Nutrition, food, supplements, exercise, sleep, stress, and lifestyle research for Crohn's disease and IBD.
Page 8 of 24 · 1124 articles
The paper identifies a molecular pathway (miR-31-5p/SATB2) linked to UC progression to colitis-associated cancer and reports that resveratrol modulates this axis in mice, suggesting a potential preventive mechanism worth...
GPX and selenium-related pathways may be important to how oxidative stress, ferroptosis, and the microbiome contribute to IBD. Understanding these mechanisms could guide future therapies.
People with IBD may hear about botanical treatments; this study provides preclinical data that Micromeria imbricata extracts showed beneficial effects in a mouse colitis model and identified compounds that dock to...
Fungi in the gut appear to influence immune pathways implicated in IBD and other autoimmune diseases, suggesting new therapeutic targets and microbiome-based interventions that could affect disease activity.
This paper outlines research strategies aiming to deliver drugs more precisely to inflamed gut tissue and to reshape immune-cell behavior — advances that could eventually lead to safer, more targeted IBD treatments. It’s...
Macrophages are central regulators of intestinal inflammation and repair; understanding their diversity and how to modulate them could lead to new, more targeted treatments for Crohn's disease and ulcerative colitis.
Short periods of extreme heat may modestly increase the chance of hospitalization for IBD and Crohn’s disease. Patients and clinicians should be aware that temperature extremes could be a trigger for worsening disease...
Researchers found a candidate shared microbial signal across colorectal cancer, Crohn’s disease, and liver cirrhosis that points to redox-related microbial functions; this could guide future biomarker or experimental...
Breakfast choices can affect digestion and symptoms for people with Crohn’s. This article offers recipes and practical tips (soluble fiber, cooked fruit, probiotics, lower-lactose options) designed to be easier on the...
If validated, impaired oxalate handling could help explain why some people with IBD react differently to the same plant-rich diet and point to new dietary or microbiome-based interventions to reduce gut inflammation.
Shows molecular correlates (reduced IL‑17 signaling and IL‑1β) linked with mucosal healing after exclusive enteral nutrition in children with Crohn's disease, which may help researchers develop biomarkers or understand...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Materials today. Bio.
PUC often behaves differently and more aggressively than adult-onset UC; understanding pediatric‑specific causes and treatments could lead to better, more effective therapies for children.
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease and Diet and lifestyle. The original article is from Nutrients.
This project investigates how estrogen receptor signaling in intestinal epithelial cells drives sex-specific responses to injury and inflammation that may influence ulcerative colitis risk and progression.
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Foods (Basel, Switzerland).
The study links a common dietary compound (oxalate) to worsened intestinal inflammation in IBD and identifies reduced gut oxalate-transport gene activity and microbiome differences as possible mechanisms—findings that...
Better detection of enteric infections during suspected IBD flares could help avoid unnecessary escalation of immunosuppressive therapy and guide appropriate antibiotic use. This review suggests MPCR finds more pathogens...
The study shows that fecal (luminal) and mucosal microbiome and metabolite profiles capture different aspects of pediatric IBD—activity versus phenotype—so combined sampling may give a fuller picture for research and...
Based on the title and source metadata, this appears to be a patient education related to Inflammatory bowel disease and Diet and lifestyle. The original article is from Cureus.
People with IBD and their clinicians need to know whether common IBD treatments change COVID-19 risk or should be stopped. This review provides practical recommendations (continue most maintenance drugs; avoid systemic...
The mucus layer and goblet cells are central to colonic barrier function; understanding goblet cell diversity and plasticity could point to new ways to restore the mucus barrier in UC and improve disease control.
The work highlights a widespread tire-derived contaminant (6PPDQ) that may worsen colitis in a mouse model by disturbing key molecular pathways; this raises questions about whether environmental pollutants could...
The study suggests a common plant compound (oxalate) may build up in the intestines of people with IBD because transporter proteins are reduced, potentially worsening inflammation. If confirmed, this could influence...
This study identifies a specific gut microbe (Turicimonas muris) and an immune pathway link by which a high-fat diet reduced experimental colitis severity in mice, suggesting diet–microbiome interactions can strongly...
The paper describes a new nanodelivery method that improves targeted delivery of 5‑ASA in preclinical models, which could eventually address limitations of oral mesalazine formulations for colonic inflammation.
This study suggests airborne, soil-associated microbes can change the gut microbiome and reduce colitis severity in mice — a possible explanation for lower ulcerative colitis rates in rural areas. If similar effects...
If donor ethnicity or specific microbial/metabolite signatures influence FMT success, results could help identify optimal donors or develop targeted microbiota-based treatments for ulcerative colitis.
This trial tests a safe, non-drug supplement (GlcNAc) as a precision-medicine approach for Crohn's disease based on a genetic variant that affects glycosylation. If successful, it could offer a new, well-tolerated...
This study suggests a new preclinical approach to help the gut lining heal in ulcerative colitis by targeting macrophage metabolism (myeloid AMPK) rather than directly treating epithelial cells. That could matter for...
This paper describes a novel nanozyme that reduced oxidative stress and inflammation in preclinical models of colitis and enteropathic arthritis — a possible future therapeutic approach that targets ROS in inflamed gut...
Low muscle mass before ileocolic resection appears linked to higher short-term surgical complications and higher rates of endoscopic recurrence — information that could affect preoperative assessment and planning for...
The ENS–gut microbiota field intersects with IBD research through shared mechanisms (neuroinflammation, neuro‑immune interactions) and potential microbiota‑based therapies, so mapping trends helps patients and clinicians...
Wearable-derived digital biomarkers aim to detect flares earlier and reduce reliance on questionnaires; patients' acceptance is essential for real-world use. High reported willingness suggests patient-centered...
Microplastics are a widespread environmental exposure that this review links to biological changes relevant to IBD — intestinal barrier damage, microbiome shifts, and immune activation — so patients and clinicians may...
The study suggests FMT can clear mucosal adherent‑invasive E. coli (AIEC) in some people with Crohn’s disease and alters mucosal microbiome features linked to inflammation, which could be relevant to microbiome‑targeted...
The intestinal barrier changes in inflammation and can alter how oral nanocarriers interact with mucus and epithelium; understanding this is important for designing delivery systems that achieve local therapeutic benefit...
Many people with IBD remain symptomatic even when tests show little or no inflammation; recognising these persistent symptoms as a separate treatment target could improve quality of life. This reframes care to address...
This study shows that sodium butyrate, a metabolite produced by gut bacteria, changed brain imaging measures and reduced inflammation in mice with experimental IBD, supporting the idea that gut-derived compounds can...
The study suggests a probiotic–ω‑3 combination (a synbiotic) might boost the anti‑inflammatory, pro‑resolving effects of ω‑3s in colonic tissue—potentially relevant for people with ulcerative colitis looking for adjunct...
IL-22 links microbial metabolites to epithelial repair and inflammation; clarifying these pathways could inform future therapies or dietary/microbiome approaches to promote mucosal healing without worsening inflammation.
This review highlights a new, non-live microbiome-based therapy approach (probiotic-derived EVs) that could in future modulate gut immunity and barrier function without using live microbes. For people with IBD, such...
Simple, routinely measured nutritional scores were associated with early (14-week) remission on vedolizumab in patients with moderate-to-severe UC, which could help identify patients more likely to respond early to this...
The study links a specific gut microbe and its metabolite to reduced inflammation and improved barrier function in ulcerative colitis models and cohort comparisons, suggesting a potential new microbiome-targeted therapy...
The study proposes a new redox-regulatory pathway (Grx1–STAT6) that helps M2 macrophages drive tissue repair and colitis recovery in preclinical models, pointing to a possible new therapeutic target to promote...
Malnutrition is common and can worsen outcomes in IBD; this case shows use of combined enteral and parenteral nutritional support for severe malnutrition in newly diagnosed Crohn’s disease, including perioperative...
Differences in urbanisation and socioeconomic development may help explain rising IBD rates in newly industrialised regions and point to where earlier diagnosis and healthcare planning might be needed. The association...
The study proposes a new oral nanoparticle that targets neutrophil-driven oxidative stress linked to mucosal barrier damage, a mechanism relevant to IBD pathology. If translatable, this approach could add a new modality...
