Condition

Ulcerative colitis

Ulcerative colitis news across medications, symptoms, monitoring, procedures, research, access, and daily life.

Page 7 of 40 · 1914 articles

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis
Advanced Science

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

The paper suggests that changes in how microbes interact (community plasticity and network structure) may underlie microbiome differences seen in ulcerative colitis and could point toward ecology-informed biomarkers or...

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Nailfold capillary density in inflammatory bowel disease: Associations with disease activity and systemic inflammation.
Microvascular research

Nailfold capillary density in inflammatory bowel disease: Associations with disease activity and systemic inflammation.

Patients and clinicians are often looking for objective, noninvasive ways to monitor IBD activity. This study suggests a simple nailfold capillary measure may reflect disease activity and add information to CRP, which...

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Menispermum dauricum rhizome alkaloids ameliorate colitis by inhibiting mitochondrial DNA synthesis via the JAK2-STAT4-AK4 pathway.
Journal of ethnopharmacology

Menispermum dauricum rhizome alkaloids ameliorate colitis by inhibiting mitochondrial DNA synthesis via the JAK2-STAT4-AK4 pathway.

This study identifies a new molecular pathway (JAK2–STAT4–AK4–mtDNA) linked to inflammatory macrophage activity in experimental colitis and presents a plant-derived alkaloid mixture (TAMR) that modulates that pathway....

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EFFICACY AND SAFETY OF ADVANCED THERAPIES AS INDUCTION THERAPY FOR ULCERATIVE COLITIS: AN UPDATED SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

EFFICACY AND SAFETY OF ADVANCED THERAPIES AS INDUCTION THERAPY FOR ULCERATIVE COLITIS: AN UPDATED SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.

Patients and clinicians choosing induction therapy for moderate‑to‑severe ulcerative colitis may find comparative efficacy and safety data useful, especially when head‑to‑head trials are limited. The review highlights...

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Multi-cohort meta-analysis, single-cell and Mendelian randomization analyses with experimental validation identify RHBDF2 as a shared mediator of ulcerative colitis and blood–brain barrier disruption
Frontiers in Synaptic Neuroscience

Multi-cohort meta-analysis, single-cell and Mendelian randomization analyses with experimental validation identify RHBDF2 as a shared mediator of ulcerative colitis and blood–brain barrier disruption

The paper suggests a molecular link (RHBDF2–ADAM17–TNFα) between ulcerative colitis and blood–brain barrier disruption, which could explain some neurological comorbidities of UC and identify targets for future therapies.

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Biologic and small-molecule therapies for inflammatory bowel disease: mechanisms, comparative evidence and the emerging pipeline
Frontiers in Pharmacology

Biologic and small-molecule therapies for inflammatory bowel disease: mechanisms, comparative evidence and the emerging pipeline

This review summarises the rapidly changing drug landscape for Crohn’s disease and ulcerative colitis, including newly approved biologics and small molecules and several emerging therapies that may affect future...

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Comments on “Upadacitinib and vedolizumab combination therapy for the management of refractory ulcerative colitis and Crohn’s disease”

Cure8 could only read part of this source from Intestinal Research, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Crohn's disease, and Inflammatory bowel disease.

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ACSS2-dependent histone lactylation amplifies ferroptotic injury via a metabolic feedback loop in ulcerative colitis
Genome Medicine

ACSS2-dependent histone lactylation amplifies ferroptotic injury via a metabolic feedback loop in ulcerative colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Genome Medicine.

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Harnessing Paeonia lactiflora-derived antioxidant carbon dots as oral nanomedicine for ulcerative colitis therapy by restoring intestinal mucosal barrier and microbiota homeostasis
Nano Today

Harnessing Paeonia lactiflora-derived antioxidant carbon dots as oral nanomedicine for ulcerative colitis therapy by restoring intestinal mucosal barrier and microbiota homeostasis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Nano Today.

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Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis
ClinicalTrials.gov

Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis

A pediatric trial of budesonide rectal foam could provide evidence about a locally acting steroid option for children with distal ulcerative colitis. Trial results may affect treatment choices for pediatric distal...

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Acetylation–ubiquitination crosstalk in NLRP3–gasdermin pyroptosis: a substrate-state framework with relevance to ulcerative colitis
Frontiers in Immunology

Acetylation–ubiquitination crosstalk in NLRP3–gasdermin pyroptosis: a substrate-state framework with relevance to ulcerative colitis

The molecular interaction between acetylation and ubiquitination on NLRP3 and GSDMD could help explain mechanisms of inflammatory cell death relevant to UC and point to new biomarker or therapeutic targets, but direct...

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The Therapeutic Potential of Berry-Derived and Berry-Based Interventions in Inflammatory Bowel Disease: A Comprehensive Systematic Review of Preclinical and Clinical Evidence
Nutrients

The Therapeutic Potential of Berry-Derived and Berry-Based Interventions in Inflammatory Bowel Disease: A Comprehensive Systematic Review of Preclinical and Clinical Evidence

Berries are a familiar, dietary source of anti-inflammatory bioactive compounds that might help reduce intestinal inflammation and improve biomarkers relevant to IBD. Patients often seek safe, complementary strategies...

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Pediococcus acidilactici ZQ-19 Ameliorates Ulcerative Colitis via Remodeling Gut Microbiota and Glutathione Redox Homeostasis
Probiotics and Antimicrobial Proteins

Pediococcus acidilactici ZQ-19 Ameliorates Ulcerative Colitis via Remodeling Gut Microbiota and Glutathione Redox Homeostasis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Microbiome, and Diet and lifestyle. The original article is from Probiotics and Antimicrobial Proteins.

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Comparative Effectiveness of Vedolizumab and Ustekinumab in Biologic-Experienced Ulcerative Colitis: A Real-World Multicenter Study from the Güntürk Group
Turkish Journal of Gastroenterology

Comparative Effectiveness of Vedolizumab and Ustekinumab in Biologic-Experienced Ulcerative Colitis: A Real-World Multicenter Study from the Güntürk Group

Patients and clinicians choosing a next biologic after prior biologic failure may find evidence here that effectiveness is broadly similar between vedolizumab and ustekinumab overall, with potential differences depending...

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Biopsy-Based Molecular Signatures Predicting Therapeutic Response in Ulcerative Colitis
International Journal of Molecular Sciences

Biopsy-Based Molecular Signatures Predicting Therapeutic Response in Ulcerative Colitis

If validated, mucosal biomarkers like SPARC and SPP1 might help predict who will not respond to infliximab, potentially guiding treatment choices and avoiding ineffective therapy for some people with UC.

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An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan
ClinicalTrials.gov

An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan

People with ulcerative colitis and their clinicians may find real-world safety and disease-activity data helpful when deciding about upadacitinib (Rinvoq) treatment. Observational registries can reveal how a drug...

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A Retrospective Study to Evaluate Treat-to-Target and Disease Modification in Adult Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting
ClinicalTrials.gov

A Retrospective Study to Evaluate Treat-to-Target and Disease Modification in Adult Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting

The study describes real-world use of a treat-to-target approach in adults with Crohn's disease and ulcerative colitis, which may influence how clinicians monitor disease and adjust therapy in routine care.

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ACEBROPHYLLINE REPROGRAMS INFLAMMATORY AND REDOX SIGNALLING IN EXPERIMENTAL ULCERATIVE COLITIS: A DOSE-DEPENDENT STUDY.
Georgian medical news

ACEBROPHYLLINE REPROGRAMS INFLAMMATORY AND REDOX SIGNALLING IN EXPERIMENTAL ULCERATIVE COLITIS: A DOSE-DEPENDENT STUDY.

Preclinical research suggests acebrophylline might reduce inflammation and oxidative stress in an experimental mouse model of ulcerative colitis, which could be an early step toward new treatments that target multiple...

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Impact of Vedolizumab on Bowel Urgency in Ulcerative Colitis: Post Hoc Analysis of the GEMINI 1, VISIBLE 1, and VARSITY Trials.
Gastro hep advances

Impact of Vedolizumab on Bowel Urgency in Ulcerative Colitis: Post Hoc Analysis of the GEMINI 1, VISIBLE 1, and VARSITY Trials.

Bowel urgency is a common, distressing symptom in ulcerative colitis that matters for quality of life. This analysis indicates vedolizumab may reduce urgency and that early improvement is linked to better clinical and...

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Ameliorative Effects of the White Jade Snail Secretion on DSS-Induced Ulcerative Colitis in Mice
Current Issues in Molecular Biology

Ameliorative Effects of the White Jade Snail Secretion on DSS-Induced Ulcerative Colitis in Mice

Preclinical work identifies a natural-product mixture that reduced inflammation, improved gut barrier markers, and changed the microbiome in a mouse model of ulcerative colitis. This could be an early step toward new...

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GART expression is associated with a proliferative and purine-metabolic ISC-like epithelial state in ulcerative colitis
Frontiers in Immunology

GART expression is associated with a proliferative and purine-metabolic ISC-like epithelial state in ulcerative colitis

The study identifies a molecular epithelial program (GART-associated) linked to proliferation and purine metabolism in ulcerative colitis, which could inform future mechanistic research and biomarker development relevant...

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Colon-targeted delivery of α-terpineol via ZIF-8 alleviates ulcerative colitis by anti-inflammatory and gut microbiota-metabolism modulation.
International journal of pharmaceutics

Colon-targeted delivery of α-terpineol via ZIF-8 alleviates ulcerative colitis by anti-inflammatory and gut microbiota-metabolism modulation.

The paper describes a novel colon-targeted delivery system that improved local drug retention, reduced dosing frequency, and changed microbiota and metabolic markers in a mouse model of UC — developments that could...

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An Oral Nanozyme Microsupplement Converts Pathological ROS Into a Colon‐Adhesive Shield for Long‐Term Neutrophil‐Directed Remission of Ulcerative Colitis
Advanced Materials

An Oral Nanozyme Microsupplement Converts Pathological ROS Into a Colon‐Adhesive Shield for Long‐Term Neutrophil‐Directed Remission of Ulcerative Colitis

The study describes a new nanozyme-based oral formulation that reduced NET formation and improved mucosal healing in a mouse model of ulcerative colitis, suggesting a novel preclinical approach to long‑term...

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The Gut–Liver Immune Axis in Celiac Disease, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Outcomes of a Rare but Significant Triad
Springer Science and Business Media LLC

The Gut–Liver Immune Axis in Celiac Disease, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Outcomes of a Rare but Significant Triad

PSC co-occurring with celiac disease appears more common than expected and is associated with a high rate of liver complications (including cirrhosis) and frequent coexisting IBD—information that may affect monitoring...

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Chinese yam polysaccharide attenuates DSS-induced ulcerative colitis by modulating gut microbiota and eicosanoid metabolism.
International journal of biological macromolecules

Chinese yam polysaccharide attenuates DSS-induced ulcerative colitis by modulating gut microbiota and eicosanoid metabolism.

This mouse study identifies a plant polysaccharide that reduced colitis-related inflammation and improved colon histology, suggesting potential microbiome and lipid‑metabolism mechanisms that could inform future research...

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Palmitoylation reprograms the intestinal mucosal barrier microenvironment: potential mechanisms and promising therapeutic targets.
Frontiers in pharmacology

Palmitoylation reprograms the intestinal mucosal barrier microenvironment: potential mechanisms and promising therapeutic targets.

The review identifies a novel molecular mechanism (S-palmitoylation) that may drive barrier dysfunction and intestinal inflammation in IBD, suggesting new non-immunosuppressive therapeutic targets that could eventually...

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Matricaria chamomilla L. Essential Oil: The Preparation and Characterization of the Self-microemulsion Drug Delivery System, and Repair Effect in Ulcerative Colitis
Pharmaceutical Research

Matricaria chamomilla L. Essential Oil: The Preparation and Characterization of the Self-microemulsion Drug Delivery System, and Repair Effect in Ulcerative Colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Pharmaceutical...

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Safety Analysis of Upadacitinib in Ulcerative Colitis and Crohn’s Disease Treatment Based on a Review of Studies
Acta Poloniae Pharmaceutica - Drug Research

Safety Analysis of Upadacitinib in Ulcerative Colitis and Crohn’s Disease Treatment Based on a Review of Studies

The review compiles trial and real-world safety data for upadacitinib in IBD and highlights monitoring needs and infection risks (notably herpes zoster), which are directly relevant when choosing or managing JAK...

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QbD aided optimization and molecular docking of pH-sensitive hydrogels for targeted colon delivery in ulcerative colitis.
RSC advances

QbD aided optimization and molecular docking of pH-sensitive hydrogels for targeted colon delivery in ulcerative colitis.

The work aims to improve colon-targeted delivery of an aminosalicylate (balsalazide) to boost local drug levels and protect the drug from gastric degradation—potentially relevant to people with ulcerative colitis looking...

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Polysaccharides from Radix Hedysari exhibited preventive effects against DSS-induced ulcerative colitis in C57BL/6 mice
Frontiers in Immunology

Polysaccharides from Radix Hedysari exhibited preventive effects against DSS-induced ulcerative colitis in C57BL/6 mice

Researchers report that a polysaccharide from Radix Hedysari reduced inflammation, improved barrier proteins, and shifted gut bacteria in a mouse model of ulcerative colitis — suggesting a potential preventive candidate...

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Grapefruit-derived nanovesicles: a promising nanoplatform for enhancing the therapeutic efficacy of andrographolide against ulcerative colitis.
Bioorganic chemistry

Grapefruit-derived nanovesicles: a promising nanoplatform for enhancing the therapeutic efficacy of andrographolide against ulcerative colitis.

Researchers are developing oral delivery methods to make promising anti‑inflammatory compounds more effective. If such platforms translate to humans, they could expand treatment options for UC by improving absorption of...

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Replies to comments on "proximally dominant inflammation at colonoscopy predicts pan-colonic histological remission following oral vancomycin therapy in pediatric ulcerative colitis".
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Replies to comments on "proximally dominant inflammation at colonoscopy predicts pan-colonic histological remission following oral vancomycin therapy in pediatric ulcerative colitis".

Based on the title and source metadata, this appears to be a patient education related to Ulcerative colitis, Inflammatory bowel disease, and Colonoscopy. The original article is from Digestive and liver disease :...

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