Evidence types
Basic science articles covering early-stage IBD research, disease mechanisms, lab findings, microbiome work, genetics, and experimental models.
Page 10 of 15 · 709 articles
The study suggests a new microbiome-based strategy that targets toxic hydrogen sulfide production and boosts host detoxification — a mechanism potentially relevant to some forms of IBD driven by sulfur-metabolizing...
The study pinpoints OTUD5 as a molecular driver of IFNγ-driven intestinal inflammation and links it to anti-TNFα nonresponse; blocking OTUD5 with a small molecule reduced colitis in mice and in human organoids, which...
The study introduces a novel preclinical therapeutic approach that selectively degrades HDAC6 and reduced inflammation in a mouse model of colitis, suggesting a potential new drug-discovery avenue relevant to ulcerative...
The study presents an AI method that combines endoscopic images and diagnostic text to predict histological healing in ulcerative colitis, which could help non-invasive assessment and reduce annotation effort in...
This work points to new genes and immune-cell mechanisms that could help explain unexplained genetic risk for Crohn’s disease and suggests that genes known for other diseases might play unanticipated roles in gut...
A probe that detects both ATP and hypochlorite may offer a more specific optical marker of oxidative/inflammatory activity in IBD models, which could aid research into disease mechanisms and future diagnostic approaches.
The study links a cellular signaling pathway that increases serotonin release from gut enterochromaffin cells to inflammation in a mouse model of ulcerative colitis. If confirmed, blocking TRPV4 could become a research...
The study suggests TIMP1 may help drive ferroptosis, inflammation, and epithelial barrier dysfunction in ulcerative colitis; targeting TIMP1 could eventually inform new therapies or biomarkers if confirmed in further...
The study proposes two transcriptomic markers (LIMK1, PKM) that may help characterize an IBD-associated, mitochondria–ER membrane–related transcriptional state and could guide future biomarker or mechanistic research.
This preclinical study links periodontal ligament stem cells to reduced colitis severity in mice by restoring macrophage mitochondrial function and activating PINK1/Parkin-associated mitophagy, suggesting a possible new...
This study suggests that specific gut bacteria targeted by systemic IgG are associated with UC activity and inflammation, which could eventually help identify microbial signals linked to flares or systemic inflammation.
IBD patients face higher risk of osteoporosis; identifying shared, apoptosis-related genes may help explain why and point to future biomarkers or therapeutic targets. The study links specific genes (WNT1, S100A8) to both...
Fibrosis (irreversible bowel scarring) is a major cause of surgery in Crohn’s disease. This study points to molecular and microbiome patterns that may help predict or distinguish fibrosis from active inflammation, which...
Fibrosis (irreversible bowel scarring) is a major cause of surgery in Crohn’s disease. Identifying molecular and microbial markers tied to fibrosis could eventually help predict who’s at higher risk and guide earlier,...
The paper maps distinct stromal cell states tied to inflamed versus fibrotic tissue niches in Crohn’s disease and shows that these states have different chromatin configurations and drug-modifiable properties — pointing...
Identifies candidate gene signatures tied to MAM-related transcriptional states in IBD that could become biomarkers or guide mechanistic research into immune–metabolic pathways relevant to disease.
The probe targets azoreductase-driven hypoxia, a mechanism linked to ulcerative colitis and other hypoxia-associated diseases; a reliable real-time imaging method could help research and eventually guide treatments.
The study suggests a specific stromal and MAPK/EGFR signalling programme linked to prior anti‑TNF failure in ulcerative colitis, which could help explain why some patients are less responsive to later therapies and point...
Preclinical data suggest sodium phenylbutyrate and suramin may reduce inflammation and oxidative stress in a mouse model of ulcerative colitis, pointing to possible therapeutic mechanisms worth further study.
This study presents a targeted immunotherapy approach designed to concentrate an immune‑modulating protein (PD‑L1‑Fc) in the inflamed colon, which could in future reduce systemic side effects of biologic immunomodulators...
The study links shared gene-expression patterns between IBD and ankylosing spondylitis and highlights STAT3 as a potential shared biomarker or therapeutic target, which could be relevant for understanding overlapping...
Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from International...
The paper describes a preclinical demonstration that a plant-derived compound reduced inflammation and changed gut microbiota and metabolite profiles in a mouse colitis model, suggesting a possible route for future...
Targeted release of mesalamine to the colon could increase local drug levels and reduce upper-GI exposure and systemic side effects. New delivery platforms may improve effectiveness for ulcerative colitis without...
The study identifies shared genetic signals and cell types (especially T cells) between ulcerative colitis and psoriasis, which could help explain their clinical co-occurrence and suggest pathways for future research or...
The study identifies a possible molecular mechanism (THRIL downregulation and inhibition of p38 MAPK/NF-κB) by which a traditional Chinese medicine preparation reduced inflammation in mouse and cell models of colitis,...
New targeted-delivery research could lead to treatments that reduce gut inflammation while also shifting the microbiome — both relevant to IBD management. However, this report is preclinical and does not mean the therapy...
Shared gut microbiome shifts across autoimmune diseases could suggest common microbial factors relevant to immune regulation and might eventually inform diagnostics or therapies relevant to people with IBD.
The study suggests anti-TNF failure in Crohn's may be driven by pre-existing cytokine interaction networks and loss of regulatory feedback, which could help explain why some patients don't respond to TNF-blocking...
The study highlights GM‑CSF as a spatial regulator of myeloid–lymphoid interactions in ulcerated ileal tissue, which may help researchers and clinicians understand mechanisms that drive inflammation and epithelial injury...
Shows that in Crohn’s disease, inflammatory changes in circulating monocytes appear before they enter the gut, which could help explain persistent intestinal macrophage dysfunction and may guide future biomarker or...
This study links blood gene signatures shared between Parkinson’s disease and intestinal inflammation to astrocyte-associated molecular changes in the brain, identifying HSP90AA1 as a candidate stress-responsive hub.
The study suggests a natural flavonoid (DHQ) can protect against DSS-induced colitis in mice and identifies a specific phospholipase-related pathway that may link phospholipid breakdown to epithelial barrier...
The study describes a novel oral delivery system that both protects stem-cell-derived extracellular vesicles and actively modifies the gut environment, which could point to new microenvironment-targeted IBD therapies.
The study presents a gut-targeted bispecific that aims to both block gut-homing/inflammatory signals and activate epithelial repair — a combined approach that could reduce systemic immunosuppression while promoting...
The study explores a novel, combined nanozyme + microbiome-derived vesicle approach aimed at reducing oxidative stress and modulating inflammation in IBD — mechanisms that are relevant to disease pathways and future...
People with UC often seek dietary strategies to help manage inflammation; this study uses AI and docking to prioritize polyphenols and foods for future testing, which could guide research and eventually inform dietary...
This study maps how Crohn’s-associated genetic variants may act at a distance in specific immune cells (ILC3), revealing new candidate genes and mechanisms — including an unexpected role for CLN3 — that could point to...
People with UC may be interested because the study identifies a traditional herbal formulation that reduced disease markers in a mouse model and changed gut microbiota and inflammatory pathways (IL‑17), suggesting...
Researchers are exploring non-drug enzyme-like catalysts to reduce oxidative stress in IBD—this study reports a new artificial antioxidase that helped reduce inflammation in cell and animal models, which could point to...
This preclinical study links cod skin–derived collagen peptides to reduced colitis severity in mice through changes in the gut microbiota and suppression of the NLRP3 inflammasome — pathways that could be relevant to...
Researchers are exploring ways to produce anti-inflammatory proteins directly at inflamed gut sites; this study describes a nanomaterial system intended to protect plasmid drugs and supply oxygen to sustain local protein...
Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease and Research and clinical trials. The original article is from Biomedical Signal Processing and Control.
Improved automated classification of colonoscopy images could help detect polyps and signs of inflammatory bowel disease sooner, potentially supporting clinicians during endoscopy.
This study reports an early-stage nanoplatform that combines targeted colon delivery of an aminosalicylate prodrug with scavenging of proinflammatory cfDNA, a dual strategy that reduced colitis severity in mice and could...
This study describes a new clay-based nanotherapy that reduced inflammation and oxidative stress in a common mouse model of colitis, suggesting a potential local treatment approach that targets multiple disease...
The study describes a new oral delivery system designed to improve colon targeting and anti-inflammatory activity of celastrol, which could eventually lead to better drug options for ulcerative colitis if advanced to...
The paper identifies a new mechanism (VDAC1-driven mtDNA release activating cGAS–STING) that may drive inflammation in ulcerative colitis and a candidate compound (senkyunolide I) that blocks this pathway in preclinical...
