Article Archive

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Mechanisms of phosphorylation in colitis regulation: PP2Acα as an emerging therapeutic target for inflammatory bowel disease
Molecular Biology Reports

Mechanisms of phosphorylation in colitis regulation: PP2Acα as an emerging therapeutic target for inflammatory bowel disease

Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease, Drug Discovery, and Research and clinical trials. The original article is from Molecular Biology Reports.

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Real-World Epidemiology of Inflammatory Bowel Disease in Italy: Treatment Patterns, Adherence, and Costs in Patients with Ulcerative Colitis Treated with Mesalazine
Drugs - Real World Outcomes

Real-World Epidemiology of Inflammatory Bowel Disease in Italy: Treatment Patterns, Adherence, and Costs in Patients with Ulcerative Colitis Treated with Mesalazine

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Mesalamine. The original article is from Drugs - Real World Outcomes.

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Propolis Flavonoids: Current Evidence in Animal Models and Future Promise for the Treatment of Ulcerative Colitis
International Journal of Molecular Sciences

Propolis Flavonoids: Current Evidence in Animal Models and Future Promise for the Treatment of Ulcerative Colitis

People with ulcerative colitis may be interested because the review identifies flavonoids in propolis as compounds that reduce inflammation and strengthen the gut barrier in animal models, and it highlights strategies to...

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β-Glucan-based oral nano/micro delivery systems: harnessing dual immunomodulatory and microbiota-modulating properties for targeted therapy of cancer and inflammatory bowel disease.
Nanoscale

β-Glucan-based oral nano/micro delivery systems: harnessing dual immunomodulatory and microbiota-modulating properties for targeted therapy of cancer and inflammatory bowel disease.

Researchers are exploring new oral delivery carriers that could deliver drugs directly to inflamed intestinal sites while also modulating immune responses and the gut microbiome. If translated, these approaches might...

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Bedside analysis of volatile organic compounds in exhaled human breath as non-invasive diagnostic tool for colon diseases.
Bioanalysis

Bedside analysis of volatile organic compounds in exhaled human breath as non-invasive diagnostic tool for colon diseases.

A breath-based VOC test could offer a noninvasive, point-of-care way to help detect or screen for colon diseases including IBD. This study shows preliminary promise—especially for ulcerative colitis—but is early-stage...

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Time trends in patients with ulcerative colitis and crohn's disease not receiving IBD-specific pharmacological treatment within one and three years of diagnosis - a nationwide cohort study.
Scandinavian journal of gastroenterology

Time trends in patients with ulcerative colitis and crohn's disease not receiving IBD-specific pharmacological treatment within one and three years of diagnosis - a nationwide cohort study.

A sizable minority of people newly diagnosed with IBD—about 1 in 5 with Crohn’s and 1 in 10 with ulcerative colitis—received no IBD-specific drugs within the first year. Understanding who is untreated and why could...

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Assessment of T helper17 Cells / Regulatory T Cells Axis and Related Cytokines in Patients with Ulcerative Colitis
The Egyptian Journal of Medical Microbiology

Assessment of T helper17 Cells / Regulatory T Cells Axis and Related Cytokines in Patients with Ulcerative Colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from The Egyptian Journal...

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Palisade Bio Presents New Clinical, Pharmacokinetic, Pharmacodynamic and Mechanistic Data Strengthening the Phase 2 Rationale for PALI-2108 in Ulcerative Colitis and Crohn’s ...

Early Phase 1 findings suggest a gut-targeted PDE4 prodrug may engage its target in diseased tissue and produce early improvements in symptoms, endoscopy, and tissue inflammation — findings that, if confirmed in Phase 2,...

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A Mesalazine–Aloperine Co-Amorphous System for Simultaneous Dissolution Enhancement, Permeability Improvement, and Synergistic Anti-Ulcerative Colitis Activity: A Combined Pharmaceutics and Network Pharmacology Study
Pharmaceutics

A Mesalazine–Aloperine Co-Amorphous System for Simultaneous Dissolution Enhancement, Permeability Improvement, and Synergistic Anti-Ulcerative Colitis Activity: A Combined Pharmaceutics and Network Pharmacology Study

Improving mesalazine delivery could increase drug reaching the colon and potentially improve treatment for ulcerative colitis. A formulation that both enhances dissolution/permeability and offers mechanistic synergy...

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Gut microbiota, microbial metabolites, and mucosal barrier dysfunction in benign anorectal disorders and ulcerative colitis: shared mechanisms, clinical links, and precision interventions
Frontiers in Medicine

Gut microbiota, microbial metabolites, and mucosal barrier dysfunction in benign anorectal disorders and ulcerative colitis: shared mechanisms, clinical links, and precision interventions

The review links microbiome, metabolites, barrier function, and immune responses across anorectal disorders and ulcerative colitis — areas that directly affect symptoms, healing, and response to therapy.

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Dietary Polyphenols as Adjunctive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients

Dietary Polyphenols as Adjunctive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

People with IBD often ask about dietary supplements. This systematic review suggests some randomized-trial evidence that polyphenol supplements—especially curcumin—may help induce clinical improvement in ulcerative...

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Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation.

A colon-targeted IFX formulation could deliver the drug directly to inflamed tissue, potentially improving effectiveness and lowering systemic side effects or dosing complexity for people with ulcerative colitis.

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Clinical Course and Predictors of Biologic Therapy, Hospitalisation and Surgery: A Five-Year Prospective Study in Newly Diagnosed Inflammatory Bowel Disease.
Alimentary pharmacology & therapeutics

Clinical Course and Predictors of Biologic Therapy, Hospitalisation and Surgery: A Five-Year Prospective Study in Newly Diagnosed Inflammatory Bowel Disease.

This study describes how often people newly diagnosed with IBD go on biologic or JAK inhibitor therapy and what happened to them over five years — including hospital visits and surgery — which helps set expectations for...

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Frequency and Risk Factors for Difficult-to-Treat Inflammatory Bowel Disease among Patients Receiving Advanced Therapies in a Korean Tertiary-Care Cohort.
Gut and liver

Frequency and Risk Factors for Difficult-to-Treat Inflammatory Bowel Disease among Patients Receiving Advanced Therapies in a Korean Tertiary-Care Cohort.

The study suggests that about one-quarter of IBD patients treated with advanced therapies develop difficult-to-treat disease, and identifies timing of therapy, age, and specific therapy choice as predictors.

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Bimekizumab efficacy across GRAPPA domains to 3 years in patients with psoriatic arthritis: a post hoc analysis of two phase 3 studies.
Rheumatology (Oxford, England)

Bimekizumab efficacy across GRAPPA domains to 3 years in patients with psoriatic arthritis: a post hoc analysis of two phase 3 studies.

Patients with PsA and clinicians choosing long‑term biologic therapy may care about both durability of PsA control and safety signals for related inflammatory conditions like IBD and uveitis. This analysis reports...

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Endoscopic intralesional platelet-rich plasma (PRP) injection after balloon dilation for colonic Crohn's disease strictures: a pilot study
Springer Science and Business Media LLC

Endoscopic intralesional platelet-rich plasma (PRP) injection after balloon dilation for colonic Crohn's disease strictures: a pilot study

Patients and clinicians exploring new, less-invasive options for fibrostenotic colonic Crohn's disease may be interested because this study reports that intralesional PRP after balloon dilation is feasible and appears...

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Challenges and opportunities facing inflammatory bowel disease in Sub-Saharan Africa: towards a contextually relevant research and practice agenda.
Journal of Crohn's & colitis

Challenges and opportunities facing inflammatory bowel disease in Sub-Saharan Africa: towards a contextually relevant research and practice agenda.

IBD cases are increasing in Sub-Saharan Africa but care and research remain limited and driven by high-income country priorities. Region-specific research and policy changes could improve diagnosis, treatment access, and...

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Type 6 secretion systems of adherent-invasive Escherichia coli isolated from Crohn's disease patients shape intestinal microbiota.
Europe PMC

Type 6 secretion systems of adherent-invasive Escherichia coli isolated from Crohn's disease patients shape intestinal microbiota.

The study identifies a bacterial mechanism (T6SS) that may help AIEC strains compete with normal gut microbes and colonize the intestinal mucosa — a process relevant to Crohn’s disease biology and future...

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Unraveling the Clinical Puzzle of Cerebral Venous Sinus Thrombosis in Ulcerative Colitis: Insights from a Systematic Review
Asian Journal of Neurosurgery

Unraveling the Clinical Puzzle of Cerebral Venous Sinus Thrombosis in Ulcerative Colitis: Insights from a Systematic Review

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Ulcerative colitis, Inflammatory bowel disease, and Complications. The original article is from Asian Journal of...

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Low baseline alanine aminotransferase is associated with primary non-response to infliximab induction in pediatric Crohn's disease: a retrospective cohort study
Frontiers in pediatrics

Low baseline alanine aminotransferase is associated with primary non-response to infliximab induction in pediatric Crohn's disease: a retrospective cohort study

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Infliximab, and Anti-TNF. The original article is from Frontiers in pediatrics.

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Therapeutic potential of maggot-derived bioactive peptides in modulating inflammatory responses in mice model of inflammatory bowel disease
Frontiers in cell and developmental biology

Therapeutic potential of maggot-derived bioactive peptides in modulating inflammatory responses in mice model of inflammatory bowel disease

Based on the title and source metadata, this appears to be a basic science related to Inflammatory bowel disease and Research and clinical trials. The original article is from Frontiers in cell and developmental biology.

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Association between Crohn’s disease and pulmonary nodule patterns: an inverse probability-weighted analysis of real-world data
Clinical and Translational Gastroenterology

Association between Crohn’s disease and pulmonary nodule patterns: an inverse probability-weighted analysis of real-world data

The study suggests pulmonary nodules are more common in people with Crohn’s disease and that age and certain medications (not disease phenotype) may better predict nodule burden — information that could influence how...

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Safety profile and potential favorable reporting signals of liraglutide in patients with ulcerative colitis: A FAERS pharmacovigilance and network pharmacology study
Pakistan Journal of Pharmaceutical Sciences

Safety profile and potential favorable reporting signals of liraglutide in patients with ulcerative colitis: A FAERS pharmacovigilance and network pharmacology study

This study raises pharmacovigilance signals and mechanistic hypotheses about liraglutide in people with ulcerative colitis — important because GLP-1 drugs are widely used and are being studied for inflammatory effects....

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