Article Archive

Page 28 of 100 · 4772 patient-friendly summaries

Advanced therapy options, choice, access, and treatment empowerment for inflammatory bowel disease (ADVOCATE-IBD): a UK-wide semi-structured interview study exploring patient preferences around advanced therapy decisions in inflammatory bowel disease
Crohn's & colitis 360

Advanced therapy options, choice, access, and treatment empowerment for inflammatory bowel disease (ADVOCATE-IBD): a UK-wide semi-structured interview study exploring patient preferences around advanced therapy decisions in inflammatory bowel disease

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Crohn's & colitis 360.

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Self-expandable metal stents versus endoscopic balloon dilatation for the treatment of strictures in Crohn's disease: a retrospective long-term follow-up of the ProtDilat study, an open label, multicenter, randomized trial.
Journal of Crohn's & colitis

Self-expandable metal stents versus endoscopic balloon dilatation for the treatment of strictures in Crohn's disease: a retrospective long-term follow-up of the ProtDilat study, an open label, multicenter, randomized trial.

Long-term results suggest endoscopic approaches—especially balloon dilatation—help many people with Crohn’s strictures avoid surgery and have fewer severe complications compared with surgical treatment.

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Gastrointestinal complications of cocaine use: a narrative literature review.
Frontiers in gastroenterology (Lausanne, Switzerland)

Gastrointestinal complications of cocaine use: a narrative literature review.

Cocaine use can trigger severe GI problems that mimic common surgical and inflammatory conditions; recognizing the link can speed diagnosis and management. Most published evidence is low-level (case reports/series), so...

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Clinical characteristics associated with advanced therapy optimization in inflammatory bowel disease in the Brazilian GEDIIB national registry
Scientific Reports

Clinical characteristics associated with advanced therapy optimization in inflammatory bowel disease in the Brazilian GEDIIB national registry

This large national-registry study identifies clinical features linked with needing optimization of biologic or small-molecule therapies in CD and UC. That helps show which patient groups more often require...

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Dietary prevention of undernutrition reduces intestinal inflammation associated with an anti-inflammatory profile of gut microbiota in a preclinical model
Scientific Reports

Dietary prevention of undernutrition reduces intestinal inflammation associated with an anti-inflammatory profile of gut microbiota in a preclinical model

Undernutrition and lean-mass loss are common and harmful in people with IBD. If dietary strategies can prevent weight and muscle loss and shift the gut microbiota toward SCFA producers, that could be relevant to...

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Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.

SMC phenotypic switching can contribute to intestinal fibrosis and motility problems in IBD; understanding macrophage regulation of SMCs could point to new treatment targets for these complications.

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Lonicerae Japonicae Flos as a Dietary Natural Product: Bioactive Constituents, Gut Health Modulation, and Therapeutic Potential in Ulcerative Colitis and Colorectal Cancer.
Food science & nutrition

Lonicerae Japonicae Flos as a Dietary Natural Product: Bioactive Constituents, Gut Health Modulation, and Therapeutic Potential in Ulcerative Colitis and Colorectal Cancer.

The review suggests LJF contains compounds that may reduce intestinal inflammation, support gut barrier health, and influence microbiota—areas directly relevant to ulcerative colitis and colorectal cancer risk. However,...

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Ultrastructural and Proteomic Signatures of Mechanoadaptive Fibroblast Remodeling across Microphysiological and Mesoscale Shear Platforms
Europe PMC

Ultrastructural and Proteomic Signatures of Mechanoadaptive Fibroblast Remodeling across Microphysiological and Mesoscale Shear Platforms

Mechanical forces in the gut may help drive fibroblast activation and early fibrosis in IBD; models that reproduce this could help researchers study and eventually target fibrotic pathways relevant to stricturing...

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Bridging the Gap Between Endoscopy and Histology Indices: A Multi-Index Comparison in 146 Ulcerative Colitis Patients
International Journal of Surgical Pathology

Bridging the Gap Between Endoscopy and Histology Indices: A Multi-Index Comparison in 146 Ulcerative Colitis Patients

Histology and endoscopy are both used to assess UC activity; knowing which histologic score is reliable and practical helps clinicians and pathologists standardize monitoring and may streamline reporting in routine care.

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An Explainable Multimodal Model for Assessing Mucosal Healing in Small Bowel Crohn's Disease: A Multicenter Study with Prospective Validation.
Journal of imaging informatics in medicine

An Explainable Multimodal Model for Assessing Mucosal Healing in Small Bowel Crohn's Disease: A Multicenter Study with Prospective Validation.

A noninvasive, explainable model that combines CT enterography radiomics with CRP could make it easier to monitor mucosal healing in small‑bowel Crohn’s disease without repeated invasive enteroscopy, especially after...

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Symptom-Based Hospitalization Risk Differs Between Ulcerative Colitis and Crohn’s Disease: A Nationwide Emergency Department Study
Bratislava Medical Journal

Symptom-Based Hospitalization Risk Differs Between Ulcerative Colitis and Crohn’s Disease: A Nationwide Emergency Department Study

The study suggests ED presentation symptoms predict admission differently in UC versus CD, which could affect triage and short-term risk assessment for IBD patients. Knowing which symptoms are stronger predictors by...

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Genetic and microbial regulation of NOD2 signaling in homeostasis and disease.
MedScience

Genetic and microbial regulation of NOD2 signaling in homeostasis and disease.

NOD2 loss-of-function is a major genetic risk for Crohn’s disease, and this review highlights that gut microbes can modulate NOD2 signaling. That connection may help explain variation in disease risk and points to...

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IRF5 promotes the progression of ulcerative colitis by regulating macrophage polarization and Toll-like receptor signaling pathway.
Biochemical and biophysical research communications

IRF5 promotes the progression of ulcerative colitis by regulating macrophage polarization and Toll-like receptor signaling pathway.

The study links IRF5 to worse intestinal inflammation in UC and shows that reducing IRF5 activity lessens disease in a mouse model, suggesting IRF5 could be a future therapeutic target or biomarker.

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Inflammation-responsive sodium alginate-based microalgal hydrogel with pH/ROS dual sensitivity for oral colon-targeted therapy of ulcerative colitis.
International journal of biological macromolecules

Inflammation-responsive sodium alginate-based microalgal hydrogel with pH/ROS dual sensitivity for oral colon-targeted therapy of ulcerative colitis.

The study presents a new inflammation-responsive oral delivery system designed to concentrate antioxidant and anti-inflammatory activity in the colon, which could—if translated safely to humans—offer a way to treat...

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Vedolizumab trough concentrations and clinical and endoscopic outcomes in inflammatory bowel disease: a systematic review and meta-analysis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Vedolizumab trough concentrations and clinical and endoscopic outcomes in inflammatory bowel disease: a systematic review and meta-analysis.

Patients and clinicians using vedolizumab may be interested because the review links higher trough concentrations to better remission outcomes—most convincingly for endoscopic remission in UC—and provides descriptive...

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The exposome and inflammatory bowel disease: a framework for primary and primordial prevention
Nature Reviews Gastroenterology & Hepatology

The exposome and inflammatory bowel disease: a framework for primary and primordial prevention

The exposome perspective emphasizes that many non-genetic, potentially modifiable environmental factors likely influence IBD risk. Understanding these factors could help guide prevention research and public-health...

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Leucine-rich alpha-2 glycoprotein as a predictor of primary non-response to anti-TNF-α therapy in biologic-naïve Egyptian IBD patients
BMC Gastroenterology

Leucine-rich alpha-2 glycoprotein as a predictor of primary non-response to anti-TNF-α therapy in biologic-naïve Egyptian IBD patients

A blood biomarker that helps predict primary non-response to anti‑TNF drugs could spare some patients ineffective therapy, reduce delays to alternative treatments, and inform shared decision‑making before starting...

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Differential modulation of ferroptosis pathways by NOX1/4 and NLRP3 inhibition in DSS-induced colitis
Scientific Reports

Differential modulation of ferroptosis pathways by NOX1/4 and NLRP3 inhibition in DSS-induced colitis

This preclinical study links NOX1/4 and NLRP3 pathways to ferroptosis and iron metabolism in a mouse colitis model, highlighting potential mechanistic targets that could inform future precision therapies for ulcerative...

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CME Exam 2: β-Glucan and Inulin Estimated Intake Are Associated With Reduced Risk of Crohn's Disease, Improved Gut Barrier and Systemic Inflammation Markers, and Multi-Omic Signatures in a High-Risk Cohort
Gastroenterology

CME Exam 2: β-Glucan and Inulin Estimated Intake Are Associated With Reduced Risk of Crohn's Disease, Improved Gut Barrier and Systemic Inflammation Markers, and Multi-Omic Signatures in a High-Risk Cohort

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Diet and lifestyle. The original article is from Gastroenterology.

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Multi-omics analyses unveil gut microbiota and metabolites signatures in deoxycholic acid-associated intestinal inflammation.
Frontiers in microbiology

Multi-omics analyses unveil gut microbiota and metabolites signatures in deoxycholic acid-associated intestinal inflammation.

The study links high levels of the bile acid DCA to microbiome and metabolite changes that correlate with intestinal inflammation in mice, suggesting a possible pathway connecting high‑fat diets to colitis risk.

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Klebsiella pneumoniae in inflammatory bowel disease and rectal cancer: from gut inflammation to a potential driver of carcinogenesis.
Frontiers in microbiology

Klebsiella pneumoniae in inflammatory bowel disease and rectal cancer: from gut inflammation to a potential driver of carcinogenesis.

The review suggests that specific Klebsiella pneumoniae strains could connect chronic IBD inflammation with rectal cancer risk, pointing to possible biomarker or prevention targets that may be relevant for people with...

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Oral manifestations of Crohn's disease: a clinical image highlighting the importance of interdisciplinary gastroenterological and dental care.
Polish archives of internal medicine

Oral manifestations of Crohn's disease: a clinical image highlighting the importance of interdisciplinary gastroenterological and dental care.

Based on the title and source metadata, this appears to be a patient education related to Crohn's disease, Inflammatory bowel disease, and Symptoms and flares. The original article is from Polish archives of internal...

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Frequent Use of Restricted Oral Intake During Hospitalization for IBD Flares Was Not Associated with Improved Clinical Outcomes: A Multicenter Retrospective Cohort Study.
Digestive diseases and sciences

Frequent Use of Restricted Oral Intake During Hospitalization for IBD Flares Was Not Associated with Improved Clinical Outcomes: A Multicenter Retrospective Cohort Study.

This study suggests routine restriction of oral intake during IBD flares (without obstruction/abscess/fistula) is common but not linked to better short-term outcomes, so unnecessary fasting may be avoidable for many...

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Design, Synthesis, and Biological Evaluation of Novel Arylethanone Oxime Ether Derivatives as Potent S1PR1 Agonists for Ulcerative Colitis Therapy
Journal of Medicinal Chemistry

Design, Synthesis, and Biological Evaluation of Novel Arylethanone Oxime Ether Derivatives as Potent S1PR1 Agonists for Ulcerative Colitis Therapy

S1PR1 drugs (S1P modulators) are an important drug class for IBD; a selective S1PR1 agonist with less S1PR3 activity could mean fewer heart-related side effects. This preclinical work highlights a possible new candidate...

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Catalytic nanozymes for ulcerative colitis: harnessing immune-redox crosstalk for mucosal healing and disease remission
Journal of Nanobiotechnology

Catalytic nanozymes for ulcerative colitis: harnessing immune-redox crosstalk for mucosal healing and disease remission

The review describes a novel preclinical approach—catalytic nanozymes—that aims to reduce oxidative stress and re-balance immune responses in ulcerative colitis, which could eventually lead to new treatments for patients...

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Single-cell insights into drug response and resistance in inflammatory bowel disease: cellular hallmarks and precision therapy.
Journal of Crohn's & colitis

Single-cell insights into drug response and resistance in inflammatory bowel disease: cellular hallmarks and precision therapy.

Single-cell and spatial multi-omics help explain why many patients do not respond to current biologics and JAK inhibitors and point toward molecular and cellular biomarkers that could one day guide more precise treatment...

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Population-specific rare variants influence age at diagnosis in Korean inflammatory bowel disease.
The Korean journal of internal medicine

Population-specific rare variants influence age at diagnosis in Korean inflammatory bowel disease.

The report identifies rare, East-Asian–enriched genetic variants that appear to affect age at IBD diagnosis and disease progression, which could help explain clinical differences in Korean patients and guide future...

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