Nutrition, food, supplements, exercise, sleep, stress, and lifestyle research for Crohn's disease and IBD.
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The work suggests MSC-derived exosomes may reduce colitis and alter the gut microbiome and metabolites (notably SCFAs) in ways linked to lower inflammation, which could inspire future therapeutic research for IBD.
The study connects microbiome disruptions to new food intolerances in people with IBD in remission, which may explain persistent food-related symptoms despite controlled inflammation and could point to microbiome-based...
This preclinical study suggests raising mesaconate in the gut can reduce inflammation in mouse models of Crohn’s disease, using either an engineered probiotic or a zinc–mesaconate formulation—approaches that could...
Engineered extracellular vesicles are an emerging, targeted therapy approach that could someday improve immune control, mucosal healing, and drug delivery in IBD and reduce colitis-associated cancer risk. The review...
Based on the title and source metadata, this appears to be an observational study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Canadian Association...
Based on the title and source metadata, this appears to be a clinical trial phase 3 related to Ulcerative colitis, Inflammatory bowel disease, and Diet and lifestyle. The original article is from JGH open : an open...
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Crohn's disease, Inflammatory bowel disease, and Microbiome. The original article is from Immunity, inflammation...
The paper suggests that changes in how microbes interact (community plasticity and network structure) may underlie microbiome differences seen in ulcerative colitis and could point toward ecology-informed biomarkers or...
Researchers are exploring ways to deliver steroids like budesonide more precisely to the intestine while avoiding stomach leakage and sudden drug release. If translated to humans, such a formulation could improve local...
Researchers are exploring ways to deliver steroids to the inflamed gut while lowering systemic side effects; a nanoparticle carrier that protects the epithelium and concentrates drug in the colon could, if translated,...
Diet and simple recipes are practical tools many people with IBD use to manage symptoms, maintain nutrition, and feel better day-to-day. Content from the Crohn’s & Colitis Foundation is directly targeted to people...
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease and Diet and lifestyle. The original article is from Cureus.
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Nano Today.
Berries are a familiar, dietary source of anti-inflammatory bioactive compounds that might help reduce intestinal inflammation and improve biomarkers relevant to IBD. Patients often seek safe, complementary strategies...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Microbiome, and Diet and lifestyle. The original article is from Probiotics and Antimicrobial Proteins.
If oxalate in certain plant foods can irritate inflamed intestines or be less well absorbed in IBD, eating large amounts could worsen symptoms for some patients. Awareness can help people track triggers rather than...
Cure8 found this source from crohnscolitisfoundation.org, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Diet and lifestyle. Open the original article for the full details.
Curcumin is a common dietary compound that reaches the colon and may interact with gut bacteria and host immune and barrier pathways implicated in IBD. Understanding these interactions could inform dietary approaches or...
Microbiome patterns in this study were linked to inflammation (fecal calprotectin) and higher chance of needing treatment escalation. If validated, enterotype stratification could help predict disease course or tailor...
This project explores whether common environmental chemicals (PFAS) might change biological processes years before IBD appears, which could help explain some cases of Crohn’s disease and ulcerative colitis and point...
Cure8 found this source from miamiherald.com, but the page could not be read reliably yet. It is tagged for Diet and lifestyle. Open the original article for the full details.
The review links TCM-derived compounds to mechanisms (microbiota, metabolites, immunity) that are implicated in progression from chronic colitis to colorectal cancer, which is an important long-term risk for people with...
People with IBD and RA often try dietary changes to manage symptoms. This trial is testing two very low-carbohydrate approaches to see if they affect symptoms, quality of life, and inflammation, and whether they are...
Diet is a potentially modifiable factor that could affect symptoms, inflammation, and the gut microbiome in ulcerative colitis; this trial aims to test whether a modified Mediterranean diet added to standard therapy...
Eating out can be challenging for people with Crohn's disease because fat content and daily symptom variability affect tolerance. Practical strategies from someone with long-term experience can help other patients...
The study suggests IBD patients can fall into two distinct gut-microbe/metabolite types that align with differences in disease severity and mental-health scores, which could help explain why patients with the same...
The paper describes a novel colon-targeted delivery system that improved local drug retention, reduced dosing frequency, and changed microbiota and metabolic markers in a mouse model of UC — developments that could...
Crohn's is becoming more common among younger Americans and long-term uncontrolled inflammation raises colorectal cancer risk. Understanding possible lifestyle and medical factors can help patients and clinicians focus...
Stories from people living with Crohn’s and another autoimmune condition show how symptoms, testing, treatments and daily planning can intersect — and may help others feel less alone and better prepared for practical...
People with IBD are at increased risk of bone loss; this study points to a microbiome-related pathway (A. muciniphila and an IDA metabolite) that might protect bone in an experimental colitis model, which could...
Localized hydrogel drug delivery aims to concentrate therapy at inflamed gut sites while reducing systemic side effects — a potentially useful approach for people with IBD who have inadequate response or intolerable...
The study explores a novel, non-invasive way to deliver an IL-23–blocking protein to the gut using engineered Lactococcus lactis, which could eventually offer an alternative to systemic biologics for controlling...
The study describes a new nanozyme-based oral formulation that reduced NET formation and improved mucosal healing in a mouse model of ulcerative colitis, suggesting a novel preclinical approach to long‑term...
Nanozyme-based therapeutics are an emerging experimental strategy that aim to reduce oxidative stress and modulate immune responses in the inflamed gut — mechanisms directly relevant to IBD pathophysiology.
Oxidative stress may be a key driver of inflammation in IBD and could point to new biomarkers or adjunctive treatments (dietary changes, antioxidant strategies, or targeted pathways like Nrf2 and ferroptosis) that...
This study explores a novel, non-invasive way to block IL-23 — an important inflammatory driver in IBD — by orally delivering small IL-23 inhibitors using engineered Lactococcus lactis in mouse colitis models.
The study suggests adding a structured 16-week exclusive enteral nutrition plan to ustekinumab treatment may improve short- and medium-term clinical and endoscopic outcomes for adults with moderate-to-severe Crohn’s...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from AMB Express.
This mouse study identifies a plant polysaccharide that reduced colitis-related inflammation and improved colon histology, suggesting potential microbiome and lipid‑metabolism mechanisms that could inform future research...
The review identifies a novel molecular mechanism (S-palmitoylation) that may drive barrier dysfunction and intestinal inflammation in IBD, suggesting new non-immunosuppressive therapeutic targets that could eventually...
The study presents a preclinical strategy to concentrate an existing antihistamine drug in the colon and reduce systemic exposure, which could improve local efficacy and safety for IBD treatment if later validated in...
Researchers report that a polysaccharide from Radix Hedysari reduced inflammation, improved barrier proteins, and shifted gut bacteria in a mouse model of ulcerative colitis — suggesting a potential preventive candidate...
EEN is a common treatment in paediatric Crohn's disease. Understanding the burdens and support needs can help families and clinicians plan practical, social, and school-based supports to improve adherence and experience...
Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Enzyme and Microbial...
Transition from paediatric to adult services is a high-risk period for gaps in care. Consensus recommendations aim to standardise pathways, support young people’s needs, and reduce barriers to effective treatment.
The paper identifies a specific probiotic strain that reduced colitis signs and improved intestinal barrier function in a mouse model, supporting further preclinical and translational work toward microbiome-based...
Personal stories can show how severe and disruptive Crohn’s symptoms can be, and that diagnosis may take time. The account also reinforces that Crohn’s is chronic and may require ongoing medical treatment plus lifestyle...
The study links a common compound in plant foods (oxalate) to intestinal inflammation in IBD, suggesting diet and oxalate metabolism may be modifiable contributors to flares.
