The study suggests a natural flavonoid (DHQ) can protect against DSS-induced colitis in mice and identifies a specific phospholipase-related pathway that may link phospholipid breakdown to epithelial barrier...

Intestinal fibrosis causes strictures that often need surgery and has few effective medical treatments; linking the microbiome to fibrogenesis suggests new prevention or treatment strategies that could reduce surgery...

Cure8 found this source from Intestinal research, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Risankizumab. Open the original article for the full...

Researchers found antisense RNA activity in gut microbes that tracks with active inflammation in IBD and with faecal calprotectin — suggesting a new microbial signal that might help understand or monitor disease...

Cure8 found this source from Alimentary pharmacology & therapeutics, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Complications. Open the original article for the full...

The study describes a novel oral delivery system that both protects stem-cell-derived extracellular vesicles and actively modifies the gut environment, which could point to new microenvironment-targeted IBD therapies.

The study suggests most adults with chronic diarrhea in this tertiary setting had organic/inflammatory disease and identifies accessible clinical and lab predictors that could help prioritize endoscopic evaluation.

People with IBD need more than flare control: they also require proactive preventive care (vaccination, cancer screening, bone and nutrition checks, and mental health support) because of risks from chronic inflammation...

Researchers measured salivary cytokines and found higher TNF‑α and IL‑10 in people with Crohn’s disease, suggesting saliva could reflect systemic immune activity and might be a noninvasive source of IBD biomarkers. For...

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Tests and monitoring. The original article is from hmpgloballearningnetwork.com.

Cure8 found this source from streetinsider.com, but the page could not be read reliably yet. It is tagged for Research and clinical trials. Open the original article for the full details.

This filing reports that PALI‑2108, an investigational oral PDE4 prodrug for IBD, showed encouraging Phase 1 signals and is moving into Phase 2 trials — a step toward more definitive efficacy data. The company also...

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Complications. The original article is from hmpgloballearningnetwork.com.

This trial tested a dietary supplement (nicotinamide riboside) as an add-on for pediatric ulcerative colitis with the goal of improving cellular metabolism in the gut lining. Patients and families may be interested...

Faecal microbiota transfer is being tested in a large Phase 3 trial as a possible new treatment approach for active ulcerative colitis, and this study also looks at safety and how the therapy changes the gut microbiome...

This trial tests a new oral drug, AC-101, for moderate-to-severe ulcerative colitis and may expand future treatment options if it proves effective and safe. The study targets patients who have failed or could not...

Patients with short bowel syndrome and their caregivers can face heavy, multidimensional burdens including dependence on parenteral nutrition/IV hydration, frequent symptoms like fatigue, increased healthcare use, and...

A reproducible large-animal colitis model could improve preclinical testing by better mimicking human gut anatomy and immune responses than rodent models. That may help translational research and therapy evaluation for...

The study presents a gut-targeted bispecific that aims to both block gut-homing/inflammatory signals and activate epithelial repair — a combined approach that could reduce systemic immunosuppression while promoting...

Hospitalizations for Crohn’s and ulcerative colitis in Brazil increased from 2015–2024, which may affect access to care, costs, and planning of IBD services. Patients and clinicians should be aware of regional and...

A rare venous occlusive disease (IMHMV) can closely mimic steroid-refractory ulcerative colitis and may require surgery for diagnosis, so clinicians and patients should consider vascular causes when colitis is atypical...

Cure8 could only read part of this source from thehealthsite.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Inflammatory bowel disease, and Research and clinical...

This review pools available human and animal studies on sodium butyrate for ulcerative colitis and highlights promising signals—especially for oral microencapsulated formulations—while noting that clinical evidence is...

Researchers are exploring antioxidant strategies for colitis because oxidative stress contributes to mucosal damage; preclinical positive signals could eventually lead to new adjunctive therapies for ulcerative colitis...

The study explores a novel, combined nanozyme + microbiome-derived vesicle approach aimed at reducing oxidative stress and modulating inflammation in IBD — mechanisms that are relevant to disease pathways and future...

People with UC often seek dietary strategies to help manage inflammation; this study uses AI and docking to prioritize polyphenols and foods for future testing, which could guide research and eventually inform dietary...

Keratoconus can threaten vision; identifying risk factors helps clinicians and patients consider prevention, early detection, and targeted eye care. Some commonly encountered issues in people with IBD—like dry eye or...

This review organizes and grades causal evidence linking individual gut bacteria, their metabolites, and host pathways in IBD—helping researchers and clinicians see which microbe–metabolite mechanisms are best supported...

People with Crohn's disease or ulcerative colitis might see more AI-based prognostic tools in the literature, but this review shows most models are not yet proven ready for clinical use because they lack key validation...

This study maps how Crohn’s-associated genetic variants may act at a distance in specific immune cells (ILC3), revealing new candidate genes and mechanisms — including an unexpected role for CLN3 — that could point to...

Patients with ulcerative colitis who cannot tolerate 5-ASA need alternative maintenance options. This study suggests azathioprine showed comparable continuation, safety, and endoscopic outcomes whether or not patients...

Intestinal ultrasound is a noninvasive imaging option that can help detect and monitor bowel inflammation without radiation. A new local program could improve access to this tool for people with IBD, including children.

Nutrition affects disease course, symptom burden, complications, and quality of life in IBD. A phenotype-based framework could help clinicians and patients personalize dietary and nutrition interventions more...

If true, the study suggests that long-term air pollution exposure may raise the risk of developing IBD and that greater adherence to a plant-based diet could be linked with a lower pollution-related risk. That may be...

Extraintestinal manifestations are common in IBD and can affect quality of life and clinical outcomes. A national consensus helps standardize recognition and multidisciplinary care, which may improve management for...

For people with UC and CMV colitis, whether to keep or stop immunosuppressive drugs during antiviral treatment may affect how quickly CMV clears from colon tissue and short-term adverse events.

Older adults with IBD may have different disease features, treatment risks (especially from steroids), and health priorities than younger patients. Understanding age-specific issues can influence treatment choices,...

People with UC may be interested because the study identifies a traditional herbal formulation that reduced disease markers in a mouse model and changed gut microbiota and inflammatory pathways (IL‑17), suggesting...

Researchers are exploring non-drug enzyme-like catalysts to reduce oxidative stress in IBD—this study reports a new artificial antioxidase that helped reduce inflammation in cell and animal models, which could point to...

Keeping IBD well controlled before and during pregnancy lowers the risk of adverse outcomes for both parent and baby; understanding which medications are safe and which should be stopped is crucial for family planning.

This project seeks to clarify how gut microbes and diet drive CD4+ T cell responses—mechanisms that are central to intestinal tolerance and to diseases like IBD. A better map of TCR–antigen pairs and how tolerance breaks...

Researchers are exploring a way to deliver biologic drugs directly in the gut using engineered B cells that become long-lived plasma cells. If successful, this could allow sustained, localized anti-inflammatory protein...

Researchers are exploring a new way to block colon-homing T cells using a GPR15-targeting peptide; if successful, this could lead to a novel mechanism for treating IBD patients who don’t respond to current therapies.

Researchers are studying whether everyday microplastic exposure could worsen gut barrier injury in IBD and contribute to inflammatory or mental-health effects linked by the gut–brain axis.

Noninvasive stool metabolite patterns could eventually help predict which people with Crohn’s disease are more likely to develop strictures or penetrating complications, and may offer markers of disease activity and...

A Cochrane network meta-analysis compares many biologic medicines used for Crohn’s disease, which can help patients and clinicians understand how different drugs and drug classes stack up for inducing and keeping...

Bronchiectasis can be an overlooked extraintestinal manifestation in people with IBD and may cause respiratory symptoms long after IBD diagnosis. Recognizing this link could speed diagnosis and lead to different...

RDW is a cheap, routinely measured blood parameter; if it reliably reflects IBD presence or activity, it could be an easy additional tool to help detect flares or support assessment without extra testing.