Nutrition, food, supplements, exercise, sleep, stress, and lifestyle research for Crohn's disease and IBD.
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The work suggests that specific gut bacteria or their metabolic products (acetate, putrescine) can limit harmful E. coli expansion and reduce inflammation in a mouse model of colitis, which could inform future probiotic...
Non-invasive fecal lipid markers could help differentiate UC from CD and improve diagnostic molecular profiling in IBD if validated, which may be useful for patients and clinicians seeking less-invasive diagnostic tools.
Someone with Crohn’s disease and limited remaining small intestine may face high-risk surgical choices. This case report suggests a specialized oral supplement used with conservative care was associated with fistula...
This study suggests noninvasive vagus nerve stimulation (taVNS) can reduce colonic inflammation and change immune signals regionally in a mouse model of ulcerative colitis—supporting a possible neuroimmune approach worth...
Micronutrient deficiencies are common in IBD and can worsen anemia, healing, and neurologic function. This study shows inpatient testing focuses on B12 while missing other commonly deficient nutrients (B1, B6, zinc),...
Identifies gene and microbiome patterns linked to progression from inflammation to irreversible bowel fibrosis in Crohn’s disease, which could eventually help predict who is at higher risk and inform prevention...
Fibrosis (irreversible bowel scarring) is a major cause of surgery in Crohn’s disease. This study points to molecular and microbiome patterns that may help predict or distinguish fibrosis from active inflammation, which...
The work points to measurable molecular and microbial patterns that may help distinguish treatable inflammation from progressive fibrosis and suggests AI could aid in building predictive tools from limited samples —...
The probe targets azoreductase-driven hypoxia, a mechanism linked to ulcerative colitis and other hypoxia-associated diseases; a reliable real-time imaging method could help research and eventually guide treatments.
Patients with IBD commonly change or restrict their diets and often want reliable guidance. This study tested automated personalized feedback plus an online nutrition portal and found improved food-related quality of...
This correction updates duplicated data points and clarifies methods in a preclinical synthetic-biology study about engineered materials that secrete therapeutic proteins for IBD, which affects interpretation and...
Malnutrition risk and nutrition insecurity can affect symptom management and overall health for people with IBD. Understanding barriers and supports helps target practical services (dietitians, social resources, digital...
The paper describes a preclinical demonstration that a plant-derived compound reduced inflammation and changed gut microbiota and metabolite profiles in a mouse colitis model, suggesting a possible route for future...
Targeted release of mesalamine to the colon could increase local drug levels and reduce upper-GI exposure and systemic side effects. New delivery platforms may improve effectiveness for ulcerative colitis without...
The study suggests a probiotic strain (Lactobacillus plantarum) reduced inflammation and prolonged remission in multiple mouse models of Crohn’s-like disease, indicating microbiome-based approaches might be promising to...
The study identifies a possible molecular mechanism (THRIL downregulation and inhibition of p38 MAPK/NF-κB) by which a traditional Chinese medicine preparation reduced inflammation in mouse and cell models of colitis,...
Bile acids shaped by gut microbes can influence inflammation and metabolism, so understanding these pathways could lead to new biomarkers or treatments relevant to people with IBD.
Shared gut microbiome shifts across autoimmune diseases could suggest common microbial factors relevant to immune regulation and might eventually inform diagnostics or therapies relevant to people with IBD.
Back-to-school planning can reduce emergencies and missed care for students with chronic conditions, including Crohn’s disease. Preparing plans, communicating with school or campus staff, and knowing where to get care...
AI could help make IBD assessments (endoscopy, histology, imaging, biomarkers) more objective and faster, which may improve monitoring, treatment selection, and early detection of complications for people with Crohn’s...
The study connects common dietary patterns to self‑reported IBD activity and quality of life, suggesting diet may be linked to symptom burden for people with Crohn’s disease and UC/IBDU.
If you have IBD, the mouth and gums may be part of shared inflammatory pathways with your gut. Periodontitis is associated with higher odds of having IBD in cross-sectional studies and has a modest link to later...
The trial tests two low-cost adjuncts — a Lactobacillus probiotic and a multi–trace-element supplement — added to biologic-based standard care to see if they help maintain remission in ulcerative colitis. If effective,...
Smart, stimuli-responsive nanocarriers could one day allow IBD treatments to act more precisely in the gut and limit side effects; that may matter to people hoping for better-targeted therapies or fewer systemic...
This study links population-level IBD epidemiology to gut microbiome changes and proposes a microbial risk score that might help detect or surveil IBD patterns. That could inform future biomarker development or...
This review suggests Aloe vera polysaccharides could support gut barrier repair, microbiome balance, and immune regulation—mechanisms relevant to IBD inflammation and healing. However, evidence is mainly preclinical and...
Nanotechnology approaches aim to improve how cytokine-targeting therapies are delivered in IBD, which could reduce systemic exposure and immunogenicity and increase local effectiveness.
The study suggests a natural flavonoid (DHQ) can protect against DSS-induced colitis in mice and identifies a specific phospholipase-related pathway that may link phospholipid breakdown to epithelial barrier...
Intestinal fibrosis causes strictures that often need surgery and has few effective medical treatments; linking the microbiome to fibrogenesis suggests new prevention or treatment strategies that could reduce surgery...
People with IBD need more than flare control: they also require proactive preventive care (vaccination, cancer screening, bone and nutrition checks, and mental health support) because of risks from chronic inflammation...
Faecal microbiota transfer is being tested in a large Phase 3 trial as a possible new treatment approach for active ulcerative colitis, and this study also looks at safety and how the therapy changes the gut microbiome...
The study presents a gut-targeted bispecific that aims to both block gut-homing/inflammatory signals and activate epithelial repair — a combined approach that could reduce systemic immunosuppression while promoting...
This review pools available human and animal studies on sodium butyrate for ulcerative colitis and highlights promising signals—especially for oral microencapsulated formulations—while noting that clinical evidence is...
The study explores a novel, combined nanozyme + microbiome-derived vesicle approach aimed at reducing oxidative stress and modulating inflammation in IBD — mechanisms that are relevant to disease pathways and future...
People with UC often seek dietary strategies to help manage inflammation; this study uses AI and docking to prioritize polyphenols and foods for future testing, which could guide research and eventually inform dietary...
This review organizes and grades causal evidence linking individual gut bacteria, their metabolites, and host pathways in IBD—helping researchers and clinicians see which microbe–metabolite mechanisms are best supported...
Nutrition affects disease course, symptom burden, complications, and quality of life in IBD. A phenotype-based framework could help clinicians and patients personalize dietary and nutrition interventions more...
If true, the study suggests that long-term air pollution exposure may raise the risk of developing IBD and that greater adherence to a plant-based diet could be linked with a lower pollution-related risk. That may be...
Researchers are exploring non-drug enzyme-like catalysts to reduce oxidative stress in IBD—this study reports a new artificial antioxidase that helped reduce inflammation in cell and animal models, which could point to...
This project seeks to clarify how gut microbes and diet drive CD4+ T cell responses—mechanisms that are central to intestinal tolerance and to diseases like IBD. A better map of TCR–antigen pairs and how tolerance breaks...
Researchers are exploring a way to deliver biologic drugs directly in the gut using engineered B cells that become long-lived plasma cells. If successful, this could allow sustained, localized anti-inflammatory protein...
Researchers are studying whether everyday microplastic exposure could worsen gut barrier injury in IBD and contribute to inflammatory or mental-health effects linked by the gut–brain axis.
Noninvasive stool metabolite patterns could eventually help predict which people with Crohn’s disease are more likely to develop strictures or penetrating complications, and may offer markers of disease activity and...
ILD is a potentially serious extraintestinal complication that appears more often with ulcerative colitis than with Crohn’s disease in this cohort study. Patients with both IBD and ILD had higher healthcare use and...
This preclinical study links cod skin–derived collagen peptides to reduced colitis severity in mice through changes in the gut microbiota and suppression of the NLRP3 inflammasome — pathways that could be relevant to...
Researchers are exploring ways to produce anti-inflammatory proteins directly at inflamed gut sites; this study describes a nanomaterial system intended to protect plasmid drugs and supply oxygen to sustain local protein...
This study explores a multi-component traditional medicine that the authors report can reduce experimental colitis and modulate inflammatory signaling and the gut microbiome — findings that could guide future preclinical...
This study reports an early-stage nanoplatform that combines targeted colon delivery of an aminosalicylate prodrug with scavenging of proinflammatory cfDNA, a dual strategy that reduced colitis severity in mice and could...
