Inflammatory bowel disease

The paper identifies berberine as an alkaloid that reduced epithelial cell pyroptosis and improved tissue injury in a mouse model of bacterial colitis, suggesting a possible new anti-inflammatory mechanism relevant to...

The review links gut microbiota changes and mucosal immune responses across IBD and IgA nephropathy, suggesting that gut dysbiosis may contribute to systemic immune-driven disease.

This review may help patients and clinicians understand how long-lasting changes in bacterial metabolism could contribute to IBD relapse and point toward future microbiome-targeted therapies aimed at restoring resilient...

This study explores a potential mechanism linking a MAP infection model to inflammatory and metabolic pathways relevant to Crohn’s disease and tests whether methylglyoxal can lessen inflammatory programming in...

Based on the title and source metadata, this appears to be an opinion or commentary related to Crohn's disease, Inflammatory bowel disease, and Tests and monitoring. The original article is from Inflammatory bowel...

Drug levels and how patients reach remission can differ depending on prior biologic use. For families and clinicians managing pediatric Crohn's, this can affect how infliximab dosing and monitoring are interpreted after...

The study points to a specific immune cell type (pro-inflammatory CD4+ macrophages) and altered cellular interactions in rectal tissue that are linked to perianal fistulizing Crohn's disease, which may help explain...

Improving colon-targeted delivery of mesalamine could increase drug concentrations at inflamed tissue and reduce release in the stomach and small intestine, which may improve effectiveness and reduce off-target exposure.

Better triage methods that combine FIT with demographics and blood biomarkers could reduce unnecessary colonoscopies while keeping sensitivity for colorectal cancer and other serious findings, which matters for...

This study reports early-stage lab and mouse evidence for new small molecules that target the JAK2–STAT3 immune signaling pathway, a pathway relevant to inflammation in ulcerative colitis. If findings are confirmed in...

Cure8 could only read part of this source from Internal Medicine, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Budesonide.

The study describes a microbiota-responsive cytotoxic CD4+ T‑cell state that associates with worse mucosal inflammation and reduced response to common biologic therapies in ulcerative colitis, suggesting a possible...

Persistent perineal sinus is a common and impactful complication after proctectomy for Crohn disease that can prolong recovery and require further care. Knowing rates of healing and risk factors can help patients and...

This work explores a novel, programmable way to deliver anti-inflammatory protein therapy (IL-10) directly in the gut using engineered yeast and wearable electronics. If further developed and translated, it could offer a...

This deal accelerates funding for a drug (RXC008) specifically targeting fibrosis in Crohn’s disease, an area with no approved anti‑fibrotic therapies and where patients often need surgery for strictures. If clinical...

Cure8 could only read part of this source from tradingview.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Inflammatory bowel disease, and Stricture.

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Guselkumab. The original article is from gastroendonews.com.

People with IBD or those who had sigmoid-colon vaginoplasty may not expect neovaginal bleeding to be related to ulcerative colitis; recognizing this link can prompt appropriate evaluation and treatment. Early diagnosis...

Because intestinal lymphoma can closely mimic Crohn’s disease, recognizing red flags (severe malabsorption, proximal small-bowel involvement, monoclonal gammopathy, poor response to IBD therapy) can change diagnosis and...

Cure8 found this source from Gastroenterology report, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Procedures and surgery. Open the original article...

The video demonstrates a bowel-preserving robotic surgical technique for ileal strictures in Crohn's disease that could help surgeons perform technically demanding intracorporeal suturing and preserve bowel length.

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Corporate Philanthropy Report.

Vitamin D appears linked to immune regulation, gut barrier health, and the microbiome—processes relevant to IBD and other intestinal disorders. Understanding this could affect how clinicians monitor and study vitamin D...

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Infliximab. The original article is from Journal of Genetic Engineering and...

Many people with IBD experience persistent fatigue, pain and faecal incontinence even when inflammation is controlled; this programme tested a supported online self-management approach to help those symptoms and assessed...

Patients and clinicians often want to know how quickly symptoms improve after starting a biologic. This study is designed to compare early patient‑reported symptom changes after starting vedolizumab versus IL‑23...

This registry will track how people with moderate to severe ulcerative colitis do on risankizumab in routine Japanese clinical practice, which may provide information about real-world remission rates and longer-term...

This animal study suggests Antarctic krill oil may reduce inflammation and weight loss in a mouse model of ulcerative colitis and works alongside changes in gut microbiota and metabolites—findings that could inform...

Self-management is central to living with UC, and this framework gives a structured way to design support that targets behaviors people need to manage the disease.

This paper offers a multi-layered ecological perspective on UC-associated microbiome changes that could help researchers identify which microbial functions or taxa are driven more by random processes versus selection in...

Fear of movement (kinesiophobia) can reduce physical activity and worsen quality of life for people with IBD.

Children with IBD often wait years for medicines to be approved after adult approvals; this review shows many ongoing paediatric trials for biologics and small molecules that could improve treatment options.

Joint inflammation is a common and impactful extraintestinal issue in IBD; recognizing and treating it appropriately affects symptoms, function, and quality of life.

Cure8 found this source from Journal of pediatric gastroenterology and nutrition, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease, Risankizumab, and IL-23 inhibitor. Open the...

The study suggests a new microbiome-based strategy that targets toxic hydrogen sulfide production and boosts host detoxification — a mechanism potentially relevant to some forms of IBD driven by sulfur-metabolizing...

Cure8 could only read part of this source from PubMed Central, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Inflammatory bowel disease, and Complications.

The study pinpoints OTUD5 as a molecular driver of IFNγ-driven intestinal inflammation and links it to anti-TNFα nonresponse; blocking OTUD5 with a small molecule reduced colitis in mice and in human organoids, which...

If dietary oxalate influences gut inflammation, it could be a modifiable dietary factor for some people with IBD and might help explain variability in symptoms. The study points to transporters as potential markers of...

Researchers and clinicians studying IBD, and patients interested in how gut microbes and immune signaling might connect bowel inflammation with fatty liver disease, will find the discussion relevant to future precision...

IBD patients often face high psychological burden; knowing whether MBCT is acceptable and feasible helps patients and clinicians weigh it as a support option. Practical barriers (time, fatigue, disease activity) and...

The study introduces a novel preclinical therapeutic approach that selectively degrades HDAC6 and reduced inflammation in a mouse model of colitis, suggesting a potential new drug-discovery avenue relevant to ulcerative...

The study presents an AI method that combines endoscopic images and diagnostic text to predict histological healing in ulcerative colitis, which could help non-invasive assessment and reduce annotation effort in...

This work points to new genes and immune-cell mechanisms that could help explain unexplained genetic risk for Crohn’s disease and suggests that genes known for other diseases might play unanticipated roles in gut...

The study suggests a novel plant-derived nanoparticle approach reduced inflammation and repaired barrier function in a mouse model of colitis and changed the gut microbiome — a potential early-stage route for new IBD...

A probe that detects both ATP and hypochlorite may offer a more specific optical marker of oxidative/inflammatory activity in IBD models, which could aid research into disease mechanisms and future diagnostic approaches.

Intestinal ultrasound is increasingly used to evaluate Crohn’s disease because it’s noninvasive, repeatable, and can detect activity and some complications—potentially reducing reliance on more invasive tests. Wider...

The study links a cellular signaling pathway that increases serotonin release from gut enterochromaffin cells to inflammation in a mouse model of ulcerative colitis. If confirmed, blocking TRPV4 could become a research...

Stigma and social support appear to meaningfully relate to quality of life for adults with IBD in Saudi Arabia. Understanding which coping strategies and support sources help could inform patient education and support...