced therapies, this study suggests upadacitinib may lead to higher rates of steroid-free clinical remission and endoscopic healing...
This pooled analysis compares multiple microbiota-directed therapies and suggests FMT, probiotics, and synbiotics may improve clinical remission in adults with IBD, with FMT also showing benefit for endoscopic remission....
Some rare autoinflammatory disorders can look like IBD but need different diagnostic thinking. Recognizing systemic signs and checking serum zinc may lead to a correct diagnosis and targeted care.
Psychiatric disorders (especially depression, anxiety, and substance misuse) are more common in people with IBD starting a few years before diagnosis and remaining higher for years after. Recognizing this link can help...
This study suggests a new, non‑live (“postbiotic”) approach—extracellular vesicles from pasteurized Akkermansia muciniphila—may reduce inflammation and improve barrier function in an experimental colitis model, which...
Researchers and clinicians are exploring how fucose metabolism affects gut barrier function, immunity, and microbiota — processes central to IBD and colorectal cancer. If validated, fucosylation biomarkers or treatments...
Better automated segmentation of inflammatory lesions could make colonoscopy assessments more objective and consistent, which matters for monitoring IBD activity and for clinical trials that rely on endoscopic endpoints.
Measuring mucosal healing across the whole gut with stool markers, ultrasound, and capsule endoscopy may give a clearer picture of whether biologic treatment is working and help guide decisions about continuing or...
The study presents preclinical data that an orally delivered biotherapeutic (EPICERTIN) promotes epithelial repair and reduces inflammation in a UC-relevant mouse model — a potential step toward therapies that directly...
If validated, a simple ultrasound-based score could reduce the need for invasive endoscopy to monitor disease activity in children with ulcerative colitis. Noninvasive monitoring is especially valuable in pediatrics.
Surgery remains an important treatment option for Crohn’s disease and may be considered earlier for some patients. Decisions about timing, technique, and perioperative care can affect long-term outcomes and recurrence...
Fibrosis causes strictures and surgery in many people with Crohn’s disease; a new immune pathway linked to fibrosis could point to future treatments. This study shows that γδ T cells and CD73-mediated adenosine signaling...
This study analyzes thousands of adverse event reports for ustekinumab in Crohn’s disease and highlights infections plus possible cardiovascular and neuropsychiatric signals that clinicians and patients may want to...
This study addresses whether removing the appendix changes long-term UC outcomes. People with UC or their clinicians might expect surgery to alter disease course; these real-world data suggest it generally does not for...
This review outlines BEVs as a microbiome-derived, engineered nanotherapy concept that could influence gut barrier repair and immune regulation—areas directly relevant to managing IBD activity and treatment resistance.
Many people with Crohn’s disease have ongoing inflammation despite stable medication. If dietary personalization can reduce inflammation, it could offer a nonpharmacologic add-on to help bridge gaps without immediate...
Most people with IBD can have children safely with modern treatments and planning; uncontrolled disease poses greater risks to pregnancy than continuing most IBD medications. Planning and specialist input before...
Biologic therapy and steroid withdrawal were temporally associated with severe eosinophilic myocarditis in a patient with ulcerative colitis — a life-threatening but potentially treatable complication. Early recognition...
Researchers identified a specific immune receptor pathway (Dectin-1–CARD9) that senses a yeast species enriched in Crohn disease ulcers, suggesting a possible microbial trigger of inflammation relevant to IBD...
This research explores a novel way to deliver probiotics and antioxidant molecules directly to inflamed colon lesions — a potential path to therapies that locally reduce oxidative stress and inflammation in IBD without...
