Condition

Ulcerative colitis

Ulcerative colitis news across medications, symptoms, monitoring, procedures, research, access, and daily life.

Page 6 of 40 · 1914 articles

Contemporary multicentre validation and comparative performance of Day 1 prognostic scores in acute severe ulcerative colitis.
Journal of Crohn's & colitis

Contemporary multicentre validation and comparative performance of Day 1 prognostic scores in acute severe ulcerative colitis.

These Day 1 scores aim to identify patients unlikely to respond to IV steroids so treatment can be escalated earlier; that could shorten delays to rescue therapy and potentially improve outcomes for people admitted with...

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Plasma lipopolysaccharide-binding protein (LBP), a proxy for intestinal permeability, relates to clinicopathological and immunological disease activity in inflammatory bowel disease patients at diagnosis and during disease course.
Journal of Crohn's & colitis

Plasma lipopolysaccharide-binding protein (LBP), a proxy for intestinal permeability, relates to clinicopathological and immunological disease activity in inflammatory bowel disease patients at diagnosis and during disease course.

A simple blood marker (LBP) that reflects bacterial exposure across the gut barrier was linked to disease severity and immune activity at diagnosis and during follow-up—especially in ulcerative colitis—so it might help...

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Lactiplantibacillus plantarum HYY-DB36 alleviated dextran sulfate sodium (DSS)-induced ulcerative colitis through regulation of intestinal flora
Journal of Food Science and Technology

Lactiplantibacillus plantarum HYY-DB36 alleviated dextran sulfate sodium (DSS)-induced ulcerative colitis through regulation of intestinal flora

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Food Science...

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Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis
ClinicalTrials.gov

Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis

People with UC and PSC have limited study data on microbiome-targeted therapies; this trial asks whether short-course oral vancomycin is feasible and safe in this specific group and will look for early signals in...

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Study of Efficacy and Adherence to Subcutaneous vs. Intravenous Vedolizumab in Patients With Inflammatory Bowel Disease Using a Novel Remote MONITORing Intervention
ClinicalTrials.gov

Study of Efficacy and Adherence to Subcutaneous vs. Intravenous Vedolizumab in Patients With Inflammatory Bowel Disease Using a Novel Remote MONITORing Intervention

Adherence to biologic therapy can affect how well treatment controls IBD; understanding whether self-administered subcutaneous vedolizumab has different adherence than IV infusion could influence treatment choices and...

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Changing Prescription Patterns in Pharmacologically Treated Patients with Newly Diagnosed Inflammatory Bowel Disease in German Gastroenterology Practices: A Real-World Study, 2015–2024
Pharmaceuticals

Changing Prescription Patterns in Pharmacologically Treated Patients with Newly Diagnosed Inflammatory Bowel Disease in German Gastroenterology Practices: A Real-World Study, 2015–2024

The study documents shifting real-world prescribing for newly diagnosed IBD in Germany, with more biologic use and less mesalazine/thiopurine in recent years — changes that could affect treatment expectations and access.

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Microbiota–host crosstalk in ulcerative colitis: mechanistic evidence and translational prospects for traditional Chinese medicine
Frontiers in Pharmacology

Microbiota–host crosstalk in ulcerative colitis: mechanistic evidence and translational prospects for traditional Chinese medicine

People with ulcerative colitis may be interested because the review explains how the gut microbiome and its metabolites could influence disease and evaluates whether traditional Chinese medicines might modify those...

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Protocol: Early Intestinal Ultrasonography for Prediction of Response to Corticosteroids or Biologics in Outpatients With Moderate to Severe Ulcerative Colitis
JCC Plus

Protocol: Early Intestinal Ultrasonography for Prediction of Response to Corticosteroids or Biologics in Outpatients With Moderate to Severe Ulcerative Colitis

If validated, early bedside ultrasound changes could let clinicians identify within days whether steroids or biologics are working, enabling faster treatment adjustments and potentially avoiding prolonged ineffective...

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Current evidence for first-line advanced therapies in pediatric ulcerative colitis: a critical review
Inflammatory Bowel Diseases

Current evidence for first-line advanced therapies in pediatric ulcerative colitis: a critical review

Families and clinicians deciding on a first biologic for a child with ulcerative colitis need to know which drugs have pediatric-specific evidence. This review shows infliximab has the strongest pediatric data, while...

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Ulcerative colitis reporting across medications: FAERS analysis and cross-species transcriptomic triangulation
Frontiers in Immunology

Ulcerative colitis reporting across medications: FAERS analysis and cross-species transcriptomic triangulation

People with IBD or their clinicians may see signals suggesting certain drugs are more often reported with ulcerative colitis; this study combines adverse‑event reports with gene‑expression comparisons to help prioritize...

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Kaempferol-3-O-glucorhamnoside alleviates DSS-induced ulcerative colitis via the arginine-polyamine metabolism pathway.
International immunopharmacology

Kaempferol-3-O-glucorhamnoside alleviates DSS-induced ulcerative colitis via the arginine-polyamine metabolism pathway.

Researchers exploring new anti-inflammatory or metabolism-targeting approaches for UC might view KA as a candidate molecule that modulates arginine–polyamine metabolism, which could point to new drug-discovery...

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Norepinephrine-driven neutrophilic inflammation accelerates ulcerative colitis progression.
Journal of autoimmunity

Norepinephrine-driven neutrophilic inflammation accelerates ulcerative colitis progression.

If local norepinephrine promotes neutrophil‑driven inflammation in UC, that could help explain disease progression in some patients and point to biomarkers (ADRB2‑rich neutrophils) that might predict response to anti‑TNF...

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New Perspectives on STAT3 in Ulcerative Colitis: Molecular Mechanisms and Dual Roles.
Cellular and molecular gastroenterology and hepatology

New Perspectives on STAT3 in Ulcerative Colitis: Molecular Mechanisms and Dual Roles.

STAT3 is a central immune signaling molecule implicated in ulcerative colitis; understanding its dual roles could influence future biomarker research and therapies for UC. The review highlights why STAT3’s...

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Contemporary outcomes and restorative pathways following colectomy for inflammatory bowel disease: a tertiary centre cohort from Aotearoa New Zealand.
The New Zealand medical journal

Contemporary outcomes and restorative pathways following colectomy for inflammatory bowel disease: a tertiary centre cohort from Aotearoa New Zealand.

This study reports real-world short-term outcomes after colectomy for IBD at a tertiary New Zealand centre, including complication rates and how often restorative surgery (ileal pouch) was later performed—information...

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Longitudinal multi-omics profiling of tofacitinib response identifies a pre-existing Janus kinase-tractable inflammatory state in ulcerative colitis
medRxiv

Longitudinal multi-omics profiling of tofacitinib response identifies a pre-existing Janus kinase-tractable inflammatory state in ulcerative colitis

If confirmed, a pretreatment mucosal JAK‑dependent inflammatory signature could help predict who will respond to tofacitinib, potentially guiding therapy choice and avoiding ineffective treatment for people with...

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The burden of inflammatory bowel disease in Asia (1990-2023) and projections to 2050: A comprehensive analysis of the 2023 global burden of disease study.
PloS one

The burden of inflammatory bowel disease in Asia (1990-2023) and projections to 2050: A comprehensive analysis of the 2023 global burden of disease study.

Rising IBD incidence and prevalence in Asia mean more people will need long-term care, specialist services, and health-system planning. Understanding regional trends helps patients and policymakers anticipate resource...

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Extraintestinal manifestations in patients with inflammatory bowel disease: focus on epidemiology
Russian Journal of Evidence-Based Gastroenterology

Extraintestinal manifestations in patients with inflammatory bowel disease: focus on epidemiology

Extraintestinal problems are common in IBD and can cause significant symptoms and treatment needs beyond the bowel. Knowing their frequency helps patients and clinicians prioritize screening and multidisciplinary care.

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Integrative Transcriptomic and Genetic Analysis Prioritizes IRF1 as a Candidate Regulatory Gene Associated with Ulcerative Colitis
Journal of inflammation research

Integrative Transcriptomic and Genetic Analysis Prioritizes IRF1 as a Candidate Regulatory Gene Associated with Ulcerative Colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of inflammation...

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Chinese herbal medicine for ulcerative colitis: product-level clinical evidence, mechanistic appraisal, and a roadmap to precision translation
Frontiers in Pharmacology

Chinese herbal medicine for ulcerative colitis: product-level clinical evidence, mechanistic appraisal, and a roadmap to precision translation

People with UC often try complementary therapies; this review shows that benefits and risks vary by specific CHM product and that current evidence is mixed and product-dependent.

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Tegoprazan regulates gut microbiota structure in Helicobacter pylori-induced ulcerative colitis mice
Folia Microbiologica

Tegoprazan regulates gut microbiota structure in Helicobacter pylori-induced ulcerative colitis mice

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Folia Microbiologica.

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Hospitalized Infection Risk and Organ-specific Infection Patterns Across Advanced Therapies in Ulcerative Colitis: A Japanese Claims Analysis.
Internal medicine (Tokyo, Japan)

Hospitalized Infection Risk and Organ-specific Infection Patterns Across Advanced Therapies in Ulcerative Colitis: A Japanese Claims Analysis.

Patients and clinicians choosing among advanced therapies for ulcerative colitis may consider infection-related hospitalization risk as one factor; this study suggests lower risk with ustekinumab versus TNF antagonists...

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Machine learning predicts relapse after anti-TNF withdrawal in ulcerative colitis using rectal biopsy transcriptomics
openRxiv

Machine learning predicts relapse after anti-TNF withdrawal in ulcerative colitis using rectal biopsy transcriptomics

Predicting who will relapse after stopping anti-TNF drugs could help avoid unnecessary flares or unnecessary ongoing treatment. A biopsy-based transcriptomic test could be a useful decision tool if validated.

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Real-world effectiveness and predictors of need for extended induction of mirikizumab therapy in ulcerative colitis
Journal of the Canadian Association of Gastroenterology

Real-world effectiveness and predictors of need for extended induction of mirikizumab therapy in ulcerative colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Mirikizumab. The original article is from Journal of the Canadian Association of...

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Impaired fatty acid oxidation and mitochondrial injury mediated by the AMPK/PPARα pathway: A key mechanism in high-fat diet-aggravated ulcerative colitis
PLOS One

Impaired fatty acid oxidation and mitochondrial injury mediated by the AMPK/PPARα pathway: A key mechanism in high-fat diet-aggravated ulcerative colitis

If you have ulcerative colitis, this preclinical study suggests high‑fat diets may worsen intestinal inflammation through metabolic and mitochondrial pathways that impair the gut barrier. Targeting the AMPK/PPARα pathway...

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Identification of Autophagy-Related Biomarkers for Subtyping and Immune Microenvironment Remodeling in Ulcerative Colitis
Springer Science and Business Media LLC

Identification of Autophagy-Related Biomarkers for Subtyping and Immune Microenvironment Remodeling in Ulcerative Colitis

This study proposes three autophagy-related genes (APOL1, CCL2, IL24) as potential biomarkers that may help classify ulcerative colitis patients into subtypes with different immune environments, which could eventually...

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Association of narrow pelvis and body composition with anastomotic stricture following total proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis
BMC Surgery

Association of narrow pelvis and body composition with anastomotic stricture following total proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis

Anastomotic strictures after TPC–IPAA can impair bowel function and quality of life; identifying preoperative pelvic and body-composition risk factors could help tailor surgical planning or follow-up.

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Early Colectomy and Long-Term Risk of Cardiometabolic Disease in Ulcerative Colitis: A Nationwide Cohort Study
American Journal of Gastroenterology

Early Colectomy and Long-Term Risk of Cardiometabolic Disease in Ulcerative Colitis: A Nationwide Cohort Study

People with ulcerative colitis face long-term health risks beyond the gut. This study suggests that getting a colectomy early after diagnosis might be linked to lower long-term risk of cardiovascular disease and type 2...

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Multi‐omics and machine learning identify neutrophil annexin A3 as a therapeutic target of ginsenoside Rb1 for comorbidity of ischaemic stroke and ulcerative colitis
British Journal of Pharmacology

Multi‐omics and machine learning identify neutrophil annexin A3 as a therapeutic target of ginsenoside Rb1 for comorbidity of ischaemic stroke and ulcerative colitis

This study links a neutrophil protein (ANXA3) to both ulcerative colitis and ischaemic stroke and suggests a compound (ginsenoside Rb1) can bind ANXA3 and reduce neutrophil hyperactivation in lab tests — a potential...

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Disease- and Region-Specific Molecular Patterns Involving miRNAs and Associated Signalling Pathways and Epithelial Cell-Fate Responses in PSC-Associated Ulcerative Colitis
Cells

Disease- and Region-Specific Molecular Patterns Involving miRNAs and Associated Signalling Pathways and Epithelial Cell-Fate Responses in PSC-Associated Ulcerative Colitis

The work highlights molecular differences between PSC-UC and typical UC that could help explain higher colorectal cancer risk in PSC-UC and suggests candidate miRNA biomarkers (eg, miR-155) for further study.

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Engineering extracellular vesicles for inflammatory bowel disease and colitis-associated colorectal cancer: from therapeutic innovation to clinical translation
Frontiers in Immunology

Engineering extracellular vesicles for inflammatory bowel disease and colitis-associated colorectal cancer: from therapeutic innovation to clinical translation

Engineered extracellular vesicles are an emerging, targeted therapy approach that could someday improve immune control, mucosal healing, and drug delivery in IBD and reduce colitis-associated cancer risk. The review...

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Efficacy of Fermented Brown Rice by Aspergillus oryzae (FBRA) in Ulcerative Colitis: A Double‐Blind Randomized Trial
JGH open : an open access journal of gastroenterology and hepatology

Efficacy of Fermented Brown Rice by Aspergillus oryzae (FBRA) in Ulcerative Colitis: A Double‐Blind Randomized Trial

Based on the title and source metadata, this appears to be a clinical trial phase 3 related to Ulcerative colitis, Inflammatory bowel disease, and Diet and lifestyle. The original article is from JGH open : an open...

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