Condition

Crohn's disease

Crohn's disease news across medications, symptoms, tests, procedures, complications, research, access, and daily life.

Page 15 of 53 · 2517 articles

Atraumatic Knee Marrow Edema-Like Signal Preceding a Low-Energy Bicondylar Tibial Plateau Fracture in a Patient with Crohn Disease: A Case Report.
Journal of visualized experiments : JoVE

Atraumatic Knee Marrow Edema-Like Signal Preceding a Low-Energy Bicondylar Tibial Plateau Fracture in a Patient with Crohn Disease: A Case Report.

Bone marrow edema–like MRI signal in people with Crohn disease and prior steroid exposure can be an early warning sign of underlying bone fragility. Recognizing worsening load-related pain with such imaging may prompt...

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Altered colonic keratin expression as a biomarker signature distinguishes IBD, microscopic colitis, and IBS – a retrospective study
BMC Gastroenterology

Altered colonic keratin expression as a biomarker signature distinguishes IBD, microscopic colitis, and IBS – a retrospective study

Biopsy-based keratin patterns might help distinguish IBD, microscopic colitis, and IBS—conditions that can look similar clinically—so this could improve diagnostic accuracy if validated.

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Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026
Annals of Gastroenterological Surgery

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Surgery is still a core part of care for certain UC and Crohn's patients despite better medical therapies. Newer surgical techniques and coordinated medical–surgical approaches aim to reduce complications and recurrence...

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Declining rates of surgery in pediatric-onset inflammatory bowel disease: a Swedish nationwide register-based cohort study 2002-2022.
Journal of Crohn's & colitis

Declining rates of surgery in pediatric-onset inflammatory bowel disease: a Swedish nationwide register-based cohort study 2002-2022.

A decreasing need for IBD-related surgery after pediatric diagnosis could mean fewer major operations and related recovery for children and young adults. It may reflect the growing use of advanced medical therapies in...

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Evaluation of the Correlation of Calprotectin and SES-CD Score at the Time of Diagnosis and Follow-up After Diagnosis in Pediatric Patients With Crohn's Disease in Korea.
Journal of Korean medical science

Evaluation of the Correlation of Calprotectin and SES-CD Score at the Time of Diagnosis and Follow-up After Diagnosis in Pediatric Patients With Crohn's Disease in Korea.

Noninvasive fecal calprotectin levels tracked with endoscopic disease activity in children with colonic Crohn's disease, suggesting FC could help reduce repeat endoscopies and better monitor treatment response.

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Layer-Resolved Spatial Transcriptomic Profiling Reveals Distinct Fibrotic and Muscularizing Submucosal Niches in Fibrostenotic Crohn's Disease

The study maps layer-specific gene programs in fibrostenotic Crohn's disease and pinpoints the submucosa as a hotspot for fibromuscular remodeling that underlies strictures and bowel obstruction risk.

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Large-scale transcriptomic meta-analysis identifies constitutive and inflammation-dependent layers in ulcerative colitis
Scientific Reports

Large-scale transcriptomic meta-analysis identifies constitutive and inflammation-dependent layers in ulcerative colitis

This study identifies reproducible molecular patterns in UC tissue that could help researchers target non-immune pathways (metabolic/mitochondrial) in addition to inflammation, and it highlights that apparently...

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Illness perceptions and perceived functional health literacy in inflammatory bowel disease: a multicentre longitudinal study
Scientific Reports

Illness perceptions and perceived functional health literacy in inflammatory bowel disease: a multicentre longitudinal study

Illness perceptions and perceived ability to understand health information are linked to self-care in IBD. If worse illness perceptions tend to lead to later increases in perceived difficulty understanding written...

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A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
ClinicalTrials.gov

A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

The study aims to map the specific peptide targets of T cells driving organ inflammation in autoimmune diseases, which could guide development of antigen-specific, tolerogenic treatments relevant to Crohn's disease and...

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Raising the Bar in Crohn's Disease: Is Transmural Healing Achievable?
Diagnostics (Basel, Switzerland)

Raising the Bar in Crohn's Disease: Is Transmural Healing Achievable?

Transmural healing may better reflect the full depth of inflammation in Crohn’s disease than mucosal healing alone and is associated with improved long-term outcomes in many studies. If validated and adopted, TH could...

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Comprehensive Phenotyping of Circulating T- and B-Cell Subsets in Patients with Ankylosing Spondylitis Associated with Crohn's Disease.
Cells

Comprehensive Phenotyping of Circulating T- and B-Cell Subsets in Patients with Ankylosing Spondylitis Associated with Crohn's Disease.

If confirmed, distinct circulating T- and B-cell patterns could help researchers and clinicians better understand immune differences in patients who have both ankylosing spondylitis and Crohn's disease, and could point...

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Factors Affecting the Adherence to Partial Enteral Nutrition Combined with the Crohn's Disease Exclusion Diet in Crohn's Disease Adult Patients.
Healthcare (Basel, Switzerland)

Factors Affecting the Adherence to Partial Enteral Nutrition Combined with the Crohn's Disease Exclusion Diet in Crohn's Disease Adult Patients.

Dietary therapy using the Crohn’s Disease Exclusion Diet plus partial enteral nutrition is an evidence-based nonpharmacologic option for active Crohn’s disease, but adult adherence is often poor. Understanding barriers...

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Application of a structured perianal skin protection protocol incorporating individualized nutritional support for incontinence-associated dermatitis in active Crohn's disease patients with diarrhea.
Medicine

Application of a structured perianal skin protection protocol incorporating individualized nutritional support for incontinence-associated dermatitis in active Crohn's disease patients with diarrhea.

Perianal skin damage from diarrhea (IAD) is common and painful in active Crohn's disease. A combined skin-protection plus individualized nutrition approach was associated with lower IAD rates, less pain, and faster...

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Is There a Way to Break the Glass Ceiling in the Diagnosis and Treatment of Extraintestinal Manifestations (EIMs) in the Course of Inflammatory Bowel Diseases? A Comprehensive Review of Diagnosis, Pathophysiology, and Treatment of EIM
Journal of Clinical Medicine

Is There a Way to Break the Glass Ceiling in the Diagnosis and Treatment of Extraintestinal Manifestations (EIMs) in the Course of Inflammatory Bowel Diseases? A Comprehensive Review of Diagnosis, Pathophysiology, and Treatment of EIM

Extraintestinal manifestations (skin, joint, eye, liver) are common in IBD and can greatly affect quality of life; better recognition and coordinated care can speed diagnosis and improve outcomes.

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Risk of hepatobiliary and colorectal malignancies in primary sclerosing cholangitis: Crohn’s disease with colonic involvement versus ulcerative colitis - a propensity-matched cohort study
Scandinavian Journal of Gastroenterology

Risk of hepatobiliary and colorectal malignancies in primary sclerosing cholangitis: Crohn’s disease with colonic involvement versus ulcerative colitis - a propensity-matched cohort study

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Crohn's disease, and Ulcerative colitis. The original article is from Scandinavian Journal of...

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Explainable random forest–SHAP framework for Montreal phenotype–stratified prediction of one-year complications in Crohn’s disease
Frontiers in Physiology

Explainable random forest–SHAP framework for Montreal phenotype–stratified prediction of one-year complications in Crohn’s disease

A model that predicts one-year risks for surgery and complications by Montreal phenotype could help identify patients at higher short-term risk and guide research into targeted monitoring or interventions.

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Small but mighty: the human mycobiome as an immunopharmacological regulator of inflammation and autoimmunity.
International immunopharmacology

Small but mighty: the human mycobiome as an immunopharmacological regulator of inflammation and autoimmunity.

Fungi in the gut appear to influence immune pathways implicated in IBD and other autoimmune diseases, suggesting new therapeutic targets and microbiome-based interventions that could affect disease activity.

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Digitally supported, patient-initiated care: Maintaining control of inflammatory bowel diseases while achieving high patient satisfaction.
International journal of medical informatics

Digitally supported, patient-initiated care: Maintaining control of inflammatory bowel diseases while achieving high patient satisfaction.

Shifting to patient-initiated, digitally supported follow-up could maintain disease control while reducing routine fixed-interval visits and improving patient experience — relevant as IBD patient numbers grow and clinic...

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Macrophage plasticity as a therapeutic target in inflammatory bowel disease: Immunomodulatory and regenerative strategies.
International immunopharmacology

Macrophage plasticity as a therapeutic target in inflammatory bowel disease: Immunomodulatory and regenerative strategies.

Macrophages are central regulators of intestinal inflammation and repair; understanding their diversity and how to modulate them could lead to new, more targeted treatments for Crohn's disease and ulcerative colitis.

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Extreme temperature events and hospitalizations for 59 autoimmune diseases in Korea: A nationwide outcome-wide, time-stratified, case-crossover study.
Environmental research

Extreme temperature events and hospitalizations for 59 autoimmune diseases in Korea: A nationwide outcome-wide, time-stratified, case-crossover study.

Short periods of extreme heat may modestly increase the chance of hospitalization for IBD and Crohn’s disease. Patients and clinicians should be aware that temperature extremes could be a trigger for worsening disease...

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A robustness-first cross-disease framework supports a candidate shared microbial redox axis and disease-specific metabolic divergence in colorectal cancer, Crohn's disease, and liver cirrhosis.
mSystems

A robustness-first cross-disease framework supports a candidate shared microbial redox axis and disease-specific metabolic divergence in colorectal cancer, Crohn's disease, and liver cirrhosis.

Researchers found a candidate shared microbial signal across colorectal cancer, Crohn’s disease, and liver cirrhosis that points to redox-related microbial functions; this could guide future biomarker or experimental...

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Therapeutic response to exclusive enteral nutrition correlates with suppressed IL-17 signaling activity and diminished IL-1β secretion in pediatric Crohn's disease
Frontiers in Nutrition

Therapeutic response to exclusive enteral nutrition correlates with suppressed IL-17 signaling activity and diminished IL-1β secretion in pediatric Crohn's disease

Shows molecular correlates (reduced IL‑17 signaling and IL‑1β) linked with mucosal healing after exclusive enteral nutrition in children with Crohn's disease, which may help researchers develop biomarkers or understand...

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Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease
ClinicalTrials.gov

Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease

Psychological distress and gut–brain interactions can worsen quality of life and IBD outcomes. A culturally tailored, scalable digital mind–body program could improve access to psychosocial care for Black and Hispanic...

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Optimizing Endoscopic Assessment of Postoperative Crohn's Disease: A Scoping Review.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

Optimizing Endoscopic Assessment of Postoperative Crohn's Disease: A Scoping Review.

Endoscopic scores guide detection and treatment of postoperative Crohn's recurrence; better scoring could change who gets earlier therapy and potentially prevent clinical or surgical relapse.

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Major cardiovascular event risk of advanced therapies in inflammatory bowel diseases: systematic review and meta-analysis
Inflammation Research

Major cardiovascular event risk of advanced therapies in inflammatory bowel diseases: systematic review and meta-analysis

A pooled analysis of cardiovascular risk tied to advanced IBD therapies could affect treatment decisions and monitoring plans because some immune-targeted drugs have been linked to cardiovascular safety concerns in other...

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Macrophage SELENOP controls neutrophil homeostasis through redox stress regulation in Crohn's disease.
Redox biology

Macrophage SELENOP controls neutrophil homeostasis through redox stress regulation in Crohn's disease.

The paper identifies macrophage SELENOP as a regulator of oxidative stress and neutrophil behavior in Crohn’s disease samples and mouse models, pointing to a new mechanism that could become a target for future treatments...

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