Condition
Broader IBD news covering Crohn's disease, ulcerative colitis, research, treatments, monitoring, and patient care.
Page 8 of 48 · 2295 articles
Cure8 found this source from streetinsider.com, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Medications. Open the original article for the full details.
Patients and clinicians considering sequencing of advanced UC therapies may care because this study reports differences in how long patients stayed on second-line treatment depending on the order of anti-TNF agents and...
Cure8 found this source from medpagetoday.com, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Community and awareness. Open the original article for the full details.
The study suggests TIMP1 may help drive ferroptosis, inflammation, and epithelial barrier dysfunction in ulcerative colitis; targeting TIMP1 could eventually inform new therapies or biomarkers if confirmed in further...
This small case series suggests upadacitinib may induce and maintain steroid-free remission in some UC patients after tofacitinib failure, a potential option for people with refractory disease.
This review highlights a potential new class of IBD drugs (RIPK1 inhibitors) that target inflammatory and cell-death pathways implicated in epithelial injury. For people with IBD, it signals an area of active research...
GLP-1 receptor agonists — drugs commonly used to treat obesity and metabolic disease — may help patients with IBD by reducing visceral fat and improving cardiometabolic health.
People labelled with IBS-D may actually have treatable organic conditions that require different tests and treatments; avoiding diagnostic mistakes can speed appropriate care and reduce unnecessary symptom-focused...
Extraintestinal lung involvement can occur in IBD and patients often ask whether anti‑TNF drugs affect lung function; this small study found only minor changes in lung volumes and diffusion over short follow‑up in mostly...
Understanding how the gut virome shapes regulatory T cells could reveal new biomarkers or therapeutic targets for IBD and related systemic immune diseases. This may help explain unexplained flares or individual...
VTE is a serious, potentially preventable complication in children with newly diagnosed IBD. Identifying risk factors could help clinicians consider which pediatric patients might need closer monitoring or future...
The study tests whether a simple blood-derived index (CRP×NLR) can help identify moderate-to-severe endoscopic inflammation when timely endoscopy is limited in hospitalized UC patients.
The study suggests a rice bran extract might reduce colitis severity in rats by shifting gut microbiota and dampening TLR4/NF-κB–driven inflammation, a pathway relevant to human IBD research.
Identifies candidate drug‑level and immune biomarker cut‑points linked with endoscopic healing in pediatric Crohn's disease, which could help guide dosing or treatment changes if validated.
The work suggests that specific gut bacteria or their metabolic products (acetate, putrescine) can limit harmful E. coli expansion and reduce inflammation in a mouse model of colitis, which could inform future probiotic...
Non-invasive fecal lipid markers could help differentiate UC from CD and improve diagnostic molecular profiling in IBD if validated, which may be useful for patients and clinicians seeking less-invasive diagnostic tools.
The study proposes two transcriptomic markers (LIMK1, PKM) that may help characterize an IBD-associated, mitochondria–ER membrane–related transcriptional state and could guide future biomarker or mechanistic research.
GI infections—especially CMV—were common in this study and much more frequent in acute severe UC than in remission, suggesting testing for infections can change diagnosis and management during severe flares.
Someone with Crohn’s disease and limited remaining small intestine may face high-risk surgical choices. This case report suggests a specialized oral supplement used with conservative care was associated with fistula...
The study evaluates how well first-line 5-ASA therapy achieves modern treatment targets (endoscopic, histologic, and biomarker remission) in real-world UC patients who are clinically in remission. Patients and clinicians...
This study suggests noninvasive vagus nerve stimulation (taVNS) can reduce colonic inflammation and change immune signals regionally in a mouse model of ulcerative colitis—supporting a possible neuroimmune approach worth...
Micronutrient deficiencies are common in IBD and can worsen anemia, healing, and neurologic function. This study shows inpatient testing focuses on B12 while missing other commonly deficient nutrients (B1, B6, zinc),...
Biologics and newer small molecules have markedly changed IBD care and outcomes for many patients, but their population-level impact depends on access, cost, and how they are used. Understanding this helps patients and...
This study addresses whether being on biologic or small‑molecule IBD drugs before colorectal surgery affects short‑term postoperative complications — a practical concern for patients and clinicians planning surgery.
If confirmed, a brain perivascular/glymphatic change linked to intestinal inflammation could help explain why sleep problems are common in Crohn's disease and point to new research targets for symptom mechanisms and...
A targeted, pH-sensitive colon delivery system could improve effectiveness and reduce systemic side effects of drugs used for UC by releasing medication in the colon and protecting it from stomach degradation. For people...
Identifies gene and microbiome patterns linked to progression from inflammation to irreversible bowel fibrosis in Crohn’s disease, which could eventually help predict who is at higher risk and inform prevention...
The T&W criteria are still used to define severe UC on admission, but relying on them alone may delay recognition of steroid non‑response and escalation decisions. Integrating biomarkers, endoscopy, and imaging can help...
Distinct circulating immune signatures could help differentiate active UC from CD and suggest disease-specific pathways that might guide future biomarkers or therapies.
If validated, blood microRNAs could become noninvasive biomarkers to help track inflammation and predict biochemical response to infliximab or vedolizumab in Crohn’s disease, complementing CRP and fecal calprotectin.
Rising incidence in east and southeast Asia means more people will live with IBD over coming decades, which affects healthcare planning, access to specialists, and resource needs. Understanding regional trajectories can...
This preclinical study links periodontal ligament stem cells to reduced colitis severity in mice by restoring macrophage mitochondrial function and activating PINK1/Parkin-associated mitophagy, suggesting a possible new...
This study suggests that specific gut bacteria targeted by systemic IgG are associated with UC activity and inflammation, which could eventually help identify microbial signals linked to flares or systemic inflammation.
Cure8 found this source from Inflammatory bowel diseases, but the page could not be read reliably yet. It is tagged for Crohn's disease, Inflammatory bowel disease, and Tests and monitoring. Open the original article for...
Short-term mental health problems (depression, anxiety, adjustment disorders) appear more common after ostomy creation than after nonostomy IBD surgery among biologic-treated adults. Awareness may help patients and...
IBD patients face higher risk of osteoporosis; identifying shared, apoptosis-related genes may help explain why and point to future biomarkers or therapeutic targets. The study links specific genes (WNT1, S100A8) to both...
A colon-targeted 5-ASA pellet could improve delivery of mesalamine to the diseased colon while reducing release in the stomach; that might increase effectiveness or reduce systemic exposure compared with standard...
Fibrosis (irreversible bowel scarring) is a major cause of surgery in Crohn’s disease. This study points to molecular and microbiome patterns that may help predict or distinguish fibrosis from active inflammation, which...
Cure8 found this source from tipranks.com, but the page could not be read reliably yet. It is tagged for Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. Open the original article for the...
Fibrosis (irreversible bowel scarring) is a major cause of surgery in Crohn’s disease. Identifying molecular and microbial markers tied to fibrosis could eventually help predict who’s at higher risk and guide earlier,...
Practical support like GI comfort kits can help people with gastrointestinal conditions who lack stable housing or social support. The itemized wish list makes it easy for community members to contribute directly.
The paper maps distinct stromal cell states tied to inflamed versus fibrotic tissue niches in Crohn’s disease and shows that these states have different chromatin configurations and drug-modifiable properties — pointing...
The work points to measurable molecular and microbial patterns that may help distinguish treatable inflammation from progressive fibrosis and suggests AI could aid in building predictive tools from limited samples —...
Many patients and clinicians assume terminal ileitis on imaging means Crohn's disease. This study suggests that, after further testing, most CT-detected terminal ileitis is due to non-Crohn's causes, so thorough...
Identifies candidate gene signatures tied to MAM-related transcriptional states in IBD that could become biomarkers or guide mechanistic research into immune–metabolic pathways relevant to disease.
The probe targets azoreductase-driven hypoxia, a mechanism linked to ulcerative colitis and other hypoxia-associated diseases; a reliable real-time imaging method could help research and eventually guide treatments.
The study suggests a specific stromal and MAPK/EGFR signalling programme linked to prior anti‑TNF failure in ulcerative colitis, which could help explain why some patients are less responsive to later therapies and point...
Preclinical data suggest sodium phenylbutyrate and suramin may reduce inflammation and oxidative stress in a mouse model of ulcerative colitis, pointing to possible therapeutic mechanisms worth further study.
