Crohn's disease

Long-term results suggest endoscopic approaches—especially balloon dilatation—help many people with Crohn’s strictures avoid surgery and have fewer severe complications compared with surgical treatment.

Mucosal colonisation by adherent‑invasive E. coli has been implicated in Crohn’s disease for some patients; this study suggests FMT can change the mucosal microbiome and clear AIEC in a small pilot cohort, which could be...

This large national-registry study identifies clinical features linked with needing optimization of biologic or small-molecule therapies in CD and UC. That helps show which patient groups more often require...

Findings about increased LRRK2 in colonic tissue may point to shared immune or genetic mechanisms between Crohn’s disease and neurological disorders, which could be relevant for future research and biomarker development.

The study suggests starting anti-TNF therapy with an immunomodulator at diagnosis may reduce surgery, hospital stays, and progression to complicated Crohn’s over 5 years — outcomes that matter to patients and clinicians...

A noninvasive, explainable model that combines CT enterography radiomics with CRP could make it easier to monitor mucosal healing in small‑bowel Crohn’s disease without repeated invasive enteroscopy, especially after...

Shifting care toward disease modification could reduce long-term bowel damage and disability for people with Crohn's disease by prioritizing earlier, more effective treatment and exploring prevention strategies.

The study suggests ED presentation symptoms predict admission differently in UC versus CD, which could affect triage and short-term risk assessment for IBD patients. Knowing which symptoms are stronger predictors by...

NOD2 loss-of-function is a major genetic risk for Crohn’s disease, and this review highlights that gut microbes can modulate NOD2 signaling. That connection may help explain variation in disease risk and points to...

Early effective treatment may change long-term outcomes in Crohn's disease. Understanding the timing of a potential "window of opportunity" could affect decisions about when to start or escalate therapy.

The paper links ileitis and changes in enterohepatic bile-acid composition to altered Th17 immune activity, suggesting bile-acid balance could influence inflammation in Crohn’s disease and might be a target for future...

Malnutrition is common in IBD and worsens clinical course and quality of life. Better screening and assessment can identify people who need nutritional support.

Patients and clinicians using vedolizumab may be interested because the review links higher trough concentrations to better remission outcomes—most convincingly for endoscopic remission in UC—and provides descriptive...

Joint swelling and fever can sometimes be caused by IBD-related inflammatory arthritis rather than infection. People with communication barriers may not report chronic bowel symptoms, delaying the correct diagnosis.

The exposome perspective emphasizes that many non-genetic, potentially modifiable environmental factors likely influence IBD risk. Understanding these factors could help guide prevention research and public-health...

A blood biomarker that helps predict primary non-response to anti‑TNF drugs could spare some patients ineffective therapy, reduce delays to alternative treatments, and inform shared decision‑making before starting...

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Diet and lifestyle. The original article is from Gastroenterology.

Based on the title and source metadata, this appears to be a patient education related to Crohn's disease, Inflammatory bowel disease, and Symptoms and flares. The original article is from Polish archives of internal...

This study suggests routine restriction of oral intake during IBD flares (without obstruction/abscess/fistula) is common but not linked to better short-term outcomes, so unnecessary fasting may be avoidable for many...

The report identifies rare, East-Asian–enriched genetic variants that appear to affect age at IBD diagnosis and disease progression, which could help explain clinical differences in Korean patients and guide future...

Setons are often used to control sepsis in complex anal fistula, but this study suggests outcomes are worse when Crohn's disease is present, meaning clinicians may view long-term setons as temporary measures in CD rather...

The findings give clinicians and patients data on how often biologic therapy leads to endoscopic remission in biologic‑naïve patients with isolated small‑bowel Crohn's disease, and they suggest similar effectiveness...

Spatially resolved profiling could identify the specific cell neighborhoods and signaling circuits that drive disease in a person’s gut tissue, which may help predict who will respond to particular biologics or small...

Noninvasive detection of intestinal fibrosis activity could help identify patients at risk of progressive scarring and surgery, and enable development or targeting of anti-fibrotic treatments for Crohn's disease.

Older adults with IBD face tradeoffs between effectiveness and safety of advanced therapies; this study aims to identify immune‑aging and frailty markers that might predict who is more likely to benefit without serious...

Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Advances and Applications...

If you're living with Crohn's disease, earlier and better diagnosis (for example, more cross-sectional imaging) may partly explain falling surgery rates over time. This study suggests system-level diagnostic improvements...

Based on the title and source metadata, this appears to be a case report related to Crohn's disease and Pediatrics and family. The original article is from Frontiers in pediatrics.

Postoperative endoscopic recurrence is common after ileocolonic resection for Crohn’s disease; this study suggests biologic drugs started after surgery are linked to lower recurrence rates. Knowing which biologics...

Cure8 found this source from crohnscolitisfoundation.org, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease, Crohn's disease, and Access, cost, and policy. Open the original article...

The findings identify a natural microbial metabolite (urolithin A) that appears to strengthen the intestinal barrier and aid tissue repair via a specific receptor and inflammasome pathway, suggesting new, more targeted...

The article highlights a natural gut-microbe product (urolithin A) that may help repair the intestinal lining by activating a protective molecular pathway.

Researchers are testing whether blocking three inflammation pathways at once can reduce tissue inflammation more than single drugs. If ex vivo results show stronger effects, it could guide development of multi-target...

Postoperative recurrence is common after intestinal resection for Crohn's disease, but clinicians currently lack reliable molecular biomarkers or validated models to predict who will relapse.

The study identifies a macrophage-driven mechanism (IL-1β–linked ferroptosis-like lipid peroxidation) that may contribute to epithelial injury in Crohn’s disease, suggesting new biological targets that could eventually...

If UPFs increase Crohn's risk by lowering DHA, that points to a measurable metabolic pathway linking diet and disease. Understanding this could inform dietary prevention strategies or targeted nutrition research for...

MRE is a key radiation-free imaging tool for children with Crohn’s disease; this review summarizes its clinical utility and how it fits with other pediatric-focused diagnostic approaches in Japan.

Genetic evidence that PBC may causally influence risk of IBD (and UC specifically) could help explain observed co-occurrence of these autoimmune diseases and point researchers toward shared pathways worth studying.

Phages shape the gut microbial community and may behave differently in inflamed guts. Understanding phage evolution in IBD could eventually inform microbiome-targeted therapies or explain disease-associated microbial...

TGF-β1 is a central regulator implicated in inflammation control, development of fibrosis, and possible cancer progression in Crohn’s disease; advances in this area could inform future treatments or biomarker...

Cure8 could only read part of this source from tradingview.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Crohn's disease, and Inflammatory bowel disease.

Biologics are commonly recommended for moderate-to-severe Crohn's disease and can change disease course by healing inflammation, so understanding their benefits, risks, and cost/access issues helps patients make informed...

An orally dosed, gut-targeted PDE4 prodrug entering Phase 2 could offer a new locally acting anti-inflammatory option for people with UC or Crohn’s, potentially with fewer systemic side effects than older PDE4 drugs.

Stopping Crohn's medications can cause flares and serious complications, and restarting treatment may be slower or less effective. Adherence and financial or practical support can help prevent these harms.

Treating fibrotic strictures would address an unmet need in Crohn’s disease — current approved drugs target inflammation, not established fibrosis. Positive Phase 2a signals could eventually lead to a new pharmacologic...

Baseline MRE features may help predict which Crohn's strictures will not improve with advanced medical therapy, informing monitoring and surgical planning. Better stratification could guide decisions about earlier...

Researchers link a bacterial metabolic pathway (pdu/pduB) in AIEC to intestinal inflammation and show that host vitamin B12 availability can reduce bacterial invasion and colitis in mice—suggesting a modifiable host...

Patients and clinicians often need real-world data on how methotrexate is actually used in IBD outside trials—this study shows it’s commonly paired with biologics, usually given subcutaneously, and has a median use of...