Evidence types
Clinical study articles covering observational research, trial reports, and human data relevant to Crohn's disease and IBD.
Page 10 of 21 · 1008 articles
If you or your clinician are using upadacitinib for Crohn’s, intestinal ultrasound early in treatment may help predict who will not respond and who is more likely to relapse on maintenance dosing, potentially guiding...
If confirmed, a simple calprotectin test on fistula scrapings could help predict which Crohn’s patients are likely to heal after primary surgical fistula closure and which may need additional therapies, potentially...
The study suggests that in some people with IBD who have Candida overgrowth, systemic antifungal therapy (fluconazole) can change gut microbes and metabolites in ways linked to better disease activity over 8 weeks. That...
This study maps cell types in newly diagnosed pediatric Crohn's and links diagnostic cell patterns to disease severity and anti‑TNF treatment response. That could help predict which children are likely to benefit from...
Cure8 found this source from The lancet. Gastroenterology & hepatology, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Research and clinical trials. Open the original article...
This study explores genetic risk variants (NOD2/CARD15) and local environmental factors (khat use) among young adults with IBD in Djibouti — information that may help explain regional differences in Crohn’s disease and...
Altered tryptophan metabolism and AhR signaling were linked to fecal-water-induced DNA damage in IBD samples, suggesting a possible pathway connecting inflammation and epithelial genotoxic stress — a mechanism relevant...
A cellular atlas that links diagnostic biopsy cell states to treatment outcomes could help predict which children are likely to have severe or anti‑TNF‑resistant Crohn's disease, informing future research on personalized...
This study maps cell-level signatures in newly diagnosed pediatric Crohn’s and links them to later severity and responses to anti-TNF treatment, which could help predict which children will respond to biologic therapy...
This matters because many patients and clinics face procurement-driven switches from reference biologics to biosimilars; early evidence here suggests short-term outcomes and treatment persistence are similar after...
Accurate recognition and standardized reporting of IBD-associated dysplasia help guide surveillance and surgical decisions because some dysplastic variants are flat, endoscopically invisible, and linked to advanced or...
JAK inhibitors are used to treat IBD and act broadly on immune signalling; understanding their cell-specific effects may explain who benefits, who doesn’t, and why adverse effects occur. This is directly relevant to...
This study looks at how immunomodulators are actually used with biologic drugs in real-world practice when a national reimbursement policy forces biologic interruptions.
Depressive symptoms during remission were associated with worse long-term physical, mental, and disease-specific quality of life, so attending to mental health can matter for overall wellbeing in IBD.
Patient-derived intestinal organoids offer a human-relevant platform that could improve understanding of pediatric IBD biology and help predict individual treatment responses — potentially reducing trial-and-error...
Anaemia is a common and impactful complication in children diagnosed with IBD; knowing how often it occurs, which subtypes are most frequent, and its link with disease activity can guide monitoring and management...
Spiritual and existential concerns can affect coping and quality of life for people with IBD, but these needs are rarely assessed systematically. Validated, culturally adapted questionnaires could help clinicians and...
The study identifies distinct fecal bile acid signatures in CRC versus UC that might help develop noninvasive tests to distinguish malignancy from chronic inflammatory disease of the colon.
The findings suggest blood DNA methylation changes may mark UC long before symptoms start; that could eventually enable earlier risk identification or research into preventing progression to symptomatic disease.
The letter highlights salidroside as a potential multi-target agent that could modulate neuro-immune interactions and protect the gut barrier — mechanisms relevant to ulcerative colitis. Patients and clinicians may see...
People with diabetes and fatty liver disease may eventually benefit from new adjunctive therapies that target liver inflammation, fibrosis, and oxidative stress; this study reports promising preclinical signals for a...
Surgery is common in Crohn’s disease and timing may relate to disease severity and long-term outcomes. Understanding factors linked to early surgery helps patients and clinicians weigh risks and expectations after...
Distinguishing acute infectious gastroenteritis from new‑onset IBD can be clinically challenging. Faecal biomarkers that help tell these apart could speed correct diagnosis and treatment and avoid unnecessary...
The study suggests Crohn’s disease is associated with altered brain network organization in regions involved in sensing the body and emotions; anxiety appears to modulate these brain circuits. This could help explain why...
Preclinical work identified a plant-root extract fraction that reduced inflammation and improved some gut-barrier and microbiome features in a mouse model of ulcerative colitis, which could guide future research into new...
Improving oral delivery and colon targeting of probiotics could make probiotic therapies more effective for ulcerative colitis by increasing survival through the gut and retention at inflamed sites. If translated to...
Identifying Giardia genotypes linked to more severe symptoms could matter for people with IBD or recurrent intestinal infections because different assemblages may relate to symptom severity and could influence diagnostic...
The study suggests that genetic and single-cell signatures of cellular senescence may affect IBD susceptibility, pointing to possible new biomarkers or pathways relevant to disease risk and future therapies.
For people with UC on long-term tofacitinib, this trial provides evidence about the chances of keeping remission after stepping down dose and about safety differences between 10 mg and 5 mg twice daily over 30 months.
Patients with UC who appear healed on endoscopy can still relapse; a biopsy-based model could help separate lower- and higher-risk patients and guide monitoring or research enrollment.
The work searches for shared blood-based gene signatures and biomarkers across HLA-B27–linked diseases (including Crohn’s disease and ulcerative colitis), which could point to common mechanisms or cross-disease...
The study suggests that polyphenols can change gut bacteria and metabolite production differently in people with IBD versus healthy controls, which could matter for designing personalized dietary interventions.
Clostridium difficile infection is an important and potentially serious complication in ulcerative colitis. A blood‑marker–based risk model could help identify higher‑risk patients noninvasively so clinicians can...
Different protein sources may affect IBD risk and relapses, especially for ulcerative colitis, and diet choices could be relevant to patients and clinicians managing IBD.
Distinguishing UC from Crohn’s colitis can be challenging but affects long-term management and surveillance. A histologic feature—homogeneity versus heterogeneity of epithelial lesions across biopsies—might help improve...
Cure8 found this source from Endoscopy, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Research and clinical trials. Open the original article for the full details.
The review summarizes how extracellular vesicles (EVs) shape immune responses and barrier repair in the gut and discusses their potential as accessible biomarkers and as vehicles for precise IBD therapies — topics that...
A wearable sensor that reliably measures inflammation markers (CRP and calprotectin) from sweat could make inflammation monitoring less invasive and more frequent for people with IBD, potentially helping detect flares...
People with IBD may be interested because the article describes a potential new probiotic genus (Weissella) that has preclinical effects on inflammation and mucosal healing—areas relevant to managing flares and...
The review proposes a low-cost, non-immunosuppressive adjunctive strategy targeting the gut microbiome and luminal metabolism to help maintain remission in UC, an area of strong patient interest but limited clinical...
Smoking is a known risk factor for Crohn’s recurrence after bowel surgery. This study suggests newer products marketed as potentially safer (HNBT and e-cigarettes) were also linked to higher postoperative endoscopic...
Clinical trials shape available treatments and evidence; if groups of children (by race, ethnicity, or sex) are underrepresented, study results may not reflect how treatments work for them. This paper identifies...
If you’re stable on ustekinumab for Crohn’s disease, this multicenter study found that switching to an approved biosimilar produced similar 6-month remission and safety outcomes to staying on the original product. That...
Cure8 could only read part of this source from The American Journal of Gastroenterology, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Inflammatory bowel disease, and...
AI tools are being tailored to IBD care; this study suggests supervised fine-tuned LLMs may help with patient communication and workflow but currently lack reliable diagnostic accuracy. Patients and clinicians should...
Understanding PTMs may help researchers identify new biomarkers or therapeutic targets for ulcerative colitis, which could eventually lead to better treatments or tests. For people with UC, this explains part of why...
This study reports preclinical evidence that an herbal extract (EGST) reduced inflammation and epithelial cell ferroptosis in a mouse model of ulcerative colitis and in cell experiments, implicating the PPARγ/GPX4...
Registries that automatically extract clinical data with AI/NLP can speed research, help identify patient cohorts for studies or trials, and may eventually support better clinical decision-making for people with IBD....
