Crohn's disease

AI could help make IBD assessments (endoscopy, histology, imaging, biomarkers) more objective and faster, which may improve monitoring, treatment selection, and early detection of complications for people with Crohn’s...

Shows that in Crohn’s disease, inflammatory changes in circulating monocytes appear before they enter the gut, which could help explain persistent intestinal macrophage dysfunction and may guide future biomarker or...

If PALI-2108 proves safe and effective in Phase 2 trials, it could add a new oral treatment option for people with ulcerative colitis and Crohn’s disease. Early Phase 1 signals and a funded Phase 2 program mean the...

This case suggests ustekinumab — a commonly used biologic for Crohn’s disease — might rarely be associated with kidney injury (FSGS). Patients and clinicians should be aware of new or worsening edema, proteinuria, or...

Growth and new approvals for Skyrizi and Rinvoq may increase treatment options and influence which drugs gastroenterologists prescribe for Crohn’s disease and ulcerative colitis. Changes in approvals, dosing options, and...

Based on the title and source metadata, this appears to be a clinical trial phase 2 related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from t.co.

The study connects common dietary patterns to self‑reported IBD activity and quality of life, suggesting diet may be linked to symptom burden for people with Crohn’s disease and UC/IBDU.

If you have IBD, the mouth and gums may be part of shared inflammatory pathways with your gut. Periodontitis is associated with higher odds of having IBD in cross-sectional studies and has a modest link to later...

Cure8 indexed source-provided abstract text from The Journal of Dermatology, but this record did not meet the threshold for a full Cure8 brief. It is tagged for Crohn's disease, Inflammatory bowel disease, and...

This study aims to identify which clinical or biological factors predict treatment response and serious complications in children with newly diagnosed IBD — information that could help tailor care for pediatric patients...

Long-term extension trials help show whether a drug’s benefits and safety persist over time. For people with Crohn’s disease, this study focuses on maintaining endoscopic improvement and clinical remission with...

Cure8 could only read part of this source from grafa.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Inflammatory bowel disease, and Research and clinical trials.

This news matters because SL-325 targets the TL1A/DR3 pathway, a novel immune target being tested for Crohn’s disease and UC; early Phase 1 data suggest a tolerable profile and prolonged target blockade that could affect...

AI models that combine CTE/MRE imaging with clinical and molecular data could improve objective classification of small-bowel Crohn's disease and help predict which patients are likely to respond to medical therapy...

Perianal fistulas are a serious complication of Crohn’s disease and can be hard to treat. This trial tested a novel extracellular-vesicle therapy (ExoFlo) delivered locally as a potential new option, so patients with...

This pilot trial explores a non-drug neuromodulation approach (auricular vagus nerve stimulation) that might influence brain–gut interactions, stress, fatigue, and quality of life in people with IBD in remission....

Early clinical data suggest SL-325 engages its target (TL1A) with a favorable safety signal, and a Phase 2b trial in Crohn’s disease is planned — meaning this could become a new treatment option in the future if later...

Faecal calprotectin appears to be the best non‑invasive test among those studied for distinguishing UC from Crohn’s disease and for reflecting mucosal inflammation. Simpler blood‑based scores may help gauge systemic...

Cure8 could only read part of this source from PubMed Central, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Natalizumab, and Biosimilars.

If you or a loved one follow emerging IBD treatments, this update signals a new PALI-2108 program moving into Phase 2 for ulcerative colitis and planned Phase 2 testing in Crohn’s disease, plus a company focus on...

Nanotechnology approaches aim to improve how cytokine-targeting therapies are delivered in IBD, which could reduce systemic exposure and immunogenicity and increase local effectiveness.

Intestinal fibrosis causes strictures that often need surgery and has few effective medical treatments; linking the microbiome to fibrogenesis suggests new prevention or treatment strategies that could reduce surgery...

The study suggests most adults with chronic diarrhea in this tertiary setting had organic/inflammatory disease and identifies accessible clinical and lab predictors that could help prioritize endoscopic evaluation.

Researchers measured salivary cytokines and found higher TNF‑α and IL‑10 in people with Crohn’s disease, suggesting saliva could reflect systemic immune activity and might be a noninvasive source of IBD biomarkers. For...

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Tests and monitoring. The original article is from hmpgloballearningnetwork.com.

This filing reports that PALI‑2108, an investigational oral PDE4 prodrug for IBD, showed encouraging Phase 1 signals and is moving into Phase 2 trials — a step toward more definitive efficacy data. The company also...

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Complications. The original article is from hmpgloballearningnetwork.com.

Hospitalizations for Crohn’s and ulcerative colitis in Brazil increased from 2015–2024, which may affect access to care, costs, and planning of IBD services. Patients and clinicians should be aware of regional and...

Cure8 could only read part of this source from thehealthsite.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Inflammatory bowel disease, and Research and clinical...

People with Crohn's disease or ulcerative colitis might see more AI-based prognostic tools in the literature, but this review shows most models are not yet proven ready for clinical use because they lack key validation...

This study maps how Crohn’s-associated genetic variants may act at a distance in specific immune cells (ILC3), revealing new candidate genes and mechanisms — including an unexpected role for CLN3 — that could point to...

Extraintestinal manifestations are common in IBD and can affect quality of life and clinical outcomes. A national consensus helps standardize recognition and multidisciplinary care, which may improve management for...

Older adults with IBD may have different disease features, treatment risks (especially from steroids), and health priorities than younger patients. Understanding age-specific issues can influence treatment choices,...

Keeping IBD well controlled before and during pregnancy lowers the risk of adverse outcomes for both parent and baby; understanding which medications are safe and which should be stopped is crucial for family planning.

Researchers are exploring a way to deliver biologic drugs directly in the gut using engineered B cells that become long-lived plasma cells. If successful, this could allow sustained, localized anti-inflammatory protein...

Researchers are exploring a new way to block colon-homing T cells using a GPR15-targeting peptide; if successful, this could lead to a novel mechanism for treating IBD patients who don’t respond to current therapies.

Noninvasive stool metabolite patterns could eventually help predict which people with Crohn’s disease are more likely to develop strictures or penetrating complications, and may offer markers of disease activity and...

A Cochrane network meta-analysis compares many biologic medicines used for Crohn’s disease, which can help patients and clinicians understand how different drugs and drug classes stack up for inducing and keeping...

RDW is a cheap, routinely measured blood parameter; if it reliably reflects IBD presence or activity, it could be an easy additional tool to help detect flares or support assessment without extra testing.

Oral granulomatous inflammation can precede intestinal Crohn’s disease and sometimes remain subclinical for years; early GI evaluation and prolonged follow-up may detect later intestinal disease earlier.

Dysplasia is the key premalignant change that raises colorectal cancer risk in people with colonic IBD. Better detection and clearer management pathways can reduce cancer risk and help patients avoid unnecessary surgery.

Surgical removal of the disease-affected ileocecal segment is common in Crohn’s disease; this study provides regional evidence that laparoscopic ICR can be safe and offers faster recovery compared with open surgery.

ILD is a potentially serious extraintestinal complication that appears more often with ulcerative colitis than with Crohn’s disease in this cohort study. Patients with both IBD and ILD had higher healthcare use and...

This bibliometric analysis summaries recent Spanish research activity in IBD, showing where work is concentrated, the mix of clinical versus basic/translational studies, and gender representation in scientific...

Imaging can reveal characteristic bowel and vascular patterns that help distinguish Crohn's, UC, celiac disease, and systemic autoimmune or vasculitic causes of GI symptoms, which may speed diagnosis and detect dangerous...

People with Crohn’s disease who need a repeat ileocolic resection may wonder whether laparoscopic surgery is a good option. This study suggests laparoscopic attempts are often successful, and if conversion is needed...

Predicting who will respond to anti-TNF drugs could help avoid ineffective treatments, reduce delays to effective therapy, and personalize care for children with Crohn's disease.

This study examines whether patterns of body size from birth through adulthood add information about IBD risk beyond adult BMI and genetic susceptibility. Results suggest life-course size trajectories may be more related...