Condition
Broader IBD news covering Crohn's disease, ulcerative colitis, research, treatments, monitoring, and patient care.
Page 25 of 88 · 4204 articles
The study suggests that a soluble fiber from foxtail millet can lessen colitis in a mouse model by changing gut fungal communities and improving barrier proteins — pointing to a possible food‑based approach worth further...
The study suggests that asymptomatic C. difficile colonization may not predict return of IBD activity in patients who are in remission, which could influence how clinicians interpret positive C. difficile tests in people...
Cure8 found this source from bioengineer.org, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Research and clinical trials. Open the original article for the full details.
Antibiotics can cause microbiome injury that increases risk of C. difficile and may worsen long-term health issues; identifying ways to protect the gut microbiome during antibiotic use could be especially relevant for...
The project investigates how TNFR1 and TNFR2 differently control epithelial repair in the colon—mechanisms that may explain why many patients on anti‑TNF biologics do not achieve lasting mucosal healing and could point...
Many people with IBD have ongoing IBS-like symptoms despite little or no intestinal inflammation. This project targets brain–gut and autonomic mechanisms that might explain symptom persistence and tests a non-drug...
The project targets a molecular regulator of tuft cells, which help control mucosal immune responses and have been linked to chronic gut inflammation such as ulcerative colitis. Discovering how OCA-T2 shapes tuft cell...
This project describes a novel off-the-shelf engineered regulatory T cell therapy aiming to promote intestinal immune regulation and mucosal healing — a different approach than current biologics. If successful, it could...
The study tests whether common environmental chemicals (PFAS) could alter protein glycosylation and raise the later risk of IBD, which could point to preventable risk factors and early biomarkers.
The paper identifies epothilone B as a repurposing candidate that may reduce neutrophil-driven inflammation and support epithelial healing in IBD models, a potential new strategy distinct from broad neutrophil...
The study identifies epithelial IFN‑I signaling as a driver of barrier failure in anti‑TNF refractory Crohn’s disease and suggests that blocking IFN‑I could be a rescue strategy for patients who do not respond to...
miRNAs are being studied as stable circulating biomarkers and possible therapeutic targets in immune diseases including IBD. Advances could eventually improve earlier diagnosis, track disease course, or lead to new...
The study links a traditional acupuncture-derived technique (ACE) to reduced colitis severity in rats and to modulation of the cGAS–STING immune pathway and macrophage marker profiles, suggesting a potential mechanistic...
The pipeline helps identify stem and progenitor epithelial cell states linked to inflammation in IBD. Knowing these cell states and biomarkers could guide research into disease mechanisms, tissue repair, and potential...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Crohn's & colitis 360.
Long-term results suggest endoscopic approaches—especially balloon dilatation—help many people with Crohn’s strictures avoid surgery and have fewer severe complications compared with surgical treatment.
Cocaine use can trigger severe GI problems that mimic common surgical and inflammatory conditions; recognizing the link can speed diagnosis and management. Most published evidence is low-level (case reports/series), so...
Mucosal colonisation by adherent‑invasive E. coli has been implicated in Crohn’s disease for some patients; this study suggests FMT can change the mucosal microbiome and clear AIEC in a small pilot cohort, which could be...
This large national-registry study identifies clinical features linked with needing optimization of biologic or small-molecule therapies in CD and UC. That helps show which patient groups more often require...
Undernutrition and lean-mass loss are common and harmful in people with IBD. If dietary strategies can prevent weight and muscle loss and shift the gut microbiota toward SCFA producers, that could be relevant to...
Findings about increased LRRK2 in colonic tissue may point to shared immune or genetic mechanisms between Crohn’s disease and neurological disorders, which could be relevant for future research and biomarker development.
SMC phenotypic switching can contribute to intestinal fibrosis and motility problems in IBD; understanding macrophage regulation of SMCs could point to new treatment targets for these complications.
Restrictive self-directed diets are common among people with IBD but can cause nutritional and psychosocial harms. An inclusive, Mediterranean-style approach may offer similar symptom benefit with fewer risks and should...
Mechanical forces in the gut may help drive fibroblast activation and early fibrosis in IBD; models that reproduce this could help researchers study and eventually target fibrotic pathways relevant to stricturing...
The study suggests starting anti-TNF therapy with an immunomodulator at diagnosis may reduce surgery, hospital stays, and progression to complicated Crohn’s over 5 years — outcomes that matter to patients and clinicians...
Histology and endoscopy are both used to assess UC activity; knowing which histologic score is reliable and practical helps clinicians and pathologists standardize monitoring and may streamline reporting in routine care.
A noninvasive, explainable model that combines CT enterography radiomics with CRP could make it easier to monitor mucosal healing in small‑bowel Crohn’s disease without repeated invasive enteroscopy, especially after...
The study suggests a new macrophage-linked mechanism (NINJ2 → ZBP1 → PANoptosis) that may drive intestinal inflammation in IBD and could become a target for future therapies or biomarkers.
Shifting care toward disease modification could reduce long-term bowel damage and disability for people with Crohn's disease by prioritizing earlier, more effective treatment and exploring prevention strategies.
The study suggests ED presentation symptoms predict admission differently in UC versus CD, which could affect triage and short-term risk assessment for IBD patients. Knowing which symptoms are stronger predictors by...
NOD2 loss-of-function is a major genetic risk for Crohn’s disease, and this review highlights that gut microbes can modulate NOD2 signaling. That connection may help explain variation in disease risk and points to...
Based on the title and source metadata, this appears to be a video related to Inflammatory bowel disease and Procedures and surgery. The original article is from hmpgloballearningnetwork.com.
Early effective treatment may change long-term outcomes in Crohn's disease. Understanding the timing of a potential "window of opportunity" could affect decisions about when to start or escalate therapy.
The paper links ileitis and changes in enterohepatic bile-acid composition to altered Th17 immune activity, suggesting bile-acid balance could influence inflammation in Crohn’s disease and might be a target for future...
The study links IRF5 to worse intestinal inflammation in UC and shows that reducing IRF5 activity lessens disease in a mouse model, suggesting IRF5 could be a future therapeutic target or biomarker.
The study presents a cell-free EV therapy that reduced inflammation in an experimental colitis model by reprogramming dendritic cells, which could inform future IBD treatments. It highlights a specific immunoregulatory...
The study presents a new inflammation-responsive oral delivery system designed to concentrate antioxidant and anti-inflammatory activity in the colon, which could—if translated safely to humans—offer a way to treat...
Malnutrition is common in IBD and worsens clinical course and quality of life. Better screening and assessment can identify people who need nutritional support.
Patients and clinicians using vedolizumab may be interested because the review links higher trough concentrations to better remission outcomes—most convincingly for endoscopic remission in UC—and provides descriptive...
Joint swelling and fever can sometimes be caused by IBD-related inflammatory arthritis rather than infection. People with communication barriers may not report chronic bowel symptoms, delaying the correct diagnosis.
This method could let researchers study human intestinal tissue and its immune environment directly, potentially improving understanding of IBD mechanisms and how individual patients’ tissues respond to therapies.
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Diet and lifestyle. The original article is from Journal of the Academy of Nutrition and Dietetics.
Low muscle mass and sarcopenia are common and can worsen outcomes in people with IBD. Identifying who is at risk can prompt earlier monitoring and interventions such as nutritional support, physical therapy, or...
The exposome perspective emphasizes that many non-genetic, potentially modifiable environmental factors likely influence IBD risk. Understanding these factors could help guide prevention research and public-health...
A blood biomarker that helps predict primary non-response to anti‑TNF drugs could spare some patients ineffective therapy, reduce delays to alternative treatments, and inform shared decision‑making before starting...
The study suggests some autoimmune diseases common in IBD patients—ulcerative colitis and primary sclerosing cholangitis—may be genetically linked to higher pancreatitis risk. That could help researchers understand...
This preclinical study links NOX1/4 and NLRP3 pathways to ferroptosis and iron metabolism in a mouse colitis model, highlighting potential mechanistic targets that could inform future precision therapies for ulcerative...
Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Diet and lifestyle. The original article is from Gastroenterology.
