Article Archive

Page 15 of 100 · 4757 patient-friendly summaries

An HOCl-responsive chemiluminescent probe for monitoring MPO-mediated HOCl generation for deep-tissue tracking and evaluation of inflammatory bowel disease.
Journal of materials chemistry. B

An HOCl-responsive chemiluminescent probe for monitoring MPO-mediated HOCl generation for deep-tissue tracking and evaluation of inflammatory bowel disease.

A new chemiluminescent probe could help researchers see and measure MPO-driven HOCl inflammation deeper in tissues, which may speed preclinical testing of IBD therapies and biomarker development.

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Tegoprazan regulates gut microbiota structure in Helicobacter pylori-induced ulcerative colitis mice
Folia Microbiologica

Tegoprazan regulates gut microbiota structure in Helicobacter pylori-induced ulcerative colitis mice

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Folia Microbiologica.

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Titanium dioxide exposure during gestation is critical to worsen DSS-induced colitis
Springer Science and Business Media LLC

Titanium dioxide exposure during gestation is critical to worsen DSS-induced colitis

If findings translate beyond mice, exposure to titanium dioxide during pregnancy could influence offspring gut barrier, microbiota, and susceptibility to inflammatory colitis — a potential public-health concern for...

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Preclinical stages of Crohn's disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials.
Gut

Preclinical stages of Crohn's disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials.

Identifying people at very early, preclinical stages of Crohn’s disease could allow enrollment in prevention trials and earlier intervention. Faecal calprotectin may help select higher‑risk first‑degree relatives for...

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Rise of prediagnostic molecular profiling in inflammatory bowel disease-can we close the door before the horse has bolted?
Gut

Rise of prediagnostic molecular profiling in inflammatory bowel disease-can we close the door before the horse has bolted?

Detecting molecular signs of IBD before symptoms could eventually allow earlier monitoring or preventive strategies, changing how and when people at risk are identified. For patients, this research points to hope that...

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EVOLVE-IBERIA: Real-world evidence on vedolizumab and anti-tumour necrosis factor-α as first- and second-line biologic treatment in Crohn's disease.
Gastroenterologia y hepatologia

EVOLVE-IBERIA: Real-world evidence on vedolizumab and anti-tumour necrosis factor-α as first- and second-line biologic treatment in Crohn's disease.

This study gives real-world comparative data on two biologic options (vedolizumab vs anti-TNFα) used early in the treatment course for Crohn’s disease, which may help patients and clinicians weigh effectiveness and...

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Comment on "Probiotics may not adhere to gut and provide benefits in inflammatory bowel disease patients based on an AOM/DSS murine model".
Journal of the Formosan Medical Association = Taiwan yi zhi

Comment on "Probiotics may not adhere to gut and provide benefits in inflammatory bowel disease patients based on an AOM/DSS murine model".

Based on the title and source metadata, this appears to be a case report related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Formosan Medical Association =...

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Subcutaneous infliximab in inflammatory bowel disease: from pharmacokinetic principles to clinical practice.
Expert opinion on biological therapy

Subcutaneous infliximab in inflammatory bowel disease: from pharmacokinetic principles to clinical practice.

A subcutaneous option for infliximab could simplify maintenance therapy, reduce infusion visits, and change how drug levels and accompanying immunomodulators are managed — issues many people with IBD and their clinicians...

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Hospitalized Infection Risk and Organ-specific Infection Patterns Across Advanced Therapies in Ulcerative Colitis: A Japanese Claims Analysis.
Internal medicine (Tokyo, Japan)

Hospitalized Infection Risk and Organ-specific Infection Patterns Across Advanced Therapies in Ulcerative Colitis: A Japanese Claims Analysis.

Patients and clinicians choosing among advanced therapies for ulcerative colitis may consider infection-related hospitalization risk as one factor; this study suggests lower risk with ustekinumab versus TNF antagonists...

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Machine learning predicts relapse after anti-TNF withdrawal in ulcerative colitis using rectal biopsy transcriptomics
openRxiv

Machine learning predicts relapse after anti-TNF withdrawal in ulcerative colitis using rectal biopsy transcriptomics

Predicting who will relapse after stopping anti-TNF drugs could help avoid unnecessary flares or unnecessary ongoing treatment. A biopsy-based transcriptomic test could be a useful decision tool if validated.

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Integrative Transcriptomic and Single-Cell Analyses Identify S100A8 as a Link Between Myeloid Inflammation and Mitophagy Dysregulation in Crohn’s Disease
Europe PMC

Integrative Transcriptomic and Single-Cell Analyses Identify S100A8 as a Link Between Myeloid Inflammation and Mitophagy Dysregulation in Crohn’s Disease

The paper points to S100A8 as a potential link between immune-cell-driven inflammation and mitochondrial stress in Crohn’s disease, which could help researchers explore new biomarkers or targets for study.

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Real-world effectiveness and predictors of need for extended induction of mirikizumab therapy in ulcerative colitis
Journal of the Canadian Association of Gastroenterology

Real-world effectiveness and predictors of need for extended induction of mirikizumab therapy in ulcerative colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Mirikizumab. The original article is from Journal of the Canadian Association of...

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Coded Gastrointestinal Diagnoses in Women Aged 18-44 Years with Iron Deficiency Anemia Without Selected Coded Alarm Features Who Underwent Same-Day Bidirectional Endoscopy: A Multicenter U.S. Electronic Health Record Study.
Digestive diseases and sciences

Coded Gastrointestinal Diagnoses in Women Aged 18-44 Years with Iron Deficiency Anemia Without Selected Coded Alarm Features Who Underwent Same-Day Bidirectional Endoscopy: A Multicenter U.S. Electronic Health Record Study.

This is relevant because many younger women with iron deficiency anemia are considered for upper and lower endoscopy to find bleeding sources or other causes. The study shows common diagnostic codes recorded after...

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Psychological Functioning and Parent-Child Mental Health Interrelations in Pediatric Gastrointestinal Autoimmune Disorders.
Clinical child psychology and psychiatry

Psychological Functioning and Parent-Child Mental Health Interrelations in Pediatric Gastrointestinal Autoimmune Disorders.

Emotional functioning and parent-child mental health are linked with anxiety, depression, and quality of life in children with IBD and other GI autoimmune disorders. Identifying these issues may help families get...

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Impaired fatty acid oxidation and mitochondrial injury mediated by the AMPK/PPARα pathway: A key mechanism in high-fat diet-aggravated ulcerative colitis
PLOS One

Impaired fatty acid oxidation and mitochondrial injury mediated by the AMPK/PPARα pathway: A key mechanism in high-fat diet-aggravated ulcerative colitis

If you have ulcerative colitis, this preclinical study suggests high‑fat diets may worsen intestinal inflammation through metabolic and mitochondrial pathways that impair the gut barrier. Targeting the AMPK/PPARα pathway...

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Effectiveness of vedolizumab to reduce bowel urgency in a Canadian real-world inflammatory bowel disease cohort
Journal of the Canadian Association of Gastroenterology

Effectiveness of vedolizumab to reduce bowel urgency in a Canadian real-world inflammatory bowel disease cohort

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Vedolizumab, and Anti Integrin. The original article is from Journal of the Canadian Association of...

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Identification of Autophagy-Related Biomarkers for Subtyping and Immune Microenvironment Remodeling in Ulcerative Colitis
Springer Science and Business Media LLC

Identification of Autophagy-Related Biomarkers for Subtyping and Immune Microenvironment Remodeling in Ulcerative Colitis

This study proposes three autophagy-related genes (APOL1, CCL2, IL24) as potential biomarkers that may help classify ulcerative colitis patients into subtypes with different immune environments, which could eventually...

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Mesaconic acid delivery via biomaterials and engineered probiotics to the gut reduces inflammation in Crohn's Diseases mouse models
bioRxiv

Mesaconic acid delivery via biomaterials and engineered probiotics to the gut reduces inflammation in Crohn's Diseases mouse models

This preclinical study suggests raising mesaconate in the gut can reduce inflammation in mouse models of Crohn’s disease, using either an engineered probiotic or a zinc–mesaconate formulation—approaches that could...

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Association of narrow pelvis and body composition with anastomotic stricture following total proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis
BMC Surgery

Association of narrow pelvis and body composition with anastomotic stricture following total proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis

Anastomotic strictures after TPC–IPAA can impair bowel function and quality of life; identifying preoperative pelvic and body-composition risk factors could help tailor surgical planning or follow-up.

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Engineering Nanomaterial Platform for Inflammatory Bowel Disease: Three-Dimensional Integration of Delivery Mechanism, Therapeutic Drug Delivery and Intelligent Material Design
International journal of nanomedicine

Engineering Nanomaterial Platform for Inflammatory Bowel Disease: Three-Dimensional Integration of Delivery Mechanism, Therapeutic Drug Delivery and Intelligent Material Design

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from International journal of nanomedicine.

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Early Colectomy and Long-Term Risk of Cardiometabolic Disease in Ulcerative Colitis: A Nationwide Cohort Study
American Journal of Gastroenterology

Early Colectomy and Long-Term Risk of Cardiometabolic Disease in Ulcerative Colitis: A Nationwide Cohort Study

People with ulcerative colitis face long-term health risks beyond the gut. This study suggests that getting a colectomy early after diagnosis might be linked to lower long-term risk of cardiovascular disease and type 2...

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Multi‐omics and machine learning identify neutrophil annexin A3 as a therapeutic target of ginsenoside Rb1 for comorbidity of ischaemic stroke and ulcerative colitis
British Journal of Pharmacology

Multi‐omics and machine learning identify neutrophil annexin A3 as a therapeutic target of ginsenoside Rb1 for comorbidity of ischaemic stroke and ulcerative colitis

This study links a neutrophil protein (ANXA3) to both ulcerative colitis and ischaemic stroke and suggests a compound (ginsenoside Rb1) can bind ANXA3 and reduce neutrophil hyperactivation in lab tests — a potential...

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Disease- and Region-Specific Molecular Patterns Involving miRNAs and Associated Signalling Pathways and Epithelial Cell-Fate Responses in PSC-Associated Ulcerative Colitis
Cells

Disease- and Region-Specific Molecular Patterns Involving miRNAs and Associated Signalling Pathways and Epithelial Cell-Fate Responses in PSC-Associated Ulcerative Colitis

The work highlights molecular differences between PSC-UC and typical UC that could help explain higher colorectal cancer risk in PSC-UC and suggests candidate miRNA biomarkers (eg, miR-155) for further study.

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Engineering extracellular vesicles for inflammatory bowel disease and colitis-associated colorectal cancer: from therapeutic innovation to clinical translation
Frontiers in Immunology

Engineering extracellular vesicles for inflammatory bowel disease and colitis-associated colorectal cancer: from therapeutic innovation to clinical translation

Engineered extracellular vesicles are an emerging, targeted therapy approach that could someday improve immune control, mucosal healing, and drug delivery in IBD and reduce colitis-associated cancer risk. The review...

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Perspectives of gastroenterologists on an educational curriculum to promote self-management in young adults with inflammatory bowel disease
Journal of the Canadian Association of Gastroenterology

Perspectives of gastroenterologists on an educational curriculum to promote self-management in young adults with inflammatory bowel disease

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Canadian Association of...

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The sustainability and environmental impact of virtual care for inflammatory bowel disease: a population-based retrospective cohort study
Journal of the Canadian Association of Gastroenterology

The sustainability and environmental impact of virtual care for inflammatory bowel disease: a population-based retrospective cohort study

Based on the title and source metadata, this appears to be an observational study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Canadian Association...

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Efficacy of Fermented Brown Rice by Aspergillus oryzae (FBRA) in Ulcerative Colitis: A Double‐Blind Randomized Trial
JGH open : an open access journal of gastroenterology and hepatology

Efficacy of Fermented Brown Rice by Aspergillus oryzae (FBRA) in Ulcerative Colitis: A Double‐Blind Randomized Trial

Based on the title and source metadata, this appears to be a clinical trial phase 3 related to Ulcerative colitis, Inflammatory bowel disease, and Diet and lifestyle. The original article is from JGH open : an open...

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Tripartite Interplay of Epithelial, Immune, and Microbiota Dysregulation in Crohn's Disease: Mechanisms and Translational Strategies
Immunity, inflammation and disease

Tripartite Interplay of Epithelial, Immune, and Microbiota Dysregulation in Crohn's Disease: Mechanisms and Translational Strategies

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Crohn's disease, Inflammatory bowel disease, and Microbiome. The original article is from Immunity, inflammation...

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Irritable bowel syndrome-like symptoms are associated with increased healthcare utilization in patients with inflammatory bowel disease
Frontiers in gastroenterology (Lausanne, Switzerland)

Irritable bowel syndrome-like symptoms are associated with increased healthcare utilization in patients with inflammatory bowel disease

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Irritable bowel syndrome, and Symptoms and flares. The original article is from Frontiers in...

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Beyond Crohn's disease: ileal Kaposi sarcoma in a transplant recipient presenting with subocclusive symptoms. A concomitant diagnosis of Crohn's disease and ileal Kaposi sarcoma.
Minerva gastroenterology

Beyond Crohn's disease: ileal Kaposi sarcoma in a transplant recipient presenting with subocclusive symptoms. A concomitant diagnosis of Crohn's disease and ileal Kaposi sarcoma.

Immunosuppressed patients with refractory or atypical Crohn’s symptoms may rarely have intestinal Kaposi sarcoma, which can change management. Recognizing this possibility could alter the need for surgery versus systemic...

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Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis
Advanced Science

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

The paper suggests that changes in how microbes interact (community plasticity and network structure) may underlie microbiome differences seen in ulcerative colitis and could point toward ecology-informed biomarkers or...

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