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Ulcerative colitis

Ulcerative colitis news across medications, symptoms, monitoring, procedures, research, access, and daily life.

Page 13 of 40 · 1918 articles

Altered colonic keratin expression as a biomarker signature distinguishes IBD, microscopic colitis, and IBS – a retrospective study
BMC Gastroenterology

Altered colonic keratin expression as a biomarker signature distinguishes IBD, microscopic colitis, and IBS – a retrospective study

Biopsy-based keratin patterns might help distinguish IBD, microscopic colitis, and IBS—conditions that can look similar clinically—so this could improve diagnostic accuracy if validated.

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Guselkumab as a Treatment Adjunct for Pyoderma Gangrenosum While Maintaining Clinical Remission of Ulcerative Colitis.
ACG case reports journal

Guselkumab as a Treatment Adjunct for Pyoderma Gangrenosum While Maintaining Clinical Remission of Ulcerative Colitis.

PG is a serious skin complication that can occur with UC. This report suggests guselkumab—an IL‑23 blocker used in IBD and dermatology—helped resolve PG in one patient without loss of UC remission, which could be...

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Probiotic drug interactions in ulcerative colitis: a microbiota and metabolite perspective
Frontiers in Microbiology

Probiotic drug interactions in ulcerative colitis: a microbiota and metabolite perspective

People with UC often use probiotics or microbiome-directed therapies alongside prescription drugs. Understanding probiotic–drug interactions could explain why individuals respond differently to IBD treatments and may...

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Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026
Annals of Gastroenterological Surgery

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Surgery is still a core part of care for certain UC and Crohn's patients despite better medical therapies. Newer surgical techniques and coordinated medical–surgical approaches aim to reduce complications and recurrence...

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Antibiotic-Refractory Chronic Pouchitis After Ileal Pouch-Anal Anastomosis: Current and Emerging Therapeutic Strategies.
Drugs

Antibiotic-Refractory Chronic Pouchitis After Ileal Pouch-Anal Anastomosis: Current and Emerging Therapeutic Strategies.

Chronic antibiotic-refractory pouchitis is a common, impactful complication after ileal pouch-anal anastomosis that can worsen quality of life and increase the risk of pouch failure. Patients and clinicians need clearer...

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Effects of grape seed extract on immune-related gene expression, inflammatory biomarkers, disease activity, and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled trial
Scientific Reports

Effects of grape seed extract on immune-related gene expression, inflammatory biomarkers, disease activity, and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled trial

Many people with UC try dietary supplements; this randomized trial tested grape seed extract and found a measurable reduction in an inflammation blood marker (hs‑CRP) but no clear improvement in most other measured...

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Qijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB pathway
Frontiers in Microbiology

Qijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB pathway

This preclinical study connects an herbal medicine to changes in gut microbiota, inflammation, and intestinal barrier function in a mouse model of ulcerative colitis — findings that could inform future research on new...

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Properties of Persea americana Mill (Lauraceae) kernels aqueous extract on acetic acid-induced ulcerative colitis in rats
Inflammopharmacology

Properties of Persea americana Mill (Lauraceae) kernels aqueous extract on acetic acid-induced ulcerative colitis in rats

People with ulcerative colitis may be interested because the study explores a plant extract that reduced inflammation markers in a common animal model of colitis, suggesting a possible new avenue for drug discovery or...

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Declining rates of surgery in pediatric-onset inflammatory bowel disease: a Swedish nationwide register-based cohort study 2002-2022.
Journal of Crohn's & colitis

Declining rates of surgery in pediatric-onset inflammatory bowel disease: a Swedish nationwide register-based cohort study 2002-2022.

A decreasing need for IBD-related surgery after pediatric diagnosis could mean fewer major operations and related recovery for children and young adults. It may reflect the growing use of advanced medical therapies in...

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Preventive administration of verapamil attenuates dextran sulfate sodium-induced colitis in mice.
Experimental and therapeutic medicine

Preventive administration of verapamil attenuates dextran sulfate sodium-induced colitis in mice.

A common heart drug, verapamil, reduced disease signs in a mouse model of colitis and altered inflammation and the gut microbiota — suggesting a possible avenue for future IBD research. These are preclinical results, so...

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Large-scale transcriptomic meta-analysis identifies constitutive and inflammation-dependent layers in ulcerative colitis
Scientific Reports

Large-scale transcriptomic meta-analysis identifies constitutive and inflammation-dependent layers in ulcerative colitis

This study identifies reproducible molecular patterns in UC tissue that could help researchers target non-immune pathways (metabolic/mitochondrial) in addition to inflammation, and it highlights that apparently...

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Illness perceptions and perceived functional health literacy in inflammatory bowel disease: a multicentre longitudinal study
Scientific Reports

Illness perceptions and perceived functional health literacy in inflammatory bowel disease: a multicentre longitudinal study

Illness perceptions and perceived ability to understand health information are linked to self-care in IBD. If worse illness perceptions tend to lead to later increases in perceived difficulty understanding written...

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Metabolic reprogramming in ulcerative colitis: integrating dietary drivers, pathogenesis, and therapeutic advances
Frontiers in Immunology

Metabolic reprogramming in ulcerative colitis: integrating dietary drivers, pathogenesis, and therapeutic advances

The review connects Western diet-driven metabolic shifts in the gut, immune cells, and microbiota to ulcerative colitis mechanisms and highlights metabolism-targeting therapies as a potential future avenue for treatment.

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Safety, Tolerability and PK of ATTO 1091 in Healthy Adult Volunteers and Patients With Ulcerative Colitis
ClinicalTrials.gov

Safety, Tolerability and PK of ATTO 1091 in Healthy Adult Volunteers and Patients With Ulcerative Colitis

This trial represents an early-stage clinical test of a new investigational drug (ATTO-1091) for people with ulcerative colitis; Phase 1 studies establish initial safety and how the drug behaves in the body, which are...

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A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
ClinicalTrials.gov

A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

The study aims to map the specific peptide targets of T cells driving organ inflammation in autoimmune diseases, which could guide development of antigen-specific, tolerogenic treatments relevant to Crohn's disease and...

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Trichostatin A ameliorates ulcerative colitis via the SERPINB5-mediated MMP9/RLN2 signaling pathway.
Pathology, research and practice

Trichostatin A ameliorates ulcerative colitis via the SERPINB5-mediated MMP9/RLN2 signaling pathway.

The paper identifies a molecular pathway (SERPINB5–MMP9–RLN2) by which the HDAC inhibitor trichostatin A reduced inflammation and protected the intestinal barrier in mouse and cell models of ulcerative colitis,...

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Is There a Way to Break the Glass Ceiling in the Diagnosis and Treatment of Extraintestinal Manifestations (EIMs) in the Course of Inflammatory Bowel Diseases? A Comprehensive Review of Diagnosis, Pathophysiology, and Treatment of EIM
Journal of Clinical Medicine

Is There a Way to Break the Glass Ceiling in the Diagnosis and Treatment of Extraintestinal Manifestations (EIMs) in the Course of Inflammatory Bowel Diseases? A Comprehensive Review of Diagnosis, Pathophysiology, and Treatment of EIM

Extraintestinal manifestations (skin, joint, eye, liver) are common in IBD and can greatly affect quality of life; better recognition and coordinated care can speed diagnosis and improve outcomes.

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Resveratrol suppresses ulcerative colitis and colitis-associated colorectal cancer via modulating the miR-31-5p/SATB2 axis
World Journal of Gastrointestinal Oncology

Resveratrol suppresses ulcerative colitis and colitis-associated colorectal cancer via modulating the miR-31-5p/SATB2 axis

The paper identifies a molecular pathway (miR-31-5p/SATB2) linked to UC progression to colitis-associated cancer and reports that resveratrol modulates this axis in mice, suggesting a potential preventive mechanism worth...

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Risk of hepatobiliary and colorectal malignancies in primary sclerosing cholangitis: Crohn’s disease with colonic involvement versus ulcerative colitis - a propensity-matched cohort study
Scandinavian Journal of Gastroenterology

Risk of hepatobiliary and colorectal malignancies in primary sclerosing cholangitis: Crohn’s disease with colonic involvement versus ulcerative colitis - a propensity-matched cohort study

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Crohn's disease, and Ulcerative colitis. The original article is from Scandinavian Journal of...

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Enteric glial cell remodeling at diagnosis is associated with reduced mucosal inflammation at follow-up in pediatric ulcerative colitis.
Human pathology

Enteric glial cell remodeling at diagnosis is associated with reduced mucosal inflammation at follow-up in pediatric ulcerative colitis.

If confirmed, a pathology marker visible on routine biopsy (EGC patterns by SOX10 IHC) could help predict which children with ulcerative colitis are more likely to have improved mucosal inflammation over the first year,...

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Statement of Retraction: Protective effect of Sarsasapogenin in TNBS induced ulcerative colitis in rats associated with downregulation of pro-inflammatory mediators and oxidative stress
Immunopharmacology and Immunotoxicology

Statement of Retraction: Protective effect of Sarsasapogenin in TNBS induced ulcerative colitis in rats associated with downregulation of pro-inflammatory mediators and oxidative stress

Based on the title and source metadata, this appears to be a regulatory update related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Immunopharmacology...

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EPS deficiency aggravates intestinal mucosal inflammation and dysbiosis through disrupting macrophage polarization balance in ulcerative colitis
Frontiers in Immunology

EPS deficiency aggravates intestinal mucosal inflammation and dysbiosis through disrupting macrophage polarization balance in ulcerative colitis

If EPS helps restrain inflammation by shifting macrophages toward an M2 phenotype and is reduced in active UC, it could help explain mechanisms of mucosal inflammation and point to new biomarker or therapeutic strategies...

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Concomitant CMV colitis in patients with moderate to severe ulcerative colitis admitted to a tertiary hospital in Iran: a retrospective study of frequency, risk factors, and subsequent clinical outcome
BMC Gastroenterology

Concomitant CMV colitis in patients with moderate to severe ulcerative colitis admitted to a tertiary hospital in Iran: a retrospective study of frequency, risk factors, and subsequent clinical outcome

CMV colitis can complicate moderate–severe UC flares and—if present—is associated here with longer hospital stays, more frequent escalation to anti‑TNF therapy, and higher colectomy risk.

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Comparative pharmacodynamic material basis of oral and colonic administration of Baitouweng decoction in experimental ulcerative colitis.
Journal of ethnopharmacology

Comparative pharmacodynamic material basis of oral and colonic administration of Baitouweng decoction in experimental ulcerative colitis.

The paper suggests that the same herbal formula can produce different absorbed components and target interactions depending on oral versus colonic delivery, which could influence therapeutic effects in ulcerative colitis...

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Differences in hepatic metabolism of Liandan Xiaoyan Formula between control and ulcerative colitis mice associated with FXR/PXR-CYP450 changes.
Journal of pharmaceutical and biomedical analysis

Differences in hepatic metabolism of Liandan Xiaoyan Formula between control and ulcerative colitis mice associated with FXR/PXR-CYP450 changes.

Disease-related changes in liver drug-metabolizing enzymes may alter how herbal formulas or medications are processed in people with UC, potentially affecting efficacy or safety. Understanding the mechanisms helps inform...

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Neutrophil activation parameter is a promising new biomarker of disease activity in ulcerative colitis.
Clinica chimica acta; international journal of clinical chemistry

Neutrophil activation parameter is a promising new biomarker of disease activity in ulcerative colitis.

A simple blood-derived neutrophil activation marker (Neut-RI) correlated with clinical disease activity in ulcerative colitis and outperformed fecal calprotectin and CRP in this study, suggesting a potential low-cost,...

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Small but mighty: the human mycobiome as an immunopharmacological regulator of inflammation and autoimmunity.
International immunopharmacology

Small but mighty: the human mycobiome as an immunopharmacological regulator of inflammation and autoimmunity.

Fungi in the gut appear to influence immune pathways implicated in IBD and other autoimmune diseases, suggesting new therapeutic targets and microbiome-based interventions that could affect disease activity.

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Digitally supported, patient-initiated care: Maintaining control of inflammatory bowel diseases while achieving high patient satisfaction.
International journal of medical informatics

Digitally supported, patient-initiated care: Maintaining control of inflammatory bowel diseases while achieving high patient satisfaction.

Shifting to patient-initiated, digitally supported follow-up could maintain disease control while reducing routine fixed-interval visits and improving patient experience — relevant as IBD patient numbers grow and clinic...

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Macrophage plasticity as a therapeutic target in inflammatory bowel disease: Immunomodulatory and regenerative strategies.
International immunopharmacology

Macrophage plasticity as a therapeutic target in inflammatory bowel disease: Immunomodulatory and regenerative strategies.

Macrophages are central regulators of intestinal inflammation and repair; understanding their diversity and how to modulate them could lead to new, more targeted treatments for Crohn's disease and ulcerative colitis.

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Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease
ClinicalTrials.gov

Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease

Psychological distress and gut–brain interactions can worsen quality of life and IBD outcomes. A culturally tailored, scalable digital mind–body program could improve access to psychosocial care for Black and Hispanic...

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Engineered microvesicle-mediated multimodal therapy resolves ulcerative colitis via synergistic immunoregulation, barrier restoration, and microbiota remodeling
Materials today. Bio

Engineered microvesicle-mediated multimodal therapy resolves ulcerative colitis via synergistic immunoregulation, barrier restoration, and microbiota remodeling

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Materials today. Bio.

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Immune–microbe interactions in pediatric ulcerative colitis: clinical features, pathogenesis, and novel targeted therapeutic strategies
Frontiers in Immunology

Immune–microbe interactions in pediatric ulcerative colitis: clinical features, pathogenesis, and novel targeted therapeutic strategies

PUC often behaves differently and more aggressively than adult-onset UC; understanding pediatric‑specific causes and treatments could lead to better, more effective therapies for children.

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Major cardiovascular event risk of advanced therapies in inflammatory bowel diseases: systematic review and meta-analysis
Inflammation Research

Major cardiovascular event risk of advanced therapies in inflammatory bowel diseases: systematic review and meta-analysis

A pooled analysis of cardiovascular risk tied to advanced IBD therapies could affect treatment decisions and monitoring plans because some immune-targeted drugs have been linked to cardiovascular safety concerns in other...

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