Article Archive

Page 29 of 100 · 4772 patient-friendly summaries

Beyond susceptibility: do population-specific rare variants shape age at diagnosis in Korean inflammatory bowel disease?
The Korean journal of internal medicine

Beyond susceptibility: do population-specific rare variants shape age at diagnosis in Korean inflammatory bowel disease?

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from The Korean journal of internal medicine.

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Is there a difference in the outcomes of long-term seton placement for complex anal fistula in patients with and without Crohn's disease?
American journal of surgery

Is there a difference in the outcomes of long-term seton placement for complex anal fistula in patients with and without Crohn's disease?

Setons are often used to control sepsis in complex anal fistula, but this study suggests outcomes are worse when Crohn's disease is present, meaning clinicians may view long-term setons as temporary measures in CD rather...

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Design, synthesis, and in vitro application of a two-photon fluorescent probe for fluorescent imaging and in vitro biological evaluation of ulcerative colitis.
Bioorganic chemistry

Design, synthesis, and in vitro application of a two-photon fluorescent probe for fluorescent imaging and in vitro biological evaluation of ulcerative colitis.

A new fluorescent probe designed from bile acids may help image inflammation and has shown anti-inflammatory/antioxidant activity in cell studies relevant to ulcerative colitis, which could inform future diagnostic or...

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Assessing the effectiveness of biologics in biologic-naïve patients with isolated small bowel Crohn's disease by double-balloon endoscopy.
Expert opinion on biological therapy

Assessing the effectiveness of biologics in biologic-naïve patients with isolated small bowel Crohn's disease by double-balloon endoscopy.

The findings give clinicians and patients data on how often biologic therapy leads to endoscopic remission in biologic‑naïve patients with isolated small‑bowel Crohn's disease, and they suggest similar effectiveness...

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Spatial multi-omics-guided drug development in inflammatory bowel disease: from mucosal immune niches to precision therapy
Frontiers in Immunology

Spatial multi-omics-guided drug development in inflammatory bowel disease: from mucosal immune niches to precision therapy

Spatially resolved profiling could identify the specific cell neighborhoods and signaling circuits that drive disease in a person’s gut tissue, which may help predict who will respond to particular biologics or small...

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Lonicerae Japonicae Flos as a Dietary Natural Product: Bioactive Constituents, Gut Health Modulation, and Therapeutic Potential in Ulcerative Colitis and Colorectal Cancer
Food science & nutrition

Lonicerae Japonicae Flos as a Dietary Natural Product: Bioactive Constituents, Gut Health Modulation, and Therapeutic Potential in Ulcerative Colitis and Colorectal Cancer

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Ulcerative colitis, Colorectal cancer, and Diet and lifestyle. The original article is from Food science &...

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Dysbiosis and Bacterial Invasion in Murine Models of Ileal Crohn's Disease
Advances and Applications in Biotechnology: Volume 4

Dysbiosis and Bacterial Invasion in Murine Models of Ileal Crohn's Disease

Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Advances and Applications...

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Improved diagnostic capability, rather than biologics, reduces surgical rates in Chinese Crohn's disease patients: A multicenter study.
Chinese medical journal

Improved diagnostic capability, rather than biologics, reduces surgical rates in Chinese Crohn's disease patients: A multicenter study.

If you're living with Crohn's disease, earlier and better diagnosis (for example, more cross-sectional imaging) may partly explain falling surgery rates over time. This study suggests system-level diagnostic improvements...

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Current practices and unmet needs in the management of Clostridioides difficile infection in pediatric inflammatory bowel disease: A national survey.
Journal of pediatric gastroenterology and nutrition

Current practices and unmet needs in the management of Clostridioides difficile infection in pediatric inflammatory bowel disease: A national survey.

Children with IBD are at higher risk for C. difficile and practices for diagnosing and treating CDI in pediatric IBD vary widely. Standardized, pediatric-specific guidance could reduce uncertainty and improve care.

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Chất lượng cuộc sống và các yếu tố ảnh hưởng ở bệnh nhân viêm ruột mạn
Tạp chí Khoa học tiêu hóa Việt Nam

Chất lượng cuộc sống và các yếu tố ảnh hưởng ở bệnh nhân viêm ruột mạn

This study identifies modifiable lifestyle factors (meal regularity and spicy/sour food intake) linked to quality of life in people with IBD, which could inform practical counseling for patients.

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Switching standard dosed intravenous to subcutaneous infliximab leads to similar drug exposure in inflammatory bowel disease patients independent of concomitant immunosuppressants (SHUFFLE study).
British journal of clinical pharmacology

Switching standard dosed intravenous to subcutaneous infliximab leads to similar drug exposure in inflammatory bowel disease patients independent of concomitant immunosuppressants (SHUFFLE study).

The findings suggest people with IBD on IV infliximab could switch to fixed-dose SC infliximab without losing drug exposure, and many may gain convenience and higher trough drug levels regardless of concomitant...

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Beyond the Bowel: A Narrative Review Examining Bidirectional Mental Health Pathways Across Disorders of Gut-Brain Interaction and Inflammatory Bowel Disease
Cureus

Beyond the Bowel: A Narrative Review Examining Bidirectional Mental Health Pathways Across Disorders of Gut-Brain Interaction and Inflammatory Bowel Disease

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease and Mental health and quality of life. The original article is from Cureus.

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Deep learning-based assessment of ulcerative colitis activity from full-length endoscopic videos with spatial characterisation and histological correlation
medRxiv

Deep learning-based assessment of ulcerative colitis activity from full-length endoscopic videos with spatial characterisation and histological correlation

Automated analysis of full-length endoscopy videos could standardise assessment of UC activity, identify spatial patterns of inflammation, and better estimate histological healing—information that may influence treatment...

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Comparative outcomes of advanced medical rescue therapies in steroid-refractory acute severe ulcerative colitis: a systematic review and network meta-analysis
Frontiers in Gastroenterology

Comparative outcomes of advanced medical rescue therapies in steroid-refractory acute severe ulcerative colitis: a systematic review and network meta-analysis

The analysis compares rescue drugs used when severe ulcerative colitis doesn't respond to IV steroids — a high-stakes situation where avoiding colectomy matters.

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COMPARATIVE REAL-WORLD EFFECTIVENESS OF BIOLOGIC THERAPIES FOR PREVENTING POSTOPERATIVE ENDOSCOPIC RECURRENCE OF CROHN’S DISEASE
American Journal of Gastroenterology

COMPARATIVE REAL-WORLD EFFECTIVENESS OF BIOLOGIC THERAPIES FOR PREVENTING POSTOPERATIVE ENDOSCOPIC RECURRENCE OF CROHN’S DISEASE

Postoperative endoscopic recurrence is common after ileocolonic resection for Crohn’s disease; this study suggests biologic drugs started after surgery are linked to lower recurrence rates. Knowing which biologics...

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Financial Hardship Among US Adults with Inflammatory Bowel Disease: A National Analysis.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

Financial Hardship Among US Adults with Inflammatory Bowel Disease: A National Analysis.

Financial barriers are common among US adults with IBD and are linked to delayed care and skipping medications — problems that can worsen disease control and quality of life.

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ULCERATIVE COLITIS EXCLUSION DIET (UCED) – AN EMERGING NEW DIETARY APPROACH FOR ULCERATIVE COLITIS
International Journal of Innovative Technologies in Social Science

ULCERATIVE COLITIS EXCLUSION DIET (UCED) – AN EMERGING NEW DIETARY APPROACH FOR ULCERATIVE COLITIS

Dietary strategies like UCED aim to modify the gut microbiome and inflammation, which could help people with ulcerative colitis who have incomplete symptom control on medication. Patients often want nonpharmacologic...

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Ex Vivo Comparison Of Combination Versus Single Therapeutic Pathway Inhibition In Human Intestinal Mucosa From Patients With Inflammatory Bowel Disease
ClinicalTrials.gov

Ex Vivo Comparison Of Combination Versus Single Therapeutic Pathway Inhibition In Human Intestinal Mucosa From Patients With Inflammatory Bowel Disease

Researchers are testing whether blocking three inflammation pathways at once can reduce tissue inflammation more than single drugs. If ex vivo results show stronger effects, it could guide development of multi-target...

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A Direct Head-to-head Comparison of Ustekinumab With Infliximab for the Treatment of Ulcerative Colitis
ClinicalTrials.gov

A Direct Head-to-head Comparison of Ustekinumab With Infliximab for the Treatment of Ulcerative Colitis

Head-to-head comparisons between biologics are uncommon but useful for patients and clinicians deciding between agents. This study specifically compares ustekinumab and infliximab for remission, safety, and quality of...

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IL1B-high macrophages promote ferroptosis-like lipid peroxidation injury in Crohn's disease intestinal epithelium.
Redox biology

IL1B-high macrophages promote ferroptosis-like lipid peroxidation injury in Crohn's disease intestinal epithelium.

The study identifies a macrophage-driven mechanism (IL-1β–linked ferroptosis-like lipid peroxidation) that may contribute to epithelial injury in Crohn’s disease, suggesting new biological targets that could eventually...

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Integrated metabolomic and genetic profiling implicate loss of docosahexaenoic acid in the link between ultra-processed foods and Crohn's disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Integrated metabolomic and genetic profiling implicate loss of docosahexaenoic acid in the link between ultra-processed foods and Crohn's disease.

If UPFs increase Crohn's risk by lowering DHA, that points to a measurable metabolic pathway linking diet and disease. Understanding this could inform dietary prevention strategies or targeted nutrition research for...

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The Impact of Perioperative Immunosuppression on Post-surgical Outcomes in Patients with Inflammatory Bowel Disease.
Digestive diseases and sciences

The Impact of Perioperative Immunosuppression on Post-surgical Outcomes in Patients with Inflammatory Bowel Disease.

This study addresses whether continuing advanced biologic therapies around abdominal surgery raises short-term postoperative risks—important for IBD patients and clinicians planning surgery.

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Clinical Outcomes of Robotic and Laparoscopic Ileal Pouch–Anal Anastomosis in Ulcerative Colitis: A Retrospective Cohort from Two Tertiary Referral Centers
Journal of Laparoendoscopic & Advanced Surgical Techniques

Clinical Outcomes of Robotic and Laparoscopic Ileal Pouch–Anal Anastomosis in Ulcerative Colitis: A Retrospective Cohort from Two Tertiary Referral Centers

Patients and surgeons weighing robotic versus laparoscopic IPAA for ulcerative colitis may care because the study suggests similar short-term complication rates between approaches in this cohort, which could inform...

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Deep learning coupled with scalable domain-specific structural validation expands RNA virus discovery from metatranscriptomes
Nature Communications

Deep learning coupled with scalable domain-specific structural validation expands RNA virus discovery from metatranscriptomes

Improved detection of divergent RNA viruses in gut metatranscriptomes could help researchers better characterize the viral component of the microbiome in IBD and explore possible viral contributions to disease biology or...

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Clinical utility of magnetic resonance enterography for pediatric Crohn’s disease: a review with illustrative cases and a focus on Japan
Japanese Journal of Radiology

Clinical utility of magnetic resonance enterography for pediatric Crohn’s disease: a review with illustrative cases and a focus on Japan

MRE is a key radiation-free imaging tool for children with Crohn’s disease; this review summarizes its clinical utility and how it fits with other pediatric-focused diagnostic approaches in Japan.

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Primary biliary cirrhosis and inflammatory bowel disease: a two-sample bidirectional Mendelian randomization study
Experimental Biology and Medicine

Primary biliary cirrhosis and inflammatory bowel disease: a two-sample bidirectional Mendelian randomization study

Genetic evidence that PBC may causally influence risk of IBD (and UC specifically) could help explain observed co-occurrence of these autoimmune diseases and point researchers toward shared pathways worth studying.

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A sesterterpenoid derivative alleviates ulcerative colitis through targeting ProRS to suppress the NLRP3 inflammasome
Science China Life Sciences

A sesterterpenoid derivative alleviates ulcerative colitis through targeting ProRS to suppress the NLRP3 inflammasome

A new small molecule that blocks the NLRP3 inflammasome via ProRS could point to future drug strategies for ulcerative colitis — a pathway involved in intestinal inflammation that matters to people with IBD. This is...

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MiR-29a deficiency disrupts gut microbiota-bile acid homeostasis and impairs the anti-inflammatory effects of lithocholic acid in colitis
Frontiers in Cellular and Infection Microbiology

MiR-29a deficiency disrupts gut microbiota-bile acid homeostasis and impairs the anti-inflammatory effects of lithocholic acid in colitis

The paper connects a host microRNA (miR-29a) to gut microbiota bile-acid metabolism and an anti-inflammatory bile acid (LCA). If similar mechanisms apply in people, it could point to new biological targets or biomarkers...

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Colon-targeted EGCG delivery remodels the gut microenvironment to enhance therapeutic efficacy in ulcerative colitis.
Journal of controlled release : official journal of the Controlled Release Society

Colon-targeted EGCG delivery remodels the gut microenvironment to enhance therapeutic efficacy in ulcerative colitis.

The study introduces a colon-targeted EGCG delivery system that reduced inflammation and improved microbial and metabolic markers in a mouse model of UC, suggesting a potential new therapeutic approach worth further...

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Unlocking the role of fungal peptide cytotoxin candidalysin in candidiasis and non-candidiasis diseases.
Biochimie

Unlocking the role of fungal peptide cytotoxin candidalysin in candidiasis and non-candidiasis diseases.

Candidalysin is a toxin from Candida albicans that can damage epithelial barriers and trigger inflammation. If candidalysin contributes to intestinal inflammation or barrier dysfunction, it could help explain fungal...

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