Nutrition, food, supplements, exercise, sleep, stress, and lifestyle research for Crohn's disease and IBD.
Page 9 of 24 · 1124 articles
The study suggests higher dietary antioxidant intake (measured by CDAI) may be linked to lower Crohn's disease risk and that inflammation biomarkers could partly explain the association—information potentially relevant...
The study describes a targeted oral delivery system for 5-ASA that aims to concentrate drug release in the colon and also leverage inulin’s prebiotic/immunomodulatory properties—potentially improving effectiveness and...
Depression is common in Crohn’s disease and appears linked to immune and microbial signals from the gut. Understanding gut–brain mechanisms could improve how mood symptoms are detected and treated in people with IBD.
Targeted oral delivery of melatonin could reduce inflammation and help repair the intestinal barrier in UC by acting on macrophages and epithelial cells. If translated to humans, this approach might offer a locally...
AMPs are central to gut immune balance and are being explored as new therapies for IBD and related gut diseases. For people with Crohn’s or IBD, understanding AMPs helps explain research directions aimed at restoring...
The study reports anti-inflammatory and antioxidant effects of a new andrographolide formulation in a macrophage model relevant to ulcerative colitis, highlighting a potential early-stage therapeutic lead that may...
People with IBD are often interested in how dietary fibers and the microbiome might influence inflammation.
Stress and psychological distress are common in people with IBD and may influence symptoms and inflammation. This trial tests whether an 8‑week MBSR program can improve psychological wellbeing and whether those benefits...
Malnutrition and growth failure at diagnosis are common in children with IBD—especially Crohn’s—and can indicate higher inflammatory burden. Monitoring and addressing nutrition and growth is important because most...
Nutritional risk, gut inflammation (measured by fecal calprotectin), and depression were linked to worse quality of life in people with IBD. Recognizing and addressing nutrition, inflammation, and mood together could...
The paper presents a proof-of-concept immune-based assay to match donors and recipients for FMT in IBD, which could help explain variable FMT outcomes and improve donor selection if validated.
The study identifies a β-glucan → IL-33 → active eosinophil pathway that reduced colitis in a mouse model, suggesting a novel immunomodulatory mechanism that could inform future IBD research.
Intestinal barrier dysfunction is a likely driver of inflammation and flares in ulcerative colitis, so therapies that restore barrier integrity could help reduce disease activity and recurrence. This review highlights...
This mouse study connects fat malabsorption, increased gut permeability, microbiome shifts, and reduced oxalate transport to higher oxalate absorption and kidney injury—mechanisms relevant to enteric hyperoxaluria seen...
Researchers are exploring ways to improve cell therapies for IBD by making therapeutic cells produce anti-inflammatory molecules like IL-10. If scalable and safe, non-viral engineering of MSCs could lead to...
The work links climate and sociodemographic context to IBD burden in tropical regions, which can influence diagnostic recognition, resource needs, and research priorities for communities where IBD is rising.
People with IBD commonly experience anxiety, depression, and other neurological symptoms. Understanding gut–brain axis mechanisms may help explain these comorbidities and point to future treatments.
This project tests whether common nanoplastics that people ingest could damage the gut barrier, alter gut microbes’ estrogen metabolism, and injure enteric nerves — processes that might increase risk or severity of IBD.
Piezo channels appear central to how mechanical signals influence the gut barrier, immunity, and secretion — processes that can affect inflammation and symptoms in IBD, IBS, and colon cancer. Understanding them could...
This project could introduce a novel, microbiome-targeted oral therapy for Crohn’s disease if the Phase II trial confirms safety and clinical benefit; that matters because many patients need new options when current...
Oral and upper-GI involvement in Crohn's can be missed and may change how disease is diagnosed and managed. A focused review helps clinicians and researchers spot gaps in diagnostics and treatment research.
Many people with IBD also have overweight or obesity; GLP-1 receptor agonists are being used for weight loss and may affect inflammation and IBD outcomes. This review summarizes current evidence on safety, effectiveness,...
The microbiome is connected to IBD through effects on immune regulation and barrier function; advances in understanding could inform future microbiome-directed therapies that matter to people with IBD.
This study reports a non-invasive fluorescence probe that detects a reactive nitrogen species (peroxynitrite) linked to intestinal inflammation and shows signal changes in cells, animal models, and mouse feces — a...
A potential link between ultra-processed food intake and Crohn’s relapse could influence dietary conversations for people in remission, but the current evidence is weak and not definitive.
Early-stage research suggests a specific probiotic strain may reduce inflammation and alter the gut microbiome and immune-related proteins in an animal model of ulcerative colitis, which could point to future therapeutic...
A naturally occurring pigment (C3G) improved inflammation and barrier markers in a mouse colitis model, which could be of interest to people exploring nutrition-related ways to support gut health.
This study describes a new microbiome-engineering approach that reduced inflammation in mouse colitis models by sequestering cysteine and altering T cell behavior. If followed up, it could point to novel future therapies...
This preclinical study suggests a heat‑killed form of Lactobacillus acidophilus LA‑5 reduced inflammation, oxidative stress, and markers of regulated cell death in a mouse model of ulcerative colitis — with effects...
FUT2-dependent intestinal fucosylation helps shape which gut microbes thrive and how the mucosa resists pathogens. For people with IBD, differences in FUT2 function and altered fucosylation may contribute to microbiome...
If blood bile acid patterns are reproducibly different in IBD and track with disease activity, they could become noninvasive biomarkers to help diagnose IBD or monitor flares. That would be useful for patients and...
Cure8 found this source from onlinelibrary.wiley.com, but the page could not be read reliably yet. It is tagged for Crohn's disease, Inflammatory bowel disease, and Diet and lifestyle. Open the original article for the...
This study describes a novel colon-targeted microgel delivery system carrying an anti-inflammatory natural compound that, in a mouse model, reduced colitis signs and altered gut bacteria — a potential new strategy for...
Diet is a modifiable factor that could influence IBD risk through effects on the gut microbiome and immune pathways.
The study shows malnutrition is common in Crohn’s disease and much more likely during active inflammation, highlighting the need for routine nutritional screening and more than one type of assessment.
Persistent fatigue is a common disabling symptom in IBD even during remission; a structured adapted physical activity program could offer a non-drug way to improve daily functioning if the trial shows benefit.
People with stricturing Crohn’s disease currently lack effective medical treatments to prevent or reverse intestinal fibrosis; this trial explores a probiotic approach (and trehalose) aimed at stimulating autophagy, a...
The study links a common dietary fiber (green banana resistant starch) to microbiota changes and production of propionate that protect the colonic barrier and reduce inflammation in a mouse model of ulcerative colitis.
This study proposes specific plant compounds and molecular pathways that could be relevant to ulcerative colitis, which may guide future lab research and drug-discovery efforts. For people with UC, it points to...
The study suggests molecular targets and pathways through which a traditional herbal formula might influence UC biology, offering testable hypotheses for future lab and clinical research.
Researchers are exploring ways to deliver drugs selectively to inflamed gut tissue in IBD to boost local effectiveness and reduce systemic side effects. Progress in smart nanoparticles and hydrogels could eventually...
Both EEN and the Crohn’s disease exclusion diet are used to induce remission in children with Crohn’s disease. Evidence that they perform similarly through 52 weeks may help families and clinicians choose the approach...
Knowing which symptoms and non-invasive biomarkers most strongly associate with UC can help patients and clinicians decide who should be prioritized for diagnostic endoscopy and for monitoring disease activity.
IBD patients sometimes use dietary strategies and supplements like curcumin for inflammation. This study describes a food-processing method that preserves curcumin activity and targets release to the intestine in lab...
People with IBD may experience cognitive symptoms; this preclinical study identifies specific quercetin glycosides that protected mice from colitis-related cognitive decline via gut microbiota and tryptophan metabolism...
Researchers identified a plant-derived molecule (oxypalmatine) that reduced inflammation in a mouse colitis model by blocking pro-inflammatory macrophage activity through the RAB8A–STAT1 pathway. This suggests a...
The study suggests that timing of eating (time-restricted feeding) may influence intestinal inflammation and gut microbiota in ways that could be relevant to IBD. If confirmed in humans, meal timing could be a low-cost...
A plant polysaccharide (PVP) reduced inflammation and preserved intestinal barrier proteins in a mouse model of ulcerative colitis, apparently by increasing a specific gut bacterium. This points to a microbiome-related...
