Article Archive

Page 14 of 100 · 4757 patient-friendly summaries

Changing Prescription Patterns in Pharmacologically Treated Patients with Newly Diagnosed Inflammatory Bowel Disease in German Gastroenterology Practices: A Real-World Study, 2015–2024
Pharmaceuticals

Changing Prescription Patterns in Pharmacologically Treated Patients with Newly Diagnosed Inflammatory Bowel Disease in German Gastroenterology Practices: A Real-World Study, 2015–2024

The study documents shifting real-world prescribing for newly diagnosed IBD in Germany, with more biologic use and less mesalazine/thiopurine in recent years — changes that could affect treatment expectations and access.

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Differential long-term efficacy of biologic and small-molecule therapies by disease location in moderate-to-severe luminal Crohn's disease: a systematic review and network meta-analysis.
Inflammatory bowel diseases

Differential long-term efficacy of biologic and small-molecule therapies by disease location in moderate-to-severe luminal Crohn's disease: a systematic review and network meta-analysis.

The analysis suggests that some biologic and small-molecule therapies work differently depending on whether Crohn's disease affects the ileum, colon, or both — information that could help tailor long-term treatment...

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A Giant Intra-Abdominal Plasmablastic Neoplasm Favoring Lymphoma Mimicking an Exacerbation of Severe Fistulizing Crohn's Disease: A Case Report.
The American journal of case reports

A Giant Intra-Abdominal Plasmablastic Neoplasm Favoring Lymphoma Mimicking an Exacerbation of Severe Fistulizing Crohn's Disease: A Case Report.

A rapidly growing abdominal mass or unexplained systemic decline in someone with Crohn's disease may represent a rare malignancy (plasmablastic neoplasm) rather than infection or a disease flare; prompt biopsy is...

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Microbiota–host crosstalk in ulcerative colitis: mechanistic evidence and translational prospects for traditional Chinese medicine
Frontiers in Pharmacology

Microbiota–host crosstalk in ulcerative colitis: mechanistic evidence and translational prospects for traditional Chinese medicine

People with ulcerative colitis may be interested because the review explains how the gut microbiome and its metabolites could influence disease and evaluates whether traditional Chinese medicines might modify those...

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Protocol: Early Intestinal Ultrasonography for Prediction of Response to Corticosteroids or Biologics in Outpatients With Moderate to Severe Ulcerative Colitis
JCC Plus

Protocol: Early Intestinal Ultrasonography for Prediction of Response to Corticosteroids or Biologics in Outpatients With Moderate to Severe Ulcerative Colitis

If validated, early bedside ultrasound changes could let clinicians identify within days whether steroids or biologics are working, enabling faster treatment adjustments and potentially avoiding prolonged ineffective...

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Current evidence for first-line advanced therapies in pediatric ulcerative colitis: a critical review
Inflammatory Bowel Diseases

Current evidence for first-line advanced therapies in pediatric ulcerative colitis: a critical review

Families and clinicians deciding on a first biologic for a child with ulcerative colitis need to know which drugs have pediatric-specific evidence. This review shows infliximab has the strongest pediatric data, while...

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Ulcerative colitis reporting across medications: FAERS analysis and cross-species transcriptomic triangulation
Frontiers in Immunology

Ulcerative colitis reporting across medications: FAERS analysis and cross-species transcriptomic triangulation

People with IBD or their clinicians may see signals suggesting certain drugs are more often reported with ulcerative colitis; this study combines adverse‑event reports with gene‑expression comparisons to help prioritize...

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Kaempferol-3-O-glucorhamnoside alleviates DSS-induced ulcerative colitis via the arginine-polyamine metabolism pathway.
International immunopharmacology

Kaempferol-3-O-glucorhamnoside alleviates DSS-induced ulcerative colitis via the arginine-polyamine metabolism pathway.

Researchers exploring new anti-inflammatory or metabolism-targeting approaches for UC might view KA as a candidate molecule that modulates arginine–polyamine metabolism, which could point to new drug-discovery...

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Longitudinal SARS-CoV-2 mRNA vaccine immunogenicity in inflammatory bowel disease in relation to anti-TNF therapy and age: a prospective cohort study.
Vaccine

Longitudinal SARS-CoV-2 mRNA vaccine immunogenicity in inflammatory bowel disease in relation to anti-TNF therapy and age: a prospective cohort study.

Patients with IBD—particularly those on anti‑TNF therapy and older adults—may have lower and faster‑waning antibody responses after mRNA COVID‑19 vaccination, which could affect timing or need for additional vaccine...

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Norepinephrine-driven neutrophilic inflammation accelerates ulcerative colitis progression.
Journal of autoimmunity

Norepinephrine-driven neutrophilic inflammation accelerates ulcerative colitis progression.

If local norepinephrine promotes neutrophil‑driven inflammation in UC, that could help explain disease progression in some patients and point to biomarkers (ADRB2‑rich neutrophils) that might predict response to anti‑TNF...

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New Perspectives on STAT3 in Ulcerative Colitis: Molecular Mechanisms and Dual Roles.
Cellular and molecular gastroenterology and hepatology

New Perspectives on STAT3 in Ulcerative Colitis: Molecular Mechanisms and Dual Roles.

STAT3 is a central immune signaling molecule implicated in ulcerative colitis; understanding its dual roles could influence future biomarker research and therapies for UC. The review highlights why STAT3’s...

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Contemporary outcomes and restorative pathways following colectomy for inflammatory bowel disease: a tertiary centre cohort from Aotearoa New Zealand.
The New Zealand medical journal

Contemporary outcomes and restorative pathways following colectomy for inflammatory bowel disease: a tertiary centre cohort from Aotearoa New Zealand.

This study reports real-world short-term outcomes after colectomy for IBD at a tertiary New Zealand centre, including complication rates and how often restorative surgery (ileal pouch) was later performed—information...

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Agomab to Present STENOVA Open-Label Extension Data of Ontunisertib at UEG Week ...

Patients with fibrostenosing Crohn’s disease face progressive strictures and limited targeted treatments; data from STENOVA’s OLE and the planned NOV‑ERA trial could advance therapies that target both inflammation and...

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Longitudinal multi-omics profiling of tofacitinib response identifies a pre-existing Janus kinase-tractable inflammatory state in ulcerative colitis
medRxiv

Longitudinal multi-omics profiling of tofacitinib response identifies a pre-existing Janus kinase-tractable inflammatory state in ulcerative colitis

If confirmed, a pretreatment mucosal JAK‑dependent inflammatory signature could help predict who will respond to tofacitinib, potentially guiding therapy choice and avoiding ineffective treatment for people with...

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Australia: where developing and developed worlds collide - a unique opportunity to understand environmental triggers of inflammatory bowel disease.
Internal medicine journal

Australia: where developing and developed worlds collide - a unique opportunity to understand environmental triggers of inflammatory bowel disease.

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Internal medicine journal.

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Faecal urgency in Crohn's disease: associations with disease location and activity, psychobiological burden and adverse outcomes.
Revista espanola de enfermedades digestivas

Faecal urgency in Crohn's disease: associations with disease location and activity, psychobiological burden and adverse outcomes.

Faecal urgency is a frequent, disabling symptom in Crohn's disease that was common in this cohort and tied to poorer quality of life, mental-health burden, and more healthcare use over one year.

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Association between Crohn's disease and pulmonary nodule patterns: an inverse probability-weighted analysis of real-world data.
Clinical and translational gastroenterology

Association between Crohn's disease and pulmonary nodule patterns: an inverse probability-weighted analysis of real-world data.

Pulmonary nodules appear more frequently in people with Crohn’s disease and have distinct patterns over time. Knowing which factors predict nodule burden can help clinicians prioritize monitoring and interpret chest...

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The burden of inflammatory bowel disease in Asia (1990-2023) and projections to 2050: A comprehensive analysis of the 2023 global burden of disease study.
PloS one

The burden of inflammatory bowel disease in Asia (1990-2023) and projections to 2050: A comprehensive analysis of the 2023 global burden of disease study.

Rising IBD incidence and prevalence in Asia mean more people will need long-term care, specialist services, and health-system planning. Understanding regional trends helps patients and policymakers anticipate resource...

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Prediction of oxygen uptake at peak exercise in patients with inflammatory bowel disease using submaximal cardiopulmonary exercise testing and the steep ramp test as a practical field test.
PloS one

Prediction of oxygen uptake at peak exercise in patients with inflammatory bowel disease using submaximal cardiopulmonary exercise testing and the steep ramp test as a practical field test.

Cardiorespiratory fitness (VO2peak) is an important health measure and may be relevant for people with IBD. Having accurate, simpler ways to estimate VO2peak makes it easier to assess fitness in clinic or studies without...

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Extraintestinal manifestations in patients with inflammatory bowel disease: focus on epidemiology
Russian Journal of Evidence-Based Gastroenterology

Extraintestinal manifestations in patients with inflammatory bowel disease: focus on epidemiology

Extraintestinal problems are common in IBD and can cause significant symptoms and treatment needs beyond the bowel. Knowing their frequency helps patients and clinicians prioritize screening and multidisciplinary care.

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Integrative Transcriptomic and Genetic Analysis Prioritizes IRF1 as a Candidate Regulatory Gene Associated with Ulcerative Colitis
Journal of inflammation research

Integrative Transcriptomic and Genetic Analysis Prioritizes IRF1 as a Candidate Regulatory Gene Associated with Ulcerative Colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of inflammation...

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Chinese herbal medicine for ulcerative colitis: product-level clinical evidence, mechanistic appraisal, and a roadmap to precision translation
Frontiers in Pharmacology

Chinese herbal medicine for ulcerative colitis: product-level clinical evidence, mechanistic appraisal, and a roadmap to precision translation

People with UC often try complementary therapies; this review shows that benefits and risks vary by specific CHM product and that current evidence is mixed and product-dependent.

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Gut microbiome-driven mechanisms in inflammatory bowel disease-associated interstitial lung disease: from dysbiosis to therapeutic implications
Frontiers in cellular and infection microbiology

Gut microbiome-driven mechanisms in inflammatory bowel disease-associated interstitial lung disease: from dysbiosis to therapeutic implications

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Microbiome, and Research and clinical trials. The original article is from Frontiers in cellular and...

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