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Colorectal cancer

Colorectal cancer news when it appears alongside Crohn's disease, ulcerative colitis, IBD risk, screening, or surveillance.

Page 2 of 2 · 75 articles

Nonconventional Colorectal Dysplasia Is Less Prevalent and Has a More Limited Morphologic Spectrum in Patients Without Inflammatory Bowel Disease.
Human pathology

Nonconventional Colorectal Dysplasia Is Less Prevalent and Has a More Limited Morphologic Spectrum in Patients Without Inflammatory Bowel Disease.

This study helps distinguish patterns of colorectal dysplasia seen in people without IBD from those seen in IBD, which may affect how pathologists and clinicians interpret biopsy findings and consider cancer risk and...

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The Fecal Immunoassay Occult Blood Test Combined With Calprotectin Sequential Linkage Imaging Endoscopy Screening Strategy for Monitoring Tumor Changes Associated With Long-duration Ulcerative Colitis
ClinicalTrials.gov

The Fecal Immunoassay Occult Blood Test Combined With Calprotectin Sequential Linkage Imaging Endoscopy Screening Strategy for Monitoring Tumor Changes Associated With Long-duration Ulcerative Colitis

This study could validate a noninvasive stool-test strategy (FIT + fecal calprotectin) to triage which long-standing UC patients need colonoscopy, potentially improving surveillance efficiency and adherence.

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Pharmacological modulation of the PD-1/PD-L1 axis: from immune tolerance in colitis to immune escape in colorectal cancer.
European review for medical and pharmacological sciences

Pharmacological modulation of the PD-1/PD-L1 axis: from immune tolerance in colitis to immune escape in colorectal cancer.

The PD‑1/PD‑L1 pathway helps suppress harmful inflammation in IBD but can later allow colorectal tumors to avoid immune attack; understanding this balance matters for patients concerned about long‑term cancer risk and...

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Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.
Materials today. Bio

Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.

IBD and other lower-GI disorders may benefit from oral hydrogel platforms that improve local drug delivery while deliberately engaging the gut microbiota. Understanding this research direction helps patients and...

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Polygenic Risk Scores Show Distinct Genetic Architectures of IBD-Associated Comorbidities.
Digestive diseases and sciences

Polygenic Risk Scores Show Distinct Genetic Architectures of IBD-Associated Comorbidities.

Shows which IBD comorbidities may be driven in part by shared inherited genetic risk and which likely reflect non-genetic factors, information that could shape future risk stratification and screening approaches for...

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Cell cycle dysregulation: a central hub in colitis-associated colorectal carcinogenesis.
Frontiers in immunology

Cell cycle dysregulation: a central hub in colitis-associated colorectal carcinogenesis.

The review connects molecular cell-cycle changes to the progression from chronic IBD to colorectal cancer, pointing to pathways and cell-cycle regulators that could become prevention or treatment targets for...

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Siglec-E functions as a brake for intestinal inflammation to protect from colitis-associated cancer 2260102
The Journal of Immunology

Siglec-E functions as a brake for intestinal inflammation to protect from colitis-associated cancer 2260102

The paper identifies Siglec‑E as an immune brake that limits colitis severity and colitis‑associated tumor development in mice, connecting an immune‑regulatory pathway to inflammation‑driven colorectal cancer risk—an...

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AhR—MMP—NK Cell Crosstalk Regulates Colonic Inflammation and Colitis-Associated Colorectal Cancer Progression 2256044
The Journal of Immunology

AhR—MMP—NK Cell Crosstalk Regulates Colonic Inflammation and Colitis-Associated Colorectal Cancer Progression 2256044

The paper identifies a biologic pathway that links epithelial AhR signaling to NK cell–mediated tumor surveillance in the colon. For people with IBD, mechanisms that increase immune escape could relate to...

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RNA-binding protein RBM47 in health and disease: molecular mechanisms, preclinical evidence, and translational challenges.
Frontiers in immunology

RNA-binding protein RBM47 in health and disease: molecular mechanisms, preclinical evidence, and translational challenges.

Researchers are investigating RBM47 because it influences RNA processing and immune pathways that could modify inflammation and disease processes relevant to IBD. If borne out, RBM47 could become a biomarker or...

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Characterization of Colorectal Dysplasic Lesions and Stratification of Their Evolving Risk in Inflammatory Bowel Disease Patients: a Prospective, Observational and Multicenter Study
ClinicalTrials.gov

Characterization of Colorectal Dysplasic Lesions and Stratification of Their Evolving Risk in Inflammatory Bowel Disease Patients: a Prospective, Observational and Multicenter Study

The study will prospectively evaluate how often dysplasia occurs, how lesions look and behave after endoscopic resection, and what factors predict local or distant recurrence—information that could change surveillance...

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Fluorescent Probes for Intestinal Diseases: Design Strategies, Imaging Mechanisms and Biomedical Applications
Advanced Functional Materials

Fluorescent Probes for Intestinal Diseases: Design Strategies, Imaging Mechanisms and Biomedical Applications

New or improved fluorescent probes could enable more sensitive, noninvasive imaging of biochemical changes in the gut, which may aid research, earlier diagnosis, or monitoring of IBD and colorectal cancer.

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Gegen Qinlian Decoction, a classic traditional Chinese medicine formula: a potential therapeutic strategy for ulcerative colitis and colorectal cancer
Frontiers in Pharmacology

Gegen Qinlian Decoction, a classic traditional Chinese medicine formula: a potential therapeutic strategy for ulcerative colitis and colorectal cancer

This review collects preclinical evidence that a traditional Chinese medicine formula (Gegen Qinlian Decoction) may act on inflammation, the gut barrier, immunity, and microbiota — all relevant to ulcerative colitis and...

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Nanoparticle technologies in the diagnosis and therapy of gastrointestinal diseases: Progress, challenges, and future directions.
Clinica chimica acta; international journal of clinical chemistry

Nanoparticle technologies in the diagnosis and therapy of gastrointestinal diseases: Progress, challenges, and future directions.

Nanoparticle technologies could eventually enable more targeted drug delivery and improved imaging for IBD and related GI diseases, which may lead to better diagnosis and less systemic side effects. However, translation...

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Potential role of PPARGC1A in linking ulcerative colitis to colorectal cancer: a novel prognostic biomarker and therapeutic target.
Translational cancer research

Potential role of PPARGC1A in linking ulcerative colitis to colorectal cancer: a novel prognostic biomarker and therapeutic target.

People with long-standing ulcerative colitis face an increased risk of colorectal cancer; this study highlights PPARGC1A as a gene that may be downregulated early in that progression, which could eventually help identify...

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