Condition

Ulcerative colitis

Ulcerative colitis news across medications, symptoms, monitoring, procedures, research, access, and daily life.

Page 5 of 40 · 1913 articles

Repurposing Fenofibrate in Modulating AMPK/NLRP3 Inflammasome in Patients With Ulcerative Colitis
ClinicalTrials.gov

Repurposing Fenofibrate in Modulating AMPK/NLRP3 Inflammasome in Patients With Ulcerative Colitis

A phase 2 trial tested whether repurposing fenofibrate (a lipid-lowering PPAR-α agonist) added to mesalamine can reduce disease activity and improve quality of life in adults with mild-to-moderate ulcerative colitis.

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Clinical Study to Evaluate the Possible Efficacy of Nifuroxazide in Patient With Ulcerative Colitis
ClinicalTrials.gov

Clinical Study to Evaluate the Possible Efficacy of Nifuroxazide in Patient With Ulcerative Colitis

This trial tests whether adding the oral antibiotic nifuroxazide to standard mesalamine improves quality of life for people with mild-to-moderate ulcerative colitis. Results, if published, could suggest a new adjunctive...

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From Mitochondrial Targeting to Mechanistic Dependency in Nanoparticle Therapy for Ulcerative Colitis
Journal of Gastroenterology and Hepatology

From Mitochondrial Targeting to Mechanistic Dependency in Nanoparticle Therapy for Ulcerative Colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...

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Digital patient-reported outcomes to evaluate treatment response to filgotinib in patients with ulcerative colitis
Patient Related Outcome Measures

Digital patient-reported outcomes to evaluate treatment response to filgotinib in patients with ulcerative colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Tests and monitoring. The original article is from Patient Related Outcome...

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Nanoformulated Curcumin Ameliorates Ulcerative Colitis via Gut Microbiota Modulation and Barrier Function Restoration
The American Journal of Chinese Medicine

Nanoformulated Curcumin Ameliorates Ulcerative Colitis via Gut Microbiota Modulation and Barrier Function Restoration

People with ulcerative colitis may be interested because the study explores a way to boost curcumin’s activity and suggests gut microbiota changes could underlie protection against colitis.

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Real-World Epidemiology of Inflammatory Bowel Disease in Italy: Treatment Patterns, Adherence, and Costs in Patients with Ulcerative Colitis Treated with Mesalazine
Drugs - Real World Outcomes

Real-World Epidemiology of Inflammatory Bowel Disease in Italy: Treatment Patterns, Adherence, and Costs in Patients with Ulcerative Colitis Treated with Mesalazine

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Mesalamine. The original article is from Drugs - Real World Outcomes.

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Propolis Flavonoids: Current Evidence in Animal Models and Future Promise for the Treatment of Ulcerative Colitis
International Journal of Molecular Sciences

Propolis Flavonoids: Current Evidence in Animal Models and Future Promise for the Treatment of Ulcerative Colitis

People with ulcerative colitis may be interested because the review identifies flavonoids in propolis as compounds that reduce inflammation and strengthen the gut barrier in animal models, and it highlights strategies to...

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Bedside analysis of volatile organic compounds in exhaled human breath as non-invasive diagnostic tool for colon diseases.
Bioanalysis

Bedside analysis of volatile organic compounds in exhaled human breath as non-invasive diagnostic tool for colon diseases.

A breath-based VOC test could offer a noninvasive, point-of-care way to help detect or screen for colon diseases including IBD. This study shows preliminary promise—especially for ulcerative colitis—but is early-stage...

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Time trends in patients with ulcerative colitis and crohn's disease not receiving IBD-specific pharmacological treatment within one and three years of diagnosis - a nationwide cohort study.
Scandinavian journal of gastroenterology

Time trends in patients with ulcerative colitis and crohn's disease not receiving IBD-specific pharmacological treatment within one and three years of diagnosis - a nationwide cohort study.

A sizable minority of people newly diagnosed with IBD—about 1 in 5 with Crohn’s and 1 in 10 with ulcerative colitis—received no IBD-specific drugs within the first year. Understanding who is untreated and why could...

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Assessment of T helper17 Cells / Regulatory T Cells Axis and Related Cytokines in Patients with Ulcerative Colitis
The Egyptian Journal of Medical Microbiology

Assessment of T helper17 Cells / Regulatory T Cells Axis and Related Cytokines in Patients with Ulcerative Colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from The Egyptian Journal...

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Palisade Bio Presents New Clinical, Pharmacokinetic, Pharmacodynamic and Mechanistic Data Strengthening the Phase 2 Rationale for PALI-2108 in Ulcerative Colitis and Crohn’s ...

Early Phase 1 findings suggest a gut-targeted PDE4 prodrug may engage its target in diseased tissue and produce early improvements in symptoms, endoscopy, and tissue inflammation — findings that, if confirmed in Phase 2,...

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A Mesalazine–Aloperine Co-Amorphous System for Simultaneous Dissolution Enhancement, Permeability Improvement, and Synergistic Anti-Ulcerative Colitis Activity: A Combined Pharmaceutics and Network Pharmacology Study
Pharmaceutics

A Mesalazine–Aloperine Co-Amorphous System for Simultaneous Dissolution Enhancement, Permeability Improvement, and Synergistic Anti-Ulcerative Colitis Activity: A Combined Pharmaceutics and Network Pharmacology Study

Improving mesalazine delivery could increase drug reaching the colon and potentially improve treatment for ulcerative colitis. A formulation that both enhances dissolution/permeability and offers mechanistic synergy...

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Gut microbiota, microbial metabolites, and mucosal barrier dysfunction in benign anorectal disorders and ulcerative colitis: shared mechanisms, clinical links, and precision interventions
Frontiers in Medicine

Gut microbiota, microbial metabolites, and mucosal barrier dysfunction in benign anorectal disorders and ulcerative colitis: shared mechanisms, clinical links, and precision interventions

The review links microbiome, metabolites, barrier function, and immune responses across anorectal disorders and ulcerative colitis — areas that directly affect symptoms, healing, and response to therapy.

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Dietary Polyphenols as Adjunctive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients

Dietary Polyphenols as Adjunctive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

People with IBD often ask about dietary supplements. This systematic review suggests some randomized-trial evidence that polyphenol supplements—especially curcumin—may help induce clinical improvement in ulcerative...

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Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation.

A colon-targeted IFX formulation could deliver the drug directly to inflamed tissue, potentially improving effectiveness and lowering systemic side effects or dosing complexity for people with ulcerative colitis.

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Clinical Course and Predictors of Biologic Therapy, Hospitalisation and Surgery: A Five-Year Prospective Study in Newly Diagnosed Inflammatory Bowel Disease.
Alimentary pharmacology & therapeutics

Clinical Course and Predictors of Biologic Therapy, Hospitalisation and Surgery: A Five-Year Prospective Study in Newly Diagnosed Inflammatory Bowel Disease.

This study describes how often people newly diagnosed with IBD go on biologic or JAK inhibitor therapy and what happened to them over five years — including hospital visits and surgery — which helps set expectations for...

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Frequency and Risk Factors for Difficult-to-Treat Inflammatory Bowel Disease among Patients Receiving Advanced Therapies in a Korean Tertiary-Care Cohort.
Gut and liver

Frequency and Risk Factors for Difficult-to-Treat Inflammatory Bowel Disease among Patients Receiving Advanced Therapies in a Korean Tertiary-Care Cohort.

The study suggests that about one-quarter of IBD patients treated with advanced therapies develop difficult-to-treat disease, and identifies timing of therapy, age, and specific therapy choice as predictors.

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Challenges and opportunities facing inflammatory bowel disease in Sub-Saharan Africa: towards a contextually relevant research and practice agenda.
Journal of Crohn's & colitis

Challenges and opportunities facing inflammatory bowel disease in Sub-Saharan Africa: towards a contextually relevant research and practice agenda.

IBD cases are increasing in Sub-Saharan Africa but care and research remain limited and driven by high-income country priorities. Region-specific research and policy changes could improve diagnosis, treatment access, and...

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Unraveling the Clinical Puzzle of Cerebral Venous Sinus Thrombosis in Ulcerative Colitis: Insights from a Systematic Review
Asian Journal of Neurosurgery

Unraveling the Clinical Puzzle of Cerebral Venous Sinus Thrombosis in Ulcerative Colitis: Insights from a Systematic Review

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Ulcerative colitis, Inflammatory bowel disease, and Complications. The original article is from Asian Journal of...

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Safety profile and potential favorable reporting signals of liraglutide in patients with ulcerative colitis: A FAERS pharmacovigilance and network pharmacology study
Pakistan Journal of Pharmaceutical Sciences

Safety profile and potential favorable reporting signals of liraglutide in patients with ulcerative colitis: A FAERS pharmacovigilance and network pharmacology study

This study raises pharmacovigilance signals and mechanistic hypotheses about liraglutide in people with ulcerative colitis — important because GLP-1 drugs are widely used and are being studied for inflammatory effects....

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Budget impact analysis of subcutaneous infliximab (CT-P13 SC) for treating autoimmune diseases in Jordan
Cost Effectiveness and Resource Allocation

Budget impact analysis of subcutaneous infliximab (CT-P13 SC) for treating autoimmune diseases in Jordan

Modeled cost savings and fewer hospital visits could affect access to infliximab for people with Crohn’s disease and other autoimmune conditions in Jordan, potentially increasing the number of patients who can be treated...

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PD-1 and PD-L1 Expression in Inflammatory Bowel Disease: A Paired Immunohistochemical Study
Biomedicines

PD-1 and PD-L1 Expression in Inflammatory Bowel Disease: A Paired Immunohistochemical Study

This study links higher mucosal PD-L1 expression to active IBD and routine disease activity measures, suggesting the PD-1/PD-L1 immune checkpoint may be involved in intestinal inflammation and could be a biomarker or...

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Tauroursodeoxycholic acid ameliorates DSS-induced ulcerative colitis via regulating TLR4/NLRP3/pyroptosis axis and Keap1/Nrf2 pathway and restoring gut barrier function.
European journal of pharmacology

Tauroursodeoxycholic acid ameliorates DSS-induced ulcerative colitis via regulating TLR4/NLRP3/pyroptosis axis and Keap1/Nrf2 pathway and restoring gut barrier function.

The study identifies a bile acid, TUDCA, that reduced colitis severity and improved gut-barrier and antioxidant pathways in mice, pointing to a potential new therapeutic approach for intestinal inflammation. This is...

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Adherence to advanced therapies in inflammatory bowel diseases: Real-world rates and predictors of non-adherence.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Adherence to advanced therapies in inflammatory bowel diseases: Real-world rates and predictors of non-adherence.

Adherence affects how well advanced IBD treatments work. Knowing which drug forms and patient factors link to missed doses can help patients and clinicians plan support strategies.

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Deep Learning Based Automated Assessment of Ulcerative Colitis Endoscopic Severity Using Local Global Transformer and Graph Convolutional Networks
Springer Science and Business Media LLC

Deep Learning Based Automated Assessment of Ulcerative Colitis Endoscopic Severity Using Local Global Transformer and Graph Convolutional Networks

Automated, objective scoring of colonoscopy images could reduce variability in Mayo Endoscopic Score assignment and support treatment decisions and monitoring for people with ulcerative colitis.

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Role of AI in Accurate and Disinformation‐Resilient Diagnosis of Ulcerative Colitis
Disinformation Security for Generative AI Applications

Role of AI in Accurate and Disinformation‐Resilient Diagnosis of Ulcerative Colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Disinformation Security...

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Contemporary multicentre validation and comparative performance of Day 1 prognostic scores in acute severe ulcerative colitis.
Journal of Crohn's & colitis

Contemporary multicentre validation and comparative performance of Day 1 prognostic scores in acute severe ulcerative colitis.

These Day 1 scores aim to identify patients unlikely to respond to IV steroids so treatment can be escalated earlier; that could shorten delays to rescue therapy and potentially improve outcomes for people admitted with...

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