Article Archive

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Efficacy and Safety of Risankizumab Among Patients With Ulcerative Colitis in East Asia: A Post Hoc Analysis of Two Randomized Clinical Trials
Journal of Gastroenterology and Hepatology

Efficacy and Safety of Risankizumab Among Patients With Ulcerative Colitis in East Asia: A Post Hoc Analysis of Two Randomized Clinical Trials

Reports effectiveness and safety of risankizumab specifically in East Asian participants from global phase 2b/3 UC trials, which may inform regional applicability of trial results for people with moderate-to-severe...

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Very Early-Onset Ulcerative Colitis Manifesting as Acute Rectal Prolapse and Persistent Hematochezia in a Three-Year-Old Child: An Observational Analytic Case Study of Diagnostic Trajectory and Multimodal Intervention
Scientific Journal of Pediatrics

Very Early-Onset Ulcerative Colitis Manifesting as Acute Rectal Prolapse and Persistent Hematochezia in a Three-Year-Old Child: An Observational Analytic Case Study of Diagnostic Trajectory and Multimodal Intervention

This case highlights that full-thickness rectal prolapse in a toddler can be caused by very early-onset ulcerative colitis rather than isolated pediatric prolapse or allergy.

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Anti-Tumor Necrosis Factor-Alpha Associated Kaposi Sarcoma in a Patient with Ulcerative Colitis: A Case Report and Literature Review
Middle East journal of digestive diseases

Anti-Tumor Necrosis Factor-Alpha Associated Kaposi Sarcoma in a Patient with Ulcerative Colitis: A Case Report and Literature Review

Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis, Inflammatory bowel disease, and Complications. The original article is from Middle East journal of digestive...

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Endoscopic and histologic healing distribution and persistent rectosigmoiditis in moderate-to-severe ulcerative colitis
Inflammatory Bowel Diseases

Endoscopic and histologic healing distribution and persistent rectosigmoiditis in moderate-to-severe ulcerative colitis

If you have moderate-to-severe UC and are treated with adalimumab (or other therapies), this study suggests the rectum may be slower or less likely to reach endoscopic and histologic healing than more proximal colon...

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Reviewer #1 (Public review): GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohn’s disease
eLife Sciences Publications, Ltd

Reviewer #1 (Public review): GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohn’s disease

The review evaluates a revised preprint linking GM-CSF, macrophages, and ILC-like cells in Crohn’s disease using human spatial transcriptomics and zebrafish experiments. It highlights limitations that matter because they...

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A macrophage-targeted TIMD4 Peptide-Nanoparticle attenuates colitis symptoms and monocyte recruitment in a mouse model
PLOS Biology

A macrophage-targeted TIMD4 Peptide-Nanoparticle attenuates colitis symptoms and monocyte recruitment in a mouse model

New mouse-model research identifies TIMD4-dependent macrophage pathways that influence monocyte recruitment and colitis severity and tests a TIMD4-derived peptide delivered in nanoparticles that reduced inflammation in...

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Blood Neutrophil to Lymphocyte Ratio as a Marker of Inflammatory Bowel Disease Severity in Iranian Adults: a Cross-Sectional Survey
Middle East journal of digestive diseases

Blood Neutrophil to Lymphocyte Ratio as a Marker of Inflammatory Bowel Disease Severity in Iranian Adults: a Cross-Sectional Survey

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Tests and monitoring. The original article is from Middle East journal of digestive diseases.

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Laparoscopic surgery is associated with reduced long-term reoperation risk in Crohn's disease.
Techniques in coloproctology

Laparoscopic surgery is associated with reduced long-term reoperation risk in Crohn's disease.

Long-term risk of needing another intestinal surgery is a major concern for people with Crohn’s disease. This study suggests laparoscopic resection may be linked to lower long-term reoperation risk compared with open...

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Risk Factors for Early Intestinal Resection in Pediatric Crohn's Disease: A Nationwide Cohort Study.
The Journal of surgical research

Risk Factors for Early Intestinal Resection in Pediatric Crohn's Disease: A Nationwide Cohort Study.

Early intestinal resection is uncommon but important in pediatric Crohn’s disease. Identifying features linked to surgery soon after diagnosis can help families and clinicians monitor higher-risk children and plan care.

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Building sustainable IBD clinical research units: a practical toolbox emerging from a Belgian multi-stakeholder initiative.
Journal of Crohn's & colitis

Building sustainable IBD clinical research units: a practical toolbox emerging from a Belgian multi-stakeholder initiative.

Stronger, more sustainable IBD research units can increase patient access to clinical studies, speed up therapeutic and biomarker advances, and make care more research-ready. Patients and clinicians in centers with...

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Assessing inflammation and predicting relapse in ulcerative colitis is more accurate when performed by IBD specialized gastroenterologists
Crohn's & colitis 360

Assessing inflammation and predicting relapse in ulcerative colitis is more accurate when performed by IBD specialized gastroenterologists

Based on the title and source metadata, this appears to be a patient education related to Ulcerative colitis, Inflammatory bowel disease, and Tests and monitoring. The original article is from Crohn's & colitis 360.

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Maladaptive sensory coding in the enteric nervous system playing a role in gastrointestinal disorders.
Frontiers in cellular neuroscience

Maladaptive sensory coding in the enteric nervous system playing a role in gastrointestinal disorders.

This review connects enteric sensory neuron dysfunction to symptoms common in IBS and IBD (pain, diarrhea, constipation, dysmotility). Understanding IPAN plasticity could point to new treatment targets that act locally...

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Knowledge, Attitude, and Practice in Inflammatory Bowel Disease: Associated Factors and the Mediating Role of Attitude.
Patient preference and adherence

Knowledge, Attitude, and Practice in Inflammatory Bowel Disease: Associated Factors and the Mediating Role of Attitude.

Self-management is central to long-term IBD control. The study shows many patients have limited disease knowledge and less favorable attitudes, which could affect adherence, lifestyle choices, and follow-up.

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Gut Microbiota-Derived β-Glucuronidase Governs the Anticolitic Efficacy of Daidzein via the ERβ-PI3K/Akt/mTOR-Autophagy Axis
Journal of Agricultural and Food Chemistry

Gut Microbiota-Derived β-Glucuronidase Governs the Anticolitic Efficacy of Daidzein via the ERβ-PI3K/Akt/mTOR-Autophagy Axis

Findings suggest a dietary flavonoid (daidzein) may reduce colitis in mice via microbial activation and host signaling pathways, pointing toward microbiome-informed nutritional approaches for IBD.

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Integrative Analysis of Whole Exome Sequencing and Gene Expression to Uncover Genetic Mechanisms in Inflammatory Bowel Disease
Genes

Integrative Analysis of Whole Exome Sequencing and Gene Expression to Uncover Genetic Mechanisms in Inflammatory Bowel Disease

Identifying genes and pathways involved in IBD can point to new biological mechanisms, potential biomarkers, and future targets for research that may eventually inform diagnosis or treatment.

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Berberine as a dual-target therapeutic for ulcerative colitis
World Journal of Gastroenterology

Berberine as a dual-target therapeutic for ulcerative colitis

The review identifies berberine as a potential adjunct therapy for UC because it may target both gut microbes and epithelial inflammasome-mediated cell death, processes important in disease activity and barrier function.

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Ebastine attenuates DSS-induced ulcerative colitis via modulation of NF-κB, oxidative stress and pro-inflammatory cytokines: evidence for antihistamine repurposing
Inflammopharmacology

Ebastine attenuates DSS-induced ulcerative colitis via modulation of NF-κB, oxidative stress and pro-inflammatory cytokines: evidence for antihistamine repurposing

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Inflammopharmacology.

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Response surface-optimized Cycas revoluta leaf extract attenuates experimental ulcerative colitis through anti-inflammatory and oxidative stress-related mechanisms
Inflammopharmacology

Response surface-optimized Cycas revoluta leaf extract attenuates experimental ulcerative colitis through anti-inflammatory and oxidative stress-related mechanisms

This study reports that an optimized Cycas revoluta leaf extract reduced colon inflammation and markers of oxidative stress in a rat model of ulcerative colitis, suggesting it could be a source of bioactive compounds...

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A Comprehensive Ayurvedic Appraisement of Ulcerative Colitis: Pathophysiological Correlations and Management Strategies Via Purishavaha Sroto Dushti and Grahani Roga
International Journal of Innovative Science and Research Technology

A Comprehensive Ayurvedic Appraisement of Ulcerative Colitis: Pathophysiological Correlations and Management Strategies Via Purishavaha Sroto Dushti and Grahani Roga

The article offers an Ayurvedic framework for understanding and managing ulcerative colitis that may interest patients seeking complementary approaches and clinicians exploring integrative care. It emphasizes dietary and...

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HIF-1α-Driven Protein Lactylation Promotes Ferroptosis and Lipid Peroxidation in Ulcerative Colitis and Is Suppressed by Quercetin.
Experimental cell research

HIF-1α-Driven Protein Lactylation Promotes Ferroptosis and Lipid Peroxidation in Ulcerative Colitis and Is Suppressed by Quercetin.

The paper identifies a metabolic pathway (HIF-1α–driven lactylation leading to ferroptosis) that may contribute to epithelial injury in ulcerative colitis and proposes quercetin as a candidate inhibitor—potentially...

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KCTD10 Modulates DSS-induced Ulcerative Colitis via Regulating Intestinal Stem Cell Function.
The American journal of pathology

KCTD10 Modulates DSS-induced Ulcerative Colitis via Regulating Intestinal Stem Cell Function.

This study identifies KCTD10 as a regulator of intestinal stem cell function and mucosal repair in experimental colitis, which could point to new mechanistic insights about why epithelial healing fails in some cases of...

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Beyond the pelvis: redefining endometriosis as a systemic inflammatory disorder. A systematic review and meta-analysis.
Autoimmunity reviews

Beyond the pelvis: redefining endometriosis as a systemic inflammatory disorder. A systematic review and meta-analysis.

If endometriosis is linked to other immune, allergic, or chronic pain conditions, people with endometriosis may benefit from broader evaluation and coordinated care beyond gynecology. The review suggests shared...

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Perianal fistulizing Crohn's disease: emerging biology, therapeutics, and roadmap for precision treatment.
Trends in pharmacological sciences

Perianal fistulizing Crohn's disease: emerging biology, therapeutics, and roadmap for precision treatment.

Perianal fistulizing Crohn's disease is a frequent, hard-to-treat complication; molecular and multiomic advances could lead to biomarkers that help choose better-targeted therapies and improve surgical–medical decision...

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