Inflammatory bowel disease

The study identifies a natural compound that reduced inflammation and improved multiple aspects of intestinal barrier function in a zebrafish IBD model, suggesting a new candidate for preclinical drug discovery relevant...

The report suggests a probiotic (VSL#3TM) added to vedolizumab may speed or increase early response in ulcerative colitis, which could interest patients and clinicians seeking ways to improve biologic induction outcomes....

The study suggests that combining different fermentable fibers may steer the gut microbiome toward more butyrate-producing bacteria and away from pro-inflammatory lineages—changes that could be relevant to IBD-related...

People with UC on or starting vedolizumab may be interested because the study tests whether adding an oral CurQD supplement improves remission rates compared with vedolizumab alone. The trial could inform whether this...

Cure8 found this source from Journal of gastroenterology and hepatology, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials....

The study links TRAIL expression to macrophage behavior and colitis severity in mice and to higher TRAIL levels in human IBD tissue, suggesting TRAIL-related pathways could influence intestinal inflammation and might be...

Environmental pollutants that are increasing in many East Asian settings — air pollution, heavy metals, pesticides, and microplastics — may contribute to rising IBD rates by affecting the gut microbiome and intestinal...

The study identifies a candidate compound (NCTD) that reduced inflammation and tissue damage in a rat ulcerative colitis model and implicates specific inflammatory, epigenetic, metabolic, and antioxidant pathways —...

The study identifies specific anti-inflammatory compounds in Artemisia scoparia and shows they reduce inflammation in cell and mouse models of ulcerative colitis, suggesting potential new leads for drug or...

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...

People with UC can develop severe neutrophilic skin complications like Sweet’s syndrome that may reflect active bowel inflammation even when recent tests suggested remission.

The paper highlights how the gut microbiome and environment can strongly influence colitis severity in genetically susceptible mice, illustrating a gene–environment–microbiome axis that may help explain heterogeneity in...

Vedolizumab blood levels can vary with disease activity; a model that links intestinal α4β7 expression to drug exposure helps explain why some patients have lower drug levels and may need different dosing. This could...

This study suggests there are distinct molecular subtypes of perianal fistulizing Crohn’s disease, and some subtypes may be more likely to benefit from surgical repair while others have higher inflammatory burden and...

The study identifies a potential new mechanism—blocking ferroptosis via CA9—for reducing intestinal inflammation in a mouse model, which could guide future IBD drug research.

Higher, optimised doses of prolonged-release mesalazine were linked with fewer clinical recurrences over 12 months in adults with mild-to-moderate UC, which could influence treatment decisions about mesalazine dose and...

This preclinical study suggests quince gel reduced inflammation, oxidative stress, and tissue injury in a rat model of ulcerative colitis and identifies quercetin as a likely active component. Findings point to possible...

Metformin is a common, inexpensive drug with possible anti-inflammatory effects; this review compiles preclinical and early clinical data suggesting it might influence ulcerative colitis biology. Readers may want to know...

Perianal fistulizing Crohn’s disease causes delayed healing and high recurrence after surgery. This study suggests a specific time-guided external traditional therapy may speed wound healing, reduce inflammation, and...

This preclinical study identifies benzoylpaeoniflorin (BPF) as a compound that improved experimental colitis in mice by changing macrophage polarization via the RNF31–DPEP2–NF-κB pathway. It highlights a possible...

Local fundraisers both raise money for IBD research/support and help build community and visibility for people living with Crohn’s disease and ulcerative colitis. Hearing personal stories can reduce isolation and point...

For people with perianal Crohn’s disease, better bedside imaging that distinguishes phlegmon from abscess can change surgery plans and may avoid unnecessary wide drainage procedures.

Depression is common in people with Crohn’s disease and can affect quality of life and ability to manage IBD. Knowing prevalence and common symptoms locally helps clinicians and patients recognize and seek appropriate...

This NIH-funded project identifies probiotic metabolic pathways that protect gut barrier integrity in a diet-dependent way, which could explain mixed clinical trial results and point to biomarkers to select patients...

The project targets innate lymphocyte pathways that help control mucosal immunity in the gut and airway — mechanisms that can drive or restrain inflammation in IBD and related diseases. Better understanding may reveal...

Researchers are trying to create modular mucosal immunotherapies that target both microbial and inflammatory drivers of diseases like colitis. If successful, this approach could lead to treatments that address the...

This project explores how gut microbes and bile acids interact to shape immune cells in the ileum — a process that may affect inflammation in Crohn’s disease and other IBDs. Understanding these mechanisms could point to...

If surgeons can safely perform a primary bowel reconnection when they encounter an intra-abdominal abscess during Crohn surgery, some patients may avoid a temporary stoma and its associated morbidity.

The study identifies specific induction exposure targets and biomarkers tied to higher chances of deep remission at 12 months in children on anti-TNF therapy, which could inform earlier dose optimization to improve...

People with IBD and their clinicians often worry that anorectal surgery like hemorrhoidectomy could cause complications, flares, or loss of continence. This study suggests that, in a selected multicenter European cohort,...

If a serious infection occurs while on an anti‑TNF drug, patients and clinicians face difficult decisions about when and whether to restart biologic therapy. This case shows one example where switching to mirikizumab...

Automated, consistent scoring of the UCEIS could reduce subjectivity and variability in endoscopic assessment of ulcerative colitis, which matters for clinical trials, central reading, and potentially treatment decisions...

Early symptomatic improvement on filgotinib may predict longer-term gains in disease-specific quality-of-life for people with ulcerative colitis, which could help patients and clinicians set expectations during...

The study identifies a fungal β-glucan that reduced inflammation and altered the gut microbiome and short-chain fatty acids in a mouse model of ulcerative colitis, which could inform future nutritional or therapeutic...

Dietary changes are common among people with IBD but long-term adherence is low; understanding what patients find acceptable and what barriers they face can help clinicians design practical, culturally sensitive dietary...

Steroid dependency affects many people with ulcerative colitis and can change long-term treatment plans. This study explores clinical factors and uses an AI clustering method to visualize different risk patterns, which...

IBD can cause inflammation outside the gut; this report shows rare eye, facial muscle, and salivary gland involvement occurring at the time of ulcerative colitis diagnosis in a child, which could affect evaluation and...

Diagnostic delays can mean a child with Crohn's disease doesn't get timely treatment. This report shows weight loss in young patients—especially girls—can be mistakenly labeled an eating disorder, so awareness and...

Standardizing inpatient IBD care with a defined index improved measurable adherence at the authors’ center, which could reduce variability in the care patients receive during hospital stays.

Altered NAD metabolism may influence inflammation and tissue repair in IBD; understanding host and microbial contributions could open new research directions for metabolic biomarkers or therapeutic targets.

The report suggests tofacitinib (a JAK inhibitor), alone or combined with ustekinumab, could be an effective option for some infants with treatment-refractory IOIBD — a population with few evidence-based alternatives. If...

Mesalazine is commonly used in UC; rare pulmonary toxicity can present with fever and progressive breathlessness. Early recognition and stopping the drug plus corticosteroids may lead to recovery and avoid invasive...

Integrated joint appointments could make it easier for children with IBD and their families to get coordinated care for symptoms, nutrition, and mental health in a single visit, which may improve access and reduce stigma...

Patients and caregivers considering or subject to insurance-driven switches from adalimumab originator to a biosimilar may want to know whether clinical status and medication continuation remain similar after switching.

ECCO 2026 presented multiple studies that could change IBD care across prevention, medical therapy (including pediatric data), complication‑directed strategies (perianal fistula), and technology‑assisted monitoring....

This matters because identifying microbiome patterns linked to infliximab response could help predict which children with IBD are more likely to benefit from the drug and guide personalized treatment decisions in the...

PTG and psychological wellbeing matter to many people with IBD. This study indicates that addressing stigma and promoting healthy lifestyle behaviours could be linked with better psychological outcomes, making these...

Many people with UC try dietary changes to manage symptoms. This randomized pilot trial directly compared two popular diets and did not find a clear difference in symptom improvement, but high dropout limits confidence.