Condition

Inflammatory bowel disease

Broader IBD news covering Crohn's disease, ulcerative colitis, research, treatments, monitoring, and patient care.

Page 19 of 88 · 4178 articles

Low Phase angle is a marker of deteriorated nutritional status and indicates a more active and endoscopically severe inflammatory bowel disease.
Clinical nutrition ESPEN

Low Phase angle is a marker of deteriorated nutritional status and indicates a more active and endoscopically severe inflammatory bowel disease.

Phase angle, an easy-to-measure BIA parameter, was lower in IBD patients with malnutrition and higher disease activity. Detecting malnutrition earlier could matter for patients' strength, healing, and overall outcomes.

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A bioactive lysate of Corynebacterium glutamicum orchestrates intestinal barrier repair mainly through L-arginine-mediated FOXO pathway.
Food research international (Ottawa, Ont.)

A bioactive lysate of Corynebacterium glutamicum orchestrates intestinal barrier repair mainly through L-arginine-mediated FOXO pathway.

The study suggests a bacterial lysate and L-arginine can restore intestinal barrier function in cell and mouse models — a process that could be relevant to IBD because barrier dysfunction contributes to disease activity.

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Drug Induced Myelosuppression and Alopecia Totalis in Ulcerative Colitis Patient: Unmasking the Enigma
Open Access Journal of Pharmaceutical Sciences and Drugs

Drug Induced Myelosuppression and Alopecia Totalis in Ulcerative Colitis Patient: Unmasking the Enigma

The report highlights a serious drug-related complication (pancytopenia/myelosuppression and hair loss) in a patient treated with azathioprine plus sulfasalazine for ulcerative colitis, suggesting clinicians and patients...

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Subcutaneous infliximab for maintenance therapy in children and adolescents with inflammatory bowel disease: a systematic review and meta-analysis.
European journal of pediatrics

Subcutaneous infliximab for maintenance therapy in children and adolescents with inflammatory bowel disease: a systematic review and meta-analysis.

Children with IBD and their caregivers may be interested in subcutaneous infliximab as an alternative to regular IV infusions because this review suggests it can maintain drug levels and remission after switching, with...

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AI-generated guidance for non-specialist physicians managing inflammatory bowel disease: expert evaluation and case-based testing of GPT-4 and DeepSeek.
Digestion

AI-generated guidance for non-specialist physicians managing inflammatory bowel disease: expert evaluation and case-based testing of GPT-4 and DeepSeek.

Non-specialist physicians often manage IBD where specialists are scarce. If reliable, AI tools could improve non-specialists' clinical reasoning and decision-making for IBD care.

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Bayesian Inference of Differential Metabolic Fluxes in Ulcerative Colitis using High-throughput Transcriptomics Data
Open Engineering Inc

Bayesian Inference of Differential Metabolic Fluxes in Ulcerative Colitis using High-throughput Transcriptomics Data

New computational tools that tie gene-expression to metabolic flux could help researchers identify metabolic pathways or biomarkers linked to ulcerative colitis, which might eventually inform research on disease...

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Nanoencapsulated flavonoids for inflammatory bowel disease: a targeted approach toward clinical application
npj Science of Food

Nanoencapsulated flavonoids for inflammatory bowel disease: a targeted approach toward clinical application

Nanoencapsulated flavonoids are proposed as a way to improve delivery of biologically active dietary compounds to the inflamed gut in IBD; a rational design framework could accelerate translation from bench research to...

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Differential Enteric Glial and Mast Cell Characteristics Distinguish Microscopic Colitis Subtypes Relative to Healthy and Disease Controls, with Treatment-Associated Reductions in Glial Reactivity and Mast Cell Degranulation in Collagenous Colitis
Cells

Differential Enteric Glial and Mast Cell Characteristics Distinguish Microscopic Colitis Subtypes Relative to Healthy and Disease Controls, with Treatment-Associated Reductions in Glial Reactivity and Mast Cell Degranulation in Collagenous Colitis

The paper identifies subtype-specific changes in enteric glial cells and mast cell activity in microscopic colitis and shows some treatment-associated reductions after budesonide; that helps explain disease biology and...

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No Independent Association Between Serum Zinc Levels and Endoscopic Disease Activity Assessed by the Ulcerative Colitis Endoscopic Index of Severity: A Single-Center Retrospective Study
GE - Portuguese Journal of Gastroenterology

No Independent Association Between Serum Zinc Levels and Endoscopic Disease Activity Assessed by the Ulcerative Colitis Endoscopic Index of Severity: A Single-Center Retrospective Study

The study suggests that serum zinc by itself may not be a reliable indicator of endoscopic inflammation in UC; nutritional status and inflammation (for example albumin and CRP) can confound zinc levels.

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Influencing factors of health-related productivity loss among patients with inflammatory bowel disease in paid employment based on the theory of social ecosystem: a mixed-methods study.
Minerva gastroenterology

Influencing factors of health-related productivity loss among patients with inflammatory bowel disease in paid employment based on the theory of social ecosystem: a mixed-methods study.

Work-related productivity loss was common in this study and linked to both clinical (disease activity, strictures, fatigue) and psychosocial factors (anxiety, depression, self-efficacy, social support).

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Decoding Personalized Nutritional, Microbiome and Host Patterns Impacting Clinical and Prognostic Features in Crohn's Disease
ClinicalTrials.gov

Decoding Personalized Nutritional, Microbiome and Host Patterns Impacting Clinical and Prognostic Features in Crohn's Disease

Understanding how individual diet and microbiome patterns relate to disease activity could help create personalized dietary approaches for children with Crohn's disease and improve monitoring using home fecal...

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A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis
ClinicalTrials.gov

A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis

This trial investigates a new oral medication (PALI-2108) for moderate-to-severe ulcerative colitis and could expand treatment options if later trials show benefit and safety. The study focuses on clinical remission at...

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Clinical utility of serum leucine-rich alpha-2 glycoprotein for assessing disease activity and mucosal healing in ulcerative colitis across different treatment settings: a prospective observational cohort study
BMC Gastroenterology

Clinical utility of serum leucine-rich alpha-2 glycoprotein for assessing disease activity and mucosal healing in ulcerative colitis across different treatment settings: a prospective observational cohort study

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Tests and monitoring. The original article is from BMC Gastroenterology.

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Stratified by baseline corticosteroid use: which advanced therapy works best for whom in ulcerative colitis?
Frontiers in Medicine

Stratified by baseline corticosteroid use: which advanced therapy works best for whom in ulcerative colitis?

The review suggests baseline corticosteroid use may change how well some advanced UC therapies work, especially IL-23 inhibitors and S1P modulators, which could affect treatment choices and trial reporting.

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Efficacy and Safety of Mirikizumab for Induction and Maintenance of Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Journal of Enterocolitis

Efficacy and Safety of Mirikizumab for Induction and Maintenance of Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Mirikizumab showed higher rates of clinical and endoscopic remission than placebo in pooled randomized trials, which could expand treatment options for people with moderate-to-severe ulcerative colitis if confirmed by...

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Probiotic Intervention With Bacillus coagulans and Lactobacillus acidophilus in Small Animals Experimental Ulcerative Colitis: Insights From a Small Animal Model
Veterinary Medicine and Science

Probiotic Intervention With Bacillus coagulans and Lactobacillus acidophilus in Small Animals Experimental Ulcerative Colitis: Insights From a Small Animal Model

An animal study found two probiotic strains reduced inflammation and inflammasome markers in an experimental ulcerative colitis model, which could inform veterinary treatments and early-stage research relevant to IBD.

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Transient Elastography for Liver Fibrosis and Steatosis in Inflammatory Bowel Disease: Current Evidence, Clinical Implications, and Future Directions
Journal of Enterocolitis

Transient Elastography for Liver Fibrosis and Steatosis in Inflammatory Bowel Disease: Current Evidence, Clinical Implications, and Future Directions

FibroScan detects liver fibrosis and steatosis that are common and sometimes under-recognized in people with IBD; identifying liver disease earlier could change monitoring or referral decisions, especially for patients...

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The Role of Astrocytes in Inflammatory Bowel Disease and Co-occurring Depression: Mechanisms and Perspectives
Cellular and Molecular Neurobiology

The Role of Astrocytes in Inflammatory Bowel Disease and Co-occurring Depression: Mechanisms and Perspectives

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Depression, and Research and clinical trials. The original article is from Cellular and Molecular...

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Long-term clinical outcomes of stem cell-based interventions in Crohn's-related perianal fistula: A systematic review and meta-analysis.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Long-term clinical outcomes of stem cell-based interventions in Crohn's-related perianal fistula: A systematic review and meta-analysis.

Perianal fistulas in Crohn’s disease are often hard to treat; this review suggests stem cell therapies can produce durable closure for many patients and appear safe over 1–4 years of follow-up.

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B.C. couple gives $10 million gift for digestive health centre at St. Paul's Hospital - Vancouver Sun
vancouversun.com

B.C. couple gives $10 million gift for digestive health centre at St. Paul's Hospital - Vancouver Sun

A dedicated Digestive Health Centre could make it easier for people with IBD (including children and teens) to access coordinated care—fewer separate visits and more centralized specialist services in one location.

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Brief report: Effectiveness and safety of recombinant zoster vaccine in inflammatory bowel disease patients aged 18 years and older: A matched cohort and self-controlled case series study.
Human vaccines & immunotherapeutics

Brief report: Effectiveness and safety of recombinant zoster vaccine in inflammatory bowel disease patients aged 18 years and older: A matched cohort and self-controlled case series study.

People with IBD are at higher risk for shingles; this study suggests the recombinant zoster vaccine reduces that risk and did not increase short-term IBD flares in the populations studied. That could inform vaccine...

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Effectiveness, safety, and clinical outcomes of treatment with the oral α4-integrin antagonist carotegrast methyl in patients with active ulcerative colitis: a multicenter observational study (CANAL study)
Inflammatory Bowel Diseases

Effectiveness, safety, and clinical outcomes of treatment with the oral α4-integrin antagonist carotegrast methyl in patients with active ulcerative colitis: a multicenter observational study (CANAL study)

This study provides real-world data suggesting the oral α4-integrin antagonist carotegrast methyl can improve patient-reported stool frequency and rectal bleeding in many people with ulcerative colitis who did not...

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Patient Perspectives on Climate Change and Sustainable Healthcare Practices: A Cross-Sectional Survey Study in Patients with Inflammatory Bowel Disease.
Journal of gastrointestinal and liver diseases : JGLD

Patient Perspectives on Climate Change and Sustainable Healthcare Practices: A Cross-Sectional Survey Study in Patients with Inflammatory Bowel Disease.

Many IBD patients in this survey expressed concern about climate change and willingness to support sustainable healthcare options—information that could influence how care pathways, device reuse, or treatment-choice...

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Empirical anti-TNF dose intensification in inflammatory bowel disease: real-world outcomes from a resource-limited setting.
Journal of gastrointestinal and liver diseases : JGLD

Empirical anti-TNF dose intensification in inflammatory bowel disease: real-world outcomes from a resource-limited setting.

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Anti-TNF, and Medications. The original article is from Journal of gastrointestinal and liver diseases :...

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Evaluation of a Mental Health Care App-Based Fatigue Management Program for Patients With Inflammatory Bowel Disease in Remission: Protocol for a Randomized Controlled Trial.
JMIR research protocols

Evaluation of a Mental Health Care App-Based Fatigue Management Program for Patients With Inflammatory Bowel Disease in Remission: Protocol for a Randomized Controlled Trial.

Fatigue greatly affects quality of life for people with IBD even in remission; if effective and scalable, a mobile CBT program could offer accessible symptom support. The trial will also examine engagement factors...

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A Comprehensive Self-Management Intervention for Individuals With Inflammatory Bowel Disease
ClinicalTrials.gov

A Comprehensive Self-Management Intervention for Individuals With Inflammatory Bowel Disease

Self-management programs that teach cognitive behavioral strategies, symptom tracking, relaxation, sleep and diet skills could help people with IBD manage symptoms and day-to-day quality of life without relying solely on...

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Palisade Bio to Present Clinical and Translational Data for PALI-2108 in Ulcerative Colitis and Crohn’s Disease at UEG Week 2026
finance.yahoo.com

Palisade Bio to Present Clinical and Translational Data for PALI-2108 in Ulcerative Colitis and Crohn’s Disease at UEG Week 2026

This press release announces upcoming presentations of early clinical and biomarker data for PALI-2108, a gut‑targeted oral PDE4 prodrug being developed for UC and Crohn’s disease. Patients and clinicians may see new...

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Heat-Inactivated Lacticaseibacillus paracasei PC-01 Alleviates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Intestinal Barrier Function
Nutrients

Heat-Inactivated Lacticaseibacillus paracasei PC-01 Alleviates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Intestinal Barrier Function

This preclinical study suggests a heat‑inactivated probiotic strain reduced colitis signs in mice and changed gut microbes and inflammatory pathways—findings that could inform future research into microbiome‑based or...

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Lactiplantibacillus plantarum Lp05 ensures immune developmental safety and protects against colitis via promoting Treg differentiation in mice
Microbiology Spectrum

Lactiplantibacillus plantarum Lp05 ensures immune developmental safety and protects against colitis via promoting Treg differentiation in mice

This preclinical study suggests a specific probiotic strain (Lp05) can increase regulatory T cells and reduce inflammation in a mouse colitis model, which could point to new microbiome-based approaches for IBD in the...

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Trpv1 deficiency aggravates intestinal barrier dysfunction and fibrosis in HFD-fed colitis mice via miR-31/Wnt16 signaling
Cell & Bioscience

Trpv1 deficiency aggravates intestinal barrier dysfunction and fibrosis in HFD-fed colitis mice via miR-31/Wnt16 signaling

The study suggests a specific macrophage pathway (TRPV1→miR‑31/Wnt16) by which high‑fat diets may worsen intestinal inflammation and fibrosis, offering possible targets for future IBD research relevant to patients with...

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