Evidence types
Clinical study articles covering observational research, trial reports, and human data relevant to Crohn's disease and IBD.
Page 11 of 21 · 1008 articles
The study identifies abnormal epithelial cell–death signaling that persists despite current therapies and may help explain why many people with IBD relapse. If validated, these pathways could point to new biomarkers or...
If you have overweight or obesity, this study suggests measurable blood proteins linked to inflammation may be associated with higher future risk of ulcerative colitis. Identifying such markers could help research on...
People with IBD and other immune conditions may develop weaker or lower‑quality antibody responses after COVID‑19 vaccination compared with healthy people, and transplant recipients showed the largest impairments. That...
Measures used in trials and care often miss what patients value most — daily function and quality of life. Learning from IBD and RA could lead to asthma outcome measures and trials that reflect patient priorities, which...
Pathology after fecal diversion can look like active IBD, which affects diagnosis and management of the diverted rectum. This study helps clarify when changes likely reflect diversion alone versus persistent inflammatory...
A strategic, pediatric-focused research agenda helps target studies where children with IBD and related conditions most need better diagnostics, biomarkers, and treatments. Prioritizing multi-center registries and...
The paper proposes ISG20 as a shared molecular link between RA and IBD, which could help explain why the two diseases co-occur and point to a candidate biomarker for identifying patients at risk of both conditions.
Diet quality was linked to gut microbiome features and exploratory differences in inflammatory markers and symptoms in adults with Crohn disease from Puerto Rico; understanding these links may help tailor dietary...
Tools that reliably measure self-care self-efficacy can help clinicians identify IBD patients who may benefit from extra self-management support. A brief, validated 10-item scale is practical for busy clinics and...
Patients, clinicians, and payers may care because the analysis addresses the relative economic value of two approved biologic options (vedolizumab and risankizumab) for Crohn’s disease treatment in Italy and could...
Because having a sibling with Crohn's disease during childhood was linked to substantially higher risk of developing Crohn's later, and the study points to early-life microbiome differences and elevated faecal...
The paper describes plant-derived compounds that reduced inflammation and partly corrected gut microbiome disturbances in lab and mouse models of colitis, suggesting a possible route to microbiome-targeted IBD therapies...
Biomarker discordance is common in treat-to-target IBD care; understanding which tests reflect local gut inflammation versus systemic response can help avoid unnecessary treatment changes and guide targeted...
PSC is closely linked with IBD (especially ulcerative colitis); understanding mechanisms that damage bile ducts could point to new future therapies or biomarkers.
If you or a patient is about to start infliximab for ulcerative colitis, routine blood counts may help identify those unlikely to respond to induction therapy; a high negative predictive value suggests these markers...
The study shows that mucosal CD3+ T‑cell density is higher in dogs with an IBD-like condition than in healthy dogs, suggesting mucosal T‑cell infiltration is part of the disease but may not reflect how sick an individual...
The study suggests that modifiable early-life factors (feeding, antibiotic exposure, activity, BMI, smoke exposure, delivery mode, diet) may influence the later risk of IBD, especially Crohn's disease, which could be...
Basal crypt dysplasia is easy to miss but linked to higher risk of advanced colorectal neoplasia in longstanding IBD. Improved recognition and use of p53 immunohistochemistry or complementary biomarkers could affect...
NUDT15 genotyping can identify people at high risk of severe thiopurine-induced myelosuppression; if cost-effective, testing could change how clinicians choose or dose thiopurines for IBD, potentially preventing serious...
This preclinical study suggests a traditional medicinal plant extract may reduce inflammation and tissue damage in an experimental model of ulcerative colitis, which could guide future drug-discovery research relevant to...
Researchers used laboratory mouse and cell models to show that total glucosides of paeony (TGP) may reduce inflammation linked to ulcerative colitis and identified molecular pathways (COX‑2/arachidonic acid, NF‑κB, MAPK,...
TL1A-DR3 is implicated in both inflammation and fibrosis in IBD, so targeting it could address active disease and reduce fibrotic complications that lead to strictures. New TL1A-blocking antibodies are already in...
Cure8 found this source from The Journal of investigative dermatology, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease, Genetics and genomics, and Research and clinical trials....
Vitamin D deficiency was common among Albanian patients with IBD and showed a weak inverse association with disease activity in ulcerative colitis, suggesting vitamin D status may relate to symptom burden or...
If validated, an imaging-derived adipose heterogeneity biomarker could help predict who will lose response to infliximab after induction, potentially guiding earlier treatment decisions and personalized monitoring for...
This paper explores whether individualized integrative management including traditional Chinese medicine might influence outcomes in patients with biologic‑refractory, surgery‑intended acute severe ulcerative colitis — a...
The study points to three bile-acid–related genes that may be linked to inflammation in ulcerative colitis and could serve as biomarkers or targets for future research into disease mechanisms and patient stratification.
This review summarizes human evidence that pesticides in the diet could affect the gut microbiome and may be linked to gastrointestinal outcomes including IBD; strongest consistent signals were for organochlorine...
The work aims to predict relapse and personalize herbal maintenance dosing for UC, which matters because better risk stratification and tailored management could reduce relapses and avoid unnecessary treatment changes.
Researchers are exploring a gut microbe–derived lipid (SoL A) that may reduce inflammation relevant to IBD. If development succeeds, it could point to new, microbiome-based therapeutic approaches for people with Crohn’s...
The project aims to enable simultaneous RNA-level profiling of microbes and host cells from human biopsies, which could reveal early microbial and host gene-expression patterns linked to subclinical Crohn’s disease and...
The study links a common plant compound (oxalate) to higher stool levels and worse inflammation in IBD, suggesting diet and gut handling of oxalate could affect disease activity and that microbiome-targeted strategies...
Adding a mesalazine retention enema to oral mesalazine improved short-term symptom relief and endoscopic signs of mucosal healing in mild-to-moderate left-sided ulcerative colitis in this retrospective study. That could...
CT-detected terminal ileitis was due to Crohn’s disease in only a small minority (12.5%) of cases in this cohort, so most patients with this imaging finding will need further testing to determine the cause.
Blood biomarkers that predict vedolizumab response could help patients and clinicians choose the most effective therapy sooner and avoid ineffective treatments. The study suggests LRG and MCP‑1 may differentiate...
If you have moderate–severe ulcerative colitis, this study suggests that typical phase III trials may exclude more than half of patients seen in specialty clinics, which can make trial results less representative of...
This paper explores whether polygenic risk scores (PRS) predict key long-term outcomes after IBD diagnosis — notably intestinal surgery — which could be relevant for risk stratification research and future clinical tools...
AI chatbots are increasingly used for health information. If chatbot answers about IBD nutrition are inaccurate or hard to read, patients could be confused or misinformed. This study assesses those risks for ChatGPT-3.5.
Faster, more accurate chart abstraction could speed IBD research and quality monitoring while reducing reviewer workload and errors, which may help registries and studies that rely on manually curated EHR data.
This study suggests that circulating monocytes in newly diagnosed Crohn’s disease are transcriptionally and epigenetically reprogrammed toward inflammatory behaviour before they reach the gut, which could help explain...
Prebiotics change how gut microbes ferment carbohydrates and produce metabolites that can affect gut health. For people with IBD, a prebiotic that is well fermented by their microbiota, increases beneficial bacteria and...
The work highlights a dietary polysaccharide that reduced inflammation and improved mucosal barrier function in a mouse colitis model through gut-microbiota changes — a mechanism relevant to IBD research and potential...
Noninvasive intestinal ultrasound with superb microvascular imaging (SMI) may help predict the presence and size of endoscopic ulcers in the terminal ileum of people with Crohn’s disease. That could improve noninvasive...
Early-onset IBD affects children worldwide and the commentary highlights that although deaths are declining, more children are living with IBD and social inequalities are widening — issues that can affect access to care,...
This study suggests that using 5‑ASA drugs early in children with Crohn’s disease was common but linked to more steroid use, delayed biologic treatment, and lower biologic durability — outcomes that matter for long‑term...
Cure8 found this source from Gut, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Research and clinical trials. Open the original article for the full details.
People with IBD often face mental-health challenges, stigma and unpredictability of symptoms. Adapting an established CBT-based digital programme with direct input from patients and clinicians can make the content more...
NUDT15 variants strongly affect how people metabolize thiopurine drugs used in IBD; knowing variant frequency helps decide whether routine pre-treatment genotyping is useful in Iran and among specific ethnic groups.
